Potential SLIs in bladder cancer. (A) Heatmap depicting the top SLI pairs in bladder cancer, with redder colors indicating higher DD scores. Similar heatmaps for each of the cancer types are available in Supplementary Fig. S1. (B) Volcano plot showing all potential SLIs for the RB1 mutation, with AHR and CDK2 identified as the top-ranking candidates based on DD (x-axis) and statistical significance (−log10P-value on y-axis). More examples in Supplementary Fig. S2. (C) Boxplots illustrating the separation in gene dependency scores between RB1 wild-type and RB1 mutant bladder cancer cell lines for the AHR and CDK2. (D) Dependency network for AHR in bladder cancer, highlighting edges that connect these genes to RB1-associated pathways. (E) Correlation plot between the dependency scores of AHR and the enrichment of RB1-related pathway across the cell lines.
