Common brain network of deep brain stimulation in epilepsy. (A) A 3D representation of the anatomical seeds of the clinically used targets for DBS in epilepsy (ANT, CMT, HC) and regions of their functional connectivity overlap calculated from resting state fMRI scans of 1000 individuals are shown on high-resolution sagittal and axial 7-tesla T1 MRI slices of the human brain. The regions that overlapped between the three functional connectivity maps of ANT, CMT, and HC (in yellow) were used to outline the common neural network implicated in seizure reduction following DBS. (B) The regions identified as the normative network model associated with common epilepsy DBS targets are shown on axial 7-Tesla T1 MRI slices. A 3-D figure with an overlay of the network represents the level of the axial slices. Regions of overlap were in the ACC, paracingulate cortex, medial frontal region, PCC, anterior insula, frontal operculum, right sensorimotor cortex, basal forebrain, medial thalamus, dorsal thalamus, dorsal and ventral mesencephalon.