Representative immunofluorescence sections showing dedifferentiated cells. (A) Pancreas from case # 309 (%diff/CGA: 3.50, %HOMA-β: 128.0), case # 682 (%diff/CGA: 7.68, %HOMA-β: 84.2), case # 306 (%diff/CGA: 8.71, %HOMA-β: 97.1) stained with CGA (green), insulin (white), endocrine cocktail (Gcg/Sst/Pp, red), and DAPI (blue) are shown. The specific area of the islet is highlighted within a white box, and enlarged to demonstrate the presence of dedifferentiated cells, indicated by yellow arrows. (B, C) The Pearson correlations between HOMA-β and 2hr C-peptide with dedifferentiated cells/CGA-positive cells. (D) Multivariate association of the clinical variable with the ratio of dedifferentiated cells in islets. Scale bars, 20 μm. The r of Pearson correlation and P values are shown in each panel. n = 13, *P < .05 was considered to be statistically significant.