Generating multispecific antibodies. Immunogen design creates novel protein fusions that direct the development of antibodies to specific epitopes on the immunogen. These antibodies are generated either in vivo, in vitro or in silico and are characterized via biophysical analysis for properties amenable to the TPP. The multispecific molecule can be generated through incorporation of several different targeting modules fused to a central Fc. The resulting molecules are then expressed at a small scale. Each molecule undergoes functional and developability assessment to ensure the biological effect and TPP are met. Candidate molecules passing these metrics are then sent for CMC development and large-scale expression for clinical trials.