A roadmap of the present and possible future of human embryo biopsy: from the development of an efficient and reproducible TE biopsy approach to novel, experimental approaches. SET, single embryo transfer; NPV and PPV, negative and positive predictive value; CCT, comprehensive chromosome testing; RCT, randomized controlled trial; OPR, ongoing pregnancy rate; PGT-M, PGT for monogenic diseases; Med hypotheses, medical hypotheses; RBMo, Reproductive BioMedicine online; Mol BioSys, molecular biosystems; Sci Rep, Scientific Reports.