Differences between SZ and HC in MRICIs. (A) The Bar Chart of the Top 3 Panels Represents the Median MRICIs and Their Standard Error (SE) of All, FE, and NFE Cohort, Respectively. Intergroup Comparisons are Performed Using Wilcoxon Rank-Sum Test. ** Represents P < .05 with Bonferroni Corrected, and * Represents Uncorrected P < .05. The Fourth Row Represents the Forest Plots of the Effect Size at Each Site, with the Black Solid Line Indicating the 95% Confidence Interval. (B) One-Sample t-Test of Voxel-Wise Deviations in GMV, FA, and FCS in Schizophrenia Patients (P < .05, FWEc Correction). (C) Voxel-Wise Correlation between Individuated Deviation of Neuroimaging Measures and MRICIs (P < .05, FWEc Correction for Nd_GMV, Cd_GMV, Ed_GMV and Cd_FA; P < .05 Uncorrected for Cd_FCS). (D) Performance of MRICIs in Distinguishing Schizophrenia Patients from Healthy Controls by SVM Classifier

Abbreviations: ES = effect size; SZ = schizophrenia patient; HC = healthy control; FE = first-episode schizophrenia patients; NFE = non-first-episode schizophrenia patients; Pd = positive symptom dimension; Nd = negative symptom dimension; Cd = cognitive symptom dimension; Ed = excitative symptom dimension; Dd = depressive symptom dimension; GMV = gray matter volume; FA = fractional anisotropy; FCS = functional connectivity strength; ROC = receiver operating characteristic; SVM = support vector machine