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Health (2 edn) Oxford Handbook of Genitourinary Medicine, HIV, and Sexual Health (2 edn)

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Disclaimer
Oxford University Press makes no representation, express or implied, that the drug dosages in this book are correct. Readers must therefore always … More Oxford University Press makes no representation, express or implied, that the drug dosages in this book are correct. Readers must therefore always check the product information and clinical procedures with the most up to date published product information and data sheets provided by the manufacturers and the most recent codes of conduct and safety regulations. The authors and the publishers do not accept responsibility or legal liability for any errors in the text or for the misuse or misapplication of material in this work. Except where otherwise stated, drug dosages and recommendations are for the non-pregnant adult who is not breastfeeding.

The genitourinary medicine (GUM) patient 46

Types of sexual practice 48

The sexual history 50

Routine examination: general principles 52

Examination 54

Principles of management and review 58

Sexual health in primary care 60

It is estimated that 1 in 7 adults over the age of 16 in the UK has attended a GUM clinic at least once. Many who attend may not harbour an active sexually transmitted infection (STI) but wish to exclude one. The ‘GUM patient’ does not fit a single stereotype. While it may be more common for young people to attend, a wide age range from <16 to >60 are seen. Their demographic characteristics vary, depending on the risk factors of the local and commuting population and the acceptability and accessibility of GUM services to potential users. Slightly more ♂ than ♀ attend, with sexuality and ethnicity varying geographically. The following groups of people are more likely to attend:

♂ aged 25–34

♀ aged 16–24

those who have changed sexual partners recently

those having multiple sexual partners

those single, separated, or divorced.

While most patients attending may feel anxious and embarrassed, some are intensely distressed. The psychological responses to STIs or risk of such include severe anxiety, depression, a strong sense of stigma, shame, feelings of guilt, low self-esteem, and anger. Strong negative responses such as these may hamper communication and lead to apparently irrational behaviour. It is necessary to understand and appraise the emotional state of the patient when providing optimum care. If a patient is aggressive, the priority should be safety while attempting to de-escalate the situation.

(graphic Chapter 5, Children p. 108)

Adolescents <16 years attending GUM have a high incidence of STIs and report a low use of reliable contraception. Some may also have suffered sexual abuse.

(graphic Sexual assault: general principles p. 102)

May attend for sexual health screen and STI risk assessment and due consideration should be given to any post-traumatic stress that may dominate the patient’s mood and emotions.

The following risk factors have been noted in various epidemiological studies. They are likely to vary over time and across different geographic regions but are useful in planning local service provision and targeting specific sexual health promotion. Clinically they are useful in risk assessment.

Age <25 years: the highest rates of gonococcal and chlamydial infections occur in age groups 16–19 years in ♀ and 20–24 years in ♂.

Being single: separated, divorced, or not in a stable relationship (compared with marital, stable relationship, or widowed status) are associated with higher rates of STIs.

≥2 partners in preceding 6 months.

Use of non-barrier contraception.

Residence in inner city.

Symptoms in partner.

History of previous STI.

Ethnicity or migration: prevalence of several infections, notably syphilis, gonorrhoea, and HIV infection, is higher in certain ethnic minority groups and immigrants

Sexual orientation: for example, syphilis, gonorrhoea, HIV, and hepatitis B virus infections are more prevalent among ♂ who have sex with ♂ (MSM).

Certain types of physical contact carry higher risks for certain infections, e.g. penetrative sex and HIV, orogenital contact and anogenital herpes.

Knowledge of the wide range of sexual practices and the vocabulary in use is of value in advising those at risk of STIs.

Heterosexuality (opposite sex): (heterophilia, ‘straight’)

Bigynist (sex between 1 ♂ and 2 ♀), bivirist (sex between 1 ♀ and 2 ♂).

Homosexuality (same sex): general (homophilia, ‘gay’, iterandria, uranism).

Cruising describes searching for MSM partners in public places, e.g. common land, saunas, bath-houses, toilets (cottaging).

