Production of progenitors following changes of the differentiation rate. Starting at equilibrium, the differentiation rate of inactive HSC is doubled from day 10 until the end of the simulation. A temporary increase in the production of progenitors is seen (A), however, after some time a new homeostatic equilibrium with reduced progenitor outputs is approached. The stem cells converge to a new equilibrium, with both lower inactive (B) and active (C) HSC outside the niche.