Multivariable Cox proportional hazards analysis of risk factors for UST failure in patients with CD. Hazard ratios of various covariates influencing the risk of UST failure in patients with CD undergoing UST treatment. Concomitant use of IMs and previous ADT exposure are identified as significant risk factors. Abbreviation: 5-ASA, 5-aminosalicylic acid; ADT, advanced therapy; CD, Crohn’s disease; IMs, immunomodulators; UST, ustekinumab.