Identification of significant enriching pathways in placentas of polycystic ovary syndrome (PCOS) patients. RNA-sequencing data of placentas between PCOS patients (n = 3) and non-PCOS individuals (n = 3) were downloaded from the GEO database and analyzed with Gene Set Enrichment Analysis. A, Bubble plot of the first 10 enriching pathways from upregulated genes (normalized enrichment scores [NES] > 0) and downregulated genes (NES < 0). B to D, Statistically significant enriching pathways were identified by standards with nominal P values less than .05 and false discovery rate q less than .5.