A, Study design and computational analysis flowchart. Study design of clonal hematopoiesis of indeterminate potential (CHIP) prevalence in Mount Sinai’s inflammatory bowel disease (IBD) cohort using whole-exome sequencing data of IBD patients (Crohn’s disease and ulcerative colitis ) and controls and associated CHIP prevalence with respect to age, demographics, and disease characteristics (medications and medical history). B, Pipeline to identify myeloid-associated clonal hematopoiesis of indeterminate potential and lymphoid-associated clonal hematopoiesis of indeterminate potential mutations.