♀ homosexuality: lesbianism, cymbalism, gynecozygous.

Bisexuality (both sexes): ambisexual, amphisexual, androgynophilia, sexoschizia.

Cybersex: use of the Internet to deliver sexual pleasure.

Arousal from kissing (basoexia), manual genital stimulation (mutual masturbation and heavy petting), body rubbing (frottage and ‘dry rooting’), rubbing buttocks (pygotripsis), feet (podophilia), kneading flesh (sarmassophilia); tickling (titillagnia), lap dancing (squatting above a sitting person and non-genital rubbing).

Penile positioning into the axilla (axillism), between breasts (coitus a mammilla and mazophallate), between legs (coitus interfermoris), between knees (genuphallation).

Insufflation: blowing air into a body cavity, usually the vagina).

Penile oral sex: fellatio, ‘blow-job’, corvus, irrumation, penosugia.

♀ genital oral sex: cunnilingus, gamahucheur, clitorilingus (clitoral tongue stimulation).

General terms for anal sex: anocratism, arsometry, buggery, coitus analis, pederasty, proctophallism, sodomy, sotadism.

Oral stimulation: analinctus and hedralingus (anal licking), anophilemia (anal kissing), analingus and rimming (anal penetration with tongue).

Specific penile anal sex: androsodomy (with ♂), anomeatia (with ♀).

Manual: fisting, brachioprotic eroticism (fist/arm into anorectal canal).

Urine: golden enema/douche/shower (urine deposited into anus/vagina/over body), urolagnia, urophilia, water sports.

Faeces (scat): coprolagnia and coprophilia (arousal), coprophagy (consumption).

Miscellaneous: hygrophilia (body fluids), blood sports (blood), mucophage (ingestion of mucous secretions), salirophilia (ingestion of sweat or saliva), felching (ingestion of semen from vagina or anus), emetophilia and Roman shower (vomit and vomiting over partner).

Sadism:arousal by inflicting pain.

Masochism (pain translated to erotic feelings).

Algophilia and doleros (arousal from pain).

Examples: caning/flagellation (using cane/whip), bondage/strangulation (physical restraint/constriction), electrophilia (arousal from electricity), meatotomy (urethral dilation).

Bestiality, zoophilia. Specific examples include cynophilia (dogs), entomophilia (insects), ophidiophilia (snakes), felching (inserting animals into vagina or anus).

Arousal enhancers: penis substitutes (dildos, vibrators, olisbos, anal, butt plugs) and genital piercings (rings, bars, beads, wires, etc).

Erection sustainers: rings and bands (e.g. cock ring).

Amyl nitrite for euphoria and sphincter relaxation.

Crack cocaine ↑ desire.

Alcohol and some tranquillizing drugs (sometimes used illicitly, e.g. ‘drug rape’) remove inhibitions.

Taking a sexual history and discussing sexual health issues are vital elements of the consultation, eliciting essential information on the STI risk. It must be non-judgemental and empathic, thereby promoting effective patient participation. When taking a sexual history:

Put the patient at ease with proper initial introduction and positioning.

Reassure regarding confidentiality.

Explain why a sexual history is needed.

Check if patient agrees to be asked personal questions.

Ideally interview the patient alone but respect the patient’s desire to have a third person present which may help to ↓ anxiety.

Avoid distractions during the consultation.

Display a non-judgemental attitude.

Do not make assumptions about patient’s sexuality or sexual behaviour.

Listen actively and maintain adequate eye contact, observing non-verbal communication.

Use language the patient understands, avoiding jargon, with appropriate intonation, pauses, and cues to gain information.

Reflect what patient says to clarify and confirm.

Pro formas ensure a systematic approach to history-taking (Algorithm 3.1). Asking when last sexual intercourse took place is a useful way to start the sexual history (details of sexual partners, contraception, and sexual risks). Presence of a third person, especially sexual partner, may inhibit this. Types of sexual practices reported can help in planning which specimens to obtain. Obtain any information patient has on the nature of sexual partner’s infection(s). Where mother-to-child transmission is relevant enquire about clinical presentations in the children.

