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Book cover for Oxford Handbook of Clinical Specialties (9 edn) Oxford Handbook of Clinical Specialties (9 edn)
Disclaimer
Oxford University Press makes no representation, express or implied, that the drug dosages in this book are correct. Readers must therefore always … More Oxford University Press makes no representation, express or implied, that the drug dosages in this book are correct. Readers must therefore always check the product information and clinical procedures with the most up to date published product information and data sheets provided by the manufacturers and the most recent codes of conduct and safety regulations. The authors and the publishers do not accept responsibility or legal liability for any errors in the text or for the misuse or misapplication of material in this work. Except where otherwise stated, drug dosages and recommendations are for the non-pregnant adult who is not breastfeeding.

Quite a few doctors hope to make patients better by taking responsibility for ordering the mileau interieur, and the credit when things go well. In psychiatry this approach is wrong. Mental health is about people (not patients) taking responsibility for themselves and their programme of change. The psychiatrist knows that his or her job is done, not when the patient is cured but when he becomes self-actuating, insightful, and interacting with the world in creative (not necessarily satisfactory) ways. So if you are hoping for a chapter dealing with mental disorders as if they were lung diseases with certain signs and agreed treatments this chapter will disappoint. Isn’t it woolly, a reader complained, to have pages on listening, dignity, etc? “Just tell me what to do.” Well, here goes. Interpersonal problems: just do what you think you should do. Anxious? Get on with it: relax; try β-blockers. Depressed? ssris, tricyclics or get wired (ect); think positive. Manic? Try lithium. Psychopathic? Tough luck. Schizophrenic? Antipsychotics; if dangerous, lock up. Psychotherapy for everything else. Phew! That’s got it over with. Now sit back and rest. Or sit back and listen…if you listen, you may be able to help, rather than beat people over the head with formulaic solutions to problems they don’t quite have.

Doctors have never been very important because nothing that happens to our bodies ever really matters. In historical terms, what happens to our bodies rarely outlives our own times. Even the exceptions to this prove a different rule: we recall forever human images burnt on to stone at their moment of immolation in Nagasaki and Hiroshima. What happened to these people was important, and transcended their times. But it is all the more true that it isn’t the way they lived, but the way they died that is important, and it is not the body or its image on stone which is important, but the image left on our minds. And so it is with psychiatrists, psychologists, and psychiatric nurses who play such vital roles in colouring our lives with hope or despair, who mitigate our madness, giving meaning, purpose, and dignity to the mental sufferings of so many of us. So when we think of them going about work, think of them burnishing humanizing images not on stone, but on the mind itself. How they do it is the subject of this chapter.

Screaming but unheard: images born of paranoid schizophrenia. Neil Houghton, the artist, says: “I was born in Bolton with a pencil in my hand. Always deep in thought and not mixing much with others. I have always been troubled with confusing and scary thoughts…diagnosed as schizophrenia. This painting is from a series chronicling a bad episode.”©Neil Houghton Gallery. When we asked him what message he would like to send doctors learning about mental illness, he replied “Patients can offer a valuable insight into their own illness.” This value he points to is troubling, hard-won, but, ultimately, liberating.
Fig 1.

Screaming but unheard: images born of paranoid schizophrenia. Neil Houghton, the artist, says: “I was born in Bolton with a pencil in my hand. Always deep in thought and not mixing much with others. I have always been troubled with confusing and scary thoughts…diagnosed as schizophrenia. This painting is from a series chronicling a bad episode.”©Neil Houghton Gallery. When we asked him what message he would like to send doctors learning about mental illness, he replied “Patients can offer a valuable insight into their own illness.” This value he points to is troubling, hard-won, but, ultimately, liberating.

graphic“Terror grips when these things happen; the signs, the lights, the storm within: death by instalments… I’m a daily subscriber.”
(Each of us bears the complete stamp of the human condition) This is the first principle of psychiatry and was proclaimed by Michel De Montaigne in 1580. The second principle has yet to be agreed but will probably include reference to the idea that the bond between therapist and patient is unbreakable by any fact or revelation and exists entirely to foster growth and development.

Before reading further, cover the next paragraph with a card and write on it what you are trying to achieve as a mental health worker. Next, turn the card over and write down what was actually in your mind as unstated goals when you were last treating someone. So often our unconscious aim is just symptom control, obedience, or simply (simply!) normality. But if you were the patient (luck changes in a moment) what would you want? The aim of this page is to help you find out, by considering one person’s answer.

Healthy (lucky!) humans are able:  To love and be loved; without this asset, humans, more than all other mammals, fail to thrive.

To embrace change—and face fear in a spirit of practical optimism.

To take risks, free from endless worst-case-scenario-gazing.

To satisfy the requirements of the group—if the person so desires.

To deploy joie de vivre, and a wide range of emotional responses, including negative emotions, such as anger (pain’s most motivating antidote).

To make contact with reality: not too rarely or too often. Human kind cannot bear very much reality.

To say “I was wrong” and learn from life and to have enough self-knowledge to heal the self and others, but not so much as to become demoralized.

To inhabit fantasy worlds, enabling hope and creativity to flourish.

To feel a sense of security, not always predicated on one’s status in society.

To enjoy self-expression—balanced by sensitivity to others’ vulnerabilities.

To feel a sense of awe and to risk enchantment (and hence disenchantment).

To gratify bodily desires and eventually to be free from desire. He who no longer desires anything for himself is both free and good, yet not superior.

To have a sense of humour to compensate if the foregoing is unavailable.

Go, go, go, said the bird: human kind Cannot bear very much reality. Time past and time future What might have been and what has been Point to one end, which is always present.

Four Quartets,  ts eliot

Happiness1graphic need not be an ingredient of mental health, as the merely happy are supremely vulnerable to events.

Whenever a person’s thoughts, feelings, or sensory impressions cause him objective or subjective harm that is more than transitory, a mental illness may be said to be present. Often the harm is to society, but this is not part of the definition of mental illness, as to include it would open the door to saying that, for example, all rapists or all those opposing the society’s aims are mentally ill. One feature of mental illness is that one cannot rely on patients’ judgment, and the judgment of family, gp, or psychiatrist has a role. If there is disparity, let it be ‘one person one vote’, if voters are acting solely in the interests of the patient. Psychiatrists have no special voting rights (or else concepts of mental illness get too medicalized). Just because psychiatrists and gps are not allowed more than one vote, this does not stop them from illuminating the debate by virtue of their special knowledge.

For convenience, English law saves others from the bother of specifying who has a mental illness by authorizing doctors to act for them. This is a healthy state of affairs only in so far as doctors remember that they have only a small duty to society, but a larger duty to their patient.

This is a condition of arrested or incomplete development of mind owing to low intelligence, p364.

Dignity on psychiatric wards

graphic

Apart from showing sympathy, nothing is more to be desired than giving our patients dignity—not the dignity that they deserve (who among us would merit an ounce of dignity on this measure?) but the dignity that confirms to our patients that, mad, bad, or rambling, they are, root and branch, body and mind, just as human as their doctors—perhaps more so, because they are suffering.1  Let patients

Decide on modes of address, ‘Miss Hudson’ may be preferred to ‘Amy, dear’. Dignity entails giving choices, and then respecting them.

Know who we are (eg wear name badges). But don’t label patients (“Go and see the new schizophrenic on Mary ward”). If you put a patient in a box the next thing you’ll do is put a lid on it—and stop thinking.

Wear their own clothes—and clothe them decently if they have none.

Choose whether to take part in research—and whether to see students.

Have personal space—both to stow their belongings, and to walk in, in private, whether alone, or with visitors.

Participate in their treatment plans; explain about common side effects.

Know what to do if a crisis develops. It’s a great help to know that you will be seen in 4 hours rather than be left to moulder all weekend.

These 7 points are congruent with nice (2012) and Human Rights law which lays out the right to life, freedom from inhuman or degrading treatment and torture, respect for privacy, the right to a fair hearing and freedom of expression. Some of these rights are inalienable, and unrevokable, even in time of war (on uk soil). So defences such as ‘the ward was busy that day’ or ‘there was no money to buy this service’ are unlikely to impress judges.

In practice, many mental health wards may do more harm than good (violence, verbal abuse, and sexual harassment eg from other patients).

Patients’ other needs: Maslow’s hierarchy and mental health

Maslow states that a healthy personality (ie fully functioning and self-actualizing) entails the meeting of a hierarchy of needs:

1

Biological needs (eg oxygen, food, water, warmth).

2
Safety needs (no present threats to safety); no pain. (Items 3–5 apply if this comfortable numbness, this ‘stye of contentment’ is inadequate).
3

Love, affection, and ‘belongingness’ needs.

4

Esteem needs (self-respect, and need for respect from others: see top box). The latter is 2-fold: being valued for what you can do or bring to your community or family—and, above all, to be valued for who you are.

5
Self-actualization needs to follow one’s calling and affirm “What I do is me: for that I came.”
Gerard Manley Hopkinsreference
If such needs are unmet, restlessness and anxiety result. To meet this need we might teach ourselves:

To be aware of the inner self and to understand our inner nature.

To transcend cultural conditioning.

To transcend the trifling and to grapple with life’s serious problems.

To refresh consciousness by appreciating beauty and all good things.

To feel joy and the worth of living. www.connect.net/georgen/maslow.htm

Uncomfortably numb on the lp ward…“Amy, dear, we are just going to put a tiny little needle in your back…you wont feel a thing….

graphicIt is important to decide if a patient has delusions, hallucinations (that the patient believes are real), or a major thought disorder (see below), because if present the diagnosis must be: schizophrenia, an affective disorder, an organic disorder, or a paranoid state (or a culturally determined visionary or spiritual experience), and not a neurosis or a personality disorder.

Patients may be reluctant to reveal odd ideas. Ask gently: “Have you ever had any thoughts which might now seem odd; perhaps that there is a conspiracy against you, or that you are controlled by outside voices or the radio?”

are auditory, visual, gustatory, or tactile sensations occurring without any stimulus. Common hypnagogic/hypnopompic hallucinations (on falling asleep or waking) do not indicate pathology. A pseudo-hallucination is one in which the person knows the stimulus is in the mind (eg a voice heard within him- or herself, rather than over the left shoulder). They are more common, and needn’t indicate mental illness, but they may be a sign that a genuine hallucination is waning. Tactile or visual hallucinations (without auditory hallucinations) suggest an organic disorder (eg alcohol withdrawal, or Charles Bonnet syndrome, p438). nb: 2–4% of the general population experience auditory hallucinations, but only ~30% of these have a mental illness (more likely if associated with distressing delusions).
are beliefs held unshakably, irrespective of counter-argument, that are unexpected, given the patient’s cultural background. If the belief arrives fully formed, and with no antecedent events or experiences to account for it, it is said to be primary, and is suggestive of schizophrenia (or genius1). Such delusions form around a ‘delusional perception’, as illustrated by the patient who, on seeing the traffic lights go green (the delusional perception) knew that he had been sent to rid his home town of materialism. A careful history will reveal that delusions are often secondary—eg a person who is psychotically depressed may come to think of himself as being literally worthless. Delusions are especially relevant if they involve persecution and loss of control.
Sometimes we cannot help feeling that others are noticing the very thing we are ashamed of. If we know the thoughts come from ourselves, and are excessive, it is an obsession, not a delusion. nb: ideas of reference have poetic as well as pathological causes, as in dramatic storms, when thunder and lightning speak to us directly, in personal messages flashed onto to sky in some cosmic rendering of our own vision.
Chimes of Freedom Bob Dylan; 1964reference
1

Hearing the thought as a voice (a hallucination)—eg from a psychosis.

2

The voice is ‘put into my head’—thought insertion (hallucination + delusion).

3

The voice is ‘my own voice’ but intrusively persistent (obsessional neurosis).

This entails bizarre thoughts, or incongruent transition from one idea to another. (Mania—flight of ideas, p354; schizophrenia, p358).

If hallucinations/delusions are present, ask:

1

What other evidence is there of mental illness? Hearing the voice of one’s dead spouse is common, and does not mean pathology.

2

Could the odd ideas be adaptive, and the patient be better off ‘ill’? A woman once believed she saw planes flying over her home, and that this data was taken from her head by the Ministry of Defence. She ‘knew’ she was playing a key role in defending Britain. When she was cured of her delusions (Ibsen’s ‘life-lie’2) she killed herself. An odd story; or is it so odd? According to the great poets, everything we cherish is an illusion, even our sense of distinctive self-hood, and without this primordial delusion, madness beckons.

Some causes of odd ideas

A typical problem is trying to diagnose a young man presenting with hallucinations and/or delusions. The question often is: Are these odd ideas due to schizophrenia, drug abuse, or physical illness?

1

Most auditory hallucinations not associated with falling asleep or waking up are caused by schizophrenia or depression.

2

In 90% of those with non-auditory hallucinations (eg seeing things), the cause is substance abuse, drug withdrawal, or physical disease.

3

Evidence that substance abuse is to blame includes:

The history: Ask the patient, the family, and friends about abuse. Be precise about timing. If ≥4 weeks elapse between abuse and starting of odd ideas, substance abuse is an unlikely cause (but substance abuse may be an enabling factor promoting later psychosis).1

Severity of symptoms: If symptoms are severe, and the quantity of drug ingested is trivial, the drug is unlikely to be causative.

Drug-seeking behaviour: Be on the lookout for this.

Physical examination: This may reveal signs of drug abuse (eg injection marks ± cellulitis), chronic alcohol abuse (eg spider naevi, liver palms, atrophic testes), or a physical medical illness (eg brain tumour).

Blood or urine tests may disclose the substance abused or give a hint of abuse (mcv⬆ and gamma gt⬆ in alcohol abuse).

Imaging: Consider cns imaging if the patient is elderly with nothing to suggest substance abuse, or if there are cns signs.

nb: middle-age is not a typical time for schizophrenia to present: alcohol abuse or a primary cns condition is more likely.

Diagnosing a substance-induced psychotic disorder implies that the patient responds to the hallucinations or delusions as if they were real. If the patient recognizes the hallucinatory nature of the experience, then consider diagnosing substance intoxication, substance withdrawal or, if there is past but no current exposure to hallucinogens, the diagnosis may be ‘flashbacks’—ie hallucinogen persisting perception disorder. This condition presents episodically up to 5 years after exposure to an hallucinogen, with flashback hallucinations—or phenomena such as geometric visual hallucinations, seeing coloured flashes, or intensified colours, dots, spots, or flashes, seeing trailing images or after-images, seeing complementary coloured images of objects gone from view, seeing halos, seeing things too small (micropsia), or seeing things too big (macropsia). These phenomena may be self-induced or triggered by darkness, stress, or fatigue.
DSM iv 313reference

We all have odd ideas: it–s our reactions to them and beliefs about them which are mad or sane or both.

What’s it like having hallucinations? Try virtual reality to find out
graphicDoctors are always getting hung up on hallucinations, those tokens used in games of clever diagnosis, without bothering to acquire real knowledge of what it’s like to have them. For doctors who have never experienced hallucinations, Professor Yellowlees has devised a virtual reality experience on Second Life: a complex, unruly 3D world where we doctors and our avatars get sucked into virtual clinics… Floors can fall away, leaving us walking riskily on stones above clouds. The eyes of a portrait flash ‘shitface’ as we pass, and a politician on an in-world tv might move in a single breath from platitudes to shouting “Go and kill yourself, you wretch!”. When it gets to the stage of our reflection in a mirror bleeding its eyes out before expiring, most of us switch off. But our patients cannot quit so easily. Virtual reality is just one way of sensitizing us to their struggles: other ways are through blogs, painting (p313), and tragedy (the Ophelia effect).

Voices in the margin are saying ‘get lost, ohcs’.

Only people can change people: ‘Alyosha’s arrival seemed to have a sobering effect on him…as though something had awakened in this prematurely aged man that had long been smothered in his soul…“For you see, my dear boy, I feel that you are the only man in the world who has not condemned me”.’
Brothers Karamazof Dostoevsky; page 25reference

On starting psychiatry you may feel unskilled. A medical problem will come as a relief—you know what to do. Do not be discouraged: you already have plenty of skills (which you will take for granted). The aim of this chapter is to build on these. No one can live in the world very long without observing or feeling mood swings, and without devising ways to minimize what is uncomfortable, and maximize what is desirable. Anyone who has ever sat an important exam knows what anxiety is like, and anyone who has passed one knows how to master anxiety, at least to some extent. We have all survived periods of being ‘down’, and it is interesting to ask how we have done this. The first element is time. Simply waiting for time to go by is an important psychotherapeutic principle. (Voltaire teasingly remarked that the role of the doctor is to amuse the patient until nature effects a cure.) Of course, there are instances when waiting for time to go by leads to fatal consequences. But this does not prevent the principle from being useful.

Another skill with which we are all more or less adept is listening. One of the central tenets of psychiatry is that it helps our patients just to be listened to. Just as we all are helped by talking and sharing our problems, so this may in itself be of immense help to our patients, especially if they have been isolated, and feel alone—which is a very common experience.

Just as spontaneous regeneration and improvement are common occurrences in psychiatry, so is relapse. Looking through the admissions register of any acute psychiatric ward is likely to show that the same people keep on being re-admitted. In one sense this is a failure of the processes of psychiatry, but in another sense each (carefully planned) discharge is a success, and a complex infrastructure often exists for maintaining the patient in the community. These include group support meetings, group therapy sessions, and social trips out of the hospital. We all have skills in the simple aspects of daily living, and in re-teaching these skills to our patients we may enable them to take the first steps in rebuilding their lives after a serious mental illness.

So time, listening, and the skills of daily living are our chief tools, and with these simple devices much can be done to rebuild the bridges between the patient and his outside world. These skills are simple compared with the highly elaborate skills such as psychoanalysis and hypnosis for which psychiatry is famous. The point of bringing them to the fore is so that the newcomer to psychiatry need not feel that there is a great weight of theoretical work to get through before he starts doing psychiatry. You can engage in the central process of psychiatry from day 1. Use the knowledge and experience gained as a foundation on which to build the constructs required for the more specific and effective forms of psychotherapy.

Listening, not judging. So often when we listen the fact that we are also judging leaks out in an unconscious disapproving gaze—and our patient clams up. This mythical ward round has adopted an extreme method to prevent this. Words waft up on thermals of hot air, unimpeded by cold or quizzical or uncomprehending gazes. So…don’t let ward rounds descend into fact-based inquisitions. As one history-taker said, “They wanted facts. Facts! They demanded facts…as if facts could explain anything!”Joseph Conrad Lord Jim
Fig 1.
Listening, not judging. So often when we listen the fact that we are also judging leaks out in an unconscious disapproving gaze—and our patient clams up. This mythical ward round has adopted an extreme method to prevent this. Words waft up on thermals of hot air, unimpeded by cold or quizzical or uncomprehending gazes. So…don’t let ward rounds descend into fact-based inquisitions. graphicAs one history-taker said, “They wanted facts. Facts! They demanded facts…as if facts could explain anything!”
Joseph Conrad Lord Jimreference
Suspending judgment

graphic

If we knew more about ourselves, we would understand more about our fellow patients, bearing in mind that ‘all gods and devils that have ever existed are within us as possibilities, desires, as ways of escape’. Herman Hesse 1919. What we want our patients to achieve is insight. Our judging does not help this. Judgment turns patients away from us. We cannot expect our patients to be honest with us if they know that we are judging them.

The good listener is not silent, but reflective—a mirror not a message. Mirrors do not judge but they enable self-judgment. Unless some criminal act is underway, it really does not matter what we think about our patients. What matters is how the patient thinks about him- or herself and his or her near-ones—and how these thoughts can be transformed.

If we judge people they will not trust us. No trust ≈ no healing.

If we judge, patients will leave us for others perhaps less well qualified.

There is no evidence that judging improves outcomes. Worse outcomes are likely if the patient feels alienated.

Patients know if we feel bad about them. They may internalize this, and assume that things will always be bad because they themselves are bad.

Despite these bullets, there is a problem that won’t go away. If we find ourselves talking to perpetrators rather than victims, we may not be wise to suspend judgment forever. If a crime is afoot putting others at risk, you may need to break confidentiality. Discuss this with a colleague. Ask yourself whether Nazi and Rwandan doctors were too nonjudgmental with their fellow patients. If ‘tout comprendre c’est tout pardonner1, then to pardon all actions is to abdicate our moral selves. What is the consequence of this—for us, and for our patients? Unless we exercise judgment, it might be thought, we may be condoning evil. ‘For evil to flourish in the world, all that is required is for the good to remain silent’. If we remain silent long enough, then will our own moral sense sicken, and die? What human duties do doctors have which trump anything that goes on in the consulting room? Whenever you think the time may have come to judge, check with yourself that it is not from outrage, or disgust, or through the exercise of pride, or from a position of power that you are judging—but reluctantly, and from duty. The dreadful history of some doctors in the twentieth century teaches that we must be human first, and physician-scientists second.

Phosphorescent patients

Dr. Quarrell’s letter—“My dear Elvet…

I am growing suspicious about the extent to which I need yr permission to have feelings about my patients. Clinical detachment is a profoundly unnatural state of mind and all sorts of evil can come of it…In Casualty amongst all that battered flesh…it was a survival tool. So it gets carried over into psychiatry. We offer our patients what appears to be human contact, human warmth—and we give them a calculated simulacrum of human contact, with no flesh, no blood, no love, no desire… I do not know how to proceed…help…this [patient] is slightly phosphorescent.”
AS Byatt 2003 p75 of A Whistling Womanreference

In judging others, we expend energy to no purpose…but if we judge ourselves, our labour is always to our profit… Thomas à Kempis.

Some time ago, a child said “To understand me you must swallow a world”. Taking this quest for truthfulness about the inner life further, one of our most rigorous therapists has said that he must perform “the essential Jonah act of allowing himself to be swallowed, remaining passive, accepting…” The sign that we are listening properly, from within the whale, so to speak, is that we are immersed in our patient and that what we are hearing could, perhaps, change us. Patients intuitively understand and respond to this level of listening. It takes great concentration. Doing something is always easier—hence Anthony Storr’s aphorism: Don’t just do something—Listen!1
Once we had the good luck to work on a psychiatric ward with a would-be surgeon, who, before he accustomed himself to psychiatry, would pace restlessly up and down the ward after clerking his patients, wondering when the main action would start, impatient to get his teeth into the business of curing people. What he was expecting was some sort of equivalent to an operating list, and not knowing where to find one he was at a loss, until it dawned that taking a history from a psychiatric patient is not a ‘pre-op assessment’, but the start of the operation itself—albeit a rather odd operation in which it is not the questions which are incisive but as often as not what happens in the silences. Even advanced textbooks of psychiatry appear to have missed this surgeon’s insight, describing psychotherapy as something which should only happen after ‘a full psychiatric history’. There is no such thing as a full psychiatric history. In describing the salient psychological events of a single day even the best authors (eg James Joyce in Ulysses) need substantial volumes. This is why this chapter is starting so slowly: to give time for these notions of listening to take root. So swallow hard. Calm your restlessness. Stop. Reflect.

Taking a history sounds like an active, inquisitorial process, with lists of questions, and the tone of our page on this process (p322 & mental state examination, p324) seems to perpetuate this error. It isn’t a question of taking anything. It’s more about receiving the history, and allowing it to unfold. graphicIf you only ask questions, you will get only answers as replies.

As the history unfolds, sit back and listen. This sounds easy, but during a busy or difficult day you will find your mind wandering (or galloping away)—over the last patient, the next patient, or some aspect of your own life. You may find yourself worrying about having to ‘section’ this patient or see the relatives afterwards. By an act of Zen, banish extraneous thought, and concentrate totally on the person in front of you—as if your life depended on it. Concentrate on the whole person—the language, the words, the nonverbal cues, and get drawn into their world. Initially don’t even think of applying diagnostic labels. Open your mind and let everything flood in. Listening is hard. We wish we did it better. We all need to practise it more.

Avoid interruptions and seeming to be too purposeful, at least for the first few minutes (or days). Expect periods of silence. If prompts are needed try “and then how did you feel?” or just “and then…”; or repeat the last words the patient spoke. Don’t be anxious if the patient is not covering major areas in the history. Lead on to these later, as the interview unfolds. Early in your career you will have to ask the relevant questions (p322) in a rather bald way (if the information is not forthcoming during the initial unstructured minutes), but it is important to go through this stage as a prelude to gaining information by less intrusive methods. Always keep in mind the chief aims of making a diagnosis, defining problems, and establishing a therapeutic relationship.

What is the point of all this listening?

graphic

Listening enables patients to start to trust us. Depressed patients often believe they will never get better. To believe that they can get better, patients need to trust us, and this trust is often starts the therapeutic process. In general, the more we listen, the more we are trusted. Our patients’ trust in us can be one of our chief motivations, at best inspiring us to pursue their benefit with all vigour. A story bears this out. One day, in 334 bc, Alexander the Great fell ill with fever. He saw his doctor, who gave him a medicine. Later he received a letter saying his doctor was poisoning him as part of a plot (it was an age of frequently fatal intrigues). Alexander went to his doctor and silently drank the medicine in front of him—then gave him the letter. His confidence was rewarded by a speedy recovery. We think it is unreasonable to expect quite this much trust from our patients, and one wonders what can have led Alexander to such undying trust in his doctor. We suspect that his doctor, above all else, must have been a good listener.

Lifeworlds, and how to keep them intact
Even if we all listen the same way, what we will hear will depend on our own expectations, anxieties, and past experience. Take this dialogue.

Doctor:

“How long have you been drinking that heavily?”

Patient:

“Since I’ve been married.”

Doctor: [impatiently]

“How long is that?”

Patient: [giggling]

“For years”. Perhaps the doctor hears ‘4 years’.

If, prosaically, all we want to know is how long her liver was exposed to alcohol, we need facts in linear historical time. But she chooses to answer in event-time, or personal time. This is Mishler’s great distinction between the voice of medicine and the voice of the lifeworld. Sometimes we must set experiences not in linear time but in the order they first become significant to a lover or parent.
Justine L Durrell 97reference
What would this patient have gone on to say if her doctor had swallowed her world? What did those giggles signify? We will never know, but they might have explained her coming death.
 Swallowing a world.
Fig 1.

Swallowing a world.

Contrary to the gmc, Aristotle (Alexander’s tutor) taught that love (not reward) is the foundation of trust.

Introduce yourself; explain how long the interview may take. Describe its aim; emphasize that “here is a safe place to talk”. Find out how the patient came to be referred, and what his expectations are. If the patient denies any problems or is reluctant to start talking, don’t hurry. Try asking “How are you?” or “What has been happening to you?” or “What are the most important things?” “Does anyone else think there is a problem?” “Who does it effect most?” These are beautiful questions because they impose no categories, and seeing what categories your patients imposes, unprompted, will often tell you rich things. Listen, without interrupting, noting exact phrases. By inhabiting and using the categories your patient gives, you may enter his world. 2 minutes may be needed for this phase—or 2 years—depending on how unspeakable and distressing his or her thoughts are. Events surrounding war, torture, rape, and family dislocations may take years before they can be told.

Agree a problem list with the patient early on, and be sure it is comprehensive, eg by asking “If we were able to deal with all these, would things then be all right?” or “If I were able to help you, how would things be different?”. Then take each problem in turn and find out about onset, duration, effects on life and family; events coinciding with onset; solutions tried; reasons why they failed. The next step is to enquire about mood and beliefs during the last weeks (this is different from the mental state examination, p324, which refers to the mental state at the time of interview). Specifically check for suicidal thoughts, plans, or actions—the more specific these are, the greater the danger. Discussing suicide does not increase the danger. Questions to consider: “Have you ever felt so low that you have considered harming yourself?” “Have you ever actually harmed yourself?” “What stopped you harming yourself any more than this?” “Have you made any detailed suicide plans?” “Have you bought tablets for that purpose?” Depression—ie low mood, anhedonia (unable to feel pleasure), self-denigration (“I am worthless”; “Oh that I had not been born!”), guilt (“It’s all my fault”), lack of interest in hobbies and friends plus biological markers of depression (early morning waking, ⬇appetite, ⬇sexual activity, ⬇weight); mania (p354); symptoms of psychosis (persecutory beliefs, delusions, hallucinations, p316); drug and alcohol use; obsessions; anxiety; eating disorders (eg in young women; often not volunteered, and important). Note compulsive behaviour, eg excessive hand-washing.

Housing, finance, work, friends, spouse/partners (negotiated or non-negotiated non-monogamy?). Physical and mental health, job, and personality of family. Who is closest to whom? Any stillbirths, abortions?

How has he spent his life? Ask about school, play (alone? with friends?) hobbies, further education, religion, job, sex, marriage. Has he always been shy and lonely, or does he make friends easily? Has he been in trouble with the law? What stress has he had and how has he coped with it? nb: noting early neurotic traits—nail-biting, thumb-sucking, food fads, stammering (not really a neurotic feature)—rarely helps.

Before all this happened, how were you? Happy-go-luckydriven, gentlesadistic,1 tenselaid-back, happydepressed, socialantisocial? Impulsive, selfish, fussy, irritable, rigid, insecure/schizotypal,2 shy, hostile, competitive? graphicTalk to whoever accompanies him, to illumine premorbid personality and current problems. But don’t let her speak for the patient (at least make sure the patient has the first and last word).

eg on retroviral drugs, or frequent asthma attacks. Next, examine the mental state (p324 & p353). You may now make a diagnosis, or decide that labelling is unwise. Ensure the areas above are covered in the light of any diagnosis so that the questions Why did he get ill in this way at this time?” and What are the consequences of the illness?” are answered.

Discussing childhood sexual abuse (csa) with an adult who is currently experiencing psychological difficulties
A frequent question to arise is ‘how far does past csa account for current problems, and how much should this issue be explored now?’ Each person is different: try to learn to use whatever your patient gives you, for their benefit. See p328 for how to talk about sexual issues. Sometimes it is possible to be optimistic, despite the fact that many patients and professionals believe that csa causes intense, pervasive harm in the general population, regardless of gender. This issue has been examined in careful meta-analyses looking at 59 studies based on college data. These show that students with csa were, on average, only slightly less well adjusted than controls. But this poorer adjustment cannot be attributed to csa: family environment is consistently confounded with csa and explains much more adjustment-variance than csa. Self-reported reactions to and effects from csa indicate that negative effects are neither pervasive nor often intense. Also, men react much less negatively than women. Even though this college study is consistent with data from national samples, this optimistic meta-analysis should not blind you to the possibility that the patient sitting in front of you might be very damaged by csa—but do not assume that csa is the underlying reason for everything.

graphicWhen in doubt, get further help.

“I’m not going to be a victim all my life just because I was abused!”

Using whatever your patient gives you to make subjective but highly accurate, even valid maps of patients’ worlds.

Doctor:

“When you are like this, what’s most difficult?”

Dawn:

“Looking after the children—and going out to work”.

Doctor:

“Which is harder?”

Dawn:

“Well, going out to work; sometimes the children help. Jo and Nick.”

Doctor:

“Anyone else?”

Dawn:

“Well—my husband? Fat chance, even when he’s sober.”

Doctor:

“So the children don’t take after him, then?”

Dawn:

“Lord no! Not yet, anyway—but all the blokes in his family drink like fish, so I’m worried for Nick when he gets that bit older.”

Doctor:

“You worry more about him than Jo?”

Dawn:

“Yes—even though Jo cannot read yet, which is a worry. But she’s got a way of looking after us somehow. She’ll be all right—she’s like her gran.”

Doctor:

“She still looks after you all sometimes?”

Dawn:

“Well, she did, but she died last year, and then I went back on drugs.”

