The dynamic interactions between core networks after monotherapy treatment in SR and NR subgroups. a) Significant monotherapy treatment status × drug efficacy interaction effects between the SR and NR groups (P < 0.005, corrected). The interaction effects were mainly distributed in PN-DMN/SCN and DMN-SN. (b) The dynamic functional connectivity (dFC) between the right angular (R.AG) and posterior cingulate cortex (PCC) in NR subgroup showed significant increase relative to SR subgroup (P < 0.005, corrected). The dFC between the right posterior insular (R.PI) and the left primary motor in NR subgroup presented significant decrease compared with SR subgroup (P < 0.005, corrected). c) The significantly reduced dFC at post-treatment relative to baseline in all patients group (P < 0.005, corrected). d) The results of post hoc analyses in the interaction effects. The gray ^* means a marginal effect in the comparison between groups (p ≦ 0.06). ^*P < 0.05, ^**P < 0.01. e) The correlations and moderation effects between the changed dynamic FC (∆FC) and positive symptom relief (⁠|$\Delta{PANSS}_P$|⁠) and mean CPZ at two time points in NR subgroup. Abbreviation: SR = responders; NR = nonresponders; L.DLPFC = left dorsolateral prefrontal cortex; R.IT/L.IT = right/left inferior temporal; L.AG = left angular gyrus; R.PHG = right parahippocampal gyrus; L.mPFC = left medial prefrontal cortex; dACC = dorsal anterior cingulate cortex; R.vAI = right ventral anterior insular; R.PI = right posterior insular; L.CAU = left caudate; R.THA = right thalamus; L.SI = left primary somatosensory cortex; L.MI/R.MI = left/right primary motor; L.AI = left primary auditory cortex; R.VI/L.VI = right/left primary visual; L.VII = left V2 area; DMN = default-mode network; SN = salience network; PN = primary network.