Figure 3.
Zonation is partially affected in Lats1flox/flox;Lats2flox/flox;AScre/+ mice. (A–C) Immunohistochemistry analyses of CYP11B1 (A), CTNNB1 (B), and DAB2 (C) in adrenal glands of the indicated ages and genotypes. Red arrow = CYP11B1+ cells between the zG and ECM region Arrowhead = DAB2+ cells in the ECM; arrow = DAB2+ cells in the zF.

Zonation is partially affected in Lats1flox/flox;Lats2flox/flox;AScre/+ mice. (A–C) Immunohistochemistry analyses of CYP11B1 (A), CTNNB1 (B), and DAB2 (C) in adrenal glands of the indicated ages and genotypes. Red arrow = CYP11B1+ cells between the zG and ECM region Arrowhead = DAB2+ cells in the ECM; arrow = DAB2+ cells in the zF.

Abbreviations: CTNNB1, β-catenin; CYP11B1, cytochrome P450, family 11, subfamily B, polypeptide 1; DAB2, disabled homologue 2; ECM, extracellular matrix; zF, zona fasciculata; zG, zona glomerulosa.

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