All families evolve their own ways of communicating, and much goes on under the surface. In this dialogue, Dawn instigates a dozen categories or concepts. In an unconscious tour d’horizon, she draws a map for us, and as we impose none of our own suggestions, we can be fairly sure they represent some of the chief landmarks in her world. Don’t place people and events on other people’s maps: let them populate their own. Don’t superimpose the quasi-objective platitudes and longitudes of time and place. It is better to let the map grow organically. You yourself are on the map, partly revealing and partly hiding the other elements. Move around a bit, and by a process of psychological parallax3 you can estimate how far your patient is from the centre of her life.

graphicThis assesses state of mind at the time of interview. Take notes under the following headings.

Appearance and behaviour: Eg signs of self-neglect; slowness, anxiety, or suspiciousness.

Mode of speech: Speech rate, eg gabbling (pressure of speech), or slow/retarded. Note content.

Mood: Note thoughts about harming self or others. Gauge your own response to the patient. The laughter and grand ideas of manic patients are contagious, as to a lesser extent is the expression of thoughts from a depressed person.

Beliefs: Eg about himself, his own body, about other people and the future. Note abnormal beliefs (delusions) eg that thoughts are overheard, and ideas (eg persecutory, grandiose). See p316.

Unusual experiences or hallucinations: “Sometimes when people are low they have unusual experiences; have you heard anything unusual recently?” Note modality, eg visual.

Orientation: In time, place, and person. What year? What season? What month/day of week? Is it morning or afternoon? What is your name?

Short-term memory: Recall a name & address 5min after learning it. Ensure he really has learned it before waiting for the 5min to elapse.

Concentration: Months of the year backwards.

Patient’s insight and degree of your rapport.

Long-term memory: Current affairs recall. Who is the monarch/head of state? This tests other functions, not just memory.

Direct questions to try

Any odd thoughts?

Might your thoughts be being interfered with?

Do you feel anyone is controlling you?

Is anyone putting thoughts into your head?

Do other people access or hear your thoughts?

Is anyone harming you?

Any plots against you?

Do you hear voices when there’s no one nearby? What do they say? Echoing you? Telling you off?

Do you see things that others cannot see?

Are you low/depressed?

Is life worth living?

Can anything give you pleasure?

Sleep and appetite ok?

Energy levels ⬆ or ⬇?

Can you concentrate ok?

Are you feeling guilty?

Is your confidence low?

Are you wanting to harm anyone? Yourself?

Any worries/anxieties?

Why are we annoyed when we blush, yet love it when our friends do so? Part of the answer to this question is that non-verbal communication is less well controlled than verbal behaviour. This is why its study can yield valuable insights into our patients’ minds, particularly when analysis of their spoken words has been unrevealing. For example, if a patient who consistently denies being depressed sits hugging himself in an attitude of self-pity, remaining in a glum silence for long periods of the interview, and when he does speak, using a monotonous slow whisper unadorned even by a flicker of a gesticulation or eye contact—we are likely to believe what we see and not what our patient would seem to be telling us.

Items of non-verbal behaviour:Dress:

Gaze and mutual gaze

Facial expression

Smiling, blushing

Body attitude (eg ‘defensive’).

(‘The apparel oft proclaims the man’)
 

Hairstyle

Make-up

Ornament (ear-rings, tattoos, piercings).

Items of non-verbal behaviour:Dress:

Gaze and mutual gaze

Facial expression

Smiling, blushing

Body attitude (eg ‘defensive’).

(‘The apparel oft proclaims the man’)
 

Hairstyle

Make-up

Ornament (ear-rings, tattoos, piercings).

Signs of auditory hallucinations:Anxious behaviour:

Inexplicable laughter

Silent and distracted while listening to 'voices' (but could be an 'absence' seizure, p206)

Random, meaningless gestures.

Fidgeting, trembling

Nail-biting

Shuffling feet

Squirming in the chair

Sits on edge of chair.

Signs of auditory hallucinations:Anxious behaviour:

Inexplicable laughter

Silent and distracted while listening to 'voices' (but could be an 'absence' seizure, p206)

Random, meaningless gestures.

Fidgeting, trembling

Nail-biting

Shuffling feet

Squirming in the chair

Sits on edge of chair.

Signs of a depressed mood:

Hunched, self-hugging posture

Little eye contact

Downcast eyes; tears

Slow thought, speech, and movement.

Signs of a depressed mood:

Hunched, self-hugging posture

Little eye contact

Downcast eyes; tears

Slow thought, speech, and movement.

What is a mental state?

A true description of mental states entails valid knowledge about current emotions plus their reactions to those emotions. These reactions are themselves emotional (eg being relieved that one’s sense of remorse over x feels authentic), as well as being the bedrock out of which beliefs and attitudes are formed. These interactions make a picture to an observer which is complex, paradoxical, subjective, error-prone, contradictory—and fascinating.

Describing and communicating mental states is the central puzzle that confronts not just psychiatrists and our patients, but also artists. Poets and songwriters summon up diverse mental states (herein lies their genius) but none can control them or their infinite progeny (what happens next). This is the province of psychiatry. If we could control mental states at will at least half our job would be done (no doubt there would be unfortunate side effects). Drugs, psychotherapy, and behavioural methods are the tools available for this task, and they all, crucially, impinge on mental state. You cannot tell if these methods are helping if you cannot access your patient’s mental state, which is why the page opposite is so important. If you think you can access mental states just by applying the formulaic regimen opposite, you will often fail, as any trip into the mind of another is not just a voyage without maps, it is ultimately a creative and metaphysical enterprise.

On this view, knowledge of mental states is doubtful, but often this is not so, eg a baby being put to the breast after separation from her mother, or an audience giving a standing ovation, or screaming fans waving at an idol, and we know without doubt that these mental states comprise unalloyed satisfaction, pleasure, and adulation. So often it’s non-verbal behaviour that allows valid judgment about mental states: don’t rely on words alone—those capricious (but indispensable) tokens of disguise and deception.

Viola: “I am all the daughters of my father’s house, and all the brothers too.” Twelfth Night

How many different selves are rolled up into your patient?

graphic

Here is an example: a person who happens to be black, who happens to be Muslim, who happens to be male, who happens to be questioning his sexual orientation while trying to be a good son and a good brother. He is trying on new identities and new relationships with Allah. How do these identities involving race, culture, religion, gender, and sexuality feed into his mental state now? In the mental state examination, give space to find out about these roles, to get a feeling for which causes most turmoil, ambivalence, and introspection, the 3 ‘vital signs’ of psychic life—tai.1 Aim to understand how good the patient is at articulating these roles. Try to understand from which platform the patient feels most comfortable in tackling his problems—and pay respect to each role separately, in order to gain trust. Try to find out how plastic or rigid each identity is—the more plastic, the easier it is for the ego to function harmoniously (ie ‘good identity integration’).

Perfect identity integration = ego death.

Lear: “Who is it that can tell me who I am?” Fool: “Lear’s shadow”.
Just as Shakespeare creates metaphysical places, such as Lear’s and Viola’s Illyria, where answers to questions of identity can take shape, so psychiatrists create spaces in the silences of mental state examinations where our multiple personas can visit each other. Our masks shift and a few rays illumine our ‘shadow selves’, as we come to know the difference between who we are and who we think we are. Acknowledging that we have a shadow is hard, but vital. Mental state examinations start this process leading to questions such as “Who knows most about who you are? Who else? How do their views differ? What truths about you do they acknowledge or hide?”

Know thyself…know thyselves.

A patient may become over-dependent on his or her doctor in many spheres of medicine. This is a particular danger in psychiatry because of the intimate and intense rather one-sided or asymmetrical relationship which may be built up between the patient and psychiatrist—who will often know more about a patient’s hopes and fears than any close friend. This encourages the patient to transfer to the therapist thoughts and attitudes that are often directed to parent-figures. This process (known as transference) powerfully stimulates doctor-dependency, sometimes with serious consequences.

Chronic illness/prescribing; inability to achieve the sick role—eg if you have chronic back pain, your suffering is hidden from others (no scars, no bleeding, etc), and you may feel delegitimized in your sick role because you cannot be diagnosed or helped. But equally, because of this, you hold power over your doctor. It is difficult for her to challenge your ideas without damaging the therapeutic relationship. So the doctor is forced to collude with your definition of ill-health. This may harm you and society.

Repeated phoning for advice, inability to initiate any plan without help from a therapist, and disallowing of your attempts to terminate treatment (eg by threatening relapse).

Clearly, in the examples above, the patient’s dependency on his doctor is non-therapeutic. At other times, for example, early in treatment, doctor-dependency may help. In these circumstances the danger is that the doctor will be flattered by his patient’s dependency on him. Most therapists either want to be loved by their patients or want to dominate them (or both), and it is important to know, in each session with each patient, just where you lie within the space marked out by these axes. Ask yourself: “Why do I look forward to seeing this patient?” “Why do I dread seeing Mr X?” “Why do I mind if this patient likes me?”

graphicWhen you feel good after seeing a patient always ask yourself why (it is so often because he is becoming dependent on you).

Planning and agreeing specific, limited goals with patients is one way of limiting dependency. If the patient agrees from the outset that it is not your job to provide him with a new job, wife, or family, he is more likely to have realistic expectations about therapy.

Planning discharge from the start of therapy helps limit doctor-dependency. Discharge is easy from the outpatient departments, but for the gp the concept of discharge is diluted by the fact of his contractual obligations. The patient is quite within his rights to turn up the day after being ‘discharged’ and demand that therapy be started all over again. The gp must have more subtle methods at his disposal to encourage the patient to discharge himself. For example, he can learn to appear completely ineffective, so that the dependency cycle (patient presents problemdoctor presents solutionpatient sabotages solutiondoctor presents new solution) is never started. Another method is to bore your patient by endlessly going over the same ground, so that the patient seizes control and walks out as if to say “I’ve had enough of this!”.

The foregoing makes patients out to be perpetual seekers after succour and emotional support—and so they may be. But a great mystery of clinical medicine is that, spontaneously and miraculously, many apparently irremediably dependent patients can change, and start leading mature and independent lives. So don’t be downcast when you are looking after such people: there is much to be said for simply offering a sympathetic ear, staying with your patient through thick and thin, and waiting for time to go by and for the wind to change. Of course, the wind may change back again, but, if it does, you will not be back at square one, for you will be able to inject the proceedings with the most powerful psychotherapeutic agent of all, namely hope.

We have chosen Psychiatry for this universal topic because if the concept of quality can be made sense of here, despite Psychiatry’s notorious lack of objectivity, then its applicability across the field medicine can be upheld. Quality is an important topic not just because it has political currency,
Lord Darzi 2008 nhs reviewreference
  but because it has important personal relevance too, for your next patient.
(derived from Hippocratic thought, ohcm p1) Perpetually reaffirm and renew your commitment to put the patient first and do whatever it takes to make your patient better. Traditional approaches to quality in psychiatry stem from this: “We need better inpatient care, with better availability of psychotherapy and more highly motivated, energetic mental health professionals who aren’t burnt out by overwhelming caseloads.”

In areas such as surgery, performance-management and quality centre around:

Efficacy

Safety

Equity (equal access to benefits)

Choice

Holistic patient experience/compassion. How do these precepts shape up in the world of psychiatry? Let’s take a look, one at a time.

If agreed guidelines exist, we can compare care received with care advised, eg in schizophrenia, in one study ~50% had poor psychosocial care (note the need for patient interviews to unearth the extent of such problems).

But beware: how do you quantify success for people whose illness precludes them from seeing themselves as being ill? Patients may have their delusions and hallucinations treated so that none are left: but this does not equate with 100% quality of care if the problem is not the delusions and the hallucinations but rather urban alienation (p391), poverty, or unemployment. The hallucinations may be a way of coping with the latter. See p316.

Monitoring metabolic effects of new antipsychotics is a safety quality marker, as is antipsychotic choice. See npsa.nhs.uk/patientsafety.  
National Patients’ Safety Agencyreference
 ,

Offering a choice as to which hospital to be compulsorily incarcerated in seems like tokenism. Also, sectorization (each team having its own geographical area) precludes choice. But because choice does not work in some areas it does not mean it has no role in others. It is legitimate to regard choice of psychotherapy, drugs, or both as a marker of quality of care in depression.

When this is looked for, ethnic minorities, children, and older people are often disadvantaged., (Obvious, perhaps, but ameliorable.)

This is discussed on p510.

graphicSome clinicians reject the new methodology: “What we have to do is get away from measurements and statistics and calculations and pieces of paper published by politicians and get back to what we know intuitively is the correct way to help people.” But what if our intuitions are wrong or contradictory? Is it possible to combine the best of the old and the new? Maybe…

(old+new) Find out who wants whatIf the patient’s views are known, comply with themmake a commitment in your heart to put your patient firstdo what it takes to make your patient betterattack all diseases with vigourpromote health where possiblepalliate where cure is impossibleupdate care in the light of evidenceset yourself targets by all means, provided one target is not to let targets skew the care you givetake steps to find out if you have actually done what you intended (audit, p506).

Only pay them if your quality goals are met? A favourite nhs tactic, but undermining of the notion of professionalism and prone to valuing the measurable over more important goals. If we had to select just one winning idea from this page to take forward to our next patient we would go with Hippocrates: make a commitment in your heart to put your patient first. This is very hard: just try it. (Did you notice how compassion got squeezed out of this page? How did that happen? Why does this always happen?)

Sexual issues are easier when an overt part of consultations (contraception, fertility, and sexual diseases). More commonly they are a covert part of other emotional or behavioural problems. We may find sexual dialogue embarrassing and avoid it—with unpredictable or fatal consequences, eg for those made suicidal by abuse or by confusing emotions relating to sexuality.

Language is important. It may be medical (eg ‘coitus’); slang (eg ‘fucking’); or socially acceptable (eg ‘having sex’). It is not advisable to use slang as people think you are trying to be fashionable. Most will expect socially acceptable language; slang may shock and may put up barriers. But occasional mirroring of the patient’s words can gain rapport. Ask if your words are acceptable.

Ambiguity is a frequent pitfall—even for the most consummately articulate of all interlocutors: “Ah!” said Mr. Woodhouse, shaking his head and fixing his eyes on her with tender concern.—The ejaculation in Emma’s ear expressed, “Ah! there is no end of the sad consequences of your going…”
Jane Austen Emma Ch 12reference
Make sure that you both know what the other is talking about! If a new phrase crops up (slang changes all the time), ask for an explanation right away (a little gentle helping on your part usually overcomes any embarrassment).
Don’t assume sexual knowledge. Not all young people know everything. Just as when we were younger, sex can be confusing and mysterious. There are still many myths, and it is just as hard as it ever was for young people to admit that they don’t know something. Sex education in schools is uneven, and may be useless or non-existent (teachers may be too embarrassed to do it).
Don’t assume a sexual orientation. It may be best to let these issues surface gradually rather than asking directly early on. Imply that it is safe to reveal feelings that are confused or non-standard. Your patient may be boxed in by societal, religious, or family views of what sexuality should be, so that suicide can seem the only way out. Through your dialogue you may be able to show that there are other options, and that “there is no straight way through this world for any of us”. If orientation is causing distress, point out that there is more to a personhood than sexuality—roles they may be good at may include being a friend, colleague, brother, daughter, or son—as well as lover, now or in the future. “You don’t need to have sex just to settle the issue of sexuality; feelings can be explored without sex acts, which can be left until you feel ready”. In helping gay people decide when to ‘come out’ eg to parents, explain that reactions can be unpredictable. “How well do you know your parents?” “How have they dealt with religious or sexual issues with your brothers and sisters?”; “Are you economically dependent on your parents?”; “Do you have a social support outside the home?”.

Don’t appear embarrassed. It is easier for people to open up if they think that you aren’t going to blush, tell them off, or, worst of all, laugh. Don’t act shocked and don’t judge; give the wrong impression and they will stop being honest with you—see p319 for further discussion of this vital point.

Act as if you have plenty of time to listen—all the time in the world.

The more you practise sexual dialogue, the easier it gets. If you avoid it, it will remain a problem to you. Also, your patients may learn techniques of sexual dialogue, helpful in their lives as a whole, augmenting self-esteem, enabling sexual negotiation (useful in negotiating safer sexual practices with partners). Also, you may lay the foundation for honest sexual dialogue between this teenager and his or her offspring, 10–40 years from now.

Have you been in any relationships that made you feel uncomfortable? Has anyone touched you in a way that made you feel embarrassed? I am wondering if anyone has hurt you in a sexual way.

Young people need to know that you will only ever breach this if they (or someone else) is in mortal danger.,

This is a common problem: the courts, the gp, or the relatives want to know “Will he be violent again if he takes the medication?”. A great deal—a man or woman’s freedom, no less, may depend on our answers. The philosophical problems with giving a straight answer to these questions are given in the box below. Regression analysis shows that 4 factors are paramount:

1

Previous violence

2

Substance abuse

3

Lack of empathy and

4
Stress.
When in doubt, use a formal risk assessment tool (see box). Some of the advantages of these tools derive simply from having a well-structured approach, others from combining specific kinds of risk factors (static and dynamic).
500, 995, 484, 682, 338, 672, 639

graphic

Imagine…there are only 24 people in the world, and each has only 2 types of moves: forward one step at a time, and, sometimes, alas, one step backwards. Surely we should be able to predict what will happen: it’s as simple as a game of draughts (chequers). We win or lose at draughts by using rules of thumb (heuristics). In 2007, for the first time, there was sufficient computing power to replace these rules of thumb by perfect knowledge. In draughts, there are >500 billion billion play-positions (500,995,484,682,338,672,639), and now each has been analysed to decide what the next best move is. Well-programmed computers are right every time. When we ask psychiatrists to do a risk assessment we want them to be right every time too. It is vital that they are. We blame them if they are wrong. Is this rational? Only if there are no more than 24 people in the world, and they only interact with each other in only one way—never moving sideways or forming attachments.
Psychiatrists do best using rules of thumb combined with validated risk assessment tools (imperfect knowledge), such as the violence risk appraisal guide. Forensic risk-assessment models all stress risk factors, but often disregard the other side of the equation: protective factors. Mediating and moderating effects must also be considered. We need to involve patients in the process of risk assessment and risk management. This may increase validity, but it also adds unpredictability: the men and women on the board are now all kings and queens in our client-centred world.
People are like icebergs, you only see the little bit on top.

Current uk community psychiatric services can be categorized as follows:

Intensivist teams: Crisis and Home Treatment, eg with 24-h phone helpline.

Support and recovery teams—Community mental health teams (cmht); asssertive outreach; rehabilitation.

Drug and Alcohol teams: part of a wide range of substance abuse services.

Inreach mental health services—residential care, acute hospital liaison, primary care liaison teams (pcl)—integrated cpns/Psychiatrists with gp practices/Hospitals with good links into secondary community services.

iapt services (improved access to psychological therapies)—offer a wide range of community-based therapies eg cbt (p373), group therapy, etc.

Typically all these services are multidisciplinary (to a varying degree) with Nurses, ots, Physios, Psychologist, Psychiatrists and Social workers.

Many of these community services are supported by 3rd-sector (voluntary) organizations eg mind, Alzheimer’s society, and other local organizations and charities that provide drop-in centres, group or individual therapy, homecare, advocacy, educational information etc.

pwd (patients with dementia) use more or less specialist Residential or Nursing homes; Social services input is very important as is close working with local councils, and health authorities. Integrated care has theoretical advantages—eg for a schizophrenic patient who is a substance abuser.,
We have all been manipulated by our patients, and it is wrong to encourage in ourselves such stiffness of character and inflexibility of mind that all attempts by our patients to manipulate us inevitably fail. Nevertheless, a patient’s manipulative behaviour is often counter-productive, and reinforces maladaptive behaviour. A small minority of patients are very manipulative, and take a disproportionate toll on your resources, and those of their family, friends, and colleagues. We are all familiar with these patients whom Ford Madox Ford describes as being like fireships on a crowded lagoon, causing conflagration in their wake. After destroying their family and their home we watch these people cruise down the ward or into our surgeries with some trepidation. Can we stop them losing control, and causing meltdown of our own and our staff’s equanimity? The first thing to appreciate is that, unlike an unmanned ship, these people can be communicated with, and you can help them without resorting to hosing them down with cold water.

One way of avoiding becoming caught up in this web of maladaptive behaviour is to set limits, as soon as this behaviour starts. In a small minority of patients, the therapist may recognize that their needs for time, attention, sedation, and protection are, for all practical purposes, insatiable. Whatever a therapist gives, such patients come back for more and more, and yet in spite of all this ‘input’ they don’t get any better. The next step is to realize that if inappropriate demands are not met, the patient will not become sicker (there may be vociferous complaints!). This realization paves the way for setting limits to behaviour, specifying just what is and is not allowed.

Take for example the patient who demands sedation, threatening to “lose control” if it is not given immediately, stating that he cannot bear living another day without sedation, and that the therapist will be responsible for any damage which ensues. If it is decided that drugs do not have a part to play in treatment, and that the long-term aim is for the patient to learn to be responsible for himself, then it can be simply stated to the patient that medication will not be given, and that he is free to engage in destructive acts, and that if he does so this is his responsibility.

The therapist explains that in demanding instant sedation he usurps her professional role, which is to decide these matters according to her own expert judgment, and that such usurpation will not be tolerated. If there is serious risk of real harm, admission to hospital may be indicated, where further limits may be set. If necessary, he is told that if he insists on ‘going crazy’ he will be put in a seclusion room, to protect others.

 Drastic measures: sometimes you have to cut yourself free…discuss with a colleague first, and explain to the patient that continuing contact is not in their best interests as you are unable to make any headway. “Your case needs a fresh pair of eyes…” This may be safer than the kind of confrontations that Henrik Ibsen dangerously engineers: “When I look back on your long career, it’s as if I saw a battlefield strewn at every turn with shattered lives.”The Wild Duck 1884
Fig 1.

Drastic measures: sometimes you have to cut yourself free…discuss with a colleague first, and explain to the patient that continuing contact is not in their best interests as you are unable to make any headway. “Your case needs a fresh pair of eyes…” This may be safer than the kind of confrontations that Henrik Ibsen dangerously engineers: “When I look back on your long career, it’s as if I saw a battlefield strewn at every turn with shattered lives.”The Wild Duck 1884

We live, as we dream—alone. Conrad; Heart of Darkness

graphicHealth entails harmonious membership of at least one social group. People who are unconnected get dementia (and die) sooner. As the saying goes, it is healthier to eat a chocolate cake with a friend than to eat broccoli alone.
graphicBeing unwanted is the worst disease that any human can experience.
Mother Teresareference
graphicLoneliness does not come from having no people about one, but from being unable to communicate the things that seem important to one.
graphicLoneliness with depression is a predictor of suicide (eg in older women).
A typical candidate for ameliorable loneliness is someone who is depressed after the loss of caregiving role—if a partner/spouse has died (p498)—or if children have flown the parental nest. Loneliness is likely to be worse if the person is shy, has limited social skills, and poor self-esteem. Some people, of course, like to avoid their fellows. For them, intrusion into their private world may cause despair; but, for most, these intrusions are welcome, and necessary for health. Loneliness seriously affects 1 in 10 older people, and contributes to alcoholism, depression, and suicide. Suspect that loneliness is important when you find your hand being gripped for comfort after you thought that a social encounter was over—also whenever there is a verbal outpouring and a ‘defeated demeanour.’

Do not assume that loneliness means social isolation. Someone who has brief visits 3 times a day, from, say, a nurse, a care assistant, and a ‘meals on wheels lady’ is not socially isolated, but may be very lonely. But if he or she gets on well with just one of these visitors, this can be enough to banish loneliness. So this is the first lesson: be nice to people, and take trouble to find out their hopes and fears. But more is possible: in general, it is depressing waiting for the doorbell to ring, so tailor your suggestions in the light of your patient’s mobility. This needs initiative on your patient’s part, but do not think you must treat your patient’s depression before you tackle a lonely lifestyle: tackling this may be the route out of depression. Areas to think about include:

What facilities already exist? Is there a local pub, day centre, or lunch club available? “God, I wouldn’t be seen dead in one of those places!” we so often hear. But take time to point out that it does not matter initially whether they get anything out of a social interaction. After all, they may meet someone of like mind, so enabling these artificial crutches to be thrown away.

Is the person religious? There may be activities and outings to plan and talk about, and reminisce over, even if not actually enjoyed at the time.

Housing: if the person is planning a move, will they be near family, and other people who speak their own language (metaphorically and literally)?

Alternative therapies, eg massage and aromatherapy, can relieve loneliness.

Adult education is a good (expensive) way to make friends; as new skills are acquired, confidence improves, and socializing becomes more pleasurable.

Involvement with community action groups may be a source of friends (and a source of frustration and disappointment—but do not expect your interventions to be without side effects: the thing is to plan for them).

Details of local community activities can be found in the uk at the local Council for Voluntary Services. Other organizations advertise at libraries.

While at the library, ask about joining a book club.

Befriending schemes can be very helpful to those who are housebound.

Technology forums such as the Internet may provide relief from boredom and loneliness—and for some this will offer the best chance of meeting with a kindred spirit, unlimited by the constraints of time and space.

Befriending others, and offering phone support is an option, whether or not one is housebound. Ask local authorities to help to get suitable phones.

Doctors have a higher than average incidence of suicide and alcoholism, and we must all be prepared to face (and try to prevent) these and other health risks of our professional and private lives. Our skill at looking after ourselves has never been as good as our skill at looking after others, but when the healer himself is wounded, is it clear that his ability to help others will be correspondingly reduced? Our own illnesses are invaluable in allowing us to understand our patients, what makes people go to the doctor (or avoid going to the doctor), and the barriers we may erect to resist his advice. But the idea of an ailing physician remains a paradox to the average mind, so that we may ask: graphicCan true spiritual mastery over a power ever be won by someone who is counted among her slaves? If the time comes when our mental state seriously reduces our ability to work, we must be able to recognize this and take appropriate action. The following may indicate that this point is approaching:

Drinking alcohol before ward rounds or surgeries.

The minimizing of every contact with patients, so that the doctor does the bare minimum which will suffice.

Inability to concentrate on the matter in hand. Your thoughts are entirely taken up with the workload ahead.

Irritability (defined as disagreeing with >1 nurse/24h).

Inability to take time off without feeling guilty.

Feelings of excessive shame or anger when reviewing past débâcles. To avoid mistakes it would be necessary for us all to give up medicine.

Emotional exhaustion—eg knowing that you should be feeling pleased or cross with yourself or others, but on consulting your heart you draw a blank.

Prospective studies suggest that introversion, masochism, and isolation are important risk factors for doctors’ impairment.

The first step in countering these unfavourable states of mind is to recognize that one is present. The next step is to confide in someone you trust. Give your mind time to rejuvenate itself.

If these steps fail, various psychotherapeutic approaches may be relevant, eg cognitive behavioural therapy (p373), or you might try prescribing the symptom. For example, if you are plagued by recurring thoughts about how poorly you treated a patient, set time aside to deliberately ruminate on the affair, avoiding distractions. This is the first step in gaining control. You initiate the thought, rather than the thought initiating itself. The next step is to interpose some neutral topic, once the ‘bad’ series of thoughts is under way. After repeated practice, the mind automatically flows into the neutral channel once the bad thoughts begin, and the cycle of shame and rumination is broken. graphicIn addition…learn from the experience!

If no progress is made, the time has come to consult an expert, such as your general practitioner. Our own confidential self-help group for addiction and other problems is the British Doctors’ and Dentists’ Group and may be contacted via the Medical Council on Alcohol (tel. 020 7487 4445uk). If you are the expert that another doctor has approached, do not be deceived by this honour into thinking that you must treat your new patient in any special way. Special treatment leads to special mistakes, and it is far better for doctor–patients to tread well-worn paths of referral, investigation, and treatment than to try illusory short cuts.

 Hands-off! Don’t get too drawn into treating your own mental illness without consulting a colleague.
Fig 1.

Hands-off! Don’t get too drawn into treating your own mental illness without consulting a colleague.

Burnout (running beyond empty)

Falling performance and personal accomplishments, emotional exhaustion, negative affect, poor leadership, and depersonalization brought on by months or years of overexposure to emotionally demanding situations at work, on the battlefield, or at home.

The Five minute speech sample and the Maslach burnout inventory.
Lack of hobbies, lack of physical activity, and lack of enough time for vacations and religious activities are all important. Pressure of work, conflict with colleagues, less personal relationships with patients, overly formal hierarchies, and suboptimal income are put forward to explain the fact that some doctors (eg urologists) in the public sector are more at risk of burnout compared with private-service urologists. Factors associated with emotional exhaustion: ‘having to deaden one’s conscience’, lack of time to provide needed care, work being so demanding that it influences one’s home life, and not being able to live up to others’ expectations.
Unreciprocated giving, violent client population leading to vicarious traumatization, frequency of on-calls. High expressed emotion (evidenced by critical comments ± negative relationships) predicts depersonalization elements of burnout.
Impulsivity, depression & money worries are predictive.

Past history of physical trauma is predictive.

 Have you felt this way?
Fig 2.

Have you felt this way?

Stress and depression

Fatigue

Non-restorative sleep

Emotional exhaustion

Motivation⬇; apathy⬆

Libido⬇

Insomnia

Guilt or denial

Paranoia/isolated

Demoralization

Amnesia

Indecision

Temper tantrums

Low personal accomplishment

Depersonalization

Vicarious traumatization

Irritability/impatience

(Difficult) Some may respond to plans such as these:

Diagnose and treat any depression (p336–7).

Allow time for the person to recognize that there is a problem.

More hobbies, and more nice holidays.

Advice from wise colleagues in the specialty (regular follow-up). Mentoring consists in forming a supportive relationship with an independent colleague for the sole purpose of support.

Return meaning and purpose to life via dialogue, self-transcendence and a sense of connectedness with others (meaning-centred psychotherapy).

Learn new professional skills—or consider early retirement.

Set achievable goals in work and leisure (eg protected time with family).

Strategies such as career counselling are said to be effective but really do no more than point a lollipop at a furnace.  Reducing stress is one (unproven) way of avoiding burnout. Psychiatrists have found their own ‘stress busting’ groups helpful—these entail problem-solving with airing of stresses—ideally accompanied by talking to colleagues for support and catharsis. Having outside interests helps, as does getting support from family and friends, time management, and exercise. On a more universal plane, graphicwe are all responsible for each other’s burnout. By being attentive to our own and others’ feelings of troubled conscience we all have a role in preventing the burnout of our colleagues. We need opportunities to reflect on our troubled consciences. Appraisals (p508) and less formal routes to this awareness are becoming more accepted by professionals.
One role of the psychiatrist/gp is to act as the terminus for patients who have been shunted from hospital department to department. The aim is to reframe symptom-offering into problems that need solving. Start by accepting that the patient is troubled and looking for helpful responses from you that are yet to be defined. After establishing rapport, agree a contract with the patient, that we will give regular consultations for listening to how the patient feels and will try to offer help, if she acknowledges that past investigations haven’t helped, that psychological factors play a part (somatization, p640), and that she agrees not to consult other doctors until a fixed number of sessions have elapsed. Also, cognitive therapy (p374) examining the way that conscious thoughts and beliefs perpetuate disability, can lead to symptom reduction.

Our stream of consciousness doesn’t progress from cradle to grave as a single line: there are separations (dissociations) and confluences, for example, when we daydream, or drive to Porlock with no recollection of the scenery along the way, only of our inner landscape. Dissociation may be adaptive, eg by annihilating pain in near-death events (fig  1). Another example: a man who was homosexually raped had no conscious memory of this, but felt irresistible urges to write insulting letters about the perpetrator.