 Taking a sexual history
Algorithm 3.1

Taking a sexual history

Conducting the consultation through an interpreter or when cross-cultural issues are relevant may be difficult. It is preferable to use an unrelated interpreter but sometimes this may not be possible.

Prior to the examination the patient should be given an explanation and his/her agreement obtained. Certain procedures require written consent (e.g. local anaesthesia, minor surgery, and clinical photography).

The examination room should be warm and comfortable with a screened area allowing privacy while the patient undresses. An examination couch with good lighting is required (with stirrups/leg rests for ♀ to allow examination in the semi-lithotomy position).

The patient should undress below the waist and be provided with drapes or gowns. Irrespective of the gender of the patient or the examiner, a chaperone must be offered (graphic GMC Guidance 2001, p. 25), who may also be able to assist in the collection of specimens and reassure the nervous patient. The acceptance or refusal of a chaperone should be documented in the patient’s notes. Chaperones should sign to confirm their attendance during the examination. Although the GMC suggests that a patient’s friend or relative could act as a sole chaperone, this is not advised in GUM as it may compromise confidentiality and the provision of relevant information to the healthcare professional (HCP).

The examination trolley should be set up prior to the examination. Specula should be pre-warmed in water, which also acts as a vaginal lubricant. Lubricating gels should be avoided whenever possible as they may inhibit the growth of Neisseria gonorrhoeae. The use of lubricants cannot be avoided for proctoscopy, but care should be taken to ensure that swabs are not contaminated. During examination the patient should be kept informed of progress, but unnecessary or facetious comments must be avoided. Convenient facilities should be available to obtain urine specimens.

A venous blood sample for syphilis and HIV should be taken with consent from patients at risk of an STI. Because of the sensitivity arising from HIV testing and the implications of a positive result, additional discussion may be required to ensure fully informed consent (graphic HIV pre-test discussion p. 436). Testing for hepatitis B and C virus may also be required.

Skin rashes/lesions, generalized lymphadenopathy, hair loss, jaundice, mucosal lesions (orogenital), conjunctivitis/uveitis, and arthritis may arise from STIs, and genital problems may be features of dermatological or systemic diseases.

Inspect the entire pubic and anogenital area ensuring that the labia are parted and the clitoral hood gently retracted.

Palpate the inguinal area for lymphadenopathy.

Urethral specimens. There is doubt about the value of routine urethral samples for Gram staining and culture for N.gonorrhoeae; however, they have been shown to be useful on occasions. Urethral sampling may be deferred until the end of the examination as it may cause discomfort. The addition of a urethral swab to an endocervical specimen ↑ the detection of chlamydial infection.

Introduce a speculum lubricated with warm water.

Inspect the vagina and cervix for atypical discharge, mucosal lesions, and signs of inflammation.

Take vaginal material from the posterior vaginal pool/vaginal walls using a loop or swab and prepare a suspension in normal saline on a slide protected with a cover-slip. An additional swab should be prepared as a Gram-stained smear.

If cervical cytology is required it is best taken at this stage.

Before microbiological sampling clean the cervix using a cotton ball held in a sponge-holder to remove vaginal material

Take an endocervical swab to prepare a Gram-stained smear and to plate onto selective medium for N.gonorrhoeae (or send in transport medium, e.g. Amies, Stuart).

Take an endocervical swab for Chlamydia trachomatis, rotating it within the walls of the cervical canal. Although cervical specimens are not essential with nucleic acid amplification tests (NAATs), it is important to inspect the cervix (especially for mucopurulent cervicitis) and to take swabs for N.gonorrhoeae. Hence it is also reasonable to screen this site for C.trachomatis.

If there are any signs or symptoms to suggest lower abdominal or pelvic pathology offer a bimanual pelvic and abdominal examination.

