Outcome of immunosuppressive treatment of Graves’ ophthalmopathy as a function of disease activity. The natural history of the activity and the severity of the eye disease are depicted by two separate curves. Immunosuppression is given at one-half maximal disease severity: the response to treatment is negligible when given at zero activity (a) but substantial when applied at peak disease activity (b). (Reproduced with permission from Wiersinga WM. Advances in medical therapy of thyroid-associated ophthalmopathy. Orbit, 1996; 15: 177–86.)