J.HAL® IgG antibodies exhibit dose-dependent binding to SARS-CoV-2 spike protein. Unpurified transfection supernatants were concentration normalized and tested for binding in a 9-point serial titration series to biotinylated SARS-CoV-2 spike protein by AlphaLISA. Representative binding profiles for 30 J.HAL® antibodies are shown in the subplots A-F above, along with the positive control antibody M-3418 (S309). Data were graphed as mean +/− SD using GraphPad prism software.