Prevalence of myeloid-associated clonal hematopoiesis of indeterminate potential (M-CHIP) and lymphoid-associated clonal hematopoiesis of indeterminate potential (L-CHIP) mutations. Prevalence of CHIP mutations in all inflammatory bowel disease (IBD) patients and controls across all ages (A), and within age cohorts ≤45 and >45 years (B). Clonal hematopoiesis of indeterminate potential was more prevalent in IBD at older ages compared to younger ages (odds ratio [OR] 3.19, 95% confidence interval [CI] 1.71-5.97, P = 2.82E−04). Prevalence of M-CHIP (C) and L-CHIP (D) in all IBD patients and controls for age cohorts ≤45 and >45 years. Both M-CHIP and L-CHIP were more prevalent in older IBD patients compared to younger IBD patients (OR 3.82, 95% CI 1.75-8.35, P = .001 and OR 3.74, 95% CI 1.44-9.72, P = .007, respectively). Prevalence of M-CHIP (E) and L-CHIP (F) in Crohn’s disease, ulcerative colitis, and controls by age cohorts ≤45 and >45 years. M-CHIP was more prevalent at older ages in UC when compared to non-IBD controls (OR 2.27, 95% CI 1.0-5.20, P = .053) and CD (OR 2.91, 95% CI 1.12-7.53, P = .028).