Models of DNA repair machinery cleaving H-DNA. Triplex H-DNA structure with scissors indicating where the labeled nucleases are proposed to cut. Black lines indicate non-repetitive DNA. Red and blue lines indicate the homopurine and homopyrimidine strands of a mirror repeat, respectively. Figure based off of the findings referenced in the text (85,95). Created in BioRender. Hisey, J. (2024) https://BioRender.com/i80j609.