Proposed algorithm for diagnosis and monitoring of AFD using clinical evaluation and multimodality cardiac imaging. *Cardiac amyloidosis, glycogenosis, hypertrophic cardiomyopathy, and mitochondriopathy. α-GalA act., alpha-galactosidase A activity; CMP, cardiomyopathies; CMR, cardiac magnetic resonance; ECG, electrocardiogram; EF, ejection fraction; ERT, enzyme replacement therapy; LS, longitudinal strain; LVH, left ventricular hypertrophy; LysoGb3, lysosomial globotriaosylceramide; PET, positron emission tomography; RV, right ventricular; SPECT, single-photon emission computed tomography.