Presentation of the holistic AF-CARE pathway in the treatment of AF, with expansion of the comorbidity and risk factor management (‘C’), with specific focus on the promotion of an active lifestyle. Specifically, we have highlighted four key pillars to promote an active lifestyle following the ‘lifestyle-care’ pathway; [c] collaboration for shared-decision making, [a] activities in daily living, [r] repeatability in engaging in this lifestyle for sustainable changes, and [e] exercise-based cardiac rehabilitation.