Urine specimens should be obtained if pregnancy testing is required or a urinary tract infection (mid-stream sample) suspected. They can also be used for chlamydia testing (1st 20mL) by NAAT and for certain enzyme immunoassays (EIAs).

 Female genital anatomy
Fig 3.1

Female genital anatomy

Inspect the entire pubic and anogenital area for skin lesions, masses, discharges, and signs of infestation. This includes the glans penis and sub-preputial sac by retracting the prepuce.

Palpate the inguinal area for lymphadenopathy and scrotal contents for masses, tenderness, and other anomalies.

Examine the urethral meatus for discharge and skin lesions, especially warts. If there is urethral exudate, any symptom of urethritis, or history of penile sexual contact with gonorrhoea, a gentle scraping from the urethra should be taken using a small plastic loop and smeared onto a microscope slide for Gram-staining. It may be necessary for the urethra to be gently massaged to obtain a specimen. Ideally samples should be taken 3–4 hours after last micturition.

The same loop can then be used to plate directly onto selective medium for N.gonorrhoeae even if there is no material to prepare a slide. If a transport medium (e.g. Amies or Stuart) is used, a separate swab is required which the laboratory should ideally receive within 48 hours for plating provided that it is kept refrigerated.

Urethral sampling for C.trachomatis can be undertaken at this time using an NAAT (or EIA). It is recommended that a fine urethral swab is inserted 1–4cm into the urethra and rotated once against the urethral wall, although in clinical practice this is often not possible. Alternatively, urine can be tested by NAAT or EIA licensed for urine specimens.

Finally, the patient should provide a first voided 20mL urine specimen (ideally having retained their urine for 3–4 hours before testing). As well as providing a test sample for C.trachomatis it can also be examined for threads, a possible indicator of urethritis. A second, mid-stream sample can be obtained especially if urinary tract infection needs to be excluded. Samples can also be tested by dipstick for blood, protein, glucose, nitrites, and leucocytes as required.

In those at risk, especially MSM, proctoscopy and screening for N.gonorrhoeae and C.trachomatis (if NAAT is available) should be offered, remembering that infection may occur without penile penetration. The anal canal and distal 5cm of the rectum should be examined with a proctoscope to check for pus (which can be sampled and prepared as a Gram-stained smear) and other lesions (e.g. warts). This also minimizes faecal contamination when taking swabs. Lubricants should be used with care around the anal sphincter to avoid rectal contamination as they may impair the isolation of N.gonorrhoeae.

Rectal testing for N.gonorrhoeae should also be offered to ♀ at risk (e.g. with symptoms, urogenital gonorrhoea, contacts of gonorrhoea, and following sexual assault). Chlamydia screening may also be considered.

Swabs for N.gonorrhoeae should be offered to those at risk especially if symptomatic, gonorrhea found at other site(s), contacts of gonorrhoea, MSM, and those sexually assaulted.

 Male genital anatomy
Fig 3.2

Male genital anatomy

At the end of the consultation the patient will require further advice and information on their condition or situation, its management, and the need, when relevant, for further follow-up which may include repeat or additional tests. It is important to make these recommendations clear and explicit with the provision of written information.

If specific treatment is required it should:

be based on regularly reviewed local or national guidelines

recognize individual factors (e.g. other medical conditions, allergies, pregnancy, etc.)

meet individual patient needs to maximize adherence (especially long-term HIV treatment).

Treatment dispensed by a nurse must be provided under local Trust ratified patient group directions.

Any medicine dispensed and advice given must be documented in the patient’s records.

Confirm that any test results relate to the patient and that complete information is available (e.g. antibiotic sensitivity).

Explain the nature of the condition and its implications.

Discuss rationale for treatment including a risk–benefit analysis and specific information on the treatment recommended, and obtain patient’s agreement.

Ensure full STI screening is offered (explaining possibility of coexisting infections).

