Relation between the histological effects on the main tumors and disease stages
| . | Histological effects in the surgical specimen . | ||
|---|---|---|---|
| . | Grade 3-1b (n = 18) . | Grade 1a-0 (n = 59) . | P-value . |
| cStage before therapy | |||
| cStage III | 7 (38.9%) | 11 (18.6%) | P = 0.0776 by Mann–Whitney U-test |
| cStage IV | 11 (61.1%) | 48 (81.4%) | |
| pStage after surgery | |||
| pStage 0/I | 4 (22.2%) | 0 (0%) | P = 0.0001 by Mann–Whitney U-test |
| pStage II | 6 (33.3%) | 5 (8.5%) | |
| pStage III | 3 (16.7%) | 14 (23.7%) | |
| pStage IV | 5 (27.8%) | 40 (67.8%) | |
| No. of downstaged patients | 11/18 (61.1%) | 12/59 (20.3%) | P = 0.0009 by Chi-square test |
| No. of metastatic nodes | |||
| 0 node | 7 (38.9%) | 4 (6.8%) | P = 0.0005 by Mann–Whitney U-test |
| 1–3 nodes | 6 (33.3%) | 19 (32.2%) | |
| 4–7 nodes | 4 (22.2%) | 10 (16.9%) | |
| 8 nodes ∼ | 1 (5.6%) | 26 (44.1%) | |
| No. of metastatic nodes per patient | 2.2 ± 3.1 | 12.0 ± 20.6 | P = 0.0482 by Student's t-test |
| . | Histological effects in the surgical specimen . | ||
|---|---|---|---|
| . | Grade 3-1b (n = 18) . | Grade 1a-0 (n = 59) . | P-value . |
| cStage before therapy | |||
| cStage III | 7 (38.9%) | 11 (18.6%) | P = 0.0776 by Mann–Whitney U-test |
| cStage IV | 11 (61.1%) | 48 (81.4%) | |
| pStage after surgery | |||
| pStage 0/I | 4 (22.2%) | 0 (0%) | P = 0.0001 by Mann–Whitney U-test |
| pStage II | 6 (33.3%) | 5 (8.5%) | |
| pStage III | 3 (16.7%) | 14 (23.7%) | |
| pStage IV | 5 (27.8%) | 40 (67.8%) | |
| No. of downstaged patients | 11/18 (61.1%) | 12/59 (20.3%) | P = 0.0009 by Chi-square test |
| No. of metastatic nodes | |||
| 0 node | 7 (38.9%) | 4 (6.8%) | P = 0.0005 by Mann–Whitney U-test |
| 1–3 nodes | 6 (33.3%) | 19 (32.2%) | |
| 4–7 nodes | 4 (22.2%) | 10 (16.9%) | |
| 8 nodes ∼ | 1 (5.6%) | 26 (44.1%) | |
| No. of metastatic nodes per patient | 2.2 ± 3.1 | 12.0 ± 20.6 | P = 0.0482 by Student's t-test |
Relation between the histological effects on the main tumors and disease stages
| . | Histological effects in the surgical specimen . | ||
|---|---|---|---|
| . | Grade 3-1b (n = 18) . | Grade 1a-0 (n = 59) . | P-value . |
| cStage before therapy | |||
| cStage III | 7 (38.9%) | 11 (18.6%) | P = 0.0776 by Mann–Whitney U-test |
| cStage IV | 11 (61.1%) | 48 (81.4%) | |
| pStage after surgery | |||
| pStage 0/I | 4 (22.2%) | 0 (0%) | P = 0.0001 by Mann–Whitney U-test |
| pStage II | 6 (33.3%) | 5 (8.5%) | |
| pStage III | 3 (16.7%) | 14 (23.7%) | |
| pStage IV | 5 (27.8%) | 40 (67.8%) | |
| No. of downstaged patients | 11/18 (61.1%) | 12/59 (20.3%) | P = 0.0009 by Chi-square test |
| No. of metastatic nodes | |||
| 0 node | 7 (38.9%) | 4 (6.8%) | P = 0.0005 by Mann–Whitney U-test |
| 1–3 nodes | 6 (33.3%) | 19 (32.2%) | |
| 4–7 nodes | 4 (22.2%) | 10 (16.9%) | |
| 8 nodes ∼ | 1 (5.6%) | 26 (44.1%) | |
| No. of metastatic nodes per patient | 2.2 ± 3.1 | 12.0 ± 20.6 | P = 0.0482 by Student's t-test |
| . | Histological effects in the surgical specimen . | ||
|---|---|---|---|
| . | Grade 3-1b (n = 18) . | Grade 1a-0 (n = 59) . | P-value . |
| cStage before therapy | |||
| cStage III | 7 (38.9%) | 11 (18.6%) | P = 0.0776 by Mann–Whitney U-test |
| cStage IV | 11 (61.1%) | 48 (81.4%) | |
| pStage after surgery | |||
| pStage 0/I | 4 (22.2%) | 0 (0%) | P = 0.0001 by Mann–Whitney U-test |
| pStage II | 6 (33.3%) | 5 (8.5%) | |
| pStage III | 3 (16.7%) | 14 (23.7%) | |
| pStage IV | 5 (27.8%) | 40 (67.8%) | |
| No. of downstaged patients | 11/18 (61.1%) | 12/59 (20.3%) | P = 0.0009 by Chi-square test |
| No. of metastatic nodes | |||
| 0 node | 7 (38.9%) | 4 (6.8%) | P = 0.0005 by Mann–Whitney U-test |
| 1–3 nodes | 6 (33.3%) | 19 (32.2%) | |
| 4–7 nodes | 4 (22.2%) | 10 (16.9%) | |
| 8 nodes ∼ | 1 (5.6%) | 26 (44.1%) | |
| No. of metastatic nodes per patient | 2.2 ± 3.1 | 12.0 ± 20.6 | P = 0.0482 by Student's t-test |
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