Cardiac resynchronization therapy for
severe heart failure: two pivotal trials. Reproduced with permission from
Bristow MR, Saxon LA, Boehmer J, et al.; Comparison of Medical
Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION)
Investigators. Cardiac-resynchronization therapy with or without an
implantable defibrillator in advanced chronic heart failure. N Engl J Med
2004; 350: 2140–50; and Cleland JG, Daubert JC, Erdmann E, et al.;
Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators. The
effect of cardiac resynchronization on morbidity and mortality in heart
failure. N Engl J Med 2005; 352: 1539–49.