Table 3 Open in new tab Uni-and...

SR (n = 23)

Univariable analysis

Model 1

Model 2

Model 3

P-value

Demographics

Age at CMR

0.97 (0.93–1.01)

0.13

Male

0.38 (0.10–1.51)

0.17

BMI

1.02 (0.89–1.16)

0.80

Serum examinations

Creatinine

1.00 (0.98–1.02)

0.71

hs-cTnI

1.00 (0.91–1.01)

0.98

NT-proBNP

1.00 (1.00–1.00)

0.04*

1.00 (1.00–1.00)

0.42

1.00 (1.00–1.00)

0.46

1.00 (1.00–1.00)

0.99

CMR conventional parameters

Heart rate

1.03 (0.98–1.08)

0.24

LV ESV

1.00 (0.99–1.02)

0.70

LV EDV

1.00 (0.99–1.01)

0.90

LV EDVi

1.00 (0.98–1.03)

0.67

LV EF

0.96 (0.92–1.01)

0.09

0.84 (0.60–1.18)

0.31

CMR LV strain

GRS

0.94 (0.87–1.00)

0.07

GCS

0.86 (0.73–1.01)

0.06

GLS

0.69 (0.55–0.87)

0.00**

0.69 (0.55–0.87)

0.00*

0.76 (0.59–0.98)

0.03*

CMR tissue parameters

Native T₁

1.01 (1.00–1.02)

0.01*

1.01 (0.99–1.02)

0.08

1.01 (0.99–1.02)

0.16

ECV

1.10 (0.99–1.22)

0.07

LGE presence

2.70 (0.78–9.35)

0.12

T₂

1.44 (1.18–1.75)

0.00**

1.44 (1.18–1.75)

0.00**

1.35 (1.10–1.65)

0.01*

Table 3

Open in new tab

Uni-and multivariable analysis by logistic regression for the identification of SR in HTxs

SR (n = 23)	Univariable analysis		Model 1		Model 2		Model 3
SR (n = 23)	OR	P-value	OR	P-value	OR	P-value	OR	P-value
Demographics
Age at CMR	0.97 (0.93–1.01)	0.13
Male	0.38 (0.10–1.51)	0.17
BMI	1.02 (0.89–1.16)	0.80
Serum examinations
Creatinine	1.00 (0.98–1.02)	0.71
hs-cTnI	1.00 (0.91–1.01)	0.98
NT-proBNP	1.00 (1.00–1.00)	0.04*	1.00 (1.00–1.00)	0.42	1.00 (1.00–1.00)	0.46	1.00 (1.00–1.00)	0.99
CMR conventional parameters
Heart rate	1.03 (0.98–1.08)	0.24
LV ESV	1.00 (0.99–1.02)	0.70
LV EDV	1.00 (0.99–1.01)	0.90
LV EDVi	1.00 (0.98–1.03)	0.67
LV EF	0.96 (0.92–1.01)	0.09
CO	0.84 (0.60–1.18)	0.31
CMR LV strain
GRS	0.94 (0.87–1.00)	0.07
GCS	0.86 (0.73–1.01)	0.06
GLS	0.69 (0.55–0.87)	0.00**	0.69 (0.55–0.87)	0.00*			0.76 (0.59–0.98)	0.03*
CMR tissue parameters
Native T₁	1.01 (1.00–1.02)	0.01*	1.01 (0.99–1.02)	0.08	1.01 (0.99–1.02)	0.16
ECV	1.10 (0.99–1.22)	0.07
LGE presence	2.70 (0.78–9.35)	0.12
T₂	1.44 (1.18–1.75)	0.00**			1.44 (1.18–1.75)	0.00**	1.35 (1.10–1.65)	0.01*

SR (n = 23)	Univariable analysis		Model 1		Model 2		Model 3
SR (n = 23)	OR	P-value	OR	P-value	OR	P-value	OR	P-value
Demographics
Age at CMR	0.97 (0.93–1.01)	0.13
Male	0.38 (0.10–1.51)	0.17
BMI	1.02 (0.89–1.16)	0.80
Serum examinations
Creatinine	1.00 (0.98–1.02)	0.71
hs-cTnI	1.00 (0.91–1.01)	0.98
NT-proBNP	1.00 (1.00–1.00)	0.04*	1.00 (1.00–1.00)	0.42	1.00 (1.00–1.00)	0.46	1.00 (1.00–1.00)	0.99
CMR conventional parameters
Heart rate	1.03 (0.98–1.08)	0.24
LV ESV	1.00 (0.99–1.02)	0.70
LV EDV	1.00 (0.99–1.01)	0.90
LV EDVi	1.00 (0.98–1.03)	0.67
LV EF	0.96 (0.92–1.01)	0.09
CO	0.84 (0.60–1.18)	0.31
CMR LV strain
GRS	0.94 (0.87–1.00)	0.07
GCS	0.86 (0.73–1.01)	0.06
GLS	0.69 (0.55–0.87)	0.00**	0.69 (0.55–0.87)	0.00*			0.76 (0.59–0.98)	0.03*
CMR tissue parameters
Native T₁	1.01 (1.00–1.02)	0.01*	1.01 (0.99–1.02)	0.08	1.01 (0.99–1.02)	0.16
ECV	1.10 (0.99–1.22)	0.07
LGE presence	2.70 (0.78–9.35)	0.12
T₂	1.44 (1.18–1.75)	0.00**			1.44 (1.18–1.75)	0.00**	1.35 (1.10–1.65)	0.01*

Due to the limitation of the SR sample size (n = 23) and statistical power, we limited each model to three variables (respecting the 1:10 rule).

SR, significant acute cardiac allograft rejection = ACR grade ≥2R and/or AMR grade ≥ pAMR1; CMR, cardiac magnetic resonance imaging; BMI, body mass index; hs-cTnI, high-sensitivity cardiac troponin I; NT-proBNP, N-terminal pro-brain natriuretic peptide; LV, left ventricular; ESV, end-systolic volume; EDV, end-diastolic volume; EDVi, end-diastolic volume index; EF, ejection fraction; CO, cardiac output; GRS, global radial strain; GCS, global circumferential strain; GLS, global longitudinal strain; ECV, extracellular volume; LGE, late gadolinium enhancement; Model 1, NT-proBNP, LV GLS, and native T₁; Model 2, NT-proBNP, native T₁, and T₂; Model 3, NT-proBNP, LV GLS, and T₂.

^*P < 0.05; **P < 0.001.

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