Administration of Akkermansia muciniphila ameliorated TNBS-induced colitis in IL-6^−/− mice. A, Body weight changes were daily monitored. B Disease activity index (DAI). E, Representative photomicrographs of HE in colonic tissues. F, Histology scores (HAI). G-H, Western blot analysis of STAT3, and p-STAT3 protein levels. I-J, ELASA expressions of STAT3 and p-STAT3. K-L, Relative mRNA level of STAT3 and p-STAT3. M-O, Representative photomicrographs of STAT3 and p-STAT3, cell nucleus. Statistical significance was determined using Student’s t-tests, ns, not significant; TNBS, trinitrobenzene sulfonic acid.