Patient flow and treatment disposition. Two patients in cohort 7 did not initiate intra and postoperative study treatment due to rapid progressive disease with corticosteroid dependency (1 pt) and a suspected meningeal bacterial infection observed during surgery (1 pt). In cohort 4, 1 patient was unable to receive the postoperative study treatment due to increased intracerebral edema and clinical deterioration. In cohort 7, 4 patients did not receive the postoperative study treatment due to various causes: 1 case of an Ommaya-related infection (C7-1), 1 case of increased intracerebral edema (C7-1), and 2 cases of neutrophilic pleocytosis (C7-2 and C7-3). In total, 8 patients received the complete study treatment, with 4 patients in each cohort. Postop: postoperative; iCav: intracavitary injection through an Ommaya reservoir; IV: intravenous; Mdn: median; admin: administration(s); PD: progression disease; AE: adverse event.