(a) Plasma ACTH concentrations before and after administration of the hydrocortisone morning dose in patients with primary adrenal insufficiency (n = 8). (b) Serum cortisol and thyroid function. Serum cortisol concentrations after administration of 15 mg hydrocortisone orally in 27 patients with primary adrenal insufficiency. Patients with concurrent overt hypothyroidism (n = 3) or hyperthyroidism (n = 1) differ from euthyroid patients (n = 23), which has to be considered when choosing appropriate glucocorticoid replacement doses. Modified from Allolio et al., Akt Endokr Stoffw, 1985: 6: 35–39.