Provide additional advice that may include:

avoidance of sexual intercourse even with condoms (until infection cleared and partner treated)

possible effects on combined hormonal contraception

additional self-help information

general sexual health promotion.

Consider sexual partner(s) and partner notification issues when indicated (with health adviser).

Agree arrangements for obtaining results and/or further review (which may include tests of cure).

Ideally medication should be dispensed, free of charge, to the patient while he/she is in the clinic.

Treatment of STIs excluding HIV/AIDS (but including initial diagnosis of and counselling support for HIV) is free without any prescription charge to all attendees at GUM clinics irrespective of their nationality. HIV/AIDS management after the initial diagnosis and counselling is subject to the standard regulations concerning entitlement to NHS hospital treatment (graphic Asylum seekers and refugees p. 36).

Primary Care Trusts (PCTs) have principle responsibility for:

ensuring that the National Strategy for Sexual Health and HIV is implemented at local level

coordinating local sexual health planning and commissioning

ensuring appropriate capacity and resources are available to deliver these standards.

Sexual health services are divided into levels as outlined in the National Strategy for Sexual Health and HIV (Box 3.1).

Box 3.1
Level 1 services

Sexual history and risk assessment

STI testing for women

HIV testing and counselling

Pregnancy testing and referral

Contraception information and services

Assessment and referral of men with STI symptoms

Cervical cytology and referral

Hepatitis B vaccination

If a primary care practice is unable to provide Level 1 service it should be made clear in the practice information and explicit arrangements made for their patients through other practices or community services. PCTs should identify and support primary care teams with special interests in sexual health which can provide locally enhanced services to a high standard. GPs and nurses need to undertake specific training to develop and maintain skills required. These services can be offered to unregistered patients or those registered with other practices. PCTs should develop provision of a full range of Level 2 services (Box 3.2) in collaboration with GUM and Community Family Planning to meet local needs and fill gaps in existing service provision.

Box 3.2
Level 2 services

Intra-uterine device insertion.

Testing and treatment for STIs.

Contraceptive implant insertion.

STI partner notification.

Invasive STI testing (until non-invasive tests are available).

For extensive testing refer to local GUM service and contact local laboratories regarding test methods and arrangements.

Test patients at high risk (under-25s and new partner in preceding 12 months).

Test for C.trachomatis and N.gonorrhoeae (the latter is particularly important if local outbreak or in a high-prevalence area). If positive for gonorrhoea refer to Level 2 or 3 service for culture and sensitivities.

MSM: urine NAAT test for C.trachomatis and N gonorrhoeae, rectal swab for N.gonorrhoeae and C.trachomatis, pharyngeal swab for N.gonorrhoeae.

Women

Vaginal discharge: trichomonas, candida, and bacterial vaginosis (high vaginal swabs). If at high risk, test for chlamydia, gonorrhoea (endocervical swabs). If trichomoniasis is suspected, consider GUM referral for immediate microscopy. If over 25 and no new partner since last tested, assess symptoms and pH paper test. If pH ↑ (i.e. >4.5) treat for bacterial vaginosis; if pH normal treat for candidiasis. If symptoms fail to resolve investigate/refer to GUM.

Urinary symptoms ± abdominal pain: STI needs to be excluded.

Men

Urethral discharge ± dysuria: test for chlamydia and gonorrhoea.

Testicular swelling: exclude STI and request MSU (especially if over age 35).

Anogenital ulceration: consider early referral to GUM. If this is not possible and herpes suspected start antiviral treatment immediately.

If local prevalence exceeds 2 in 1000 (local PCT data) all men and women registering with a general practice should be offered an HIV test. Otherwise a risk assessment should be performed (graphic Chapter 38, p. 436). Positive test: refer to GUM.

Consider sexual and contact history. If positive syphilis serology, refer to GUM. If positive hepatitis B serology, refer to gastroenterology. If patient at risk of hepatitis B administer hepatitis B vaccination (graphic Chapter 24, p. 296).

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