Disease control rate (DCR). Bar graphs demonstrating the proportion of patients with DCR (defined by partial response + minor response + stable disease) within each cohort: patients with enhancing disease versus no enhancing disease when ivosidenib was started; patients who started ivosidenib as first-line versus subsequent-line treatment; WHO grade 2 versus 3; astrocytoma vs oligodendroglioma. The total sample size of each group is shown numerically within each bar. Comparing groups with chi-square test, there was a statistically significant (P < .05) difference between nonenhancing versus enhancing and first-line versus subsequent-line ivosidenib but there was no statistically significant difference based on grade and tumor type. Astro = astrocytoma; DCR = disease control rate; oligo = oligodendroglioma.