Siat7A expression was increased in the hypertrophic left ventricle and promoted cardiac hypertrophy. (A) Representative HE and IHC images of human left ventricles (n = 10). (a, b, c, and d) The morphology of human cardiomyocytes are shown. Positive immunoreactive signals for Siat7A expression are shown by brown deposits in the cell (e, f, g, and h). (B) The recordings for MAP of shNC-saline group, shNC-ANGII group, and shSiat7A-ANGII group rats (n = 12/group). (C) Representative ex vivo bioluminescence images of isolated hearts in rats receiving injection of scramble shRNA or shSiat7A (n = 5/group). The control heart received injection of saline. (D) Assessment of heart weight-to-body weight ratio (n = 6/group). (E) The analysis of Siat7A mRNA in left ventricles (n = 5/group). (F) Representative immunoblots of Siat7A expression in the left ventricular walls and the analysis to show the significant difference in levels of Siat7A between each group (n = 5/group). (G) Representative HE and IHC images of rat left ventricular wall (n = 5/group). The upper panels display HE staining showing the morphology of cardiomyocytes. The lower panels display the IHC images for Siat7A expression. Positive immunoreactive signals for Siat7A expression are shown by brown deposits in the cell. (H) Assessment of the myocyte cross-sectional area (n > 300 cells per group). mRNA levels of ANP (I), BNP (J), and α-skeletal actin (n = 5/group) (K). (L) Representative echocardiography of left ventricular chambers (n = 6–8/group). (M) Assessment of left ventricular LVID-s, LVPW-s, EF%, and FS% (n = 6–8/group). The P-values were evaluated by ANOVA followed by a post hoc Tukey test.