Volume 8, Issue 2, April 2025
Review Articles
Fc gamma receptor polymorphisms in antibody therapy: implications for bioassay development to enhance product quality
Statement of Significance: FcγR polymorphisms influence therapeutic antibody efficacy by altering receptor expression and immune responses. This review highlights the critical role of these polymorphisms in optimizing bioassays to accurately assess antibody quality and ensure consistency in manufacturing, ultimately leading to improved therapeutic outcomes.
Fundamental properties and principal areas of focus in antibody–drug conjugates formulation development
Statement of Significance: This article comprehensively reviews and summarizes the formulations of commercial antibody–drug conjugates (ADCs) for the first time. The discussion extends to essential factors in drug product manufacturing and logistics processes. Additionally, the unique technical challenges of ADC formulation development compared to unconjugated antibody and the corresponding solutions are elucidated.
A systematic review of the avian antibody (IgY) therapeutic effects on human bacterial infections over the decade
Statement of Significance: The dose-dependent therapeutic effects of antibody have been reported in the treatment of some infections include: oral, skin, gastrointestinal and…. The insignificant effect of this antibody against neurological bacterial infections. Comparison of the effective dose and administration route of antibody in bacterial infections. The possibility of side effects such as antibody-dependent increase.
