| Date . | Medication . | ACTH (normal range 6-50 pg/ml; 1.32-11 pmol/L) . | Cortisol (normal range 4-22 µg/dL; 110-607 nmol/L) . | DHEA-S (normal range 15-205 µg/dL; 408-5578 nmol/L) . | 24-hour UFC (normal range 4-50 µg/24 hours; 11-138 nmol/24 hours) . | Symptoms . |
|---|---|---|---|---|---|---|
| 2015 | None | <5 pg/ml (<1.1 pmol/L) | 17.8 µg/dL (491 nmol/L) | N/A | 217 µg (599 nmol) | Weight gain, hypertension, hirsutism, acne, irregular menses |
| Sept. 2015 | Unknown mifepristone dose | N/A | N/A | N/A | 7.6 µg (21 nmol) | None |
| Aug. 2021 | Mifepristone 900 mg daily | 10 pg/ml (2.2 pmol/L) | 12.8 µg/dL (353 nmol/L) | 48 µg/dL (1306 nmol/L) | 11 µg (30 nmol) | Vague symptoms |
| Sept. 3, 2021 | Started osilodrostat 2 mg twice daily | N/A | N/A | N/A | N/A | None |
| Sept. 17, 2021 | Osilodrostat 2 mg twice daily | <5 pg/ml (<1.1 pmol/L) | 26.7 µg /dL (737 nmol/L) | 102 µg/dL (2776 nmol/L) | 372.1 µg (1026.5 nmol) | None |
| Oct. 4, 2021 | Increased osilodrostat 3 mg twice daily | N/A | N/A | N/A | N/A | None |
| Oct. 18, 2021 | Osilodrostat 3 mg twice daily | <5 pg/ml (<1.1 pmol/L) | 30.3 µg/dL (836 nmol/L) | 138 µg/dL (3755 nmol/L) | 912.8 µg (2518 nmol) | Hypertension, hirsutism |
| Oct. 29, 2021 | Increased osilodrostat to 4 mg twice daily | N/A | N/A | N/A | N/A | Hypertension, hirsutism |
| Nov. 11, 2021 | Osilodrostat 4 mg twice daily: increased to 6 mg twice daily | <5 pg/ml (<1.1 pmol/L) | 33.7 µg/dL (929 nmol/L) | N/A | 1043 µg (2877 nmol) | Hypertension, hirsutism, weight gain |
| Nov. 29, 2021 | Increased osilodrostat to 8 mg twice daily | N/A | N/A | N/A | N/A | Hypertension, hirsutism |
| Dec. 9, 2021 | Osilodrostat 8 mg twice daily, increased to 10 mg twice daily | 1.1 pg/ml (0.24 pmol/L) | 16.1 µg/dL (444 nmol/L) | N/A | N/A | None |
| Dec. 28, 2021 | Osilodrostat 10 mg twice daily | <5 pg/ml (<1.1 pmol/L) | 9.1 µg/dL (251 nmol/L) | 10.2 µg/dL (278 nmol/L) | N/A | None |
| Jan. 26, 2022 | Stopped osilodrostat, start hydrocortisone | N/A | 2.3 µg/dL (63 nmol/L) | N/A | N/A | Nausea |
| Feb. 25, 2022 | Hydrocortisone 10 mg twice daily | 6 pg/ml (1.3 pmol/L) | 5.2 µg/dL (143 nmol/L) | N/A | N/A | None |
| March 3, 2022 | Hydrocortisone 10 mg twice daily | 42 pg/ml (9.2 pmol/L) | 3.5 µg/dL (97 nmol/L) | 7 µg/dL (190 nmol/L) | N/A | None |
| March 23, 2022 | Hydrocortisone 10 mg twice daily | 25 pg/ml (5.5 pmol/L) | 3.9 µg/dL (108 nmol/L) | N/A | N/A | None |
| May 12, 2022 | Hydrocortisone 10 mg twice daily | 100 pg/ml (22 pmol/L) | 5.6 µg/dL (154 nmol/L) | 3 µg/dL 82 nmol/L) | N/A | None |
| July 11, 2022 | Hydrocortisone 10 mg twice daily | 79 pg/ml (17.4 pmol/L) | 5.5 µg/dL (151 nmol/L) | N/A | 4.3 µg (11.9 nmol) | None |
