Frailty, sarcopenia, and chronic pain associations with C282Y homozygosity. Forest plot showing odds ratios by health measures comparing C282Y homozygous subjects to those with the common genotype, by sex and age group. Logistic regression models adjusted for age and technical covariates. C282Y homozygote men aged 60–70 years (n = 593/95,137); aged 60–64 years (n = 315/51,331); and aged 65–70 years (n = 278/43,806). C282Y homozygote women aged 60–70 years (n = 719/105,838); aged 60–64 years (n = 407/60,954); and aged 65–70 years (n = 312/44,884). Polymyalgia rheumatica is not in the figure because there were too few observations for the subgroup analyses (see Supplementary Tables 1 and 2).