Logic of scenarios for lipid-lowering treatment intensification and percentage of patients flowing through the treatment intensification logic in the simulation. High-intensity statin was defined as atorvastatin ≥40 mg, rosuvastatin ≥20 mg, or simvastatin 80 mg; patients who initiated high-intensity statin therapy in the simulation were set to receive atorvastatin 80 mg. ^aAlirocumab 75 mg biweekly. ^bEvolocumab 140 mg biweekly/420 mg monthly.