Increased detachment rate of the fitter clone leads to faster extinction of the inferior clone. In all 3 panels, 10% of the niche-bound stem cells belong to the mutated clone at the beginning of the simulations. In panel A, the 2 subpopulations have equal fitness; therefore, the cell counts do not change over time. In panel B, the division rate of the mutated clone is increased by 20% compared with the healthy clone. This results in a competitive advantage and eventual out-competition of the healthy cells. In panel C, the detachment rate of the mutated clone is tripled in addition to the increased division-rate. The increased detachment leads to an increased activation and thus to faster out-competition of the healthy cells.