 This lady has the knack of dissociating her body and replacing it with the airy nothingness of a summer sky. Roland Penrose, the artist, intuited this adaptive response to extreme events in her past: he did not know when he painted this that at aged 7 that Lee Miller, whose portrait this is, was raped, and had suffered traumatic douches to deal with the ensuing gonorrhoea. Nor could he have known that in 1945 she would be the first photographer to document the overflowing ovens of Nazi concentration camps, no doubt using her dissociative skills to keep her camera steady. How did she end up as the leading fashion photographer of her day? The nested funnels at the foot of the picture suggest an answer: the mind has an infinite capacity to distil one experience through another, and to channel experiences in new, creative ways.
Fig 1.

This lady has the knack of dissociating her body and replacing it with the airy nothingness of a summer sky. Roland Penrose, the artist, intuited this adaptive response to extreme events in her past: he did not know when he painted this that at aged 7 that Lee Miller, whose portrait this is, was raped, and had suffered traumatic douches to deal with the ensuing gonorrhoea. Nor could he have known that in 1945 she would be the first photographer to document the overflowing ovens of Nazi concentration camps, no doubt using her dissociative skills to keep her camera steady. How did she end up as the leading fashion photographer of her day? The nested funnels at the foot of the picture suggest an answer: the mind has an infinite capacity to distil one experience through another, and to channel experiences in new, creative ways.

Night & day, Roland Penrose, reproduced by permission of The Penrose Collection.

Amnesia is the commonest type: see box. Depersonalization: Feeling of being detached from one’s body or ideas, as if one were an outsider, observing the self; “I’m in a dream” or “I’m an automaton” (unrelated to drugs/alcohol) eg from stress.

Dissociative identity disorder: The patient has multiple personalities which interact in complex ways. It is present in 3% of acute psychiatric inpatients.

Fugue: Inability to recall one’s past ± loss of identity or formation of a new identity, associated with unexpected, purposeful travel (lasts hours to months, and for which there is no me).

(~6yrs) shows that ~5% of those referred to a cns hospital who had hysteria/dissociation diagnosed turned out to have organic illness.

Exploring life stresses may help. Be ready to recognize psychological components of physical illness, and get expert psychiatric help, while leaving the door open for new diagnoses.

Is this amnesia dissociative?1

Has a physical cause been carefully discounted? (Drugs, epilepsy, etc.)

Is the patient young? Beware making the first diagnosis if >40yrs old.

Have the symptoms been provoked by stress? Ask the family.

Do related symptoms ‘make sense’ (eg aphonia in a news-reader)?

What is the pattern of amnesia? If for distant and near memories, then dissociation is more likely (vs organic causes) than if the amnesia is for shorter-term memory.

Indifference to major handicap, la belle indifférence, is of little diagnostic use, see fig  1.

Is malingering likely? The answer is usually ‘No’, except in prisons and the military (when secondary gain is easy to identify).

Is there a dissociative personality? The dissociative experiences scale (des) screens for this: a 28-item visual analogue scale about the proportion of time spent on dissociative experiences (not those from drugs/alcohol) going from the normal, eg being so absorbed in tv that we are unaware of events around us, to severe forms, eg of having no memory of cardinal personal events, or feeling that our body belongs to another. In dissociative disorders, typical des scores are ≳30; most others score nearer 0.
 This Lady tells us why we must not place weight on la belle indifférence. She has her dead Son on her lap, yet her expression is of serene indifference, not overt sorrow. Michelangelo makes no error here, justly recognizing that dissociation is an adaptive reaction to calamity, be it ‘hysterical’ (21%) or real (29%).84
Fig 1.
This Lady tells us why we must not place weight on la belle indifférence. She has her dead Son on her lap, yet her expression is of serene indifference, not overt sorrow. Michelangelo makes no error here, justly recognizing that dissociation is an adaptive reaction to calamity, be it ‘hysterical’ (21%) or real (29%).
Detail from Pietà by Michel-angelo, San Pietro, Vatican, © S Traykov, by permission.
Doctors are wrong in 4%:They called my symptoms hysterical—until they understood my multiple sclerosis better”.
Calibrating our sensitivity to psychosomatic eventsgraphic

Why do some doctors preferentially diagnose somatic illness? Why, when confronted by unexplained symptoms, do we often subconsciously try to fit them to a physical ailment? The reason is usually that prescribing a pill is easier than changing, or regulating, intrapsychic events. The patient and the doctor may collude with this approach, and then get angry when it yields nothing. Alternatively, some doctors are so used to diagnosing psychopathology that they are all too prone to launch into treating someone’s depression and malaise, rather than their endocarditis or brucellosis. There is no single correct approach. We all make errors: the point is to find out in which direction you tend to make errors, then allow for this in your work.

Some patients are naively keen to name their condition, eg ‘fibromyalgia’, or ‘somatization disorder’. Being able to name a disease or a condition is to start to control it. But it’s only a start. In time, having named a condition may not prove all that helpful—and neither may seeing a string of experts. This paves the way for a cognitive shift that may allow progress—even healing—to come about. As one patient said “I stopped focusing on the specific diagnoses years ago, and switched to finding the best ways to increase my overall wellness. I use what I learned about my fibromyalgia to inform my choices, and have figured out what works best for me…Experts are just people, and are sometimes wrong…”.

graphicEach year 40% of us have quite severe feelings of depression, unhappiness, and disappointment. Of these, 20% experience a clinical depression, in which low mood occurs with sleep difficulty, change in appetite, hopelessness, pessimism, or thoughts of suicide. Diagnosis of major depression:

1

Loss of interest or pleasure—anhedonia in daily life with dysphoric mood (ie ‘down in the dumps’) plus ≥4 of the following (the first 5 are ‘biological’ symptoms)—present nearly every day for at least 2 weeks:

2

Poor appetite with weight loss (or, rarely, increased appetite).

3

Early waking—with diurnal mood variation (worse in mornings).

4

Psychomotor retardation (ie a paucity of spontaneous movement, or sluggish thought processes), or psychomotor agitation.

5

Decrease in sexual drive and other appetites.

6

Evidence of (or complaints of) reduced ability to concentrate.

7

Ideas of worthlessness, inappropriate guilt or self-reproach.

8

Recurrent thoughts of death and suicide, or suicide attempts.

Ignorance

Preoccupation with physical disease

Psychiatric labels are hated

Doctors & patients collude “not to open that can of worms”

It’s hard to spot depression coexisting with other illness.

Classify as:

Mild; moderate; severe.

With/without biological features.

With/without delusions or hallucinations.

With/without manic episodes (ie bipolar not unipolar). These replace the old reactive/endogenous labels. ΔΔ:Cyclothymic disorder; substance-induced mood disorder; schizophrenia, dementia; mood disorder due to a general medical condition.

Genetics: identical twins reared apart show 60% more concordance for depression than dizygotic twins (nb: these twin studies are suspect; see Psychiatr  q 2002 71 for the reasons why).

Biochemistry: there are excess 5-hydroxytryptamine (5ht2) receptors in the frontal cortex of brains taken from suicide victims. See ohcm p442.

Endocrinology: ♀:♂ >1:1; dexamethasone suppression test (ohcm p217) is abnormal in ⅓. 17β-estradiol may help perimenopausal depression; risk rises 2-fold, in proportion to lh & fsh. See also ghrelin (p530) & melatonin (sad, p404).

Stressful events (births, job loss, divorce, illness): seen in 60%.

Freudian reasons:graphic depression mirrors bereavement, but loss is of a valued ‘object’, not a person. There is ambivalence with hostility turned inwards.

Learned helplessness: if punishment is unrelated to actions, but is perceived as random, the response is helplessness and depression.
Vulnerability factors: physical illness, pain, and lack of intimate relationships may allow depression to arise and be perpetuated.

There is no clear distinction between the low moods we all get and illness needing vigorous treatment, but the lower the mood and the more marked the slowness, the more vigorous the treatment needs to be.

Psychological treatment (eg cognitive therapy, p373) is part of the treatment of all depression; it may be all that is needed in milder depressions.

Presence of biological features or stress predicts a good response to antidepressants (p340) especially if symptoms are severe. Not everyone wants drugs. Discuss all options. Herbalism can work: hypericum (St John’s wort) may be useful in mild to moderately severe depression.  nb: omega 3 supplements may reduce suicidal behaviour.
1.2g of eicosapentaenoic acid+ 0.9g decosahexaenoic acid/dayreference

Delusions or hallucinations prompt a physical treatment: drugs (antidepressants ±antipsychotic drugs, p360) or ect (p342; beware: mania may result).

Treat depression in bipolar illness as above (with ssri, risk of mania is low).
Lithium or valproate prophylaxis may be needed (p354).

Reasons to admit: Social circumstances; high suicide drive; isolation.

Who is likely to benefit from antidepressant drugs?

(see p340)

Sometimes antidepressants need to be prescribed as a matter of urgency—eg if suicide is likely (see below) or, for example, if a mother’s functioning is so impaired so that she cannot look after her family. If you cannot persuade the patient to start therapy, enlist the help of his or her family, and of a colleague. They may be able to persuade the patient where you have failed.

Those who have had low mood or loss of desire for pleasure (anhedonia) most of the day for at least the last 2 weeks and who show ≥4 of the following 7 markers of severe depression are at especial risk of suicide.

Suicide plan or ideas of self-harm.

Unexplained guilt or worthlessness.

Inability to function (eg psycho-motor retardation or agitation).

Concentration impaired.

Impaired appetite.

Decreased sleep/early waking.

Energy low/unaccountable fatigue

graphicEnquire about these whenever depression is possible.

 Has he planned the time?1 Has he planned the method?
Fig 1.

Has he planned the time?1 Has he planned the method?

nb:

treatment may still be needed if these criteria are not met: listen to the story. People often don’t accept that they are depressed as “There is nothing to make me depressed”. It helps to suggest that they could still be depressed, and that treatment could be very helpful. Give them time to go away and think about it, perhaps discussing it with someone they know (get consent). Try “Would your wife (or partner) say you were depressed? Please could you ask and let me know?” Such patients often return enriched by dialogue and reflection, and are successfully treated. This may not be over-medicalizing a patient’s symptoms .There is evidence that such patients are simply inexperienced in understanding their depression: when they next become depressed, their views much more nearly match those of their doctor.

Over-diagnosing severe depression

This is undesirable as patients lives are medicalized and drugs with significant side effects are needlessly given—as has been happening in the uk following nice and qof recommendation of use of the phq-9 diagnostic tool.97graphic

In some areas prescriptions for antidepressants have tripled from 1992–3 to 2006–7 without clear benefits.

Depressed mothers: do the needs of her children dictate the speed and risks of therapy? Drs have infinite ways to blackmail women…

Antidepressants for adjustment disorder and bereavement?
Adjustment disorder is one of the ways that stress causes psychopathology (other mechanisms reflect extraordinarily severe responses—acute stress reaction and post-traumatic stress disorder, p347). In adjustment disorder there is ‘marked distress that is in excess of what would be expected given the nature of the stressor’ (dsm-iv). In normal adaptive reactions to stress, functioning is less impaired. If there is an adjustment disorder and there are <5 signs of a major depression (above) antidepressants may not help much.
graphicDistinguish suicide from non-suicidal self-harm (eg a cry for help—common, but every non-fatal event may be fatal next time,1 hence treating both here; it is most prevalent in teenage girls; >1%/yr). Suicide is commoner in islands and east Europe, and rarer in Islamic peoples. Incidence: 106/yr (~1/1000uk). Risk ⬆ if: bipolar disorder; depression; borderline personality disorder (p366); anorexia; substance abuse; past self-harm; farmers; vets; doctors and all other prisoners; poor problem-solving; recession/unemployment; serious illness; spring sunshine (affects serotonin neurotransmission and impulsivity).
can be a form of protest,2 or a way of avoiding pain or shame, and of keeping honour/autonomy, the noble Roman in us preferring suicide to humiliation.2 Other themes “Giving up an unequal struggle”; “I’m worthless”; “I’m invisible, disconnected from society”.

Communicating a message, or gaining power by escalating conflict, often after an argument with a partner. Immaturity, inability to cope with stress, weak religious ties, and availability of drugs (psychotropics and alcohol are popular poisons) are also important, as is ‘copy-cat’ behaviour: when celebrities try suicide, others follow.

Disease, depression, bankruptcy; anything engendering rumination and hopelessness., (esp. if psychiatric care is reduced). Bullying, sexuality, intolerable stress to succeed, and falling behind in homework are also factors. If this mirrors your own state after trudging through endless handbook pages, shut this book, and take an immediate holiday.

Think of a target with 3 concentric rings. The inner ring is the circumstances of the attempt: what happened that day; were things normal to start with? When did the feelings and events leading up to the act start? Get descriptions of these in detail. Was there any last act (eg a suicide note)? What happened after the event? Was this what he/she expected?

is the background to the attempt: how things have been over the preceding months. Might the attempt have been made at any time over the last months? What relationships were important over this time?

is the family and personal history (p322).

Now…come to the bulls eye, the intention lying behind the act, and the present feelings and intentions. Does the attempt reflect a wish to die (a grave, not-to-be-ignored sign); a wish to send a message to someone; or to change circumstances? Ask: “If you were to leave hospital today, how would you cope?” Examine the mental state (p324; is there is any mental illness?) Summary:

Any plan? What? When? Where?

Are the means available?

Ever tried before? How seriously?

Preparations (making a will, giving things away).

Before arranging hospital admission, ask what this is for. Is it only to make you feel happier?—or to gain something that cannot be gained outside hospital. Ask: Why will discharge be safer in a few weeks rather than now?

Agree a contract offering help (p339), by negotiation. Discuss confidentiality, then talk with family as to how problems are to be tackled. Treat depression.

Problem-solving therapy helps by pointing out how she coped with past problems. The aim is to engender a greater ability to cope in the future and to help with immediate personal or social problems.
Follow-up, either alone or with the family, with preventive strategies:Access to: Samaritans & doctors; on-line help (Facebook is addressing this). ⬇Access to: Guns/poisons.  Less: Poverty & dead-end work; alcohol/drugs; isolation; sexual coercion; suicide website availability. More: God; family caring; shared meals; justice; sexual equality; poetry.graphic
Nuclear confrontations “I’ll kill myself if you leave me…”
The best approach is probably not to encourage patients to counter with “I hate you: if you go on threatening, it’s me who’ll commit suicide…”. To avoid mutually assured destruction, explain that it’s worth acknowledging close feelings (including negatives ones), emphasizing that a healthy relationship cannot be based on threats, and that there should be more to life than a single relationship, especially one based on coercion. It may be good to reflect aloud on past times when there was more range of things which made life worth living, and to explain that it’s possible to get back to a balanced state through dialogue and giving and receiving pleasure.
Ellis & Newman, Choosing to Livereference

The psychiatrist may become enmeshed in these webs of suicide threats, and may wrongly assume that because someone threatens suicide, they should be admitted to hospital (compulsorily if necessary) so that they can be kept under constant surveillance, and suicide prevented. This reasoning has 3 faults. The first is the idea that it is possible to prevent suicide by admission. There is no such thing as constant surveillance. Second, admission may achieve nothing if it removes us from the circumstances we need to learn to cope with. Third, we must distinguish between suicide gestures, which have the object of influencing others’ behaviour, and a genuine wish to die.3

Before death, many suicide victims see a gp, and it is wise to be alert to undercurrents of suicide which only sometimes surface during consultations. Ask unambiguously about suicide plans (p322). On deciding that a threat is more manipulative than genuine, very experienced therapists may influence the person’s use of suicide behaviour by forcing him to face the reality of his suicide talk, eg by asking: “When will you kill yourself?” “How will you do it?” “Who will discover the corpse?” “What sort of funeral do you want? Cremation, burial, with or without flowers?” “Who will come?”

See opposite for risk factors for suicide; they may be of no help in individual cases, so aim to think dynamically of risks and protective factors (eg family support), with suicide occurring after key events that accumulate risk.

graphicTake all suicide threats seriously—but emphasis differs depending into which group the patient falls. Aim to form a contract with the patient, eg:

The therapist will listen and help if the patient agrees to be frank, and to tell the therapist of any suicide thoughts or plans.

Agreement about which problems are to be tackled is made explicit.

Agree the type of change to aim for and who will be involved in treatment (eg family, friends, gp). Agree the timing and place of sessions.

An agreement to collaborate with the therapist, and to do any homework.

Not all self-harm is suicidal

Cutting can relieve stress; in helping people reduce the need to self-harm they may find addressing these questions helpful:

1

Have I got a solid support system I can call on if I feel like cutting?

2

Have I got 2–3 people I feel comfortable to talk to about cutting with?

3

Have I got a list of things I can do as an alternative to cutting?

4

Have I got a place to go if I need to leave home so as not to hurt myself?

5

Can I get rid of everything I might use to harm myself, without panicking?

6

Am I prepared to feel scared, frustrated while cutting down my cutting?

“I was 7 years old the first time I brought a blade across my skin and watched the first trickle of blood streaming down my body…”

nice

graphicDrugs improve mood and ⬆synaptic availability of noradrenaline or 5ht. Your own personal qualities and psychotherapy (p370) are as important as drugs. Encourage socializing, exercising, and countering negative thoughts (p372).

Uncomplicated depression in middle age—little suicide risk: If a cheap agent is essential, try dosulepin, ≤150mg at night (start with 25mg; max 225mg/day, in hospital). Explain side effects (below); warn about driving/machinery use. Explain that benefits take weeks to develop. Avoid if arrhythmia risk (eg post mi). ssri alternative: citalopram 20mg/day, unless qt is long (works fastest); only use max dose of 40mg if lft ok and <65yrs old; consider sertraline 50mg/day (if not responding in 2wks, switching to paroxetine 20–40mg/day is better than continuing sertraline).
Depression with intellectual disability: Try ssris eg fluoxetine, 20mg/24h po (doubled after 3wks if needed). t½ ≈3 days. If ♀, consider combining with 0.5mg/day folic acid: folate is low in major depression, and supplements may help.

Past history of good response to tricyclics, now suicidal: Try lofepramine, 70mg/12h (less likely to be fatal in overdose; less risk of fatal arrhythmias).

Depression in an adolescent: See p390; tricyclics/ssri have problems.
Unlicensedreference

Depression if elderly: ?Avoid ssri; halve dose of tricyclic (ses may be worse).

Depression + psychosis:  ect (p342) ± antipsychotics (p360) may be needed.

Bipolar child: Get help; aripiprazole, olanzapine & risperidone have a role.

Depression in those insisting on driving: Paroxetine (20mg each morning, increased by 10mg increments; max: 50mg/24h) is safer than tricyclics. It is the ssri most associated with the unpleasant dystonias on withdrawal.

Depression + disordered sleep pattern: Tricyclic, eg dosulepin, as above. If suicidal mirtazapine (blocks 5ht2, h1, and 5ht3—15mg at bedtime, max 45mg) may have a role. Warn not to rely on the ‘fact’ that daytime sleepiness usually wears off after a few weeks. nb: ordinary ssris can aggravate insomnia. Sleep is such a restorative for some patients, so give them the best chance.

Depression not responding to  ssri: Venlafaxine (snri1) maygraphic have a role.

Pregnancy/breastfeeding: Tricyclics may be best; p408; get expert help.

Depression with obsessive–compulsive features: Clomipramine or an ssri.

Depression with Parkinson’s disease:  ssri (nortriptyline 2nd choice).

Post-stroke depression: Nortriptyline is ?better than fluoxetine.

Depression at menopause:  hrt may help but ⬆ breast cancer risk, p256.

Depression+sexual dysfunction: Mirtazapine or bupropion.

Depression + obesity: Fluoxetine sometimes leads to weight⬇.

Worried about drug interactions: Citalopram and sertraline have lowest risk. Most ssris inhibit cyp450 enzymes so can ⬆levels of many drugs.

Depression in psychiatrists: In a survey of psychiatrists, most said “I’d want citalopram, fluoxetine, or venlafaxine; in severe depression I’d want ect.”

Citalopram & sertraline:

Nausea, vomiting, dyspepsia, diarrhoea, abdominal pain—also rash, sweats, agitation, headache, insomnia, tremor, anorgasmia♂+♀/erectile dysfunction (sildenafil helps), Na+⬇, gi bleeding. Fluoxetine as above (insomnia & agitation commoner). Fluvoxamine as for citalopram but nausea more common. Paroxetine as for citalopram except more antimuscarinic effects and sedation, also extrapyramidal symptoms (rare). Sertraline may attenuate happiness, rapture, and love.

Amitriptyline—common se: sedation, dry mouth, urine retention, blurred vision, postural hypotension, tachycardia, constipation. Other se: arrhythmias; convulsions (dose-related). Clomipramine, dosulepin, doxepin as for amitriptyline. Imipramine and lofepramine less sedating than amitriptyline. Trimipramine more sedating than amitriptyline.

ssri issues
ssris are under a cloud as a 2008 meta-analysis shows their effects in depression may be no greater than placebo. Also, in one cohort study in the elderly (n=60,746) ssris had the highest hazard ratios for falls (1.66) and hyponatraemia (1.52). All-cause mortality was also higher vs tricyclics. There is also the question of suicidal behaviour. In adults, research using the uk gp research database for 1993–9 found risk of suicidal behaviour wasn’t significantly greater with ssris than vs tricyclics (but strong suicidal drive is reported). Venlafaxine is also problematic. In teenagers, the position is complex, and prescribing bodies tend to recommend that no antidepressants be used—but this is unworkable for those many teenagers with formidable mental health problems where there is lack of availability of cognitive therapies, or they are not working. Here the small risk of suicide (≲1:4000graphic) may be the least bad option. Before prescribing: get informed consent from the teenager and the parent/carer. Ensure meticulous follow-up, and ensure that it really is a major depression you are treating, using detailed questionnaires to aid diagnosis.
A patient-centred approach to depression

We can feel perplexed with antidepressants; it can feel like trial and error when prescribing them. What works well in one person may not help another. There seems to be an ever increasing choice of drugs and conflicting information on safety. In this context, the following may be helpful:

Discuss choice of drug and non-pharmacological therapy. Cognitive therapy is known to be as effective as antidepressants in mild to moderate depression. Combined use is better than either treatment alone.,

Discuss side effects, not all side effects are undesirable (ssris may help premature ejaculation). Warn that there may be an initial worsening of symptoms in the first weeks so persevere before therapeutic effects are seen.

Assess after 4–6 weeks. If effective continue for at least 4–6 months after recovery, if stopped too soon 50% relapse. If no effect, increase dose and review in 2 weeks. If still no response, increase dose if it is safe to do so (unless poorly tolerated), review in 2 weeks. If no response or poor tolerability, switch to an alternative class of antidepressant (special method, p369).
Recurrent depression: of those who have one episode of major depression 50–85% will have further episodes. Continuing antidepressants lowers the odds of relapse by ~65%, which is about half the absolute risk.

8 pharmacological actions are known, and over 20 antidepressants exist. How do all they lead to a similar response? Why is there a delay? 2 theories: The

Postulates that a change in receptor sensitivity by desensitization and down-regulation of different receptors (not just ⬆neurotransmitter at the synapse) leads to clinical effects after a few weeks. The

This suggests the effect of increased neurotransmitter at the synapse initiates a sequence of events to give the anti-depressant response. This includes up and down regulation of various genes with subsequent varying expression of receptors and critical proteins.
Have a non-pharmacological arm to every treatment plan…
Exercise (in wild Nature, eg on or near watergraphic), tai chi (p753), Yoga, social interaction, psychotherapy (p370), counselling (p380), reading clubs, meditation, poetry (reading/writing). Join a club, eg Ramblers. Rest from work. People may not want drugs, equating them with moral failure? If still unconvinced, an alternative therapy, eg St John’s wort, may be acceptable?
There is mri evidence for the idea that ect interrupts the hyperconnectivity between the various areas of the brain that maintain depression.

nice recommends ect is used only to gain rapid (if short-term) improvement of severe symptoms after an adequate trial of other treatments has proven ineffective and/or when the condition is considered to be potentially life-threatening, in individuals with:

Severe depression

Catatonia (eg associated with schizophrenia.)
A prolonged or severe manic episode. Emergency ect is possible, eg in some elderly patients, but rarely used (but the success rate is good, eg 80%). Carry on antidepressants when ect ends: this may prevent recurrences.graphic  Typical course length: 6 sessions (2 per week).

Recent subdural/subarachnoid bleed; no consent (p402; involve relatives, but they cannot consent for an adult). Cautions Recent stroke mi, arrhythmia, cns vascular anomalies.

Anaesthetic problems; amnesia; delirium/agitation (may respond to donepezil). Parkinsonism may improve.

Check the patient’s identity and that ‘nil by mouth’ for >8h.

Ensure a detailed medical history and physical examination has been done, and any illnesses investigated and treated as far as possible. High anaesthetic risk?—See p614; seizure threshold ⬆ if on concurrent benzodiazepines or anticonvulsants; also ⬆risk of heart complications if on tricyclics. Liaise between psychiatric and anaesthetic staff. Do benefits outweigh risks?

ect is frightening; give calm reassurance away from the site where ect is going on. (Patients should not witness other patients having ect.1)

Are the consent forms in order (p402; see below)? In the rare instances in the uk where ect is given without consent, a second opinion from the Mental Health Commission must state that the treatment is necessary (p402).

Ensure that fully equipped resuscitation trolleys are present including a functioning defibrillator, suction apparatus, and pulse oximeter.

Ensure anaesthetist (senior & ect trained) knows of allergies ± drugs interfering with ga. For countering ect-induced vagal stimulation, she may use atropine before using an ultra-short-acting anaesthetic agent with muscle relaxation (eg suxamethonium) to minimize the seizure’s muscular component.

The ect machine: checked recently? Reserve machine to hand? What charge/energy is to be given? Which waveform will be used (bidirectional or modified sinusoidal, or unidirectional)? See manufacturer’s information.

Put jelly on the electrode sites (not enough to allow shorting). See fig  1.

When the anaesthetist gives the word, give the shock. Be prepared to restrain the patient if paralysis is incomplete. While the current passes, the muscles will contract. This will cease as the current ceases. After ~10sec, further clonic spasms occur, lasting ~1min. The only sign may be lid fluttering. Clonus is probably needed for ect to be fully effective.

Then coma position and bp/pulse, etc until conscious. Ask the anaesthetist to try iv  midazolam for those (few) who get very agitated during recovery.

 Electrode position: a–b =10cm; a is 4cm from the green dotted line.
Fig 1.

Electrode position: a–b =10cm; a is 4cm from the green dotted line.

Consent for today’s shock is suspect if yesterday’s ect has made you unable to remember your basic biography (am I divorced?). Reflect on the blogs opposite, and on Hay’s paradox: the organ giving consent is the organ affected. As in all metaphysical paradoxes, don’t get overly wound up by the lack of any way out: remember that humans are quite good at this sort of thing, yourself included. Start from the basic principle that if your patient’s wishes are known, comply with them. Hay’s paradox is partial because the organ giving consent is not uniformly affected, and decision-making may be rational. But if the deluded patient says “I want ect because it fries the transmitter the Pope put in my head” you may need legal backing to endorse consent. But don’t be too intellectually arrogant in dismissing a patient’s reasoning: after all, none of us knows how ect works, and all are entitled to an opinion.
What is the correct ‘dose’ of unilateral ect?

There is no universal answer, but there is evidence that therapeutic effects of ect are proportional to seizure length. Be sure that you have adequate training on this issue by the consultant in charge of the session. Dose is better measured in millicoulombs (mC) than milliamps. It depends on seizure threshold, which varies 40-fold among patients. A moderately ‘suprathreshold’ dose (eg 200% above seizure threshold) usually gives seizures of adequate duration, while aiming to minimize cognitive side effects—according to the Royal College of Psychiatrists ect Handbook.

Doses need to change depending on response, and dose of propofol in the anaesthetic: also, seizure threshold rises by ~80% as courses progress. A ‘good’ seizure is one which is of adequate duration (~15sec during early sessions; duration is less important later), with both a tonic and a clonic phase. Some machines allow eeg monitoring—useful as anaesthesia renders seizure analysis difficult. If the seizure lasts >2min, tell the anaesthetist, who will give a bolus of diazepam, or ga agent.
The frequency and speed of response of ect varies according to indication, eg bipolar depression patients show more rapid improvement and need fewer treatments than unipolar patients. One retrospective study has found that female patients respond better to ect than male patients.
Quotes from the blogsphere:graphic What’s it like to have ect?
“There is no treatment in psychiatry more frightening than ect…There is also no treatment in psychiatry more effective than ect.”
“Nighty-night” says the blue mask with piercing green eyes, and an instant later, I feel myself falling into yummy unconsciousness. When I awake from the treatment, I am back in my hospital room. My brain feels very foggy. I can’t remember what day it is or anything that happened that morning. I try to call my husband at home, but I can’t remember my phone number and have to look it up in an address book I find in my nightstand. Waves of excruciating pain surge through my head, and I beg for pain medicine…This whole scenario repeats itself each day for the next week and a half. As the days pass, the headaches grow more and more unbearable, but life in general grows surprisingly more tolerable…Gone are the days filled with inescapable agony, misery, despair and a desperate determination to die. In short, I have my life back…”
“My memory seems pretty bad. I forget lots of common easy things that have no reason to be forgotten. This never happened prior to electroconvulsive treatment. My memory was picture perfect before. I have a mix of depression and anxiety. I find that with the ect I also like 10mg Prozac… It’s strange how these meds always did me a little bit of good by themselves, but that with ect they work so much better.”
“I’ve always had a super good memory. It is unreal how poor it is now. But I don’t mind. It’s almost comical.” “After you recover from depression, people encourage you to rebuild your life but…[after ect] I couldn’t even remember what my life was.” (≈⬇retrograde autobiographical memory.)

graphic“It’s frightening, it’s quick, and it works—and I might give it a go.” (jml)

graphicAnxiety is a universal experience (♀:♂ ≈2:1); it is, according to some reckonings, the chief factor limiting human potential; it causes much suffering, costing the uk ≳£5 billion/yr. Neurosis refers to maladaptive psychological symptoms not due to organic causes or psychosis, and usually precipitated by stress. Apart from free-floating anxiety and depression, such symptoms are: fatigue (27%), insomnia (25%), irritability (22%), worry (20%), obsessions, compulsions, and somatization (p640)—all more intense than the stress precipitating them would warrant. Symptoms are not just part of a patient’s normal personality, but they may be an exaggeration of personality: a generally anxious person may become even more so, ie develop an anxiety neurosis, as a result of job loss. The type of neurosis is defined by the chief symptom (eg anxiety, obsessional, depressive). Before diagnosing neurosis, consider carefully if there is underlying depression needing antidepressants.
Classifying anxietydsm-iv

Generalized anxiety disorder (gad): anxiety +3 somatic symptoms and present for ≥6 months

Panic disorder

Phobia, eg agoraphobia

Post-traumatic stress disorder

Social anxiety disorder

Obsessive–compulsive disorder

Symptoms of anxiety:

Tension, agitation; feelings of impending doom, trembling; a sense of collapse; insomnia; poor concentration; ‘goose flesh’; ‘butterflies in the stomach’; hyperventilation (so tinnitus, tetany, tingling, chest pains); headaches; sweating; palpitations; poor appetite; nausea; ‘lump in the throat’ unrelated to swallowing (globus hystericus); difficulty in getting to sleep; excessive concern about self and bodily functions; repetitive thoughts and activities (p346). Children’s symptoms: Thumb-sucking; nail-biting; bed-wetting; foodfads.

Genetic predisposition; stress (work, noise, hostile home), events (losing or gaining a spouse or job; moving house). Others: Faulty learning or secondary gain (a husband ‘forced’ to stay at home with agoraphobic wife).

Listening is a good way to ⬇anxiety. Explain that headaches are not from a tumour, and that palpitations are harmless. Anything done to enrich patients’ relationship with others may well help.

