octn1^-/- influenced microbiota profile. Panel A: Shannon index box plots calculated on gut microbiota of octn1^-/- and WT mice. P value, corrected for FDR, was determined by Mann-Whitney test. Panel B: Principal Coordinates Analysis (PCoA) plot of Bray Curtis dissimilarity matrix of octn1^-/- and WT animals. P value is by PERMANOVA test. Panel C: Relative abundance of different bacterial phyla in octn1^-/- and WT; comparisons were by DESeq2 statistics (P value FDR < .05).