Figure 3.
Secondary structure model for MYC intron 1 predicted with RNAfold using DMS reactivities and 600 bp folding window. The model includes highlighted portions of exon 1 and exon 2 (light blue), the splice sites marked with arrows, annotations for eCLIP binding data are shown (purple), base pairs co-predicted with ScanFold from either −1 (green) or −2 (blue) z-score motifs, and statistically significant covarying base pairs (emphasized green bars). Normalized DMS reactivities are presented on a scale from 0.0 to 1.0, the most reactive bases were set to a maximum value of 1.0. The start and end of major structural domains and motifs are given as a region of nucleotide positions in reference to the model beginning at nucleotide 1, which corresponds with transcript coordinate 988.