Beneficial effects appear to equal meditation or relaxation. Acute anxiety responds better than chronic anxiety.
Intensive but time-limited group stress reduction intervention based on ‘mindfulness meditation’ can have long-term beneficial effects.
(p373) and relaxation appear to be the best specific measures with 50–60% recovering over 6 months.

employs graded exposure to anxiety-provoking stimuli.

augment psychotherapy:

1

Benzodiazepines (eg diazepam 5mg/8h po for <4wks. ses/withdrawal, p368, limit utility).

2
ssri (p340, eg paroxetine in social anxiety).
3
Azapirones (buspirone, 5ht1a partial agonist; 5mg/8–12h; ?less addictive/sedating than diazepam, and few withdrawal issues).
4
Old-style antihistamines (eg hydroxyzine).graphic
5
β-blockers.
6
Others: pregabalin and venlafaxine.
Teach deep breathing using the diaphragm, and tensing and relaxation of muscle groups, eg starting with toes and working up the body. Practice is essential. cds aid learning; in some contexts, eg stress, relaxation is not as good as cognitive restructuring.
Initially the therapist induces progressively deeper trances eg using guided fantasy and concentration on bodily sensations, such as breathing. Later, some patients will be able to induce their own trances. It powerfully reduces anxiety, and is useful, eg medical contexts (eg post-op).
gad often gets better by ~50yrs (often replaced by somatization).
Some remarks on adolescent anxiety and mood swings

Anxiety is the engine in us, and also our steering wheel, weaving us in and out of the fast or slow lanes of our lives. Some of us seek out anxiety as a way of feeling alive (the tightrope walker, or the falconer, placing the meat for his bird between his own eyes). The lives of others are dominated by the imperative of minimizing anxiety, to the extent that some of us never leave home, either physically or metaphorically. Anxiety implies heightened awareness, which is why it is one of the dominant colours in the artist’s metaphysical palette. The artist makes us anxious so that we see familiar objects differently. Anxiety, up to a point, makes us sit up, and take note; beyond a certain level (different in all of us, and different at different times) anxiety is counter-productive: we become preoccupied with the feeling itself, which chokes our ability to act (angere =to choke gives us anxiety and angina).

Anxiety is reduced by the chief cns inhibitory neurotransmitter, gaba (gamma-amino-butyric-acid) which counteracts excitatory limbic system effects of glutamate. Stress releases allopregnanolone (thp) which increases gaba’s calming effects in adults. But in adolescents (at least in adolescent mice), thp has the opposite effect. thp has 2 roles: 1 in the limbic system it tranquillizes; 2 in the hippocampus of adolescents thp does the opposite (the hippocampus is important for emotion regulation, as well as memory). This reflects adolescents’ enhanced expression of α4βδ  gabaa receptors in the hippocampus. This may explain why, in some adolescents, and maybe other individuals, calmness is unattainable (activating the break also activates the accelerator, so responses are amplified into unpredictable mood swings).
Quotes from the blogsphere: what’s it like to have panic attacks?
“I worry about everything: from the detergent I use to the war in Iraq. I am just completely ridiculous with it. To the point where I experience panic attacks, which are terrifying experiences. They feel like heart attacks. Worry steals every happy moment away. It takes away my drive, my ambition, my sense of adventure, my ability to relax, my ability to have fun. I’m aware of it, and I cannot seem to stop it, nor control it…”
“I woke up in my bed, in the middle of the night. I was sweating, but I was cold. I was so scared that I literally could not move—all my muscles were locked in position. My heart was racing, and I was breathing so hard that anyone listening would have thought I had just run a marathon…”
“I felt like I had a tennis ball wedged in the middle of my chest, below my breastbone and above my stomach. It was tight, made me breathe erratically…and caused me to panic… I couldn’t drive like a normal human being—I had to stop every 20 minutes or so to let yet another panic attack pass. I usually had to get out of the car, walk around it a few times…”
“The dentist was in a hell of a hurry…I tried to tell him I was not having any reaction (to the anaesthetic). I had a panic attack…his hand, scrambled out of the chair trailing hoses & drills, scuttled across floor on hands and knees trying to escape. Then I had an asthma attack brought on by panic and it was touch and go for a while. Oh, did I mention that I wet myself?”
“It had been two years since my last panic attack (deep breathing, meditation, and generally better stress management eliminated even the tiniest hint of an attack) before I began to plan my trip home…”
Immunizing ourselves against neurosis: one man’s methodologies

Bagpipes

Seneca (ad65)1

Surfing

Sea-bathing

Self-hypnosis

Exercise

Pretending to be a tree

Playing with dolphins

graphicinvolve anxiety in specific situations only, and leading to their avoidance. These are labelled according to specific circumstance: agoraphobia (agora, Greek for market place) is fear of crowds, travel, or situations away from home; social phobias (where we might be minutely observed, eg small dinner parties); simple phobias, eg to dentists, intercourse, Friday the 13th (triskaidecophobia), spiders (arachnophobia, p372), beetles (paint them red with black spots on and they are charming ladybirds). There may also be free-floating ‘fear of fear’, or fear of disgracing oneself by uncontrollable screaming.

Elicit the exact phobic stimulus. It may be specific, eg travelling by car, not bicycle. Why are some situations avoided? If deluded (“I’m being followed/persecuted”), paranoia rather than phobia is likely. For panic attacks, try cognitive-behaviour therapy (p373, ± eg paroxetine 20–50mg/day po).,

Compulsions are senseless, repeated rituals. Obsessions are stereotyped, purposeless words, ideas, or phrases that come into the mind. They are perceived by the patient as nonsensical (unlike delusional beliefs), and, although out of character, as originating from themselves (unlike hallucinations or thought insertion). They are often resisted by the patient, but if longstanding, the patient may have given up resisting them. An example of non-verbal compulsive behaviour is the rambler who can never do a long walk because every few paces he wonders if he has really locked the car, and has to return repeatedly to ensure that this has, in fact, been done. Cleaning (eg hand-washing), counting, and dressing rituals are other examples.

cns imaging implicates the orbitofrontal cortex and the caudate nucleus. Successful treatment is reflected by some normalization of metabolism in these areas.

Behavioural (or cognitive) therapy (p372). Clomipramine (start with 25mg/day po) or ssris (eg fluoxetine, start with 20mg/day po) really can help (even if patients are not depressed): see p340.

“That afternoon, I found that when I got home from school, I couldn’t get around the house or do normal things without performing rituals to cancel out bad thoughts over and over again. It was weird and I didn’t want to do it, but if I didn’t I would feel a lot of anxiety and panic like something was very wrong. I kept having to enter and re-enter through the front door. I ended up spending about 3 or 4 hours in the bathroom because I couldn’t get out of there because every time I tried to do the perfect ritual, my body would itch or something else would go wrong and I had to redo the rituals over again. After a few hours, I wanted to get out of there bad, I felt like a prisoner in my own bathroom!”
This is an unpleasant state of disturbed perception in which people, or the self, or parts of the body are experienced as being changed (“as if made of cotton wool”), becoming unreal, remote, or automatized (“replaced by robots”). There is insight into its subjective nature, so it is not a psychosis, but the patient may think he is going mad. Depersonalization may be primary, or part of another neurosis. cns imaging shows that it is associated with functional abnormalities in the sensory cortex in areas where visual, auditory, and somatosensory (cross-modal) data integrate.

These are psychosensory feelings (akin to depersonalization) of detachment or estrangement from our surroundings. Objects appear altered: buildings may metamorphose in size and colour. The patient acknowledges the unreality of these ideas, but is made uneasy by them.

(Our isolation in an alien or unreal universe, and our estrangement from ourselves, are major themes of leading novelists such as Albert Camus.)
(formerly hysteria) Clinical details: p334. Example of mass hysteria spread by tv—Pokeman induced ‘seizures’: see ‘the Pokeman contagion’.

Behaviour therapy (p372 ± antidepressants) if he really wants to change.

Stress and post-traumatic stress disorder

Near-death; war; rape; earthquake; torture; crimes of passion; shipwreck

Smoking, alcohol, and chattering are popular methods. If drugs must be used, propranolol 10mg/8h po may ⬇autonomic symptoms (ci: asthma; heart failure; heart block). Alternatives: exercise, singing, progressive relaxation (p344),counselling (p380).

Fearful; horrified; dazed

Helpless; numb, detached

Emotional responsiveness⬇

Intrusive thoughts

Derealization (p346)

Depersonalization

Dissociative amnesia

Reliving of events

Avoidance of stimuli

Hypervigilance

Concentration⬇

Restlessness

Autonomic arousal: pulse⬆; bp⬆; sweating⬆

Headaches; abdo pains

Suspect this if symptoms (box) become chronic, with these signs (may be delayed years): difficulty modulating arousal; isolated-avoidant modes of living; alcohol abuse; numb to emotions and relationships; survivor guilt; depression; altered world view in which fate is seen as untamable, capricious or absurd, and life can yield no meaning or pleasure.  nb: some people have this with no known stressor: dsm-iv wrongly calls this adjustment disorder, whereas it is a form of existentialism that only the healing power of story-telling can transform ‘by serving as an axe for the frozen sea inside us.’
Franz Kafkareference
mri implicates the anterior cingulate area, with failure to inhibit amygdala activation ± lowered amygdala threshold1 to fearful stimuli.,
Debriefing may do more harm than good. Macbeth’s ‘sweet oblivious antidote to cleanse the stuffed bosom of that perilous stuff which weighs upon the heart’ has yet to be found. Is the best advice to try to forget or ignore the past? Macbeth’s doctor asserts (Act V) that such a patient ‘must minister to himself’, when he had been unreasonably but royally commanded to ‘raze out the written troubles of the brain’—and perhaps tragic literature can offer more than medicine here,graphic as demonstrated by the many soldiers who have benefitted from Jonathan Shay’s book Achilles in Vietnam. In narrative exposure therapy, adults or children are asked to describe what happened in great detail (what they saw, heard, smelled, felt, the movements they recall and how they felt and thought at the time). Initial distress is marked, but as sessions are long, habituation ensues as more and more details are recalled. Emphasize integrating emotional and sensory memory within a detailed autobiographic narrative. After 4 sessions, scores on intrusion and avoidance may drop markedly; but don’t expect despression to resolve.  Eye movement desensitization and reprocessing (emdr) may also have a role.graphic
After the 2004 Indian Ocean tsunamis, psychopathology was as common as physical injury: who advised practical outreach help, and to avoid mental health labels (contrary to nice’s medicalizing approach to ptsd).
Amitriptyline, mirtazapine, paroxetine, and atypical anti-psychotics (p360) can help (warn of ses and withdrawal phenomena, p340).,

Rehearse teamwork—and techniques of stress inoculation (by exposure), and desensitization (by helping real casualties, eg if preparing for war). Keeping combatants in tight-knit groups cemented by the ties of mutual interdependency is recommended by military strategists. nb: morphine use at the time of injury may be protective. www.killology.com

graphicEating disorders are common—don’t expect your patient to fit neatly into any category: ‘Eating disorder not otherwise specified’ is the commonest type; categories such as purging disorder and non-fat-phobic anorexia nervosa are newly proposed categories that may be appropriate to use.

graphicThe most fatal of all mental illnesses (~20%, if severe). There is a compulsive need is to control eating, as if worth equates with shape (a notorious western cult). Low self-worth is common and weight loss becomes an over-valued idea even when weight is very low. This is achieved by over-exercising, induced vomiting, laxative abuse, diuretics, or appetite suppressants. Many also have episodes of binge eating, followed by remorse, vomiting, and concealment.

1

Weight <85% of predicted (taking into account height, sex, and ethnicity, p181), or bmi ≤17.5kg/m2.

2

Fear of weight gain, even when underweight, leading to dieting, induced vomiting, or excessive exercise.

3

Feeling fat when thin.

4

Amenorrhoea: 6 consecutive menstrual cycles absent unless on the Pill (in women), or ⬇libido.

♀:♂≳4:1 (men are more likely to be undiagnosed; don’t assume that a fragile sexual identity exists in these men). Typical age of onset is mid-adolescence—but may be older than 60yrs.

0.7% in teenage girls and no restriction to a particular ethnic group.

20:100,000 in females aged 10–39 (stable over the last 20 years).

crf hypothesis;1 55% concordance in monozygotic twins in some areas.

Depression; anxiety; obsessive compulsive features (=anankastic); perfectionism; anxious–avoidant–dependent personality; substance abuse; tv (esp. soap-opera) watching; image-aware work (eg ballet); past teasing or criticism for fatness. Adverse life events and difficulties; most commonly in the area of close relationship with family or friends; low self-esteem; impulsivity; rarely dietary problems in early life; parents preoccupied with food; family relationships that leave the person without a sense of identity. There is scant evidence that the chief problem is psychosexual immaturity (antecedent sexual abuse is not a specific risk factor).

Fatigue; cognition⬇ (cerebral atrophy) altered sleep cycle; sensitivity to cold; dizziness; psychosexual problems; dental caries; constipation; fullness after eating; subfertility/amenorrhoea; ⬇wcc; anaemia; ⬇platelets; glucose⬆⬇; ⬇K+; ⬇PO43; ⬆bicarbonate; ⬆lft; ⬆amylase if binging/purging; ⬆T3/T4; normal or ⬇tsh; ⬇lh; ⬇oestrogen; ⬆gh; ⬆cortisol; ⬆cck; normal prolactin; ⬇renal function; osteoporosis if malnourished; bp⬇; ⬆qt interval; amorphous ovaries. In early onset disease, functional mri shows ⬇blood flow to the temporal lobe unilaterally. Also: ⬇visuo-spatial ability; ⬇visual memory; ⬆speed of information processing.

(can be used for prevention)1 Do you ever make yourself sick because you feel too full? Do you worry you’ve lost control over eating? Have you recently lost more than one stone in 3 months? Do you believe you are fat when others say you are thin? Does food dominate your life?

Depression, Crohn’s/coeliac disease, hypothalamic tumours.

graphicbmi <13 or below 2nd centile graphicWt loss >1kg/wk graphicT°: <34.5° graphicVascular: bp <80/50; pulse <40; Sa O2 <92%; limbs blue and cold graphicMuscles: unable to get up without using arms for leverage. graphicSkin: purpura graphicBlood (mmol/L): K+ <2.5; Na+ <130; ⬇PO43 <0.5. graphicecg: long qt; flat t waves.

Aim to restore nutritional balance (eg weight gain of 1.5kg/week; final bmi 20–25). Treat complications of starvation. Explore comorbidity. Involve family/carers. Address factors maintaining the illness. Severe anorexia (bmi <15kg/m2, rapid weight loss + evidence of system failure) requires urgent referral to eating disorder unit (edu), medical unit (mu) or paediatric medical wards (p). Re-feeding is considered ‘treatment’ under the Mental Health Act 1983/Children Act 1989, and it may be needed if insight is lacking. In moderate anorexia (bmi 15–17.5, no evidence of system failure) routine referral can be to the local community mental health team (cmht)/adolescent unit or edu if available. In mild anorexia (bmi >17.5) focus on building a trusting relationship and encouraging use of self-help books and a food diary. If there is no response within 8wks, consider referral to secondary care. No drug treatments for anorexia nervosa are validated by good randomized trials. Fluoxetine (20–60mg/day) prevents relapse in open trials.graphic Monitor q–t interval. There is wide variability in the availability of psychological therapies and no uniform approach. Cognitive therapies (p372), analytic, interpersonal, supportive, or family therapy (±parent-to-parent consultations3) may be tried. In children and adolescents consider family therapy.  Olanzapine may help (unlicensed use).
(On rapid intake of calories). Signs: rhabdomyolysis, respiratory or cardiac failure, bp⬇, arrhythmias, seizures, coma, sudden death. Re-feeding syndrome is very rare when with home re-feeding. Acute gastric dilatation can occur if a poorly nourished patient binges. Monitor serum PO43 (stop re-feeding if falling). Also watch for glucose⬆, K+⬇, and Mg2+⬆.,,
43% recover completely, 36% improve and ~20% develop a chronic eating disorder. 5% die (mostly from suicide or direct medical complications, eg K+⬇ and prolonged q–t interval predisposing to arrhythmias). Median time between diagnosis and death is ~11 years. Mortality is higher if: aged 20–29 at presentation, delayed access to treatment, bingeing and vomiting.
1

Recurrent episodes of binge eating characterized by uncontrolled overeating;

2

Preoccupation with control of body weight

3

Regular use of mechanisms to overcome the fattening effects of binges, eg starvation, vomit-induction, laxatives, over-exercise

4
bmi >17.5.
♀:♂≈9:1. Prevalence (rising in developed countries) ≈ 0.5–1.0% in young women. Social class distribution: even. In Britain, young Muslim Asian women are at ⬆risk. Homosexuality/bisexuality may be a specific risk factor for bulimia in males (asexuality is more typical in ♂ anorexia nervosa).

Urbanization (not a risk factor for anorexia); premorbid obesity. Commoner in ♀ relatives of anorectics, suggesting a shared familial liability. Genetic contribution of 54–83%.

Age of onset: ~18yrs.

Fatigue, lethargy,4 feeling bloated, constipation, abdominal pain, oesophagitis, gastric dilatation with risk of gastric rupture, heart conduction abnormalities, cardiomyopathy (if laxative use), tetany, occasional swelling of hands and feet, irregular menstruation, erosion of dental enamel, enlarged parotid glands, calluses on the back of the hands (Russell’s sign, from tooth marks during induction of vomiting), oedema (use of laxatives and diuretics), metabolic alkalosis, hypochloraemia, hypokalaemia, metabolic acidosis (if laxative use), less commonly hyponatraemia, hypocalcaemia, hypophosphataemia, hypomagnesaemia, abnormal eeg, abnormal menstrual cycle, blunted response of tsh and growth hormone to thyroid releasing hormone.

Mild symptoms: support, self-help books and food diary similarly to anorexia. Referral to cmht or edu (above) in case of no response, moderate or severe symptoms, and to a medical unit if medical complications. Anti-depressants have the most robust evidence at usual doses but fluoxetine may be needed at up to 60mg/day. Cognitive therapy can help (p370-1
In 2–10yrs, 50% improve, 20% show no change.

graphic(Acute confusion, delirium) The key feature is impaired consciousness with onset over hours or days. It is difficult to describe; take any opportunity to be shown it. You have the sense when trying to communicate that your patient is not with you. He is likely to be disoriented in time (doesn’t know day or year) and, with greater impairment, in place. Sometimes he is quiet or drowsy; sometimes agitated, and you are called when he is disrupting the ward. Or he may be deluded (for example, accusing staff of plotting against him/her) or hallucinating. If there is no past psychiatric history, and in the setting of a physical illness or post-surgery, a confusional state is particularly likely—especially if symptoms are worse at the end of the day.

If agitated, consider anxiety (usually readily distinguished on history-taking). If onset uncertain, consider dementia.

(box 1)Infection; drugs (benzodiazepines, opiates, anticonvulsants, digoxin, l-dopa); u&e⬆⬇; hypoglycaemia; Pa O2⬇; Pa CO2⬆; epilepsy; alcohol withdrawal; trauma; surgery (esp. if pre-op Na+⬇ or visual or hearing loss).

u&e, fbc, blood gases, glucose, cultures (blood, msu), lft, ecg, ct, cxr±lp.

Find the cause. Optimize surroundings and nursing care. Examine with above causes in mind; do tests; start relevant treatment, eg O2.

If agitation is distressing the patient, and non-drug methods fail, consider haloperidol 1–10mg iv/im/po or risperidone 0.5–4mg/24h po (smallest dose possible, esp. if elderly). Monitor bp. Wait 20min to judge im effects. Amnesia and cognition may worsen (se: bp⬇⬆, stroke, insomnia, dyspepsia). Music, muscle relaxation, and massage (mmm) is a better approach to agitation.

Nurse ideally in a moderately lit quiet room with same staff in attendance. Reassure and re-orientate often. A compromise between a quiet room and a place where staff can keep under surveillance has to be made. Monitor bp.

6% of those ≳65yrs.

Global intellectual deterioration without impairment of consciousness—plus memory loss. Get a history from friends/relatives. Exclude depression (may need a drug trial). Behaviour: restless; no initiative; repetitive, purposeless activity; sexual disinhibition; social gaffes; shoplifting; rigid routines.

Speech: syntax errors; dysphasia; mutism.

Thinking: slow, muddled; delusions. Poor memory. No insight.

Perception: illusions, hallucinations (often visual).

Mood: irritable, depressed; affect blunt; emotional incontinence (much crying).

fbc; b12; folate (mcv⬆ suggests alcoholism, or low b12 or folate); esr (malignancy); u&e, lft, ɣgt, Ca2+ (renal/hepatic failure, alcoholism, malignancy, endocrinopathy (Ca2+ ⬆ or ⬇). tsh (hypothyroidism).

Serology: syphilis (ohcm p419hiv.

ct/mri excludes tumours, hydrocephalus, subdural, stroke etc. Volumetric mri to subtype the dementia, eg medial temporal (mtl) and hippocampal atrophy≈Alzheimer’s disease (ad); in frontotemoral dementia temporal lobe atrophy is more inferior, and there may be marked asymmetry. In Lewy-body dementia, mtl is relatively spared.  dat may help.1  flair mri (fluid attenuated inversion recovery) for ischaemic damage (often co-exists with ad).
graphicInvolve the patient in her own therapy. Exclude the treatable. Relatives may feel unable to look after the immobile, incontinent, aggressive, patient who keeps wandering. Good palliative care, walking frames, catheters, day care, holiday admission, an attendance allowance, electronic tagginggraphic2 ± an lasting power of attorney can help. If not, long-stay institutional care may be needed. Agitation: mmm before drugs, as above.
Statins (relative risk 0.29); antioxidants.
Causes of organic reactions
Acute (delirium)Chronic (dementia)

Degenerative

Alzheimer’s; Huntington’s (ohcm p694); Lewy-body (ohcm p478), cjd & Pick’s (p650)

Other cns

Cerebral tumour or abscess; sub-dural haematoma; epilepsy; acute post-trauma psychosis

Tumours; subdural haematoma; multiple sclerosis; Parkinson’s; normal pressure hydrocephalus

Infective

Many, eg meningoencephalitis; septicaemia; cerebral malaria; trypanosomiasis

Late syphilis; chronic or sub-acute encephalitis; cns cysticer-cosis; cryptococcosis; hiv

Vascular

Stroke (or tia); hypertensive encephalopathy; sle

Thromboembolic multi-infarct (arteriosclerotic) dementia

Metabolic

u&e⬆⬇; hypoxia; liver and kidney failure; non-metastatic cancer; porphyria; alcohol withdrawal

Liver and kidney failure non-metastatic or metastatic cancer

Endocrine

Addisonian or hyperthyroid crisis; diabetic pre-coma; hypoglycaemia; hypo/hyperparathyroidism

T4⬇; Addison’s; hypoglycaemia hypopituitarism; hypo-/hyperparathyroidism

Toxic

Alcohol; many drugs (check data-sheet/statement of product characteristics); lead; arsenic; mercury

‘Alcohol dementia’; barbiturate abuse; too much manganese or carbon disulfide

Deficiency

Thiamine; b12; folate; nicotinic acid

Thiamine; b12; folate; nicotinic acid

Causes of organic reactions
Acute (delirium)Chronic (dementia)

Degenerative

Alzheimer’s; Huntington’s (ohcm p694); Lewy-body (ohcm p478), cjd & Pick’s (p650)

Other cns

Cerebral tumour or abscess; sub-dural haematoma; epilepsy; acute post-trauma psychosis

Tumours; subdural haematoma; multiple sclerosis; Parkinson’s; normal pressure hydrocephalus

Infective

Many, eg meningoencephalitis; septicaemia; cerebral malaria; trypanosomiasis

Late syphilis; chronic or sub-acute encephalitis; cns cysticer-cosis; cryptococcosis; hiv

Vascular

Stroke (or tia); hypertensive encephalopathy; sle

Thromboembolic multi-infarct (arteriosclerotic) dementia

Metabolic

u&e⬆⬇; hypoxia; liver and kidney failure; non-metastatic cancer; porphyria; alcohol withdrawal

Liver and kidney failure non-metastatic or metastatic cancer

Endocrine

Addisonian or hyperthyroid crisis; diabetic pre-coma; hypoglycaemia; hypo/hyperparathyroidism

T4⬇; Addison’s; hypoglycaemia hypopituitarism; hypo-/hyperparathyroidism

Toxic

Alcohol; many drugs (check data-sheet/statement of product characteristics); lead; arsenic; mercury

‘Alcohol dementia’; barbiturate abuse; too much manganese or carbon disulfide

Deficiency

Thiamine; b12; folate; nicotinic acid

Thiamine; b12; folate; nicotinic acid

denotes a leading cause.

1

Alzheimer’s disease is progressive, but some problems, eg aggression, may improve in time. Both rate of change and length of life vary greatly. Should you try to explain to your relative what the diagnosis is? There is no easy answer. The advantage of frank talking is that he can participate in his care (the vexed issue of stopping driving may be easier to handle). Also, in the early stages, he can consent to plans. Most would want to be informed if they got Alzheimer’s.

2

Take opportunities to talk of your predicament with other people in the same position. This is often just as useful as talking to doctors. The Alzheimer’s Disease Society exists to put you in touch: uk  tel: 020 7306 0606.

3

Accept offers of help, eg with carer programmes, and of daycare and respite care:1 you certainly deserve, and need, a break from time to time.

4

Help for carers:uk

Carers Allowance (>£58/wk2)

Attendance Allowance

Council tax rebate from Social Services

Local voluntary organizations

Annual health checks to look after the emotional/physical lives of carers

Direct payments

Help in balancing work and care. There are 6 million carers in the uk. ~50% give 20h care a week; >1 million give more than 50h/wk. We all need to be aware of this huge burden being carried by carers.
5

Lock up any rooms in the house which you do not use. Your relative will not notice this restriction—and this may make your life much easier.

6

Lock drawers which contain important papers or easily spoiled items to prevent him storing odd things in them, such as compost, or worse.

7

Remove locks from the lavatory—so he/she cannot get locked in.

8
Sexual activities may stop; spouses should try not to fall into the trap of asking “What’s the matter with me?” (nb: ssri or cyproterone acetate titrated to 50mg/12h help ♂ hypersexuality3 and other aggressive problems).
9

Prepare yourself psychologically for the day when he/she no longer recognizes you. This can be a great blow, unless you prepare for it.

graphicA common scenario. “Doctor, I think my memory is failing. I go into a room full of people I know and cannot remember a single name: the only name to come is Alzheimer….” Is this mild cognitive impairment (and relatively static) or is it ad? (progressive). What most doctors do is some sort of memory test, but a better approach is to get a history from a friend/spouse (“Does he ever get lost in familiar territory/at home? trouble with shopping, and counting out cash etc) and then do some visuo-spacial tasks, eg “Draw a house with a door, a side, a chimney and a few windows” or “draw a clock face and put the numbers in and set to time to 2 : 30.” A drawing is useful because it is a permanant snapshot of an unfolding process, and can be compared over time. Clock drawing is also part of systematic diagnostic methods—the tym test (Test Your Memory, ohcm p85). See box 1 for a brief memory test.

It is not clear if the problem is amyloid plaques and neurofibrillary tangles (are they epiphenomena?). Selective loss of temporal lobe synapses may be more important ±loss of whole neurons in the hippocampus, amygdala, temporal lobe and subcortical nuclei (ohcm p492). Treatment doesn’t focus on any of these areas, but assumes that what is important is loss of cholinergic function (?one reason why drugs often disappoint in ad). Vascular effects may trump any of the above (95% of ad patients show cns ischaemia).

1st-degree relative with ad; Down’s syndrome; homozygosity for the apolipoprotein (Apo) e e4 allele; picalm, cl1 and clu gene mutations; vascular risk factors such as ⬆bp, diabetes, dyslipidaemia, ⬆homocysteine,1 atrial fibrillation; ⬇physical and cognitive activity; depression. Evidence on smoking and alcohol is inconsistent: ≳2u/day of alcohol accelerated onset of ad by 5yrs in one study (others say red wine may be protective); ≳20 cigarettes/day≈2yrs; ApoE e4 genotype≈3yrs. graphicDelaying onset by 5yrs would ⬇prevalence by ~50%.

In stage i of ad there is amnesia and spatial disorientation. In stage ii (some years later): personality disintegration, eg with aggression, psychosis, agitation, depression, and focal parietal signs, eg dysphasia, apraxia, agnosia, and acalculia. Parkinsonism may occur. She may use her mouth to examine objects (hyperorality). stage iii Neurovegetative changes with apathy (or ceaselessly active—akathisia), wasting, immobility, and incontinence, ± seizures and spasticity.

7yrs from clinical (overt) onset.

Get expert help to increase cns acetylcholine by inhibiting the enzyme causing its breakdown (donepezil; rivastigmine; galantamine). Memantine, a nmda (n-methyl-d-aspartate) receptor antagonist, may help moderate to severe ad. Cautions: creatinine⬆; epilepsy. se: confusion, headache, hallucinations, tiredness; rarer: vomiting, anxiety, hypertonia, cystitis, ⬆libido. Dose: initially 5mg each morning; ⬆ in steps of 5mg at intervals of 1wk to 10mg/12h.

graphicp351. Exclude treatable dementias (b12, folate, syphilis serology, t4, hiv). ct/mri (p352). Treat concurrent illnesses (they worsen dementia). Avoid sedatives and neuroleptics (longevity, fluency, and cognition all suffer). In most, dementia progresses. Involve relatives and relevant agencies.

b vitamins to lower homocysteine;1 long-chain omega-3 fatty acids/n-3  pufas, eg eicosapentaenoic acid (epa+dha), in flax, walnuts, tuna, mackerel, and herring oil show promise.,  More fruit (?risk ⬇ by ⅓);  cognitively stimulating hobbies (a 1-point ⬆in cognitive activity score can ⬇risk by ⅓).
A cohort study of 678 nuns showed that education and use of syntactically and imaginatively rich language at 18yrs old predicts onset of ad ~50yrs later.
Hodgkinson’s Abbreviated Mental Test Score (max=10) & other tests

Check that he is fully awake and not in pain.

Present year and own age

2

Name of your country’s

1

Time to nearest hour

1

president, ruler or premier

Recognition of people

1

Memorize address (42 West St, Hull)

1

Name of place

1

Date of world war (i or ii)

1

Birthday (day & month)

1

Count backwards from 20 to 1

1

Present year and own age

2

Name of your country’s

1

Time to nearest hour

1

president, ruler or premier

Recognition of people

1

Memorize address (42 West St, Hull)

1

Name of place

1

Date of world war (i or ii)

1

Birthday (day & month)

1

Count backwards from 20 to 1

1

Alternative: tym test, ohcm p85; Mini-mental State cannot be printed for copyright reasons
is tested by memory tests (above); scores of ≤6 suggest confusion or dementia (correct in ~80%). Serial changes mean more than a one-off value. Other illness can lower scores (eg ⬇cardiac output).

Increasingly, do you find that…

You forget what you are saying or reading in mid-sentence?

You have to rely on lists whereas previously this was not necessary?

Thought is slow or imprecise, harmonizing poorly with motor control?

Mental agility is lacking, with powers of concentration declining?

Is there difficulty executing fast movements of eyes or limbs, or difficulty in walking?—eg with spastic ataxic gait or quadriparesis of hiv–1  associated cognitive/motor complex, or psychomotor retardation, ± release reflexes such as a snout response, or hyperactive deep tendon reflexes.

nb: including an ‘informant report questionnaire’ improves the efficiency of the mental test score as a screening tool for dementia.
(eg executive function).

Verbal fluency and initiation: Ask the patient to recall as many words as possible in 1 minute starting with ‘s’ ; fewer than 10 is abnormal.

