Relative changes in dialysate lactate and glycerol in adipose tissue in men (n = 7) and in women (n = 7) after drinking 500 ml water (22 C). CTRL, Control, Ringer’s solution only; BBL, local β-adrenergic blockade by 100 nm propranolol added to the perfusion medium; BBS, systemic β-adrenergic blockade by ingestion of 100 mg metoprolol. Data are given as means ± se. In men, dialysate lactate increased significantly (P < 0.01) after water drinking, and this effect was prevented by systemic but not local β-adrenergic blockade. In contrast, in women, dialysate lactate did not change significantly after water drinking alone but increased significantly (P < 0.05) in the presence of systemic β-adrenergic blockade. Dialysate glycerol increased slightly but nonsignificantly in men. However, that increase was not observed during β-adrenergic blockade. In women, no changes at all were observed in dialysate glycerol with any protocol used.