| Date . | Medication . | ACTH (normal range 6-50 pg/ml; 1.32-11 pmol/L) . | Cortisol (normal range 4-22 µg/dL; 110-607 nmol/L) . | DHEA-S (normal range 15-205 µg/dL; 408-5578 nmol/L) . | 24-hour UFC (normal range 4-50 µg/24 hours; 11-138 nmol/24 hours) . | Symptoms . |
|---|---|---|---|---|---|---|
| 2015 | None | <5 pg/ml (<1.1 pmol/L) | 17.8 µg/dL (491 nmol/L) | N/A | 217 µg (599 nmol) | Weight gain, hypertension, hirsutism, acne, irregular menses |
| Sept. 2015 | Unknown mifepristone dose | N/A | N/A | N/A | 7.6 µg (21 nmol) | None |
| Aug. 2021 | Mifepristone 900 mg daily | 10 pg/ml (2.2 pmol/L) | 12.8 µg/dL (353 nmol/L) | 48 µg/dL (1306 nmol/L) | 11 µg (30 nmol) | Vague symptoms |
| Sept. 3, 2021 | Started osilodrostat 2 mg twice daily | N/A | N/A | N/A | N/A | None |
| Sept. 17, 2021 | Osilodrostat 2 mg twice daily | <5 pg/ml (<1.1 pmol/L) | 26.7 µg /dL (737 nmol/L) | 102 µg/dL (2776 nmol/L) | 372.1 µg (1026.5 nmol) | None |
| Oct. 4, 2021 | Increased osilodrostat 3 mg twice daily | N/A | N/A | N/A | N/A | None |
| Oct. 18, 2021 | Osilodrostat 3 mg twice daily | <5 pg/ml (<1.1 pmol/L) | 30.3 µg/dL (836 nmol/L) | 138 µg/dL (3755 nmol/L) | 912.8 µg (2518 nmol) | Hypertension, hirsutism |
| Oct. 29, 2021 | Increased osilodrostat to 4 mg twice daily | N/A | N/A | N/A | N/A | Hypertension, hirsutism |
| Nov. 11, 2021 | Osilodrostat 4 mg twice daily: increased to 6 mg twice daily | <5 pg/ml (<1.1 pmol/L) | 33.7 µg/dL (929 nmol/L) | N/A | 1043 µg (2877 nmol) | Hypertension, hirsutism, weight gain |
| Nov. 29, 2021 | Increased osilodrostat to 8 mg twice daily | N/A | N/A | N/A | N/A | Hypertension, hirsutism |
| Dec. 9, 2021 | Osilodrostat 8 mg twice daily, increased to 10 mg twice daily | 1.1 pg/ml (0.24 pmol/L) | 16.1 µg/dL (444 nmol/L) | N/A | N/A | None |
| Dec. 28, 2021 | Osilodrostat 10 mg twice daily | <5 pg/ml (<1.1 pmol/L) | 9.1 µg/dL (251 nmol/L) | 10.2 µg/dL (278 nmol/L) | N/A | None |
| Jan. 26, 2022 | Stopped osilodrostat, start hydrocortisone | N/A | 2.3 µg/dL (63 nmol/L) | N/A | N/A | Nausea |
| Feb. 25, 2022 | Hydrocortisone 10 mg twice daily | 6 pg/ml (1.3 pmol/L) | 5.2 µg/dL (143 nmol/L) | N/A | N/A | None |
| March 3, 2022 | Hydrocortisone 10 mg twice daily | 42 pg/ml (9.2 pmol/L) | 3.5 µg/dL (97 nmol/L) | 7 µg/dL (190 nmol/L) | N/A | None |
| March 23, 2022 | Hydrocortisone 10 mg twice daily | 25 pg/ml (5.5 pmol/L) | 3.9 µg/dL (108 nmol/L) | N/A | N/A | None |
| May 12, 2022 | Hydrocortisone 10 mg twice daily | 100 pg/ml (22 pmol/L) | 5.6 µg/dL (154 nmol/L) | 3 µg/dL 82 nmol/L) | N/A | None |
| July 11, 2022 | Hydrocortisone 10 mg twice daily | 79 pg/ml (17.4 pmol/L) | 5.5 µg/dL (151 nmol/L) | N/A | 4.3 µg (11.9 nmol) | None |
Values in parenthesis are International System of Units.