Cognitive estimates: Ask to give educated guesses to questions which they are unlikely to know the answer, eg “How old is the oldest person in the country?” “How many camels are there in Holland?”

Abstract thinking: Proverb interpretation (however interpretation highly dependent on educational, cultural factors). Explain the linkage between pairs: eg poem & statue; praise & punishment; orange & banana.

Tests of ‘response inhibition’ and ‘set shifting’—eg a triangle and square test: draw an alternating sequence of triangles and squares—and ask the patient to copy what you are doing. Only the grossly impaired will keep drawing just one of the shapes (perseveration).

Clock drawing test: ‘draw a large clock face, put the numbers in, put the hands in to show ten past five’. Tests frontal (executive) and dominant parietal (praxis) function, and is an adjunct to mental test scores.

Quotes from the blogsphere.

My mother has Alzheimer’s…

“Each morning she wakes up smiling and walks out not knowing she has soiled herself… She doesn’t know why she is being stripped and washed. It’s like a daily physical and emotional rape. Her cries echo in my ears even when she is not crying. In her lucid moments she says, “Anu, I don’t know what I’m doing. Why is this happening to me?”.

“My kids are petrified of old age and though they are very young, they keep asking me if I will become like my mother when I grow old. I have no time to spend with my husband…I can see my marriage getting affected, but after staying awake with my mother in her room for days and then dragging myself to work, not sleeping even four hours for weeks, I’m exhausted emotionally and physically. There are days I drive on the highway and wish a truck would crush me.” Would Anu consider a nursing home? “My mother will die. Even though she is in an advanced stage of Alzheimer’s she knows she is with family. In her lucid moments she asks, “Tum mujhe chod to nahin dogey na?” (You won’t desert me will you?)”. Courtesy of Kavita Chhibber

This page is dedicated to Anu & her family.

graphic“‘There’s been a fatality on the line…Neither of us guessed it was you, even though you’d tried to kill yourself before. We called it a nervous breakdown when Bristol University sent you home for ‘undisciplined behaviour.’ As our memories faded and you seemed set for a brilliant career, no one spoke about this first episode. “I’ve been to the bottom,” you used to say, “I’m strong.” We put the horror behind us. It was over. Then when your charisma and enthusiasms grew wild again, and aggressive, we said “Zoë is just being Zoë”. We were in denial and so were you. We followed your lead. You gave up your job and against everyone’s advice, went to Morocco “to find myself”. I loved the emails you sent in those first weeks, full of enthusiasm about Islamic culture, learning Arabic and meeting the love of your life. Then the emails grew wilder, your projects more farfetched, but we suspected nothing until we arrived to find you in full blown mania: attacking the hotel staff, knocking my glasses off my nose, refusing to eat, hectoring everyone in earshot with grandiloquent schemes to save the universe…Perhaps you were too fine for us? The beat of the drum you danced to didn’t fit with our drab, calculating world; or was it random misfirings, turning your reactions from vivid to florid?” Letter to a Lost Daughter D. Schwarz; Chipmonka  Prevalence may be increasing in those <19yrs oldgraphic (0.25% in 1994; 1% in 2003).

Irritability (80%), euphoria (71%), lability (69%).

Grandiosity (78%); flight of ideas/racing thoughts (71%); distractibility/poor concentration (71%); confusion (25%), many conflicting lines of thought urgently racing in contrary directions; lack of insight.

Rapid speech (98%), hyperactivity (87%), ⬇sleep (81%), hypersexuality (57%), extravagance (55%).

Delusions (48%), hallucinations (15%). Less severe states are termed hypomania. If depression alternates with mania, the term bipolar affective disorder is used (esp. if there is a history of this). During mood swings, risk of suicide is high. Cyclical mood swings without the more florid features (as above) are termed cyclothymia.

Infections, hyperthyroidism; sle; thrombotic thromocytopenic purpura; stroke; water dysregulation/Na+⬇; ect.

Amphetamines, cocaine, antidepressants (esp. venlafaxine), captopril, steroids, procyclidine, l-dopa, baclofen.

(Age at onset: <25.)

Infections, drug use, and past or family history of psychiatric disorders. Do: ct of the head, eeg, and screen for drugs/toxins.

Psychotic symptoms (p316); cycling speed; suicide risk. graphic for acute moderate/severe mania: olanzapine 10mg po, adjust to 5–20mg/day (se: weight⬆; glucose⬆), or valproate semisodium, eg 250mg/8h po (Depakote®; may be ⬆ rapidly to 1–2g/24h). nb: some people are most fulfilled and creative when manic and don’t want to change; others recognize, in retrospect, that use of mental health law (a last resort) was a turning point.

Those who have bipolar affective disorder after successful treatment of the manic or depressive episode should have a mood stabilizer for longer-term control. If compliance is good, and u&e, ecg, and T4 normal, give lithium carbonate 125mg–1g/12h po. Adjust dose to give a plasma level of ~0.6–1mmol/L Li+, on day 4–7, ~12h post-dose. A range of 0.4–1 may be equally valid;graphic consider a tighter range if elderly (⬆sensitivity to Li+ neurotoxicity).

Check Li+ levels weekly (~12h post-dose) until the dose has been constant for 4wks; then monthly for 6 months; then 3-monthly, if stable; more often if on diuretic, nsaids, ace-i (all ⬆ Li+) or on a low-salt diet or if pregnant (?avoid Li+).

If Li+ levels are progressively rising, suspect progressive nephrotoxicity.

u&e + tsh 6-monthly; Li+  se: hypothyroidism; nephrogenic diabetes insipidus). graphicAvoid changing brands [Li+⬇⬆]. graphicEnsure you can contact urgently if Li+ >1.4mmol/L. graphicToxic signs: vision⬇; d&v; K+⬇; ataxia; tremor; dysarthria; coma.

Helping those with mania and a high risk of suicide

Risk of suicide is high if:

Previous suicide attempt

Family history of suicide

Early onset of bipolar disorder

Extent of depressive symptoms (eg hopelessness)

Increasingly bad affective signs

Mixed affective states

Rapid cycling

Abuse of alcohol or drugs.
Lithium reduces risk of suicide. If contraindicated, olanzapine + fluoxetine may be better than lamotrigine (below).  graphicBut don’t rely on drugs. Often people with mania won’t take them anyway. As one bipolar writer said “I do not believe that a complex problem can be solved simply by popping pills…I thrive in the extremes of my cycles, and the words pour from my mind and hand. All that evaporates in wellness,1 so I imagine it would dissolve completely if I chemically alleviated my malady. I will not dilute my intensity and drain my writing. I feel dead in wellness, so I fear that I would feel just as lifeless if I was ‘cured.’ My identity is also still so blended with this disorder. It is a fundamental part of me and shapes my world. I accept this disorder as a forming force in my life and value how it has made me. It tested me; it made me stronger; it made me different; it gave me my creativity…It is not just a disease to be remedied; it is a real part of me that I need to learn to cope with and adapt to. I need to discover how to control it, rather than allow it to dominate me so that I can live with it as a vital aspect of my life.”  Cognitive therapy (p373) is of great value in helping people (who retain some insight) ride their cycles without falling off.

Blogs subverts ideas of disease and cure: “I feel dead in wellness”

When lithium does not give good control

Note that abrupt cessation of lithium precipitates acute mania in up to 50% of patients. Discontinuation should be gradual over 2–4 weeks.

Anticonvulsants:
Semisodium valproate (se: hyperandrogenism if ♀) and carbamazepine (400mg/8h po; swallow whole; do not chew) are next steps. Some authorities say most specific indication may be in rapid cyclers (≥4 acute mood swings/yr). Lamotrigine may be as good as citalopram in bipolar depressive states.
Antipsychotics:
Olanzapine has a role. In one meta-analysis, there was no difference in overall efficacy of treatment between haloperidol and olanzapine or risperidone. Some evidence suggests that haloperidol could be less effective than aripiprazole.
Anticonvulsants such as lamotrigine, gabapentin and topiramate are potential mood stabilizers. Lamotrigine has the strongest evidence.
Combination treatments:
(Often tried). Lithium plus carbamazepine may be synergistic. Lithium (or valpoate) plus an atypical antipsychotic, eg risperidone or olanzapine may help if unresponsive to monotherapy.,
Lithium (or an alternative mood stabilizer) reduces risk of mood fluctuations from mania to depression in people with bipolar affective disorder. For depression occurring during lithium treatment antidepressants can be used: selective serotonin reuptake inhibitors (ssris) bupropion, and venlafaxinegraphic are said by expert committees to be best. Taper from 2 to 6 months after remission to minimize manic relapse.
Consider monoamine oxidase inhibitors for anergic (=lacking in energy) bipolar depression.  ect also has a role (p342), and meta-analyses support use of omega 3 oils (only for when mood is low).

graphic

Prevalence:0.3–0.66%

graphicSchizophrenia is a common chronic/relapsing condition often presenting in late teens/early 20s with psychotic symptoms (hallucinations, delusions); disorganization symptoms (incongruous mood, abnormal speech and thought); negative symptoms (apathy, self-neglect, blunted mood, ⬇motivation, withdrawal); and, sometimes, cognitive impairment., It has major implications for patients, work and families.

~0.15 : 1000/yr.

~1%.

Some experts hold that the term ‘schizophrenia’ has outlived its usefulness as it implies that all people with schizophrenia have the same pathology—and hence need antipsychotics. A more nuanced approach is to avoid diagnostic labels, certainly for the 1st 6 months, and not to use antipsychotics automatically. Dopamine dysregulatory disorder (box) is a new name—without the pejorative overtones of violence, fear and unpredictability.

In its florid form, psychosis is the archetype of the layman’s ‘madness’ But, the usual picture is less obvious: the patient may be sitting alone, quietly attending to his or her voices. If hallucinations, delusions, or a thought disorder (defined on p358) are present, the cause ‘must’ be either schizophrenia and related disorders, a disorder of affect (mania or depression or both, p336), or be organic (eg drug misuse, head injury). So the term psychosis is not in itself a diagnosis, but is a useful term to employ, while the underlying diagnosis is being formulated. Beware labelling people; remember that even during the best of times, only a thin veil separates us from insanity.

Many genes implicated in schizophrenia also ⬆ risk of bipolar disorder.International Schizophrenia Consortium Some are susceptibility genes (needing environmental triggers). Genome-wide studies point to a gene coding myosin on chromosome 22 and a region of >450 gene variants, in the major histocompatibility complex (mhc) region on 6p. The dysbindin gene on chromosome 6 is important too. Early use of cannabis is a trigger: those with vv homozygosity of the catechol-o-methyl-transferase gene (comt; risk ⬆×10 compared with mm variants). The timing of triggers is important. Those starting cannabis at 15yrs old are 3× more likely to develop schizophreniform psychosis.,
People with schizophrenia may suffer unusual neurodevelopment either through inheriting genes and/or some insult to the brain that impairs its development. This leads to subtle cognitive and behavioural effects in childhood and then psychosis at or just after adolescence. Relevant prenatal/obstetric events: early rupture of membranes, gestational age <37 weeks, incubator use, winter births).
shows differences in the brains of those with schizophrenia (and their 1st degree relatives): eg larger lateral ventricles, reduced frontal lobe and parahippocampal gyrus. Reduced (particularly on left) temporal lobe, hippocampus (subserves memory/emotion) and amygdala (involved in expression of emotion). mri has shown diffuse reduction in cortical grey matter associated with poor premorbid function.  nb: use of psychotics may also cause brain shrinkage—eg up to 20%. However, schizophrenia also has an onset later in life, particularly women over 30. It has been estimated that about 40% of people who develop schizophrenia have a developmental problem, but the majority are not remarkably different from the general population and have no cognitive deficits. So what are the other pathways that lead to psychosis?
Being brought up in cities increases the risk of schizophrenia (uk incidence is particularly high in London), and there are higher levels of schizophrenia in migrant groups such as Asians and African-Caribbeans (?mechanism through social adversity, racial discrimination, social isolation). The associated ‘stress’ on the brain has been suggested to affect the morphology of the brain via hormonal influences as well as the stress of being psychotic resulting in high cortisol levels causing further brain changes.
Physical and metaphysical insights into schizophrenia
One idea is that there is misreading of inner speech. If you think of your favourite poem, you can produce its words in your mind, but you know that you produced them. A person with schizophrenia produces words in the mind in a similar way but then may misinterpret them as coming from an outside source. We know that during hallucinations, muscle activity resembling phonation is detectable in the tongue. Sub-vocal speech can be picked up from the larynx, and this may correspond to what the hallucinations are telling the patient to do. We know that during inner speech Broca’s area is activated, and imaging studies show that auditory hallucinations activate Broca’s area, indicating that they result from misattributing inner speech. But why do sufferers not realize it is their own inner speech? Shergill has shown that during auditory hallucinations there is also activation in the auditory cortex, temporal lobe and subcortical areas. This reflects the activation of a system used when we are listening to external speech but not to our internal speech. This is why some minds are tricked into thinking the words come from outside.
Whatever increases dopamine worsens psychosis, while blocking dopamine helps treat psychosis. Dysregulation of mesolimbic dopamine underlies the positive symptoms of psychosis. Dopamine mediates our attachment of salience or importance to ideas and objects hence excess mesolimbic dopamine leads to attaching salience to all sorts of unrelated phenomena. Sufferers cannot have a rational explanation and instead create what seems to them a convincing explanation: it is this we call a delusion. Note that the best philosophers (eg David Hume, 1711–76) show that the notion of causation is based on just such a delusion: there being no true or demonstrable connection between cause and effect—just a relationship that exists between ideas in our minds. Any being that has this power of making causal connections (attaching salience to unrelated events) has adaptative advantage, but is a hair’s breadth from psychosis. It is in this ‘hair’s breadth’ (opposite) that we run our lives. Without our ability to attach salience there would be no such thing as love at first sight—maybe no love at all. Our humanity and our tendency to psychosis are two sides of one coin. This is why we owe the mentally ill an especial duty of care: they are suffering for what makes us human.

reduce the underlying dopaminergic drive and this attenuates the abnormal attribution of salience. So people stop hallucinating or they stop thinking their neighbours are persecuting them, but they still believe that last week there really were voices telling them to do things.

Mental illness may seem unfathomable; for others the turmoil of a ‘mental breakdown’ is later seen as a ‘mental breakthrough’: we need to see purpose in all things, including our mental illnesses. Quote from a blog, from a man with schizophrenia: “I was a passionate, devout Christian and believed I had found ultimate truth. A snowball of odd tragedies struck, which turned things around making life an inner hell. The powerlessness of not being able to cope with it all led to deep depression as well. I thought my life was truly over…” (an awful lot happened in these dot-dot-dots…but things did get better) “…I attained a level of transcendence and awareness that I never had before. My cognitive, writing, speaking, communication, insight and understanding abilities suddenly reached a level on their own. It was then that I was able to understand higher spiritual truths. So I was wondering then. Perhaps my soul or higher self wanted to evolve to a higher awareness level and when it was in the process of doing so, my physical brain had trouble adjusting to it, so it started misfiring and malfunctioning, which created those obsessions and delusions. Perhaps that is the reason behind some mental illnesses.”,
graphicSchizophrenia entails distorted thinking and perception, eg delusions and hallucinations. These are common, eg in 1) Affective psychoses (depression, bipolar disorder); 2) Substance abuse psychotic disorders (eg alcohol, cannabis); 3) Psychosis due to a medical disorders (eg brain tumour); and 4) Schizophenia-like non-affective disorders (brief psychotic disorder; delusional disorder; schizophreniform disorder). When diagnosing schizophrenia look for:
1

Thought insertion: “He’s is putting ideas into my head” Thought broadcasting: “People overhear my thoughts”. Thought withdrawal: “Thoughts are being taken out of my head”, or repeating of thoughts—écho des pensées.

2
Delusions of control, influence, or passivity, clearly referred to body or limb movements or thoughts, actions, sensations. Delusional perceptions (a rare non-icd-10 example is perception broadcasting, eg “I am a webcam”).
3

Hallucinatory voices giving a running commentary on a patient’s behaviour, or discussing the patient among themselves.

4

Persistent delusions of other kinds that are culturally inappropriate and completely impossible (“Rasputin has put a transmitter in my brain”).

5

Persistent hallucinations in any modality (somatic, visual, tactile) which occur everyday for weeks on end.

6

Breaks or interpolations in the train of thought, resulting in incoherence or irrelevant speech—knight’s move thoughts that change direction, flying off at tangents, with odd logic, or neologisms (made up words).

7

Catatonic behaviour, such as excitement, posturing, or waxy flexibility, negativism, mutism, echopraxia (involuntary imitation of the movements).

8

Negative symptoms (apathy, paucity of speech, blunting or incongruity of affect, eg laughing at bad news) usually resulting in social withdrawal.

(1–5 are co-extensive with Schneider’s 1st rank symptoms of schizophrenia.)

The main criterion is at least one very clear symptom (and usually two or more if less clear-cut) belonging to any of the groups 1–4 above, or symptoms from at least two of groups 5–8. Because many people have brief psychosis-like symptoms, do not diagnose schizophrenia unless symptoms last for ≳6 months and symptoms are present much of the time for at least one month, and there is marked impairment in work or home functioning. Also, ‘rule out’ other causes of psychosis (eg bipolar disorder, drugs/alcohol, cns tumours, head injury).

icd-10 distinguishes the following subtypes of schizophrenia: Paranoid (commonest subtype, here hallucinations and/or delusions are prominent). Hebephrenic (age of onset 15–25yrs, poor prognosis, changes in mood prominent with fleeting fragmented delusions and hallucinations). Catatonic (characterized by stupor, excitement, posturing, waxy flexibility, and negativism). In simple and residual types, negative symptoms predominate.

Lack of insight,97% auditory hallucinations,74% ideas of reference,70% paranoia,66% flat affect,66% persecutory delusions.62%

Social withdrawal,74% apathy,56% lack of conversation,54% anhedonia (inability to feel pleasure),50% psychomotor retardation,48% overactivity,41% self-neglect,30% posturing ± odd movements.25%

Sudden onset; no negative symptoms; supportive home; ♀ sex (better social integration); later onset of illness; no cns ventricular enlargement; no family history (data from who  disability assessment schedule). Overall, only 10% ever have one episode. With treatment, ≤7% need intensive input/hospital admission for >2yrs after 1st admission. 28% go >2yrs without needing further hospital admission. Lifetime risk of schizophrenia: ~1%. Suicide rates: 10% in acute phase; 4% in chronic.
Managing violence

(after the Maudsley Prescribing Guidelines)

A person can be violent as a result of psychiatric illness, substance misuse, personality disorder, or physical illness. Or it may be the result of adverse ward environments: overcrowding, noise, alienation, and nowhere to go (no blue skies or green fields). This is the danger if sequestration on the ward is the result of withdrawal of privileges for ‘bad behaviour’.

Recognize early warning signs: tachypnoea, clenched fists, shouting, chanting, restlessness, repetitive movements, pacing, gesticulations. Your own intuition may be helpful here. At the first hint of violence, get help. If alone, make sure you are nearer the door than the patient.

Do not be alone with the patient; summon the police if needed.

Try calming and talking with the patient. Do not touch him. Use your body language to reassure (sitting back, open palms, attentive).

Get his or her consent. If he does not consent to treatment, emergency treatment can still be given to save life, or if serious deterioration.

Use minimum force possible. Rapid tranquillization (rt) is the use of medication in controlling behaviour. It should only be used as a last resort when non-pharmacological methods of behaviour control have failed.

graphicDe-escalation graphicTime-out graphicPlacement, as appropriate.

Offer oral treatment. If the patient is prescribed a regular antipsychotic, lorazepam 1–2mg or promethazine 25–50mg avoids risks associated with combining antipsychotics. Oral options if not already on regular oral or depot antipsychotic: (olanzapine 10mg, quetiapine 100–200mg, risperidone 1–2mg or haloperidol 5mg). Avoid using more than one antipsychotic to avoid qt prolongation (rapid tranquilization predisposes to arrhythmias).

Repeat after 45–60min. Monotherapy with buccal midazolam 10–20mg may avoid the need for im drugs (unlicensed).

If 2 doses fail or sooner if the patient is placing themselves or others at significant risk—consider im treatment. Consider the patient’s legal status and consider consulting a senior colleague. Options:

Lorazepam 1–2mg im (dilute with equal volume of water for injections) Have flumazenil to hand ∵ respiratory depression. Be cautious if very young or elderly, and those with pre-existing brain damage or impulse control problems, as disinhibition reactions are more likely.

Promethazine 50mg im is useful in a benzodiazepine-tolerant patient. Promethazine has slow onset, but is often effective. Dilution is not needed before im injection. It may be repeated up to 100mg/day. Wait 1–2h to assess response. It is an extremely weak dopamine antagonist

Olanzapine 10mg im; don’t combine olanzapine with im benzodiazepine.

Aripiprazole 9.75mg; vs olanzapine it’s less hypotensive but ?less effective.

Haloperidol 5mg is last-choice as incidence of acute dystonia is high; ensure im procyclidine is to hand. Repeat after 30–60min if insufficient effect.

Consider iv treatment if an immediate effect is needed: Diazepam up to 10mg as Diazemuls® over ≥5min. Repeat after 5–10mins if insufficient effect (up to 3 times). Have flumazenil to hand.

Seek expert advice from consultant or senior clinical pharmacist on call. Options are limited. im amobarbital, paraldehyde & ect have been tried.

graphicMontor vital signs every 5–10min for 1h, and then half-hourly until ambulatory (if he refuses, observe for signs of pyrexia, hypotension, oversedation and wellbeing. If unconscious, monitor oximetry. A nurse must accompany until ambulatory. Monitor ecg, u & e & fbc if high-dose im antipsychotics used.

The liquid cosh creates perfect institutionalized zombies—or it may be no worse than padded cells or manacles?  graphic

Don’t dawdle! Delaying antipsychotics worsens negative symptoms. They can be dramatic, but managing schizophrenia is much more than drugs; it requires an individualized care plan that includes psychosocial interventions (eg supported employment with cognitive training)—and support for families.
Before starting an antipsychotic ask about personal/family history of diabetes, hypertension, and cardiovascular disease. Give advice on diet, weight control and exercise. Perform bp, weight, fasting blood glucose, lipid profile, fbc, ecg if on clozapine or zotepine. Additional 6-monthly monitoring of lft, u & e, prolactin, weight, HbA1c is recommended.

Typical antipsychotics (chlorpromazine, haloperidol 0.5–3mg/8h po) help symptoms in ~¾ of those with acute schizophrenia; they are less good for negative symptoms. Blockade of d2 receptors is the main reason for their antipsychotic effect—and the cause of side effects that often make people stop their tablets. Treating extrapyramidal side effects (epse)

Parkinsonism: ⬇dose, change to atypical, or try procyclidine 2.5mg/8h po; increase if necessary; max 30mg/24h

Acute dystonia can occur within hours of starting antipsychotics.

Procyclidine 5–10mg im or iv (may take ½h to work), repeat after 10min, max 30mg/24h

Akathisia—occurs within hours to weeks of starting antipsychotics, restlessness may be very distressing; so use lowest possible dose or change to atypical—treatment may be needed with propranolol ~20mg/ 8h po ± cyproheptadine 4mg/6h po

Tardive dyskinesia (chewing, grimaces, choreoathetosis) may be irreversible; but try tetrabenazine 12.5–50mg/6–24h po.

Galactorrhoea, amenorrhoea, oligomenorrhoea, female/male infertility. Reduce dose or switch to quetiapine. If not tolerated try amantadine 100mg/24h po; max 200–300mg/24h po.

are those causing no or minimal epse. They differ from one another significantly in pharmacodynamic and unwanted effects, which influences choice. Atypical antipsychotics relieve psychotic symptoms as effectively as typical drugs,, and may lower relapse rates.  nice says to consider oral atypical antipsychotics ‘in the choice of 1st-line treatments for individuals with newly diagnosed schizophrenia’.graphic Not all trials agree.
Atypical antipsychotics: amisulpride, aripiprazole, clozapine, olanzapine, quetiapine, risperidone, sertindole, zotepine, paliperidone (a once-a-day drug). Risperidone recently came top of the list when psychiatrists were asked “If you become psychotic, what would you want?”n=543  Clozapine is restricted to those resistant to, or intolerant of, other antipsychotics (agranulocytosis risk ≲0.8% in 1st yr of graphic; specialist monitoring is needed). Sertindole is only available on a named patient basis due to significant qtc prolongation and fatal arrhythmias. Except for clozapine which definitely causes less epse, there is no clear advantage for any one atypical antipsychotic over another, so side effects are important in tailoring treatment to the individual patient. Most unwanted effects are dose-related, so ‘start low increase slow’. All antipsychotics ⬇seizure threshold (esp. zotepine & clozapine).
Elderly, children and adolescents may get more side effects. In breastfeeding, most atypicals enter breast milk. Trials of use in pregnancy are few; weigh up potential benefits against harm to mother, fetus and neonate. Avoid breastfeeding. Extrapyramidal side effects (epse) are rare with quetiapine and clozapine, and uncommon with aripiprazole and zotepine. Can occur at high doses with amisulpride, olanzapine and risperidone.
Aripiprazole, clozapine and quetiapine have no or minimal effect on serum prolactin, olanzapine does at higher doses.
All atypicals can cause sexual dysfunction, eg erectile dysfunction, ⬇libido, ⬇arousal, anorgasmia, eg from ⬆prolactin (check level) and ⬇semen volume/viscosity; retrograde ejaculation (α1-receptor antagonism, eg with risperidone). In one study, ~30% had stopped their drugs at some point owing to sexual side effects. So ask about sex (p328; few will volunteer this information). If experiencing problems, adding cabergoline, bromocriptine, or amantadine, or switching to quetiapine may be appropriate.
is common, and ⬇compliance and ⬆risk of cardiovascular events and diabetes (greatest with olanzapine and clozapine, moderate with risperidone, sertindole, and zotepine; least with amisulpride and aripiprazole).
Prevalence in schizophrenia is twice the expected rate; antipsychotics further increase risk (esp. clozapine and olanzapine).
Olanzapine and risperidone ⬆risk of stroke in the elderly when used to treat behavioural symptoms of dementia. Postural hypotension is common (α1 adrenoreceptor blockade). Long qtc on ecg with zotepine, sertindole; fatal myocarditis and cardiomyopathy (clozapine).

~40% of those on clozapine (30% if on olanzapine or risperidone; 15% if on amisulpride, quetiapine, or sertindole).

If acutely disturbed use the rapid tranquillization protocol (p359)

Approach patients with optimism and empathy

Provide comprehensive information and consult any advance directive

Discuss antipsychotic choice with the patient and start promptly if distressed and symptoms not tolerable, otherwise refer to specialist in the mental health service (mhs).

Quetiapine 25mg/12h on day 1; 50mg/12h on day 2; 100mg/12h on day 3; 150mg/12h on day 4; then adjust according to response (eg 300–450mg daily in 2 doses; max 750mg/24h).

Case reports & 1 randomized trial give hope that minocycline (200mg/day, as early as possible) can ⬇ negative symptoms.graphic

Risk is divided into risk to self, others, and risk of self-neglect. Look at past psychiatric and forensic history. Is there past violence or suicidal or self-harming behaviour? Ask yourself where is the patient to be treated? Do they have insight? Can they be managed at home? (via early intervention/home treatment teams), or do they need to be an in-patient (Mental Health Act). Risk assessments are an important component of the management of a person with mental health problems: graphicp329.

Cross-taper (p369) to a new drug; if all fail, combination therapy is often tried, eg olanzapine with either amisulpride or risperidone, or quetiapine with risperidone. In theory, by acting on different receptors benefit may occur. But often it doesn’t go according to plan, and safety issues are opaque. Aripiprazole plus non-clozapine atypicals may worsen psychosis.

towards the end of acute episodes look at treating residual symptoms, eg difficult thoughts, voices, negative symptoms. Aim for quick recovery and relapse prevention through education ± cbt, p372–4.

Address carers issues (embarrassment, self-blame, and shame are prevalent).

It is possible that particular social circumstances may result in alterations in dopamine that make relapse more likely. Addressing issues with housing, employment, support groups, benefits and social skills training are all just as important as being concordant with medication.

Co-ordinate via an allocated key-worker and a multidisciplinary team (to look at biological, psychological, social and risk issues). It is performed through the Care Programme Approach (cpa). Family therapy may have a role. If concordance with medication is an issue depots are useful, risperidone is now available as a long-acting injectable form (so less ep ses compared to the older ‘typical’ depot preparations).
Relapse is not always a disaster, and drug se can be bad. Respect his decision, unless sectioning is needed. His life may become more meaningful. We tend to be over-impressed by +ve symptoms (eg hallucinations) which respond better to drugs than –ve symptoms.

(See ohcm p374)

“Visiting prostitutes is unfulfilling, empty, terrible…but I keep going.”

Cannabis is commonly used by young people (33% men and 22% women), ecstasy is the commonest class a drug (9% of men and 4% of women aged 16–24). Heroin users make up ~70% of Home Officeuk notified addicts. For nicotine and alcohol addiction, see p512 & p363. Other drugs: hydrocarbons/glue sniffing, barbiturates, opiates, lsd, ecstasy.
Individual factors (age, gender, personality, family background) and interact with external factors such as surrounding culture, price, availability, setting, advertising. Inherited vulnerability is equally important.

Arrests for larceny, to buy drugs

Odd behaviour, eg visual hallucinations, elation, mania

Unexplained nasal discharge (cocaine sniffing)

The results of injections: marked veins; abscesses; hepatitis; hiv

Repeated requests for analgesics, with only opiates acceptable.

Follows administration of alcohol or other psychoactive substances resulting in disturbances of level of consciousness, cognition, perception, affect, or behaviour.

A pattern of psychoactive substance use that is causing actual damage to the mental or physical health of the user

3 or more of the following:

1

Strong desire or sense of compulsion to take the substance (craving).

2

Difficulty in controlling substance use (onset, termination, level of use).

3

A physiological withdrawal state when reducing or ceasing substance use.

4

Tolerance: increased doses are required to produce the original effect.

5

Progressive neglect of alternative pleasures or interests.

6

Persisting use despite clear evidence of harmful consequences.

is ideally as part of a regimen in which a contract is made with the patient (p339), eg in a special clinic or in primary care, provided the gp has an interest and commitment.rcgp.org.uk  Daily observed methadone dosing is the norm (nb: monthly supplies are not necessarily abused). Drugs used: methadone, eg 20–70mg/12h po, reducing by 20% every 2 days (caution: there is no reliable formula for heroin dose equivalence). Cocaine use by patients on methadone is a big problem, and is associated with a poorer prognosis. Disulfiram has a role here.N=67 A non-addictive alternative is lofexidine (α2-noradrenergic agonist like clonidine)—eg 0.2mg/6h po, increased by 0.4–0.8mg increments/day (max 0.8mg/8h); a 5-day regimen may be better than 10-day ones. se: drowsiness, bp⬇, pulse⬇, dry mouth, rebound hypertension on withdrawal.  Buprenorphine is a synthetic partial agonist at ¼-opioid receptors. It may be safer then methadone; t½ ≈35h. Start at 0.8–4mg sublingnally per 24h, titrate by 2–4mg increments (max 32mg/day, maintenance: 12–24mg/day reached within ~1–2 weeks). Cautions: liver dysfunction; intoxication with other drugs (eg cns depressants). Naltrexone is an opioid antagonist (blocks euphoria—useful in former addicts to prevent relapse, eg 25mg/24h po after suitable opioid-free period). Warn patient of possible withdrawal reactions and monitor patient for 4h after 1st dose; monitor lft.

