Development of an ion channel focussed approach to seizure detection. Ion channels in the brain have been associated with seizure (e.g. potassium channels, sodium channels, GABA-A and nicotinic acetylcholine receptors),^17,18 however the full complement of ion channels linked to seizure is yet to be resolved. Determination of the ion channel profile of various subtypes of hiPSC-derived neuronal cells followed by assessment of their impact on the seizurogenic phenotype would allow for creation of an in vitro ion channel panel for earlier seizure detection. Ion channels determined as possessing a seizure risk could be transfected into a routinely used cell line and this panel of cells expressing one specific ion channel per cell could be used to screen compounds for seizure risk.