Aortic valve with accumulation of small bodies containing Gb3 (A, toluidine blue staining). Endomyocardial biopsy reveals interstitial fibrosis and hypertrophic myocytes with myofibrillar loss and extensive vacuolization. Most myocytes appear empty due to tissue processing (B). In some cardiomyocytes, clusters of round bodies are found consisting of Gb3 deposits (C). Masson trichrome staining.