Tailor to specific needs (residential or outpatient care, in groups or 1-to-1). Counselling, motivational therapy, cognitive therapy (p372), Alcoholics Anonymous, ‘12 steps programme’, family therapy (p386) are all valuable ways to address triggers, motivation to change, and relapse prevention. Counsel about hiv & hepatitis C risk, needle exchange, and safe sex.

As strong cravings precede relapse, anti-craving drugs seem to be a promising but unvalidated approach. See acamprosate, p363.

Barbiturate withdrawal may cause seizures±death; withdraw as an inpatient (⅓ of the previous daily dose as phenobarbital; lower the dose over 2wks).

See p513 for prevention

Alcohol causes as much harm as smoking and hypertension. Abuse implies that repeated drinking harms a person’s work or social life. Addiction implies:

Difficulty or failure of abstinence

Narrowing of drinking repertoire

Increased tolerance to alcohol

Often aware of compulsion to drink

Priority is to maintain alcohol intake

Sweats, nausea, or tremor on withdrawal.

tolerance, worry about drinking, ‘eye opener’ drinks used in the mornings, amnesia from alcohol use, and attempts to cut down. 2 points is tweak +ve (?more sensitive than cage questions).,

(normal in 50% of alcoholics). Fatty liver: Acute, reversible; hepatitis; 80% progress to cirrhosis (liver failure in 10%) Cirrhosis: 5yr survival 48% if alcohol intake continues (if it stops, 77%).

Poor memory/cognition; cortical/cerebellar atrophy; retrobulbar neuropathy; fits; falls; accidents; neuropathy; Korsakoff’s/Wernicke’s encephalopathy (ohcm p728; graphicurgent parenteral vitamins are needed).

d&v; peptic ulcer; erosions; varices; pancreatitis.

Hb⬇; mcv

Arrhythmias; bp⬆; cardiomyopathy; fewer  mis (?benefit only if ≳55yrs).

Heavy drinking disrupts calcium metabolism (osteoporosis risk⬆).
Fertility⬇; sperm motility⬇ (in 34 precisely analysed medical students).

gi & breast.

Alcohol is related to violent crime and suicide. In medical students, alcohol correlates with events such as missing study, sexually escapades, fisticuffs, etcn=194 ♀ and ♂ students are equally prone to use alcohol at high doses to relieve stress (this carries on into later years).

Regular heavy drinking induces hepatic enzymes; binging inhibits enzymes; it’s probably not a good idea to indulge in both and hope for the best. Be alert with phenytoin, warfarin, tolbutamide, etc. nb: paracetamol may cause ⬆n-acetyl-p-benzoquinoneimine (it is hepatotoxic).

(Delirium tremens) Pulse⬆; bp⬇; tremor; fits; visual or tactile hallucinations, eg of insects crawling under the skin (formication). graphic:

Admit; monitor vital signs (beware bp⬇).

For the 1st 3 days give diazepam generously, eg 10mg/6h po or pr if vomiting—or ivi during fits; chlordiazepoxide is an alternative. After a few days, ⬇diazepam (eg 10mg/8h po from day 4–6, then 5mg/12h po for 2 more days). β-blockers, clonidine, carbamazepine, and neuroleptics (if no liver damage) are adjuncts (not advised as monotherapy).
Does the patient want to change? If so, be optimistic, and augment his will to do so. Should abstinence or controlled intake be the aim? If the former, remarkable recovery of organs (eg hippocampus) is possible.
Treat coexisting depression (p336). Refer to specialists. Self-help/group therapy (Alcoholics Anonymous) help, ± drugs which produce a nasty reaction if alcohol is taken (disulfiram 200mg/24h po). Reducing the pleasure that alcohol brings (and craving on withdrawal) with naltrexone 25–50mg/24h po (an opioid receptor antagonist) can halve relapse rates.N=111  se: vomiting, drowsiness, dizziness, joint pain. ci: hepatitis; liver failure; monitor lft. Get expert help. Acamprosate (ohcm p445) can treble abstinence rates. ci: pregnancy, severe liver failure, creatinine >120¼mol/L; se: d&v, libido ⬆ or ⬇; dose example: 666mg/8h po if >60kg and <65yrs old. Economic analysis supports its use, at least in some communities.N=448

(Education, counselling, goal-setting + monitoring of ɣgt in those who have social or physical problems from alcohol, but who do not exhibit full dependency.) 50% of trials show that ɣgt falls in the intervention group, but none show clear improvement in alcohol-related morbidity. More costly regimens fare no better.

is common; help with housing & rent, problem-solving, communication, drink refusal, and goal setting can help this desperate problem.N=114
Below-average general intellectual functioning which originated during the development period and is associated with impairment in adaptive behaviour (Heber 1981). People with learning difficulties are atrisk for mental illness. Four subtypes: Mild (iq 50–70): Accounts for 80% of people with learning disabilities. There is useful development of language, and learning difficulty only emerges as schooling gets under way. Most can lead an independent life. Moderate (iq 35–49): most can talk and find their way about Severe(iq 20–34) limited social activity is possible. Profound(iq <20): simple speech may be unachievable. Special schooling and medical services are needed, as is adequate care and counselling for the families involved. In the uk, lack of resources and ambiguous community responsibilities are big problems.  Further information: ask mencap (tel.uk 020 7454 0454).

27 per 1000 (80% have iq 50–70). People with learning difficulties are at ⬆risk for mental illness compared to the general population.

Physical: Sensory and motor disabilities, epilepsy, incontinence. Psychiatric: All psychiatric disorders can occur but the presentation is modified by low intelligence. In the diagnosis of psychiatric disorder, emphasis is given to the behavioural manifestation of the disorder.

Physical causes are found in 55–75% of severely learning disabled individuals. Chromosomal abnormalities: Down’s syndrome, fragile X syndrome p648. Antenatal causes: Infections, alcohol, hypoxia, nutritional growth retardation, hypothyroidism. Perinatal causes: Cerebral palsy. Post-natal causes: Injury, infections, impoverished environment.

Arson and sexual offences (usually exhibitionism in males or, more rarely, ‘public disrobing’ in women) are examples of offences. Care is needed in questioning learning-disabled people about an alleged offence, due to increased suggestibility and risk of making false confessions. Treatment may centre on issues of accepting that the offence took place, the taking responsibility for offences, accepting the intention of the offending behaviour, and on victim awareness. Behavioural approaches might focus on masturbatory satiation, covert sensitization, and stimulus control procedures.

Cause(s) of the learning disability

Associated medical conditions

Intellectual and social skills development

Psychological and social functioning

Dialogue with and support for carers.

Prevention and early detection is the aim—as is care in generic (eg nhs) services (minimized specialist care) unless there are complex physical, emotional and behavioural issues.

Regular assessment of attainments and disabilities

Advice, support, and help for families—eg teaching parents how to be better ‘tutors’ can help

Arrange special needs teaching at school and training/occupation

Housing and social support to enable self-care

Medical, nursing, and other services, as outpatients, day patients, or inpatients

Psychiatric and psychological services usually from a community-based multidisciplinary team.

Side effects of medication may not be apparent as learning-disabled patient may not be able to draw attention to them

Antipsychotics can lower seizure threshold and patients with learning disability are more likely to get seizures

Behavioural therapy is widely used.

Human rights for those with learning difficulties
The 14 specific rights below must be taken in the context of general psychiatric rights:

To have a professional skilled in dealing with your condition

To receive treatment based on sound evidence

To have treatment in a setting which is decent, humane, and non-abusive

Regimes must promote a fulfilling social life

Active participation in all decisions taken about care.

1

Ensure full assessment within the context of joint strategic needs assessment by Social Services, gps, and other professionals fully trained in ‘partnership working’.

2

Include the person in all decisions affecting him or her.

3

Promote enriching activity to counter idle humdrum impoverished living.

4

Listen to concerns of both the person and their carer.

5

Derive personalized care plans via dialogue with the person and carer(s).

6

Explain what the options are, ideally in terms that he/she understands.

7

Help him or her decide from a defined list of genuine choices.

8

Don’t hurry through consultations “to get back to normal people”; spend more time; go slowly. Not being able to give a good history doesn’t mean you can skip this bit: it means you must use other methods to get the information, eg discussions with carers or direct observation.

9

Don’t be pleased because they are not complaining of anything. No reported symptoms and no complaints about circumstances does not let you off the hook! You may need to insist to carers that a nasty but apparently painless ulcer be treated—or that a fire-escape be unblocked.etc etc

10

Check for physical illnesses which may otherwise go unreported.

11
Watch for neglect/abuse from well-meaning under-trained over-worked staff (who may desperately crave your support and encouragement).
12

Don’t reach too readily for drugs to curb behaviour. Consider all options.

13

Be aware of local authority Protection of Vulnerable Adults protocols.

14

No tokenism! (paying lip service to the above without intending change).

Are all lives of equal value? We are better doctors if we believe so.

graphicPersonality comprises lasting characteristics which make us who we are: easygoing or anxious; optimistic or pessimistic; placid or histrionic; ambitious or stay-at-home; fearless or timid; self-deprecatory or narcissistic1 (self-love, founded on a grandiose belief in one’s unique superiority). Personality can change and develop quite quickly, eg after religious conversion in which a timid man is remoulded into a fearless activist. Personality is a spectrum lying between the above opposites. Statistical analysis reveals that all these distinctions overlap, and are describable in terms of a few orthogonal dimensions (eg neuroticism/psychoticism; introvert/extrovert). Those with abnormal personalities are defined as occupying the extremes of the spectrum. Abnormal personality only matters if it is maladaptive, causing suffering either to its possessor or his associates. In general, psychological symptoms which are part of a personality disorder are harder to treat than those arising from other causes.
dsm-iv classification of personality disorders
ClusterDescriptionDisorder

A

Odd or eccentric behaviour

Paranoid; schizoid; schizotypal (p323)

B

Dramatic or emotional behaviour

Antisocial (psychopathic); Borderline; histrionic; narcissistic1

C

Anxious or avoidant behaviour

Avoidant; dependent; obsessive–compulsive

dsm-iv classification of personality disorders
ClusterDescriptionDisorder

A

Odd or eccentric behaviour

Paranoid; schizoid; schizotypal (p323)

B

Dramatic or emotional behaviour

Antisocial (psychopathic); Borderline; histrionic; narcissistic1

C

Anxious or avoidant behaviour

Avoidant; dependent; obsessive–compulsive

He dislikes showing his feelings, and he’d rather be cruel than put his real feelings into words…he doesn’t care for anyone and perhaps he never will’. So says Dostoevsky; lesser psychologists dwell on reckless, antisocial acts, impulsivity, lack of guilt ± social and legal nonconformity. Dostoevsky’s definition lasts because of its brevity—and that telling word perhaps. Can we change? What must change before psychopaths can love? This perhaps blowing in from 19th-century Russia sends a shiver down our 21st-century spines: perhaps all the psychopaths we lock up might be able to change. What needs to be unlocked? Read Crime and Punishment to find out.

Treatment is problematic unless there is a strong will to change. Peer pressure/group therapy (p376) may motivate. It is rarely wise to use drugs, but there is evidence that ssris (p341) may help aggressive personality disorder.

There is unstable affect regulation, poor impulse control, and poor interpersonal relationships/self-image, eg with repeated self-injury, suicidality, and a difficult life-course trajectory. Associations: adhd;2 learning difficulties. Genetics and adverse childhood events (eg abuse) are predispositions. Intervene (and refer) early with specific management plan, addressing work, Dialectical behaviour therapy, inpatient hospital programmes, and drugs can reduce depression, anxiety, and impulsive aggression. Eventually, supportive interpersonal dyads are achievable.2011nice
Obsessional personality: The rigid, obstinate bigot who is preoccupied with unimportant (or vital) detail. Emotionally unstable personality: Tendency to form intense relationships and rapid fluctuations in mood, with impulsivity. Histrionic personality: The self-centred, sexually provocative (but frigid) person who enjoys (but does not feel) angry scenes. Schizoid personality: Cold, aloof, introspective, misanthropic.
The anatomy of psychopathy
Psychopathy seems to entail a genetically driven difference in connectivity (via the uncinate fasciculus) between the parts of the brain driving empathy, conscience (free will, or rather free won’t) and impulse control (the orbito-prefrontal regions). It is not a fault necessarily, or a disease, or always a disadvantage (look at medical hierarchies!). This has serious ethical and legal implications, eg a defence of “my brain made me do it”.

Drs as psychopaths…

Managing dangerous psychopathy: beyond medicine and the law

People with dangerous and severe personality disorder (dspd3) and people with other psychopathic features form the bulk of forensic psychiatry. Therapeutic psychiatry is sometimes unfairly criticized for abandoning psychopaths—as if they were too much trouble. This easy criticism does not take into account civil liberties: patients must either want treatment, or they must have a treatable mental illness before they can be detained.

It is against this background that the suggestion has arisen that those with a history of psychopathic violence should receive care outside penal and health set-ups. However, this is no guarantee against injustice: for example, a man without psychopathy who poisoned his wife might be free to marry again after 12 years in prison, but a man with psychopathy who had held hostages without harming them might never be free to rebuild his life. Hence considerations of natural justice make renewable sentencing hazardous.

Methods of trying to treat dspd include cognitive therapy and anti-libininal drugs (not always amounting to chemical castration).4

dspd units at Broadmoor and Rampton hospitals have not chalked up successes matching their huge expense.Prof Peter Tyrer; 2010 As a leading dspd psychotherapist says: “The only way that somebody with personality disorder is going to make progress is through their own efforts. They can be helped by professionals, but nobody else can do it for them in terms of arriving at that understanding of their own responsibility for what’s happened.”Tony Maden;2010 tinyurl.com/yeyvyyk

When patients’ requests for anti-libidinal drugs4 may be valid

Hyperarousal (frequent sexual rumination/preoccupation, difficulties in controlling sexual arousal, high levels of sexual behaviour).

Intrusive sexual fantasies or urges.

Dangerous paraphilias (sadism; necrophilia). Highly repetitive paraphilic offending such as voyeurism or exhibitionism may also respond to drugs.

In the context of an offender in the community, the offender’s manager must get prior authority to use anti-libidinal medication, and request the offender’s gp to refer the offender to the ‘approved psychiatrist’.

graphicThe withdrawal syndrome may well be worse than the condition for which the drug was originally prescribed. So try to avoid benzodiazepine use, eg relaxation techniques for anxiety, or, for insomnia, a dull book, sexual intercourse, and avoiding night-time coffee may facilitate sleep. If not, limit hypnotics to alternate nights.

30% of those on benzodiazepines for 6 months experience withdrawal symptoms if treatment is stopped, and some will do so after only a few weeks of treatment. Symptoms appear sooner with rapidly eliminated benzodiazepines (eg lorazepam vs diazepam or chlordiazepoxide). It is not possible to predict which patients will become dependent, but ‘passive dependent’ or neurotic personality is partly predictive. Symptoms often start with anxiety or psychotic symptoms 1–2 weeks after withdrawal, followed by many months of gradually decreasing symptoms, such as insomnia, hyperactivity, panic, agoraphobia, and depression. Irritability, rage, feelings of unreality and depersonalization (p334, p346) are common; hallucinations less so. Multiple sclerosis may be misdiagnosed as there may be diplopia, paraesthesiae, fasciculation, and ataxia. Gut symptoms include d&v, abdominal pain, and dysphagia. There may also be palpitations, flushing, and hyperventilation symptoms. The problem is not so much how to stop benzodiazepine treatment, but how to avoid being manipulated into prescribing them unnecessarily. This is addressed on p330.

Augment the patient’s will to give up (stress disadvantages of continuous graphic).

Withdrawal is harder for short-acting benzodiazepines, so change to diazepam.

Agree a contract to prescribe a weekly supply, and not to add to this if it is used up early.

Withdraw by ~2mg/week of diazepam. Warn to expect withdrawal symptoms, and not to be alarmed.

All antidepressants may cause a discontinuation syndrome. Distinguish between this and withdrawal symptoms (implies addiction). Patients often worry that they may get hooked on antidepressants which can affect compliance. Discontinuation symptoms are explained by the theory of receptor rebound, eg an antidepressant with potent anticholinergic effects may be associated with diarrhoea on withdrawal, ~30% get the syndrome and it may mimic the original symptoms of the illness. Withdrawal is best over ≳4 weeks unless fluoxetine is co-prescribed (it has a long t½, so no withdrawal regimen is needed, and it also helps reduce symptoms, see box).
Fluoxetine may help withdrawal from paroxetinegraphic

Days 1–3: 30mg paroxetine + 10mg fluoxetine

Day 4: 20mg paroxetine+ 20mg fluoxetine

Day 5: 10mg paroxetine + 20mg fluoxetine

Days 6–9: 0mg paroxetine + 20mg fluoxetine

Then stop fluoxetine.
Onset is within ~5 days of stopping, sometimes after cross-tapering or missing doses. Usually mild and self-limiting but can be prolonged and severe (“a dark frightening tunnel…I was that frayed I’d have killed”). Some symptoms are more likely with certain drugs.

Common:

Agitation, irritability, ataxia, movement disorders, insomnia, cognition⬇, slowed or pressured speech. Occasionally:

Hallucinations, paranoid delusions. The most troublesome maois: tranylcypromine, when metabolized, has amphetamine-like properties so can have true withdrawal syndrome.

Common:

’Flu symptoms; insomnia; ⬆dreaming. Rarer:

Movement disorders; mania; arrhythmias. The most troublesome tricyclics: amitriptyline; imipramine.

Common:

’Flu-like symptoms; headaches; nasty shock-like sensations; dizziness; insomnia; tears/irritability/fury; vivid dreams. Occasionally:
Movement disorders; poor concentration/memory; delirium. The most troublesome ssris: Paroxetine; venlafaxine (both have short half-lives). graphicConsider stopping alcohol before starting withdrawal, and starting meditation and an exercise programme., Tell friends “I won’t be myself for a while.”
Swapping antidepressants: how to cross-taper
When an antidepressant has failed to work at an adequate dose, or is poorly tolerated, changing drug is appropriate. Avoid abrupt withdrawal when swapping antidepressants; cross-tapering is preferred. Speed of cross-tapering is best judged by patient tolerability. nb: co-administration of some anti-depressants is absolutely contraindicated, see below—dangers include precipitating the serotonin syndrome (restlessness; diaphoresis, ie excessive sweating); tremor; shivering; myoclonus; confusion; convulsions; death).
Example of cross-tapering based on the Maudsley regimen
Week 1Week 2Week 3Week 4

Withdrawing amitriptyline from 150mg/24h

100mg/24h

50mg/24h

25mg/24h

Nil

Introducing sertraline

25mg/24h

50mg/24h

75mg/24h

100mg/24h

Example of cross-tapering based on the Maudsley regimen
Week 1Week 2Week 3Week 4

Withdrawing amitriptyline from 150mg/24h

100mg/24h

50mg/24h

25mg/24h

Nil

Introducing sertraline

25mg/24h

50mg/24h

75mg/24h

100mg/24h

When swapping from maois or tranylcypromine to any other antidepressant, withdraw and wait for 2 weeks (the time taken for monoamine oxidase to be replenished); for moclobemide wait 24h. Do not co-administer clomipramine and ssris or venlafaxine. Beware fluoxetine interactions (may still occur for 5 weeks after stopping, due to long half-life).

graphicAs usual, it was dialogue that combed out my muddle.Arthur Miller Timebends 88

Medicine has three great branches: prevention, curing by technical means, and healing—and psychotherapy is the embodiment of healing: a holistic approach in which systematic human dialogue becomes a humanizing enterprise for the relief of suffering and the advancement of self-esteem. Questions such as “What is the meaning of my life” and “what is significant?” are answered in a different way after exposure to a gifted psychotherapist. Changes occur in cognition, feelings, and behaviour. This is why psychotherapy is dangerous and exciting: it changes people. Hence the need for supervision and ongoing training and self-awareness on the part of the therapist.

Psychotherapy stands in stark contrast to the increasingly questioned technical, machine-based realm of medicine, and we accord it great prominence here, in the hope that our explicit descriptions, and their reverberations throughout our books will produce corresponding reverberations in our minds and in our daily work in any branch of medicine, to remind us that we are not machines delivering care according to automated formulae, but humans dealing with other humans. So, taken in this way, psychotherapy is the essence of psychiatry—and the essence of all psychotherapy is communication. The first step in communication is to open a channel. The vital role that listening plays has already been emphasized (p320).

It is not possible to teach the skills required for psychotherapy in a book, any more than it is possible to teach the art of painting in oils from a book. So what follows here (p372–5) is a highly selective tour round the gallery of psychotherapy, in an attempt to show the range of skills needed, and to whet the reader’s appetite. It is not envisaged that the reader will try out the more complicated techniques without appropriate supervision.

The psychotherapies may be classified first in terms of who is involved in the treatment sessions: an individual, a couple, a family, or a whole group; and secondly they may be classified by their content and methods used: analytic, interpersonal, cognitive, behavioural.

(more details: p372) aim to change behaviour, eg if avoiding crowded shops (agoraphobia) is the issue, a behavioural approach focuses on the avoidance-behaviour. Such approaches will define behavioural tasks that the patient is expected to carry out between sessions.

(p374) focuses on thoughts and assumptions, promulgating the idea that we respond to cognitive representations of events, not to raw events alone. If this is so, cognitive change may be required to produce emotional and behavioural change. So in the above example of agoraphobia, the therapist would encourage articulation of thoughts associated with entering crowds. The patient might report that she becomes anxious that she might be about to faint—fearing that everyone will think her a fool. These thoughts would be looked at using a Socratic approach: “Have you in fact ever fainted? How likely would you be to faint? If someone fainted in front of you in a shop, what would you think? Are they foolish?”

(p382) are concerned with the origin and meaning of symptoms. They are based on the view that vulnerability arises from early experiences and unresolved issues, eg from childhood. The therapist adopts a non-dominant stance, encouraging the patient to talk without inhibitions. The therapist encourages change by suggesting interpretations for the content of the patient’s talk.

This is tackled on p388.

Definitions of psychotherapy

There are important differences in how people use the term psychotherapy. The first recorded definition states that

Psychotherapy includes every description of therapeutics that cures by…intervention of the psychical functions of the sufferer.F Eeden 1892 Med Mag

This definition is worth bearing in mind because, uniquely, it focuses on the content of the intervention made by the patient, not on the specifics of the therapist’s intervention. The most general modern definition, and the one employed in this section, is summarized thus:

Psychotherapy denotes treatment of mental disorders and behavioural disturbances using…support, suggestion, persuasion, re-education, reassurance, and insight in order to alter maladaptive patterns of coping, and to encourage personality growth.Dorland&s Medical Dictionary

Some commentators draw a distinction between counselling and psychotherapy—but using the above definition (or any definition that recognizes the great heterogeneity of psychotherapy) no valid distinction can be made, unless it is between the various types of psychotherapy. The main issue to bear in mind is that psychotherapy can be more or less specific, and more or less involved in, and driven by, theory.

So is ‘just being nice to patients’ in the course of one’s medical activities an example of psychotherapy at work? The answer is ‘no’—not because being nice is therapeutically neutral, but because one’s attention is not focused on planning change through the systematic use of interpersonal techniques.

The issue of training is very important, and here are some questions that might usefully be addressed to anyone offering psychotherapy:

1

Is there proof of efficacy? Ask for evidence of long-term results.

2

What qualifications does the therapist hold? Is he or she supervised?

3

Is the recommended regimen tailored to the patient’s unique needs?

4

How will progress be monitored?

5

Is confidentiality assured?

6

Is there support and follow-up after the formal programme ends?

Inside the speech-bubble: The therapist is precariously supported by a tripod of confidentiality, training and peer-based supervision. The couch hardly ever exists in practice, but it stands for a place where anything can happen—where we sit side-by-side with our shadow selves and hear the stuff of dreams, nightmares, and realities, uncushioned by workaday self-deceptions. It contains its own labyrinth. ©Miriam Longmore
Fig 1.

Inside the speech-bubble: The therapist is precariously supported by a tripod of confidentiality, training and peer-based supervision. The couch hardly ever exists in practice, but it stands for a place where anything can happen—where we sit side-by-side with our shadow selves and hear the stuff of dreams, nightmares, and realities, uncushioned by workaday self-deceptions. It contains its own labyrinth. ©Miriam Longmore

graphic

Behavioural therapy aims to change a person’s behaviour using one of several techniques depending on the condition. When used in conjunction with cognitive therapies (see p374) the term cognitive-behavioural therapy is used (cbt).

Phobias.

The anxiety-provoking object or situation is presented in vivo or in imagination (prolonged in vivo in flooding).

Implosion involves imagined exposure to stimuli in a non-graded manner.

The patient then stays with the anxiety-provoking stimuli until there is habituation (ie he becomes accustomed to the anxiety by frequent exposure), and the avoidance response is extinguished.

Mild/moderate anxiety.

A system of exercises & regular breathing to progressively relax individual muscle groups. Aim to achieve relaxation in all postures: recumbency is easiest (?from ⬇baroreceptor load).

Link the relaxed state with pleasant, imagined scenes so that relaxation can be induced by recalling the imagined scene.

Phobic disorders.

Patients form a hierarchy of fears about the phobic stimulus. Therapy uses graded exposure (least fearsome first) to real or imagined stimuli,
Joseph Wolpereference
while patients perform relaxation techniques until anxiety is extinguished. It is ethically less controversial than flooding as progress up the hierarchy is only when patients are completely comfortable with the current level; eg fig  1 can be preceded by an almost neutral image, such as ψ.

Involves exposure to an anxiety-provoking stimulus (eg a toilet seat for patients fearing contamination).

The patient is subsequently prevented from carrying out the usual compulsive behaviour or ritual until the urge to do so has passed

Obsessions.

The patient is asked to ruminate and then taught to interrupt the obsessional thoughts by arranging a sudden intrusion, eg snapping an elastic band on the wrist.

Obsessional thoughts occurring without compulsive rituals.

Undesired sexually deviant thoughts.

Aversive therapy involves producing an unpleasant sensation in the patient in association with an aversive or noxious stimulus (eg electric shocks, chemically induced nausea, pain) with the aim of eliminating unwanted behaviour.

Covert sensitization involves the use of aversive stimuli in imagination (eg the approach of a policeman to arrest him/her for his/her undesirable behaviour).

Alcohol dependence syndrome (disulfiram used to induce nausea if alcohol is consumed).

Sexual deviations.

Punishment procedures are generally ineffective unless patients are taught more appropriate behaviours.

Aims to modify a patient’s social behaviour in order to help overcome difficulties in forming/maintaining relationships.

Video is used to define and rate elements of a patient’s behaviour in standard social encounters

The patient is then taught more appropriate behaviour by a combination of direct instruction, modelling, video-feedback and role play.

Patients with social deficits due to a psychiatric disorder.

Positive reinforcement improves behaviour: tokens are given when desirable behaviour is displayed. These can later be exchanged for goods or privileges.

Children (p210)

Learning disabled patients

Addictive disorders

Chronic psychiatric disorders.

Patients become mercenary as they only behave well in exchange for tokens.

It does not prepare people for a world where rewards are subtle and delayed.

The acquisition of new behaviours by the process of imitation.

Lack of social skills and assertiveness.

Examples: two clients were troubled by inappropriate touching of the opposite sex, and a third involved exhibitionism. In one case of touching, feedback was used to decrease inappropriate touching. In the other case of touching, scheduled massage was used to shift stimulus control to an appropriate setting. In the case of exhibitionism, a combination of self-monitoring, private self-stimulation, and dating-skills training were used to suppress the behaviour. Behaviour therapy also has a role in paraphilias such as voyeurism and masochism/sadism. It is controversial when consent is an issue (eg following a court’s recommendation).
Cognitive elements can be added with the aim of minimizing self-deception regarding the effects of paraphilia behaviour.

is used eg in obsessive-compulsive behaviour (eg obsessive cleaning of some putatively contaminated object). The therapist gradually exposes the client to contaminated objects, preventing the compulsion by reducing anxiety about contamination, eg by breathing techniques.

helps change how we think and hence how we feel. Fig 2 is a vicious circle if thoughts are negative and lead to hostile, negative actions. By defining these relationships, cbt lets us see how thoughts and feelings interact; by changing thoughts, the cycle is broken or turned into a virtuous cycle—eg to prevent relapse after voluntary abstinence vis-à-vis impulse control disorders (eg bulimia). For purely cognitive therapy, see p374.

The abstinence violation effect (ave) is a pivotal construct describing our cognitive and affective response to re-engaging in self- or court-prohibited behaviour. ave refers to the client’s belief that abstinence, once broken, always leads to relapse (“Now I’ve eaten one chocolate the whole box must go—and I then I’ll have to empty the fridge and now I’m on the slippery slope leading straight to the ice-cream in the freezer…”). The false creation of an all-or-none requirement, loss of feeling of control, and ensuing failure resulting in guilt, self-blame and lowered self-esteem can all be tackled by cognitive-behaviour therapy, eg by identifying high-risk situations and ‘offence precursors’. These may be feeling lonely and rejected, after a break-up with a partner—or stress at work. In the case of paedophilia, cbt can be combined with group therapy and one way to confront paedophiles with the reality of their offence yet which is helpful because it provides their first opportunity to express their feelings, sexual fantasies and thoughts about paedophilia. In general, the effects of cognitive-behavioural treatment for the most serious forensic inpatients (arson, violence, rape) are sometimes quite good in terms of oppositional-defiant/egotistical behaviours—and there are also (unreliable) improvements in psychopathological symptoms, personality traits, and coping.

Beck suggests that a person who habitually adopts ways of thinking with depressed or anxious cognitive distortions will be more likely to become depressed or anxious when faced with minor problems. The cognitive distortions in cognitive theory include: Arbitrary inference—conclusions drawn with little or no evidence to support them. Selective abstraction—dwelling on insignificant (negative) detail while ignoring more important features or stimuli. Overgeneralization—drawing global conclusions about worth/ability/performance on the basis of single facts. Magnification/minimization—Gross errors of evaluation with small bad events magnified and large good events minimized. These mechanisms lead to distortions within the cognitive triad of the self, the world and the future.

In cognitive therapy, the patient first learns to identify cognitive distortions from present or recent experiences with the use of daily records/diaries.

The patient records such ideas and then learns to examine the evidence for and against them, ie tests out beliefs in real life.

The patient is encouraged to undertake the pleasurable activities that were given up at the onset of depression or anxiety.

In this way, cognitive restructuring takes place when the patient is able to identify, evaluate and change the distorted thoughts and associated behaviour.

Patients are evaluated to get a good history and background information to better understand the nature of the difficulties for which treatment is being sought.

Assessment tools or questionnaires may be used.

Treatment usually takes place on a weekly basis and focuses on current issues.

A treatment plan is formulated with clear goals and objectives and progress is monitored.

The number of sessions varies with the type of difficulties being treated.

Patient’s participate actively in their own therapy.

The patient prefers to use psychological interventions, either alone or in addition to medication.

The target problems for cbt (extreme, unhelpful thinking; reduced activity; avoidant or unhelpful behaviours) are present.

No improvement or only partial improvement has occurred on medication.

Side effects prevent a sufficient dose of medication from being taken over an adequate period.

Significant psychosocial problems (eg relationship problems, difficulties at work or unhelpful behaviours such as self-cutting or alcohol misuse) are present that will not be adequately addressed by medication alone.

Depression

Generalized anxiety or panic disorder

Phobias

Obsessive-compulsive disorder

Post-traumatic stress disorder

Hypochondriasis

Bulimia

Schizophrenia

Bipolar affective disorder

Sexual abuse.

It is difficult to carry out therapy if the patient is feeling severely depressed and has very poor concentration. There is a need to pace sessions so as not to disappoint or overwhelm the patient. Patients may have difficulty talking about their feelings of depression, anxiety, shame or anger.