Abbreviations: DHEA-S, dehydroepiandrosterone sulfate; N/A, not available; UFC, urine free cortisol.
| Date . | Medication . | ACTH (normal range 6-50 pg/ml; 1.32-11 pmol/L) . | Cortisol (normal range 4-22 µg/dL; 110-607 nmol/L) . | DHEA-S (normal range 15-205 µg/dL; 408-5578 nmol/L) . | 24-hour UFC (normal range 4-50 µg/24 hours; 11-138 nmol/24 hours) . | Symptoms . |
|---|---|---|---|---|---|---|
| 2015 | None | <5 pg/ml (<1.1 pmol/L) | 17.8 µg/dL (491 nmol/L) | N/A | 217 µg (599 nmol) | Weight gain, hypertension, hirsutism, acne, irregular menses |
| Sept. 2015 | Unknown mifepristone dose | N/A | N/A | N/A | 7.6 µg (21 nmol) | None |
| Aug. 2021 | Mifepristone 900 mg daily | 10 pg/ml (2.2 pmol/L) | 12.8 µg/dL (353 nmol/L) | 48 µg/dL (1306 nmol/L) | 11 µg (30 nmol) | Vague symptoms |
| Sept. 3, 2021 | Started osilodrostat 2 mg twice daily | N/A | N/A | N/A | N/A | None |
| Sept. 17, 2021 | Osilodrostat 2 mg twice daily | <5 pg/ml (<1.1 pmol/L) | 26.7 µg /dL (737 nmol/L) | 102 µg/dL (2776 nmol/L) | 372.1 µg (1026.5 nmol) | None |
| Oct. 4, 2021 | Increased osilodrostat 3 mg twice daily | N/A | N/A | N/A | N/A | None |
| Oct. 18, 2021 | Osilodrostat 3 mg twice daily | <5 pg/ml (<1.1 pmol/L) | 30.3 µg/dL (836 nmol/L) | 138 µg/dL (3755 nmol/L) | 912.8 µg (2518 nmol) | Hypertension, hirsutism |
| Oct. 29, 2021 | Increased osilodrostat to 4 mg twice daily | N/A | N/A | N/A | N/A | Hypertension, hirsutism |
| Nov. 11, 2021 | Osilodrostat 4 mg twice daily: increased to 6 mg twice daily | <5 pg/ml (<1.1 pmol/L) | 33.7 µg/dL (929 nmol/L) | N/A | 1043 µg (2877 nmol) | Hypertension, hirsutism, weight gain |
| Nov. 29, 2021 | Increased osilodrostat to 8 mg twice daily | N/A | N/A | N/A | N/A | Hypertension, hirsutism |
| Dec. 9, 2021 | Osilodrostat 8 mg twice daily, increased to 10 mg twice daily | 1.1 pg/ml (0.24 pmol/L) | 16.1 µg/dL (444 nmol/L) | N/A | N/A | None |
| Dec. 28, 2021 | Osilodrostat 10 mg twice daily | <5 pg/ml (<1.1 pmol/L) | 9.1 µg/dL (251 nmol/L) | 10.2 µg/dL (278 nmol/L) | N/A | None |
| Jan. 26, 2022 | Stopped osilodrostat, start hydrocortisone | N/A | 2.3 µg/dL (63 nmol/L) | N/A | N/A | Nausea |
| Feb. 25, 2022 | Hydrocortisone 10 mg twice daily | 6 pg/ml (1.3 pmol/L) | 5.2 µg/dL (143 nmol/L) | N/A | N/A | None |
| March 3, 2022 | Hydrocortisone 10 mg twice daily | 42 pg/ml (9.2 pmol/L) | 3.5 µg/dL (97 nmol/L) | 7 µg/dL (190 nmol/L) | N/A | None |
| March 23, 2022 | Hydrocortisone 10 mg twice daily | 25 pg/ml (5.5 pmol/L) | 3.9 µg/dL (108 nmol/L) | N/A | N/A | None |
| May 12, 2022 | Hydrocortisone 10 mg twice daily | 100 pg/ml (22 pmol/L) | 5.6 µg/dL (154 nmol/L) | 3 µg/dL 82 nmol/L) | N/A | None |
| July 11, 2022 | Hydrocortisone 10 mg twice daily | 79 pg/ml (17.4 pmol/L) | 5.5 µg/dL (151 nmol/L) | N/A | 4.3 µg (11.9 nmol) | None |
