Enrichment of neurological disease genes and neurotransmitter receptors and transporters genes in each cell cluster across species. a) Cell-type enrichment level of 26 gene sets associated with neurological diseases in humans, macaques, mice, and TS. Bar plot showing the standard derivation of a certain disease risk gene set, with species-related cell types indicated below the plot. Asterisks denote the BH-corrected P-value < 0.05 calculated using EWCE (permutation test). b) Cell-type enrichment level of 11 gene sets associated with neurotransmitter receptors and transporters in the four species. AD, Alzheimer's disease; ADHD, attention deficit hyperactivity disorder; ALD, alcohol dependence; ANO, anorexia nervosa; ASD, autism spectrum disorder; BIP, bipolar disorder; FTD, frontotemporal dementia; HD, Huntington's disease; MDD, major depression disorder; MS, multiple sclerosis; OCD, obsessive–compulsive disorder; PD, Parkinson's disease; SASP, senescence-associated secretory phenotype; SCZ, schizophrenia; TOS, Tourette syndrome.