Evidence is increasingly available that cbt is as effective as pharmacological therapy for mild to moderate depression, with the added advantage that relapses are less likely. In one study, gps’ knowledge of depression, and attitudes towards its treatment showed no major difference between intervention and control groups at 6 months—ie training had no discernible impact on patients’ outcomes. One reason for this may be that skills were indeed learned, but that there was insufficient time to apply these skills in ordinary general practice, where depression may be only one of a series of problems presented to the gp in a single 10-minute consultation.
Applying cognitive therapy, using the example of depression

We respond to cognitive representations of events, not raw data. Mood and thoughts can form a vicious cycle. Using the example of depression: low mood leads to gloomy thoughts and memories (eg dwelling on exams you did badly in, rather than those in which you performed well). These gloomy thoughts make you feel more depressed (mood) and this lowering of mood makes your thoughts even more gloomy. Cognitive therapy tackles this circle by tackling the thoughts. Take, say, the thought: “I’m a failure, and all my friends are avoiding me”. In cognitive therapy the process is to:

Clarify the thought exactly; don’t let it be just a vague negative belief.

Look for evidence for and against the proposition in the thought.

Look for other perspectives.

Come to a conclusion. nb: 6 sessions are better than fewer.N=104

The therapist encourages the patient to find other explanations by challenging him, eg by examining what “I’m a failure” means. “What are the main areas in your life?” “What do you count as success or failure?” Catastrophizing denotes how we see disasters in small mishaps, eg “he didn’t like my hat…he doesn’t like me…nobody likes me”. There are many kinds of biased thinking that cognitive therapy helps us to recognize: eg black and white thinking, over-generalizing (as when one failure as a symbol of everything).

Is it possible to apply these lessons in primary care? Yes; if full training is offered. Randomized trials of cbt in primary care with less extensive training (4 half-days) and hence with more realistic costs have been disappointing. The lesson is: if the benefits of cbt are to be brought to primary care, what is needed is time: time to learn a new skill, and, above all, time to exercise it.

The nhs has been recruiting cognitive therapists to meet the needs of all those with moderate and severe depression and anxiety who might benefit from it. Cost: £170 million. Projected savings (by getting people back to work) £12 billion/yr. Until access is improved computerized cbt is one option.

JML undergoes NICE-approved computerized cognitive therapy

Depression Relief® is a self-help, educational internet program for those feeling depressed. jml signed up for the course to bring readers a 1st -hand account. Initial assessment suggested he was significantly depressed as there was nowhere to say that his early-morning waking was not from depression but from eagerness to get on with authoring ohcs pages.etc etc Quite correctly, he was told “You may also wish to consider seeing your doctor or healthcare professional if your symptoms do not improve or become worse. You should definitely do this if you are feeling hopeless and don’t want to go on…”. Sections include: “Taking the 1st step to controlling your depression”; “You can move your mood”; “Actions speak louder than words”; “Focus on the positive”; “Redefine your problems”; “Don’t go blaming yourself”; “Relax away your sorrows”; “Using your imagination”; “Get physical”; “Open up and share your feelings”.

Here are some snippets to get the flavour: “After a week or two of writing down your positive thoughts in your mood log, you will be ready to learn how to use these positive thoughts to change your negative thinking.”

Impression: professional; humorous (not too); surprisingly humanizing.

The computer will see you now&.

Groups are interactive microcosms in which the patient can be confronted by the effect his behaviour and beliefs have on others, and be protected during his first attempts to change.1 This implies that group psychotherapy (as with all psychotherapies) is only practical for those who want to change.

We know that the most suitable patients are:

1

Those who enter into the group voluntarily, not as a result of pressure from relatives or therapists;

2

Those who have a high expectation from the group, and do not view it as inferior to individual therapy;

3

Those who have adequate verbal and conceptual skills. See also psychodynamic psychotherapy p382.

Personality disorders

Addictions Drug and alcohol dependence

Victims of childhood sexual abuse

People with difficulties in socialization

Major medical illnesses—eg breast cancer.N=50

Clearly the selection procedure needs to be carried out by an experienced psychotherapist. He will aim for a group of, say, 6–8 members balanced for sex, and avoiding mixing the extremes of age. He will decide if the group is to be ‘closed’, or whether it will accept new patients during its life. He will usually take on a co-therapist of the opposite sex, and he will prepare the patients in detail before the group starts. The life of the group (eg 18 months) will develop through a number of phases (‘formingnormingstorming’). First there is a settling-in period when members seem to be on their best behaviour, seeking to be loved by the therapist, and looking to him for directive counselling (which he rarely provides). Next is the stage of conflict, as the patient strives to find his place in the group other than through dependency on the leader. Frustration, anger, and other negative feelings are helpful by testing the group’s trustworthiness. It is worth learning that expressing negative feelings need not lead to rejection—and this is a vital prelude to the next stage of intimacy, in which the group starts working together.

Typically the therapist steers the group away from outside crises and searches for antecedent causes towards the here and now—eg by asking “Who do you feel closest to in the group?” or “Who in the group is most like you?” “Who would you say is as passive (or aggressive) as you are?” He/she must avoid sacrificing spontaneity, and learn to use what the group gives, eg “You seem very angry that John stormed out just now”. He avoids asking unanswerable questions, especially those beginning “Why?”. He promotes interaction, observation, and learning. Special methods used to augment this process include written summaries of group activities, video, and psychodrama.

combines cognitive and group therapy (16 group sessions in 3 weeks). In social phobia, it’s better than individual therapy.

Those who are unlikely to benefit include those with severe depression, acute schizophrenia, or extreme schizoid personality (cold, aloof, hypersensitive introverts); hypochondriacs; narcissistic (self-admiring) or paranoid (suspicious and pessimistic about the role of others); sociopathic types (they have low thresholds for frustration and little sense of responsibility)—but sociopathy is difficult to treat by any means, and group therapy may be the least bad option, as other members of the group may provide the only valid mirror that can be held up to these people, and other people may provide the impetus for change. See psychodynamic psychotherapy, p382.

Children don’t say what they really think…They can’t say what they hope in case it’s gone in a flash if anyone truly says no. AS Byatt Babel Tower 144

graphicThrough play a child becomes aware of what he or she knows. When that knowledge is disturbing, play can re-form, recast and redeem that knowledge. Parents hold the key cards for influencing a child’s behaviour—love, mutually understood channels of communication, systems of rewards, and knowledge of right and wrong. It is the families without these, which are most likely to need the help of professionals. graphicNever underestimate a child’s capacity for insight: don’t expect children’s methods of communicating insight to mesh with adult’s. Play, rather than talk, may be its medium.
1

Take time early on to make friends with the child. Don’t rush.

2

Accept the child on his own terms—exactly as he or she is.

3

Avoid questioning, praising, or blaming. Be totally permissive.

4

Don’t say “Don’t”, and only restrain to prevent serious imminent harm.

5

Show the child that he or she is free to express any feeling openly.

6

The responsibility for making choices is always the child’s alone.

7

Follow wherever the child leads: avoid directing the conversation.

8

Use whatever he gives you. Reflect his or her feelings back to him.

9

Encourage the child to move from acting-out his feelings in the real world, to expressing them freely in words and play.

10

Prepare the parents for change in the child.

Child and therapist play together to give the child a way to verbalize his innermost fantasies. As Virginia Axline explained to one of her 5-year-olds, play therapy is “a time when you can be the way you want to be. A time you can use any way you want to use it. A time when you can be you”.Axline V: Play Therapy Dibs: in Search of Self

Evidence vis-à-vis ‘activity-based interventions’ (broader than Axline’s play therapy) is mixed: no effect on war-torn children, but good effects on social functioning after sexual abuse, neglect, and in autism.
Art therapy is the use of art materials for self-expression and reflection in the presence of a trained art therapist. No previous experience or skill in art is needed as the art therapist is not primarily concerned with making an aesthetic or diagnostic assessment of the client’s work. The chief aim is to effect change and growth in self-esteem through use of art materials in a safe and facilitating environment. Patients stop being patients, and take the initiative in externalizing pain and problems through self-expression.  graphicThe person becomes his or her own therapeutic agent. What higher ideal is there in medicine? It is far ahead of our drug-based models of care, and taps into ancient ideas about health, self-healing, and the proper relationship among humans.
As ever, the relationship between therapist and client is vital, but art therapy differs from other psychotherapies as it is a 3-way process between client, therapist and artefact. The therapist’s evaluating of the art establishes the intellectual, spiritual, cultural, and emotional status of clients in ways that are helpful to those who find it hard to express thoughts and feelings verbally. It can be a mistake for therapists to interpret the art: leave this to the client.
Art therapists have good understanding of art processes with sound therapeutic knowledge. They work with individuals and groups in residential or community settings, eg mental health (eg anorexia and dementia, where art therapy can improve interactive and coping skills), learning disabilities, child and family centres, palliative care, disaster zones, and in prisons. baat.co.uk
nice says we must always consider non-drug treatments for depression—so what are the experiences of uk primary care? In one setting with 3 artists in residence in Dursley (a ceramicist, a poet, and a painter) there was a reduction in anxiety, an increase in self-esteem, and fewer consultations from ‘heartsink’ patients. Art therapy also helps coping in the context of cancer.

Occupying the interval between the spilling of our lives and their congealing into history, crisis intervention recognizes that moments of maximum change are times of greatest therapeutic opportunity.1 Debate these questions:

What events have led to these difficulties? Thoughts/actions in the last days.

What is his mental state now (p324)? Depressed? Suicidal? Psychotic?

In the past how has he been able to combat stress and to resolve crises?

What solutions to this crisis have been tried? How have they failed?

Who are the significant people in his life? Can you rely on any of them?

If he has been very badly affected by the crisis, you may insist on postponing all normal obligations/responsibilities to allow concentrated contact (‘intensive care’) in a therapeutic environment—eg a hospital or crisis unit.

Take practical steps to safeguard patient’s commitments (eg transport of children to foster parents).

Choose the best way of lowering arousal (time spent talking is often preferable to administering anxiolytics, which may only serve to delay the natural process of adaptation). If the patient is shocked, stunned, or mute, take time to establish the normal channels of communication.

As soon as the person is receptive, promote a sense of hope about the outcome of the crisis. If there is no hope (a mother, consumed by grief, after losing all her children in a fire), then this too must be addressed.

The next step is to encourage creative thinking about ways whereby the patient might solve the problems. Start by helping him think through the consequences of all options open to him. Then help compartmentalize his proposed solutions into small, easily executed items of behaviour.

 Crisis intervention teams must be responsive, immediate, accessible, and available out of hours—anywhere.
Fig 1.

Crisis intervention teams must be responsive, immediate, accessible, and available out of hours—anywhere.

As the immediate crisis passes, and the patient has reasonable psychological functioning, it will be necessary to put him back in charge of his own life. A period of counselling is likely to be appropriate. This is described on p380. Making a contract about therapy is important in encouraging the patient to transfer from the ‘sick role’ to a self-dependent, adult role.

Crisis intervention often focuses on loss of face, loss of identity, or loss of faith—in oneself, in one’s religion, one’s goals, or one’s roots.

Meta-analyses suggest that crisis intervention is a viable part of home-care, and can be used during the acute phase of any mental illness.
graphicAll home-care packages for severe mental illness need crisis management plans. Where implemented, this keeps the vulnerable in contact with staff (nnt≈13 over 1yr) and reduces family burden (nnt≈3), and is a more satisfying form of care for patients and families. It is also said to be cheaper. In one trial, availability of a crisis-resolution team reduced admission rates from 59% to 22% at 8 weeks—and was highly cost-effective.

graphicAre you afraid of uncomfortable questions? Here are some asked by a very experienced psychotherapist.1

?

Are you a saint? or have you ever…

?

Felt so bored and irritated by certain patients you want to quit?

?

Longed for the consultation to end, at any price?

?

Can you say you have never felt a flicker of sexual interest in a patient?

?

Have you never imagined the death of certain patients and the relief that would bring, not just to them but to us, their impotent carers?

?

Have you never resented the demands of people for whom illness seems to have become a way of life?

?

Whose thoughts have not sometimes drifted off towards their own concerns—to the need for sleep, food, or distraction or to some family, career, or future plans?

 We may imagine doing all sorts of things to our patients. The crime is not the thought but the deed. The vital thing is to not to bury these things but to know that they are just that: imaginings. Perhaps we can use them in the service of our work? If the stressed, isolated doctor had been aware of and able to voice his fantasies maybe he would not have end up in custody or in bed with his sexually abused, vulnerable and depressed patient.
Fig 1.

We may imagine doing all sorts of things to our patients. The crime is not the thought but the deed. The vital thing is to not to bury these things but to know that they are just that: imaginings. Perhaps we can use them in the service of our work? If the stressed, isolated doctor had been aware of and able to voice his fantasies maybe he would not have end up in custody or in bed with his sexually abused, vulnerable and depressed patient.

graphicThe key to good doctoring is not regulation or revalidation, but fostering the ability to put ourselves in our patients’ shoes. And we can use the feeling patients engender in us to understand how the patients nearest and dearest are frustrated, perplexed and deluded. For example, excessive worry about a patient may be the result of being infected by the patient’s anxiety—beyond what is reasonable. This is know as projective identification.

Why does bad or harmful practice continue, despite gmc guidelines? It is because we are motivated by forces of which we are unaware.

Good novelists (and counsellors) are somehow large enough to embody the world—so their characters (clients) are not just recreated in their own image. Nothing human is alien to them. Such exercise of the imagination is what enables virgins to counsel prostitutes—which they can, if they are submerged in and are fully aware of human affairs outside themselves.

Current problems and stresses (eg experiencing acute psychological distress in response to life events or relationship problems).

Brief anxiety disorders, especially when anxiolytic drugs not required.

Painting the triptych (fig  1)

Listening, understanding, and reflecting

Note how past stress has been coped with

Producing an agreed full list of problems

Redefining problems in terms of attainable goals

Use of therapeutic contracts to negotiate small behaviour changes

Aim for adult relationships between patient, family, and therapist, eg with a contract vis à vis duties, frequency, and duration of therapy, and what is expected of the client (homework), eg learning anxiety-reducing techniques, and carrying out rewards, eg cooking an extra-nice meal with the family if the client achieves an anxiety-provoking task such as shopping

Talking out (not acting out) anger in safe but cathartic ways

Reassurance. The therapist must not only give overt reassurance, but also by his demeanour he must reassure the patient that whatever he reveals (eg incest or baby battering), he will not be condemned.

 Nondirective counselling is a triptych of blanks: Where do you want to go? How will you get there? How will you know you have arrived? Just fill in the blanks….
Fig 1.

Nondirective counselling is a triptych of blanks: Where do you want to go? How will you get there? How will you know you have arrived? Just fill in the blanks….

After Yellow Painting by Barnett Newman.

Not all counselling is nondirective: problem-solving models of counselling (box) are sometimes directive, and may be appropriate if you know the client well.

‘Giving expert advice’: patients may need medical, legal or financial advice. It may be best if this comes from a specialist agency not involved in the counselling

Patients with personality disorder, where the problems are too deep seated to be changed by counselling. Here there must be an awareness of the need to refer such patients for more formal psychotherapy.

There are many people who seem to need continuous psychotherapy, as they that find daily activities pose unending stress. The smallest decisions are insurmountable problems, and the patient, lacking even a glimmer of insight, seeks support at every turn. What can we offer here?

Relevant to all forms of psychiatric disorder.

Listening to what (s)he is saying, picking up verbal and non-verbal cues. Ensure a reasonably full account of the situation and problems

Reassurance: relieve fears, boost self-confidence and promote hope,

Explain to a patient why they are experiencing certain symptoms

Guidance and suggestion with regard to a particular problem

Expression of feelings eg anger, frustration and despair within a supportive setting.

Patients can become dependent on the therapist and not be able to cope when therapy comes to an end—see p326 for how to deal with this.

Where tested against cognitive therapy, this less sophisticated therapy sometimes comes out well, eg in long-term schizophrenia care, and also in care of adolescents with major depression—but not in minor depression.
Counselling in primary care

Counselling has long been a central activity in primary care. Don’t think of this as the expert handing down treatment to poor, benighted patients. It’s more of a joint exploration between two humans who know each other reasonably well. On occasion, roles may be reversed—for example, following a medical disaster, a doctor, who may be blameless, may become so relentlessly and excoriatingly self-questioning that despair ensues. In these circumstances, it has been known for counselling and support from the original victim or one of his or her relatives to restore the doctor to health, and avert resignation.

Many uk general practices employ or have access to counsellors. This huge growth reflects the fact that people love to be listened to, and that gps themselves may not have the time or inclination to satisfy this need. It is hard to prove the effectiveness of counselling, especially as skills and training vary markedly. But this does not mean it is ineffective.

There are 3 facets to counselling in general practice:
1

In some patients, problem-solving strategies are used, with the counsellor using a non-directive approach.

2

In fostering coping strategies, the therapist helps the patient to make the most of the position they are in (eg afflicted by a chronic disease).

3

In cognitive therapy, we concentrate on elucidating negative thinking, and help patients learn how to intervene in negative cycles of thinking.

Randomized trial evidence:
Counselling and cognitive-behaviour therapy carried out in primary care are both more effective in treating depression than usual gp care in the short term. But in one study, there was no difference in outcome after 1 year.n=197  nb: ‘no difference’ may indicate that too few counselling sessions were offered—or, perhaps that gps were already effective counsellors—or maybe more focused counselling would be more effective.
Therapeutic communities, and the example of substance misuse

Therapeutic communities (tcs) are a popular treatment for the rehabilitation of iv drug users and dealing with personality disorders—in both the usa and Europe. The rationale is that the benefits of peer-feedback (group therapy) can be magnified in the microcosm of a therapeutic community. Also these communities provide a safe environment for those with complex needs.

In trials of residential therapy vs therapeutic communities the latter can come out better vis à vis staying off drugs and not reoffending (eg if the ‘residential’ arm of the trial is prison). Life in a community is more beneficial (vis à vis reoffending or reusing drugs) if it is for 12 months compared with 6 months. After the time in the community, aim to give continuing aftercare. However, there is little evidence that tcs offer major benefits compared with other residential treatment, or that one type of tc is better than another.
European tcs adapt the early harsh behaviourism found in the us by concentrating more on milieu-therapy and social learning emphasizing dialogue and understanding. Either professionals or ex-addicts can provide input.

Individual dynamic psychotherapy is based on the premise that a person’s behaviour is influenced by unconscious factors (thoughts, feelings, fantasies). Evidence for the existence of unconscious activity include

Dreams

Artistic and scientific creativity

Hysterical symptoms (p334)

Abreaction1

Parapraxes—‘slips of the tongue’.

Our immune system protects our physical integrity, and our psychological vulnerabilities are shielded by psychological defences. In both cases, overactive defences can lead to trouble, eg:

Delusional projection/paranoia

Denial

Distortion.

Projection2

Schizoid/autistic fantasy

Dissociation (p334)

Acting out (box)

Hypochondriasis

Passive aggression.

Repression

Displacement3

Reaction formation4

Intellectualization.

Altruism

Humour

Suppression

Anticipation

Sublimation5.
The past patterns (transfers) our present reactions to people. If we have trusted our parents, we will be likely to trust our doctors, teachers, and friends. The intense psychotherapeutic relationship brings these assumptions to the fore where they can be examined, understood, and learned from. We in turn have unconscious reactions to patients based on our past, ie countertransference. Errors from countertransference arise when we react as though our patient were a significant person in our early life (if our mother was an alcoholic we may be oversolicitous or rejecting with alcoholics). Our reactions are also a key to our patient’s feelings: if a patient makes us feel rejected (as alcoholics often do), perhaps that person himself was rejected as a child and turned to the bottle in compensation.

The patient’s difficulties must be understandable in psychological terms.

The capacity to think about problems in psychological terms.

There must be motivation for insight and change.

The ability to communicate thoughts and feelings through talking.

The ability to reflect and think about their feelings.

The capacity to remember dreams.

The ability to tolerate frustrating or distressful feelings without engaging in impulsive behaviour.

There should be a history of at least one sustained relationship in the past or current life.

Dissociative/conversion disorders

Depression

Psychosomatic disorders

Personality disorders

Relationship problems

Grief.

The therapist provides a secure frame—a regular time and place and her own consistency and acceptingness. The patient narrates vignettes about himself and his life (~3/session). The therapist listens carefully, to the stories and to her reactions to them. She then makes linking hypotheses, or interpretations that offer meaning. Previously inexplicable behaviour begins to make sense. Meanwhile, the patient forms a close relationship with the therapist based on empathy, genuineness, and non-possessive warmth (shown experimentally to be key factors) and sometimes challenge. These may be novel experiences for the patient that can be internalized as he works through difficulties safely. Reactions to ending will bring up past unprocessed losses.

Psychodynamic therapy can be time-limited (brief dynamic psychotherapy)—suitable for circumscribed problems, eg unmourned grief, or open-ended (box 3) eg if there are severe personality disorders or complex needs.N=1053 In depression, 16 sessions seem to be no better than 8.
Acting out: the oldest defence mechanism

The Id is king: Whenever he battles with his conscience—he wins!

Acting out is making something happen or doing something instead of dealing with the corresponding feeling, eg when we unconsciously engage in actions or any non-verbal communication, or take on psychosomatic symptoms, instead of examining our true feelings. We fail to acknowledge to ourselves what we really feel and experience. It is a kind of unconscious self-destructive anger and as such is the opposite to sublimation.5 For example, a client may become accident-prone, attempt suicide, or commit unconscious self-sabotage (eg destroying his friends or work).
We also ‘act out’ desires forbidden by our Super ego but intensely desired by our Id. We cope with pressure to do what we think is wrong simply by siding with our Id. Immaturity, cognitive short-sightedness, counter-suggestibility, and ‘contrarian tendencies’ all play a role in acting out.
Patients often act out with us as an expression of transference. Joyce is stamping her foot saying “You take such poor care of me. It shows you don’t want me as a patient. Why not get rid of me?” A plea for love and a simultaneous self-destructive attempt to replicate past rejections?
Sexual acting out is common too, eg in institutionalized (motherless) female adolescents, heterosexual acting out wards off regressive wishes, kindled by object loss, to reunite symbiotically with the pre-oedipal mother.

graphicWhat the hell! I’ll do it now and repent tomorrow.

Cautions: when dynamic psychotherapy might not be right
1

Repeated admissions, many suicide attempts, repeated risk-taking, and severe somatization suggest insufficient ego strength for psychotherapy.

2

A history of repeated failed ventures or dropping out of relationships.

3

In general, patients with acute psychosis are less amenable.

4

Severely depressed patients may be too slowed up and too unresponsive.

5

Over-sedation may hinder capacity to access feelings (?reduce doses).

6

Patients who are actively abusing alcohol or illicit drugs are problematic.

7

No real motivation to change or grossly unreal expectations of therapy.

Has psychoanalysis changed the world? graphic
The world is no better than before psychoanalysis came along with its perceived promises of explaining us to ourselves and self-realization. Either the explanations are wrong or explaining things doesn’t help—or we have missed the point of psychoanalysis. It may be charming to learn, for example, that the anorgasmia of a patient seen in today’s clinic is explained by the specific psychodynamics of an ‘anal-retentive defence against pre-oedipal fears of anal-sadistic impulses and fear of ego-loss’. Likewise it is not clear that extended pre-orchidectomy counselling dwelling on anticipated narcissistic grief will actually improve outcomes. But note that as soon as we learn about the concept of narcissistic grief we never forget it: it’s like a promise of eternal love; it assumes its own truth, and if we dare to test it, it can only ever be us who are found to be wanting.
Psychoanalysis took ages to get under way for a young mother happily named Joyce, who had inexplicably severe eczema. But things started happening by interview 236. Latent fears of being lesbian surfaced at this point and the psychiatrist was rewarded by the perfect sentence “It used to be if I just thought of her, I could start scratching”. But was the patient rewarded as well as the psychiatrist? It is impossible to know if any benefits were related to the specifics of the psychodynamic process—or just to the extraordinary input of time and attention. Either way, though, we must accept that psychoanalysis has more than entered and populated our consciousness: it’s made it into our unconscious—so we cannot reject it, even if we want to.
This is an example of couple therapy: often the problem is not specifically sexual, and sexual difficulties may recede once other aspects of the relationship improve. Here, specific sexual dysfunctions are considered in the light of a modernized Masters & Johnson approach using a model of sexual response entailing excitation, plateau, orgasm, and resolution.
Start with a full (joint) description of the problem. This may be premature (or delayed) ejaculation, female frigidity (anorgasmia), erectile dysfunction, or dyspareunia (eg from spasm—vaginismus—or other physical causes). How did the problem start (eg after childbirth)? Was there ever a time when sex occurred as desired? Is the problem part of some wider problem? What does your partner expect from you? Are you self-conscious or anxious during sex? Are there medical problems, eg ischaemic heart disease, or mastectomy; prosthesis use is discouraged at intercourse as it delays confrontation with and acceptance of mastectomy. Techniques of body imagery and sensate focus (below) have special roles here.,

Early experiences; present practices; any hints pointing towards transexualism, commercial sex work, or drug abuse? Orientation to either or both sexes. Difficulties with other partners? When did you meet? What attracted you to each other?

Alcohol, hypotensives (erectile dysfunction, ed); ssris (delayed ejaculation); β-blockers, finasteride, the Pill, and phenothiazines (loss of libido).

(ohcm p222): diabetes, cord pathology, prolactin⬆, drugs.

1

Defining the task which the couple wishes to accomplish.

2

Reducing the task to a number of small, attainable steps.

3

Asking the couple to practise each small step in turn.

4

At the next session, discussing difficulties encountered.

5

Ameliorating maladaptive attitudes.

6

Setting the next task.

(Both relate to performance anxiety, and vaginismus may be part of a generalized anxiety-defence mechanism). One sequence to agree with the couple might be:
1

A ban on attempted sexual intercourse (to remove fear of performance failure). Education and ‘permission’ giving (ie to talk about and engage in ‘safe’ sexual fantasies) is vital.

2

Touching without genital contact, ‘for your own pleasure’, initially, with any non-genital part of the body, to explore the range of what pleases, and then to concentrate on whatever erogenous zones are found (‘sensate focus’).

3

Touching as above ‘for your own and your partner’s pleasure’.

4

‘Homework’ using a vaginal dilator and lubricating jelly.

5

Touching with genital contact, first in turn, later together. Problems in taking the initiative may now surface. In premature ejaculation, the partner stimulates the penis, and as orgasm approaches the man signals to his partner, who inhibits the reflex by squeezing his penis at the frenulum.

6

Concentrate on playing down the distinction between foreplay and intercourse, so that anxiety at penetration is reduced.

7

Vaginal containment in the female superior position so that she can stop or withdraw whenever she wants. She concentrates on the sensation of the vagina being filled.

8

Periods of pelvic thrusting, eg with a ‘stop–start’ technique.

nb: the evidence for such techniques is not all that good for premature ejaculation. For vaginismus, success rates of >93% have been obtained.
Drugs such as sertraline (unlicensed) can improve ejaculatory control.
Sexual universals
There is much more to helping people with sexual difficulties than is outlined opposite: it is just one approach to one problem. Such behavioural approaches may not be suited to dealing with forbidden, haunting, and disturbing sexual feelings, fantasies, and urges. Experiential psychotherapy and psychodynamic approaches are valid alternatives. Also, we should not focus on performance of acts at the expense of promoting the quality of erotic connection and the attainment of transcendent levels of intimacy.
These are the 3 primary colours of the sexual realm—mixed in different proportions at different times in our lives to give millions of subtle or clashing tones. Each emotion-motivation system is associated with a specific constellation of neural correlates and a distinct behavioural repertoire. Sex therapy has different tasks in each of these areas. In any therapy the following universals need to be addressed:
Never assume that a patient is too old or too ill for sexual issues to be relevant. graphicAssume that everyone has a sex life, perhaps in fantasy only (fantasy is always found to be an important component of sexuality).

Treat sexual problems holistically—eg there may be relevant medical, drug, or other psychopathologies (depression is common).

Psychological approaches are always important, whatever is offered by way of physical props or drugs such as sildenafil. Men randomized to receive group therapy + sildenafil had more successful intercourse than those receiving only sildenafil. Group psychotherapy also significantly improves erectile dysfunction compared to sildenafil alone.

Psychological events have physical sequelae, and physical events have psychological sequelae.

All pleasure, including all erotic pleasure, is either purely sensory or arises from associations of ideas: this offers many points of intersection for negative operators, such as distraction, spectatoring, guilt, anxiety, fear of failure, pain, and inappropriate stimulation.

As in all walks of life: graphicwhen in doubt…communicate. This is the basis of the salutogenesis approach to sexual health. Salutogenesis asks not what disease is present but how and individual or a couple stay healthy. And the answer is often ‘through communication’ and ‘by being intimate’. Intimacy may be a more powerful determinant of health than improved diet, stopping smoking, genetic vulnerabilities, and prescription drugs.
All humans have a need to give as well as to take. Reawakening this instinct may be an important part of therapy.n=1

What used to be called family therapy is now better known as systemic practice, which is an evolving body of ideas and techniques focusing on a person’s difficulties within the context of the people and culture that surround them. Therapy is based on the assumption that most people have the resources and potential for resolving life’s difficulties. Therapists may work with individuals or families. Screening rooms may be used where co-therapists observe family interactions during therapy via a one-way screen.

Its origins began in cybernetics. Behaviour maintains itself by feedback loops, eg disruptive behaviour in a son draws divorcing parents together. This led to strategic therapy—the paradoxical approach where the symptom is prescribed so interrupting the behaviour–problem cycle. Structural therapy, sought to be more objective. A family can be described in terms of dimensions. Research interviews have given rise to a measure of ‘expressed emotion’ (ee) which is associated with severity of chronic illness in many disorders (eg schizophrenia, anorexia nervosa, cystic fibrosis). Therapy includes prescribed exercises, eg parents may agree to go out for a meal at a secret location. In an over-involved family, this strengthens parental executive subsystems, providing opportunity for disengagement and management of concomitant anxiety. Systemic family therapy was pioneered by the Milan School, emphasizing family behaviour according to ‘myths’, ‘scripts’, and family secrets, which dominate the inter-generational transmission of repeating behaviours. Drawing a genogram (family tree) with the family is a good way to reveal these. Hypothesizing, maintaining a neutral stance and the use of circular questioning are important components.

consider that knowledge is developed by story-telling not through the logico-scientific method, working on the basis that there is no single truth about the reasons for problems but that ‘truths’ are constructed via conversations between therapist and therapee. People can be maintained in problem-saturated lives by ‘viewing themselves in the context of a dominant knowledge’. By constructing an alternative knowledge, they can be liberated to challenge the problem. Narrative therapists help by restoring people’s control over their problems via externalizing the problem. Faecal soiling is popularly viewed as an act committed by the child as a response to family dysfunction. But if it is viewed as a struggle between the family and the problem by identifying the ‘sneaky poo’ as the enemy, then the family can be engaged in a battle against it. The use of written letters is also considered a useful tool.

makes use of a structured approach to draw on people’s resilience, and motivate problem solving. It centres conversations on solutions, not problems. “If it works, do more of it. If it doesn’t work do something different. No problem happens all the time.”

Session 1Session 2 and beyond

1 Why have you come?

1 What’s got better?

2 How may we be of help?

2a Elicit: Ask about positive changes

3 The miracle question (below)

2b Amplify: Ask for details on +ve changes

4 Exception questions

2c Ensure he notices and values change

5 Spectograms

2d Start again. Ask what else is better.