| Date . | Medication . | ACTH (normal range 6-50 pg/ml; 1.32-11 pmol/L) . | Cortisol (normal range 4-22 µg/dL; 110-607 nmol/L) . | DHEA-S (normal range 15-205 µg/dL; 408-5578 nmol/L) . | 24-hour UFC (normal range 4-50 µg/24 hours; 11-138 nmol/24 hours) . | Symptoms . |
|---|---|---|---|---|---|---|
| 2015 | None | <5 pg/ml (<1.1 pmol/L) | 17.8 µg/dL (491 nmol/L) | N/A | 217 µg (599 nmol) | Weight gain, hypertension, hirsutism, acne, irregular menses |
| Sept. 2015 | Unknown mifepristone dose | N/A | N/A | N/A | 7.6 µg (21 nmol) | None |
| Aug. 2021 | Mifepristone 900 mg daily | 10 pg/ml (2.2 pmol/L) | 12.8 µg/dL (353 nmol/L) | 48 µg/dL (1306 nmol/L) | 11 µg (30 nmol) | Vague symptoms |
| Sept. 3, 2021 | Started osilodrostat 2 mg twice daily | N/A | N/A | N/A | N/A | None |
| Sept. 17, 2021 | Osilodrostat 2 mg twice daily | <5 pg/ml (<1.1 pmol/L) | 26.7 µg /dL (737 nmol/L) | 102 µg/dL (2776 nmol/L) | 372.1 µg (1026.5 nmol) | None |
| Oct. 4, 2021 | Increased osilodrostat 3 mg twice daily | N/A | N/A | N/A | N/A | None |
| Oct. 18, 2021 | Osilodrostat 3 mg twice daily | <5 pg/ml (<1.1 pmol/L) | 30.3 µg/dL (836 nmol/L) | 138 µg/dL (3755 nmol/L) | 912.8 µg (2518 nmol) | Hypertension, hirsutism |
| Oct. 29, 2021 | Increased osilodrostat to 4 mg twice daily | N/A | N/A | N/A | N/A | Hypertension, hirsutism |
| Nov. 11, 2021 | Osilodrostat 4 mg twice daily: increased to 6 mg twice daily | <5 pg/ml (<1.1 pmol/L) | 33.7 µg/dL (929 nmol/L) | N/A | 1043 µg (2877 nmol) | Hypertension, hirsutism, weight gain |
| Nov. 29, 2021 | Increased osilodrostat to 8 mg twice daily | N/A | N/A | N/A | N/A | Hypertension, hirsutism |
| Dec. 9, 2021 | Osilodrostat 8 mg twice daily, increased to 10 mg twice daily | 1.1 pg/ml (0.24 pmol/L) | 16.1 µg/dL (444 nmol/L) | N/A | N/A | None |
| Dec. 28, 2021 | Osilodrostat 10 mg twice daily | <5 pg/ml (<1.1 pmol/L) | 9.1 µg/dL (251 nmol/L) | 10.2 µg/dL (278 nmol/L) | N/A | None |
| Jan. 26, 2022 | Stopped osilodrostat, start hydrocortisone | N/A | 2.3 µg/dL (63 nmol/L) | N/A | N/A | Nausea |
| Feb. 25, 2022 | Hydrocortisone 10 mg twice daily | 6 pg/ml (1.3 pmol/L) | 5.2 µg/dL (143 nmol/L) | N/A | N/A | None |
| March 3, 2022 | Hydrocortisone 10 mg twice daily | 42 pg/ml (9.2 pmol/L) | 3.5 µg/dL (97 nmol/L) | 7 µg/dL (190 nmol/L) | N/A | None |
| March 23, 2022 | Hydrocortisone 10 mg twice daily | 25 pg/ml (5.5 pmol/L) | 3.9 µg/dL (108 nmol/L) | N/A | N/A | None |
| May 12, 2022 | Hydrocortisone 10 mg twice daily | 100 pg/ml (22 pmol/L) | 5.6 µg/dL (154 nmol/L) | 3 µg/dL 82 nmol/L) | N/A | None |
| July 11, 2022 | Hydrocortisone 10 mg twice daily | 79 pg/ml (17.4 pmol/L) | 5.5 µg/dL (151 nmol/L) | N/A | 4.3 µg (11.9 nmol) | None |
Values in parenthesis are International System of Units.
Abbreviations: DHEA-S, dehydroepiandrosterone sulfate; N/A, not available; UFC, urine free cortisol.
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