IGF-I levels in patients with aromatase deficiency before and during estradiol (E2) therapy, and in normal subjects. n.s., Not significant. *, t test for paired data; **, t test for unpaired data for the comparison of aromatase-deficient patients before estrogen treatment (E2) and normal subjects; ***, t test for unpaired data for the comparison of aromatase-deficient patients during estrogen treatment (E2) and normal subjects.