Geographic representation of heart failure randomized controlled trial participants compared with world prevalence of heart failure. Prevalence of adults from each region enrolled in heart failure randomized controlled trials between 2000 and 2020 (left) and worldwide adult prevalence of heart failure by region (right). Detailed region data not available for 76 871 (32.8%) out of a total 234 287 enrolled participants; they were excluded from the analysis. Adult global prevalence of heart failure from the Global Health Data Exchange registry.