Table 4.

Multivariable analysis comparing durability postexposure and durability postescalation.

HR (95% CI)P-valueHR (95% CI)P-value
Proactive vs reactive0.42 (0.25, 0.70).0010.44 (0.26, 0.74).002
Montreal classification—disease location
 L1—ilealRefRef
 L2—colonic0.74 (0.37, 1.46).3801.01 (0.51, 2.00).979
 L3—ileocolonic0.60 (0.32, 1.11).1010.77 (0.41, 1.42).400
 L4—isolated upper GI0.48 (0.06, 3.84).4911.18 (0.15, 9.41).875
Montreal classification—disease behavior
 B1—uncomplicatedRefRef
 B2—stricturing1.34 (0.73, 2.48).3481.10 (0.61, 1.97).759
 B3—penetrating2.10 (1.10, 3.98).0241.97 (1.05, 3.68).034
Perianal disease0.40 (0.24, 0.67)<.0010.35 (0.21, 0.58)<.001
Tumor Necrosis Factor Naïve0.63 (0.39, 1.01).0450.54 (0.33, 0.90).017
Concurrent immunomodulator use0.75 (0.48, 1.18).2120.71 (0.45, 1.14).155
HR (95% CI)P-valueHR (95% CI)P-value
Proactive vs reactive0.42 (0.25, 0.70).0010.44 (0.26, 0.74).002
Montreal classification—disease location
 L1—ilealRefRef
 L2—colonic0.74 (0.37, 1.46).3801.01 (0.51, 2.00).979
 L3—ileocolonic0.60 (0.32, 1.11).1010.77 (0.41, 1.42).400
 L4—isolated upper GI0.48 (0.06, 3.84).4911.18 (0.15, 9.41).875
Montreal classification—disease behavior
 B1—uncomplicatedRefRef
 B2—stricturing1.34 (0.73, 2.48).3481.10 (0.61, 1.97).759
 B3—penetrating2.10 (1.10, 3.98).0241.97 (1.05, 3.68).034
Perianal disease0.40 (0.24, 0.67)<.0010.35 (0.21, 0.58)<.001
Tumor Necrosis Factor Naïve0.63 (0.39, 1.01).0450.54 (0.33, 0.90).017
Concurrent immunomodulator use0.75 (0.48, 1.18).2120.71 (0.45, 1.14).155
Table 4.

Multivariable analysis comparing durability postexposure and durability postescalation.

HR (95% CI)P-valueHR (95% CI)P-value
Proactive vs reactive0.42 (0.25, 0.70).0010.44 (0.26, 0.74).002
Montreal classification—disease location
 L1—ilealRefRef
 L2—colonic0.74 (0.37, 1.46).3801.01 (0.51, 2.00).979
 L3—ileocolonic0.60 (0.32, 1.11).1010.77 (0.41, 1.42).400
 L4—isolated upper GI0.48 (0.06, 3.84).4911.18 (0.15, 9.41).875
Montreal classification—disease behavior
 B1—uncomplicatedRefRef
 B2—stricturing1.34 (0.73, 2.48).3481.10 (0.61, 1.97).759
 B3—penetrating2.10 (1.10, 3.98).0241.97 (1.05, 3.68).034
Perianal disease0.40 (0.24, 0.67)<.0010.35 (0.21, 0.58)<.001
Tumor Necrosis Factor Naïve0.63 (0.39, 1.01).0450.54 (0.33, 0.90).017
Concurrent immunomodulator use0.75 (0.48, 1.18).2120.71 (0.45, 1.14).155
HR (95% CI)P-valueHR (95% CI)P-value
Proactive vs reactive0.42 (0.25, 0.70).0010.44 (0.26, 0.74).002
Montreal classification—disease location
 L1—ilealRefRef
 L2—colonic0.74 (0.37, 1.46).3801.01 (0.51, 2.00).979
 L3—ileocolonic0.60 (0.32, 1.11).1010.77 (0.41, 1.42).400
 L4—isolated upper GI0.48 (0.06, 3.84).4911.18 (0.15, 9.41).875
Montreal classification—disease behavior
 B1—uncomplicatedRefRef
 B2—stricturing1.34 (0.73, 2.48).3481.10 (0.61, 1.97).759
 B3—penetrating2.10 (1.10, 3.98).0241.97 (1.05, 3.68).034
Perianal disease0.40 (0.24, 0.67)<.0010.35 (0.21, 0.58)<.001
Tumor Necrosis Factor Naïve0.63 (0.39, 1.01).0450.54 (0.33, 0.90).017
Concurrent immunomodulator use0.75 (0.48, 1.18).2120.71 (0.45, 1.14).155
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