Intact HIV-1 DNA. A, The absolute change in the number of intact HIV-1 DNA copies between week 48 and baseline, after correction for DNA shearing (median and IQR are reported; whiskers represent 1.5 IQR). Graph based on complete cases B/F/TAF = 33, DTG/3TC = 72, with outliers >1.5 IQR excluded (B/F/TAF = 5, DTG/3TC = 6). B, The relative change of intact HIV-1 DNA copies per million CD4 T cells from baseline, after correction for DNA shearing. Estimated mean values are reported with upper and lower confidence interval limit estimates, calculated using an ordinary linear regression model applied to change from baseline in natural log-transformed imputed data. Multiple imputations analysis in the intention-to-treat exposed set (n = 130) adjusted for baseline response value, CD4 nadir, and time on antiretroviral therapy. The triangle symbol represents the observed median change. Closed dots contain measurements above the LOD; open dots contain measurements below the LOD, replaced by the LOD/2, adjusted for cell input and DNA shearing index. C, Dynamics of intact HIV-1 DNA in the 2 treatment arms expressed as log₁₀ copies/million CD4⁺ T cells at baseline (day 0) and after 48 weeks. Abbreviations: 3TC, lamivudine; B, bictegravir; DTG, dolutegravir; F, emtricitabine; HIV-1, human immunodeficiency virus-1; IQR, interquartile range; LOD, limit of detection; TAF, tenofovir alafenamide.