6 Agreed achievable tasks

3 Ending. How can you get back on track?

Session 1Session 2 and beyond

1 Why have you come?

1 What’s got better?

2 How may we be of help?

2a Elicit: Ask about positive changes

3 The miracle question (below)

2b Amplify: Ask for details on +ve changes

4 Exception questions

2c Ensure he notices and values change

5 Spectograms

2d Start again. Ask what else is better.

6 Agreed achievable tasks

3 Ending. How can you get back on track?

“If you woke up and a miracle had occurred in the night, how would you know? How would your life be different?”

Search with the client for possible exceptions.

“On a scale of 0 to 10, how much would you like your miracle to happen?” “What would have to happen/What would you have to do to make your score move from 3 to 4?”

Family structure and functioning427
Family structure is viewed by Minuchin as an invisible set of functional demands that organize family interactions. These transactional patterns are self-regulating in a way that attempts to return a family to its habitual mode and minimize anxiety.

(McMaster model) The 6 dimensions allowing any practitioner to describe family functioning are:

Problem solving: Can the family act together to solve everyday emotional and practical problems? Can they identify a problem, develop, agree, and enact solutions, and evaluate their performance? Success may be dependent upon functioning in other dimensions.

Congruence of verbal and non-verbal communications: Are communications clear and direct or are there hidden agendas or hidden meanings? Do people listen to one another?

Roles: Who is in charge and how are executive decisions made? Who provides for the family? Who is concerned for the child’s education and emotional development? Families may function most effectively when roles are appropriately allocated and responsibilities explicit.

Affective involvement: Relationships in families tend to exist on a continuum from over-involved (enmeshed) to disinvolved (dis-engaged). Empathic involvement is ideal. This depends on development, as greater involvement is needed for babies than adolescents. Enmeshment may lead a child to be so anxious about a parent that they feel unable to leave them, and avoid school as a consequence.

Affective responsiveness: How do individual family members respond emotionally to one another both by degree and quality? Welfare feelings would include love, tenderness, and sympathy. Emergency feelings would include fear, anger, and disappointment.

Behavioural control: How is discipline maintained? Is there negotiation? Is it flexible? Chaotic? Absent? (depends on quality of communication).

Triangulation: When parents are in conflict, each demands the child sides with them. When the child sides with one, they are automatically considered to be attacking the other. The child is paralysed in a no-win state where every movement is a perceived attack on a parent.

When an individual is singled out by the family as the sole cause of the family troubles. This serves to temporarily bury conflicts that the family fear will overwhelm them.

Derived from a family interview: reflects hostility, emotional over-involvement, critical comments, and contact time.

Beware making false dichotomies into supported and unsupported therapies. Randomized trial methodologies don’t suit all therapies.graphic  graphic What follows does not entirely avoid the trap Westen alludes to. Also be aware of many different variations on a theme, eg cognitive and analytic therapy (cat) and dbt (dialectical behaviour therapy).1

Psychological therapy should be routinely considered as an option when assessing mental health problems.B

Patients who are adjusting to life events, illnesses, disabilities or losses may benefit from brief therapies such as counselling.B

Post-traumatic stress symptoms may be helped by psychological therapy, with most evidence for cognitive-behavioural methods. Routine debriefing following traumatic events is not recommended.A

Depression may be helped (but is often not cured) by cognitive therapy or interpersonal therapy. A number of other brief structured therapies for depression may be of benefit, such as psychodynamic therapy.A

Anxiety disorders with marked symptomatic anxiety (agoraphobia, panic disorder, social phobia, obsessive-compulsive disorders, generalized anxiety disorders) are likely to benefit from cognitive-behaviour therapy.A

Psychological intervention should be considered for somatic complaints with a psychological component with most evidence for cbt in the treatment of chronic pain and chronic fatigue.C

Eating disorders can be treated with psychological therapy. Best evidence in bulimia nervosa is for cbt, interpersonal therapy (ipt) and family therapy for teenagers. Treatment usually includes psycho-educational methods. There is little strong evidence on the best therapy type for anorexia.C

Structured psychological therapies delivered by skilled practitioners can contribute to the longer-term treatment of personality disorders.C

Psychological therapy shows benefits over no treatment for a wide range of mental health difficulties

There is evidence of counselling effectiveness in mixed anxiety/depression, most effective when used with specified client groups, eg postnatal mothers, bereaved groups

cbt has been found helpful. Some evidence of efficacy has been shown for other forms of psychological therapy. Single-session debriefing appears to be unhelpful in preventing later disorders

cbt and ipt (interpersonal psychotherapy) can effectively reduce symptoms of depression. Benefit has also been found for other forms of psychological therapy, including focal psychodynamic therapy, psychodynamic interpersonal therapy and counselling

cbt effectively reduces symptoms of panic and anxiety. Behaviour therapy and cognitive therapy both appear effective in treatment of obsessional problems

Psychological therapies have benefit in a range of somatic complaints including gastrointestinal and gynaecological problems. cbt has been found more effective than control therapies in improving functioning in chronic fatigue and chronic pain

Efficacy of cbt and ipt in bulimia has been established. Individual therapies have shown some benefit in anorexia, with little to distinguish treatment types. Early onset of anorexia may indicate family therapy, and later onset, broadly based individual therapy

A number of therapy approaches have shown some success with personality disorders, including dialectical behaviour therapy, psychoanalytic day hospital programme and therapeutic communities.

This section (to p398) deals with some aspects of childhood mental health—but many issues in child psychiatry overlap with pages in the adult section of this chapter, and also with paediatrics. The psychiatry of attempted suicide is a good example. Many of these patients will be in the last phases of childhood, and it is unclear which service will suit them best. As ever, take a holistic view of your patient, and design a care plan which takes these facets into account.

Abuse, p146

Alcohol abuse, p363

Anorexia and bulimia, p348

Asperger’s syndrome, p638

Attention deficit disorder, p212

Autism, p394

Bedwetting, p211

Bullying, p395

Cultural issues in mental health, p492

Depression: children/adolescents, p390

Drug addiction, p362

Dyslexia, p396

Encopresis/enuresis, p210 & p211

Existential crises p390

Family therapy, p386

Holistic assessment p99–100

Language disorders, p215

Learning problems, p314, p364

Parasomnias, p392

Play therapy, p377

Psychosis and psychosis-like symptoms in children, p391

School refusal, p212

Sleep disorders, p392

Substance abuse, p362

Suicide, p338

Talking to young people about sex, p328

Tics & Tourette syndrome, ohcm p714

Adolescents face major mental health challenges owing to existential crises (p390), changing looks, emerging sexualities, identity problems, exam pressure, family break-up, ready availability of drugs and alcohol, media pressures, and the onset of adult responsibilities (eg when they get pregnant). Psychotic illness also often starts in adolescence, and may be partly related to urban stress (p391).

What can we do to help? Paediatricians, psychologists, psychiatrists, counsellors, gps, and so on all have a role of course—but access to them depends on the fact that a problem has occurred. This is often a bit late—which is why teachers have such an important role in promoting mental health.

Some schools offer classroom-based workshops such as MasterMind: Empower Yourself With Mental Health. MasterMind-type initiatives work by creating a toolbox for mental health by making a safe place for discussion of mental health and emotionally charged topics. The aim is to increase student knowledge of mental health issues, and to provide the tools to develop and maintain mental health (eg techniques in de-stressing). Instructional materials address topics identified through needs assessment. These and other written exercises are combined with peer-teaching-peer group activities, individual assignments, and open discussion. Students can ask questions anonymously, and through interaction they build each other’s self-esteem (provided they are not feeling totally negative). When these interventions have been evaluated, it is found that students’ enthusiasm and participation increases throughout the course, and they give high satisfaction scores to the topics covered.

Of course, we all want to know what mental illness are prevented—but this is to ask the wrong question. Mental health issues will never be cured or go away—they are part of what it means to be an adolescent. The question is more “How are these adolescents adjusting to their self-made world?” and “Is adolescence proving to be a humanizing or an alienating experience?” The answers to these questions are more metaphysical than quantitative.

We often have the impression that the incandescent adolescent sitting in front of us is burning too brightly within his sullen shell—and our foreknowledge of his impending death in a shoot-out, stabbing, or drug-overdose seems inevitable. graphicWhat is not inevitable is that he should go to his grave without anyone having tried to help. The following pages may serve as a first step.

Accepting that the big task of adolescence is forging new independent identities, it comes as no surprise that the main signs of depression in this group spell ersatz: a German word we use to mean fake.1  Existential hopelessness related to dawning awareness of freedom to narrate one’s own life and death; relationship & sexual problems; anger in the face of conflicting adult values; tearfulness when it all goes wrong, and overzealous attachment to false gods (eg causing body image dissatisfaction and self-harm).

Features as seen in adults:Features common in childhood:

Low mood

Defiance; running away from home

Loss of interest and self-esteem

Separation anxiety ± school refusal

Socially withdrawn

Complaints of boredom; poor school work

Psychomotor retardation

Antisocial behaviour

Tearful; feelings of guilt

Insomnia (often initial, not early waking)

Anxiety

Hypersomnia

Lack of enjoyment in anything

Eating problems

Features as seen in adults:Features common in childhood:

Low mood

Defiance; running away from home

Loss of interest and self-esteem

Separation anxiety ± school refusal

Socially withdrawn

Complaints of boredom; poor school work

Psychomotor retardation

Antisocial behaviour

Tearful; feelings of guilt

Insomnia (often initial, not early waking)

Anxiety

Hypersomnia

Lack of enjoyment in anything

Eating problems

One-to-one interviewing is usually best. Consider the possibility of concealed factors (eg past child abuse, bullying, p395). Parents can be interviewed separately (ask the child’s permission, and see the child alone, again, if appropriate, after seeing the parents, to report back: this helps avoid seeming to collude with the parents). nb: parents are often unaware of depression in their children.

Assessment is often hard: questions may be answered by silence or a shrug. If not getting anywhere, keep listening, or offer silences—but do not give up.

Always ask about thoughts of suicide/self-harm. Any past attempts? 15–20% make further attempts (⬆risk if: conduct disorder, ⬆alcohol use, hopelessness, or in local authority care). Self-harm may be a form of communication—a message in a bottle; not always ‘picked up’ and sometimes it is difficult to decipher the teenager’s exact intentions. Refer urgently if risk is considered significant. Adolescents with conduct disorders can be manipulative and extremely difficult to assess—an urgent second opinion is frequently of help.

Ideally this should be a combined approach:

1
Social: addressing sources of distress (eg bullying) and removing opportunities for self-harm (eg no paracetamol at home). Improve sense of belongingness, especially if he/she feels on the margins of society (eg for reasons of sexuality, or because of substance abuse).
2

Psychological: encourage verbalizing of moods; explore the vocabulary of internal states. Counsellors, good teachers, and youth workers help here.

3

Cognitive therapy (cbt, p373) helps (often unavailable in primary care).

4
If criminality and gang culture is at work, peer mentorship may help.
5
Drugs: often disappointing (and dangerous); but as 1–4 above is often insufficient in major depression, drugs (eg fluoxetine or escitalopram 10mg/day need to be considered. nice exclude 1st-line use, even in severe depression, but this obsessively self-exculpating ban may do more harm than good. If marked sleep disturbance, consider mirtazapine. If drugs are used:

Evaluate risk/benefit ratio (try to include parents in the discussion).

Monitor suicide ideation ≳weekly for 1st month, then ≳every other week.

Before an antidepressant is initiated, a safety plan should be in place with an agreement with the patient and family that the patient will be kept safe and will contact a responsible adult if suicidal urges get too strong.

Ensure the availability of psychiatric help 24/7.
Specific drugs to avoid if <18yrs old, if possible (bnf/csm): citalopram, paroxetine, sertraline. Also tricyclics, venlafaxine, and fluvoxamine.,
‘Psychotic’ symptoms may not mean psychosis (angels, demons, etc)
In many centres, early-onset schizophrenia is diagnosed with the same criteria as adults (p358) as it seems to be continuous with later-onset forms (eg more males being affected). This is simplistic, as delusions and hearing voices are common in children and are essential to some forms of play.
Visions may relate to folklore or religion, eg nocturnal hallucinations in up to 40% of teenage boys studying in stressful ultra-orthodox Yeshivas where there is a belief in demons and dead souls who visit at night.n=302
Another example is delusional erotomania (p640) which is commoner in adolescents living in places such as China where expressing sexual interest has to be indirect. There are many other examples where to equate delusions and hallucinations with psychopathology would be wrong.

Hearing unwanted tunes (earworms) is common: if there is any psychopathology, it will be more likely to be obsessions rather than psychosis.

Hallucinations are more common in the isolated and withdrawn; here their importance may lie in alerting you to this fact.,

graphicThose which are imperative (“kill so-and-so”) or exciting strong emotions.

graphicThose heard unambiguously outside the head.

graphicThose referring to ideas that the person feels are not their own.

graphicMultiple voices talking at once, and especially voices talking to each other.

Sometimes hallucinations resist diagnosis. This is not in itself a problem as the diagnosis will sooner or later become clear. Meanwhile, ask yourself whether these odd ideas are likely to indicate that your patient is at increased risk of serious outcome, eg suicide.,

Substance abuse; drugs; schizophrenia; anxiety/depression; hypomania; head injury; epileptic aura; migraine; Charles Bonnet syndrome (p438); sle; encephalopathy (eg lead exposure); infections (herpes, ebv-associated Alice-in-Wonderland syndrome, ohcm p708); stress; abuse.

mri/ct may be indicated, eg in olfactory hallucination.
graphicEarly intervention helps, and may reduce chances of later chronic schizophrenia, so refer promptly. If you are the child’s gp, ensure there is a treatment plan with a named worker, incorporating antipsychotics (if indicated, p360) with psycho-educational, psychotherapeutic, and social components. New antipsychotics (p361) are rarely specifically licensed for children, but their use in well-monitored environments is encouraging.  ses are legion; they may not be as bad as older drugs see p361.,
Risk of psychosis rises when young people with a genetic predisposition (expressed as poor social and cognitive functioning) have to cope with urban life, poverty, isolation, crime, and inequality. What can be done to alleviate urban stress and gang culture?

Autonomy for housing estates (Housing Associationuk may help)

Wardens drawn from the local community

Training schemes

Clubs (for art/self-expression)

Sport

Debates

Very local radio

Skills/time banks (where those with skills deposit hours of help which others can ‘cash’)

Cycle repairs (if you learn to fix an unclaimed bike, you keep it)

Children’s centres

Saturday school/healthy living

Prostitution and drug abuse initiatives agreed with police

Avoid punishment/imprisonment.
Spontaneous improvement of psychotic-like symptoms occurs in the majority of children. In one follow-up study, many developed chronic mood disorders; <50% met diagnostic criteria for a major disorder (schizoaffective or bipolar disorder, depressive disorder, ‘psychotic disorder not otherwise specified’). In those not developing a mood or psychotic disorder, disruptive behaviour disorders are very common.
Try plenty of daytime activity (each hour of sitting ⬆sleep latency by 3mins). Insist on a routine wind-down 1 hour before bedwarm bath for 10mina storythen straight into a darkened bedroom.
Gurney methodreference

For those not appreciating these visitations from the pure of heart, consider refusing to play and buy earplugs to lessen the impact of screaming—or let the child into the bed. Or try extinguishing the behaviour by attending to the child ever more distantly: cuddle in bedcuddle on bedsitting on child’s bedvoice from doorwaydistant voice. Try to avoid hypnotics. If essential, consider Weldorm Elixir® (cloral betaine); dose if >2yrs: 30mg/kg, max 1g/day.

Hunger/colic (infants); poor routines (preschool); worry (adolescence). Bedroom tv may be to blame. Try behavioural therapy before hypnotics. Day-time sleepiness: Causes: night sleep⬇; depression; sleep apnoea (ohcm p186); narcolepsy;1 encephalitis lethargicans (rare in children): suspect this whenever sleepiness occurs with extrapyramidal effects, oculogyric crises, myoclonus, inversion of diurnal rhythms, obsessions, and mood change. Possible causes: influenza; flu vaccination;graphic measles; q fever; mycoplasma; hypothalamic lymphoma. mri: subcortical involvement.

Of all our non-insane automatisms, somnambulism is the most familiar and striking, literally (rarely) as households may be endangered when the bloodiest dreams of junior somnambulists are enacted. The young are by far the best sleepwalkers (the old may emulate them eg if stress is augmented by excess alcohol or caffeine use, and lack of stage IV sleep—our deepest sleep). Any psychic event associated with sleep may be termed a parasomnia. Parasomnias comprise:

Arousal disorders (sleep-walking; night terrors; ‘confusional arousal’)

Sleep–wake transition disorders (rhythmic head-banging disorder)

rem sleep parasomnias (rapid eye movement sleep associated nightmares, sleep paralysis, hallucinations, and rem sleep behaviour disorder (box 1).

Others.1

Suffering from night terrors is often a familial problem. The child awakens frightened, hallucinated, and inaccessible—and is obviously alarmed.

It is common to observe movement in children during sleep: it is their repetitive nature which allows the diagnosis of rhythmic movement disorder. The movement may be body-rocking, leg-rolling, or head-banging (this ‘jactatio capitis’ may lead to subdurals, fractures, eye injuries, and false accusations of abuse). Tongue-biting may suggest epilepsy. But do not try to be too obsessive in differentiating parasomnias from nocturnal epilepsy, for 3 reasons:

1

Our definition of epilepsy is tested to destruction by the parasomnias (‘epilepsy is intermittent abnormal brain activity manifesting as simple or complex seizures’).

2

Those with clearly defined parasomnias are at risk of developing tonic–clonic nocturnal seizures later in life.

3
Some parasomnias are signs of autosomal-dominant nocturnal frontal lobe epilepsy (adnfle). adnfle is associated with abnormalities in genes coding nicotinic acetylcholine receptor α4-subunit (chromosome 20). eeg: rhythmic slow anterior activity; video polysomnography: sleep-related violent behaviour, sudden awakening and dyskinetic or dystonic movements, and complex behaviours ± enuresis).
Bedtime clonazepam; amitriptyline; carbamazepine. If not working, consider self-hypnosis or waking ½h before the expected event.
Sleep architecture and rem sleep behaviour disorder

We sleep in one of two states: rapid eye movement sleep (rem sleep ≈25% of all sleep) and non-rapid eye movement (nrem, which has 4 stages). In rem sleep, breathing is irregular, bp rises, and tone lapses (atonia; paralysis). eeg during rem sleep is similar to that in wakefulness and associates with dreaming. Tricyclics, ssris, and serotonin-norepinephrine reuptake inhibitors may all suppress rem.

In rem sleep behaviour disorder, rem paralysis is incomplete or absent, with acting out of dreams that are vivid and violent (with shouting, punching, kicking, flailing etc enough to endanger bed-partners).

Associations/causes:

Parkinson’s disease, dementia (may be an early sign), alcohol and drug withdrawal (eg ssri).

Polysomnography:

Muscle tone ⬆ during rem sleep.

Treatment:

Sleep alone; remove all dangers from the sleep environment. Put the mattress on the floor. Clonazepam 0.5mg at bedtime may help.

Sleep paralysis

When we sleep we trawl forbidden seas, arranging and being rearranged by the flotsam and jetsam of our waking lives. As our nets descend through the various stages of sleep, our Sovereign Reason or Will usually remains quietly on deck, but if by chance it descends with the nets then, like the tail wagging the dog, it adopts and propagates a life of its own, which may be full of danger. Because our vessel has been vacated, Marie-Celeste-style, we are judged, in Law, not to be responsible for our actions while asleep—be they theft, arson, or homicide. Without will or wind, our vessel, like Coleridge’s Mariner’s (see poem below), is moved ‘onward from beneath’ by secret forces. So here we have the model of Reason and Will residing, during sleep, either upstairs or downstairs: but in sleep paralysis, neither is the case—the tail cannot wag the dog, nor the dog wag his tail. Sleep paralysis may involve complete paralysis of all voluntary muscles, even the diaphragm. For anyone who has experienced it, it is frightening, unforgettable, and difficult to describe—like being aware during anaesthesia with total neuromuscular blockade.

Sleep paralysis was first described by Ishmael during a reverie on deck, sleeping between Queequeg, the cannibal whaler from the South Seas, and his harpoon, before Herman Melville embarks them on the Pequod’s voyage to track down Moby Dick: “At last I must have fallen into a troubled nightmare of a doze; and slowly waking from it—half steeped in dreams—I opened my eyes, and the before sunlit room was now wrapped in outer darkness. Instantly I felt a shock running through all my frame; nothing was to be seen, and nothing was to be heard; but a supernatural hand seemed placed in mine. My arm hung over the counterpane…for what seemed like ages piled on ages, I lay there frozen with the most awful fears … thinking that if I could but stir it one single inch, the horrid spell would be broken.”
Moby Dick p44 Penguinreference

Till noon we quietly sailed on

Yet never a breeze did breathe:

Slowly and smoothly went the ship,

Moved onward from beneath.

Under the keel nine fathom deep,

From the land of mist and snow,

The spirit slid: and it was he

That made the ship to go.

The Rime of the Ancient Mariner Samuel Taylor Coleridge (part v)

asds are the lifelong pervasive developmental disorders of our times.1  Prevalence: ≥1:200 ♂:♀ ≈4:1. Managing autism is a huge challenge. It is a triad of:
1

Impaired reciprocal social interaction.

2

Impaired imagination (± abnormal verbal and nonverbal communication).

3
Restricted repertoires of activities and interests.
Unknown; severity correlates with testosterone in amniotic fluid. graphicGenes (on chromosome 11p12 ± neurexin) play a part. If one child is affected, risk of the next pregnancy being affected is ~5–10%. Blood glutathione levels are low and this may jeopardize cns & gi antioxidant activity. There is associated epilepsy in 30%. Any association with mmr vaccine (p151) is thought to be due to changing definition of autism at the time that mmr was introduced.
≳6 items, with ≳2 from ‘A’ symptoms, and one each from ‘B’ and ‘C’. Telling comments before the age of ~2yrs are: “he does not respond to his own name; he hates his routine being changed; he is not interested in toys.”

Unawareness of the existence and feelings of others (treating people as furniture; being oblivious to others’ distress or need for privacy).

Abnormal response to being hurt: he doesn’t come for comfort; or makes a stereotyped response, eg just saying “Kiss it better kiss it better kiss it…”.

Impaired imitation (eg does not wave ‘bye-bye’ or copies/echoes without understanding, eg waves on passing a door when no one is in fact leaving).

Repetitive play: eg solitary, or using others as mechanical aids.

Bad at making friends (lack of empathy). If he tries at all, the effort will lack the social conventions, eg reading the phone directory to uninterested peers.

Little babbling, few facial expressions or no gestures in infancy.

Avoids mutual gaze; no smiles when making a social approach; does not greet his parents; stiffens when held.

Does not act adult roles; no interest in stories; no fantasy/pretend play.

Odd speech, eg echolalia (repetitions); odd use of words (“Go on green riding” for “I want a go on a swing”); odd use of pronouns (“You” instead of “I”).

Difficulty in initiating or sustaining reciprocal roles in conversations.

Stereotyped movements (hand-flicking, spinning, head-banging).

Preoccupation with parts of objects (sniffing or repetitive feeling of a textured object, spinning wheels of toys) or unusual attachments (eg to coal).

Marked distress over changes in trivia (eg a vase’s place).

Insists on following routines in precise detail.

Narrow fixations, eg lining up objects, or amassing facts about weather.

chat screening test: sensitivity 38%; specificity is 98% if done at 1½yrs old.
Early intensive behavioural intervention (eibispeech therapy ±special schooling. eibi starting at 3yrs old can ⬆iq in >60% and enhance motor, social, and living skills.  Selfhelp:uk 020 81830 0999. Parent training helps communication, enriches parental knowledge of autism, enhances parent–child interaction, and ⬇parental maternal depression. Encourage parents to attend more to ‘good’ behaviours, and to have clear rules. Social skills training/role-play can help. Get benefits/Disability Living Allowance.uk Other partly successful behavioural approaches include that of Lovaas.
have a small role: fish  oils (may help tantrums and self harm); atomoxetine (hyperactivity); risperidone (irritability; repetition; social withdrawal; se: weight⬆).
Eliminating gluten & casein is popular but unproven.

70% remain badly handicapped; 50% have useful speech; 15% lead an independent life.

Boys will be boys… The unacceptable alibi?

graphicEvery individual should have the right to be spared oppression and repeated, intentional humiliation, in school as in society at large. Bullying is important not just because it is unacceptable, but also because it leads to depression, somatization, withdrawal, submissive behaviour, school phobia, vomiting, sleep disturbance, drug abuse, poor communication, and suicide.
graphicMost parents don’t know their offspring are bullies or being bullied.
graphicBullying is bad for bullies: antisocial behaviour persists into adulthood with impaired reciprocal diadic relationships (≈poor love life).
27% of primary and middle school children report bullying each term, and 10% of secondary pupils. In a study of prevalence, 4% were direct bullies, 10% bully/victims (both bully and victim), and 40% victims. Pure victims have poor health. Pure bullies have fewest health problems.

Rumour-spreadingexcluding othersracial abusehostile staringpunking1victimizationpushingviolencetorturemurder.

Isolation, looking different, being small, or gay, or seeming gay.
targeting bullying or emotional distress may reduce the severity of both problems.  Liaise with the school. School-wide policies do work. Psychotherapy has a role. Ensure that the bully doesn’t prosper from bullying, so learning to ‘achieve dominance over others by the abuse of power’.
The hardest task is to combat the ethos among bystanders, which allows bullying to continue as if it were ‘none of my business’.
This implies that we all have a role in minimizing bullying. Bullying in health services is well-documented, and most of us have suffered from insecure people abusing positions of power. We fear to act when we are bullied as we might get a bad reference or because we don’t think our own humiliation is important. It is easier to take a more rational view when we see others being bullied: we must not allow it. Remember that the bullier may not be able to stop the behaviour without help—which is available: see www.nhs-exposed.com.
are successful in primary schools but less so in secondary schools.
Teachers are often aware of homophobic bullying but are confused, unable, or unwilling to help. Citizenship education programmes may be important here.  When the teacher is the bully: Problems may become very deep-rooted. Studies of bullying by teachers reveal the subtlety and complexity of teachers’ strategies for distancing themselves from being held accountable for intimidation.

On a universal level, we can recognize that we are all potential bullies, when stressed, frightened, overworked, or threatened by uncontrollable events (such as patient demand). We stop ourselves from being bullies, more or less successfully, by intrapsychic appeals to well-respected mentors who ‘would never behave like that’, and by communicating our feelings to our colleagues directly before they are forced underground only to resurface as bullying. Try: “I’m feeling rather stressed at the moment: tell me if I seem bullying or hectoring—but we’ve got to get this job done, and I suggest doing it like this…”

You are trying to bully me is a phrase which may be used correctly, or it may be an attempt to stop someone in authority from pursuing her proper role. The test is: “Is this action tyrannical, and is its purpose to belittle me, or is it that I am being asked to do something I don’t want to do by someone who is honestly trying to make an institution work?” Professors of Organizational Behaviour emphasize that everyone suffers if dynamism and the promotion of change are mistaken for bullying.

Reading ability usually goes hand-in-hand with intelligence, but when this is not so, and someone with, say, an iq of 130, finds reading difficult, the term dyslexia is often used. The term ‘specific learning difficulty’ is preferred by some people, as ‘dyslexia’ is often a term used by parents to help cope with having a child whose general intellectual skills, including reading, are less than hoped for. nb: dyslexia can be associated with other speech and language disorders: consider referral to a speech and language therapist (salt).

There is a problem with appreciating phonemes, eg that ‘cat’ comprises /c/, /a/, and /t/. Breaking up unfamiliar words into phonemes and having a go at stringing them together is the central act of learning to read. This is what needs to be taught, educationalists say, and children should not be made to rely on unstructured guesswork (the ‘look and say’ approach) which is now discredited as the sole means of equipping children for reading.

Quite often, distortion/jumbling of text during reading is reported. Visual aids have been used with some success to improve reading.
Children with dyslexia also have difficulty in telling how many syllables there are in a word (don’t we all? “How many syllables are there in strength?” analytical dyslexics may ask). They also have difficulty with verbal short-term memory—eg for meaningless strings such as phone numbers. There is also a problem with telling if two words rhyme or not, and in distinguishing phonemes which sound similar (eg /k/ and /g/). There may also be left/right muddle. Genetics: Boys are more afflicted than girls, and show stronger genetic effects (up to 50% of boys are dyslexic if their fathers are). Genes on chromosomes 1, 2, and 15 are implicated, and linkage on chromosome 6 near the hla complex may explain associations between dyslexia and autoimmune diseases.
Boys learn language later than girls and are more prone to dyslexia. Finding candidate genes (eg dyx1c1) seems easy, but remember: genes don’t specify cognitive processes; they code regulatory factors, signalling molecules, receptors, and enzymes that interact in complex ways, modulated by environmental influences, in order to build and maintain a person’s brain.
cns examination shows left-sided cerebral lesions (rare) or changes may be seen postmortem, eg in perisylvian regions ± unusual asymmetry of the plenum temporale (Wernicke’s area), with cortical dysplasia and scarring. In vivo characterization of this asymmetry is becoming possible.

Perhaps dyslexia reflects weak connectivity between anterior and posterior parts of the language areas of the brain, and the angular gyrus. Positron emission images show that when dyslexic adults perform rhyme judgments and verbal short-term memory tasks they activate less than the full set of centres normally involved with these tasks. www.shianet.org/~reneenew/hist.html

Note that there is functional mri observation of specific involvement of one subsystem of the visual pathways which prevents rapid processing of brief stimuli presented in quick temporal succession (magnosystem hypothesis).
The gaps test aims to diagnose children before school starts.,
Make sure the ‘dyslexia’ is not from lack of teaching. The person may gain insight by discussing his or her problem with fellow sufferers, and by finding out about past dyslexics such as Leonardo da Vinci. Special educational programmes are available for addressing dyslexic problems, as the phonetic approach to learning to read usually presents problems. nb: ‘wait-and-see’ is not wise—studies support identification before school with exercises in sound categorization using rhyme and alliteration, with special teaching of letters.
You may be asked about dietary supplements with highly unsaturated fatty acids (hufa, eg Efalex®). These do play a role in neurodevelopment, but evidence of benefit in dyslexia from large randomized trials is sparse. They appear to reduce dyslexia-associated delay in dark adaption.

The next pages concern the psychiatrist as jailer. To reflect on this let us follow one patient’s journey, along the edge of chaos, to his straightjacket via a series of verbatim tweets from the manic streets of Paris (with proposed timings).

3pm  Bought two velvet screens covered with hieroglyphic figures…to consecrate the forgiveness of heaven.

4pm  Met my friend George…wet through and tired out…laid on his bed.

6pm  Marvellous goddess appeared to me saying “I am the same as Mary, the same as your mother”.

7pm  Said to George “Let’s go out”.

7.15pm  Crossing Pont des Arts explaining the transmigration of souls to him.

7.20pm  Told George…I have the soul of Napoleon in me commanding me to do great things.

7.30pm  In the Rue Du Coq I bought a hat. While George is waiting for my change I went to the Palais-Royal…everyone staring at me.

7.50pm  A persistent idea is fixing itself in my mind…there are no more dead.

8pm  Went through the Galerie de Foy saying “I have committed a sin…”.

8.10pm  Somewhat interested in little girls dancing in rings.

8.15pm  Café de Foy…Dense crowd…nearly suffocated.

8.20pm  Extricated by 3 friends…into a cab…taken to Hospice De La Charité.

3.02am  Walking about various wards…I’m like a god with powers of healing.

3.05am  Laying my hands on some patients now.

3.20am  Going up to a statue of the Virgin Mary…

3.21am  Taking off its crown of flowers in order to test the power in me.

3.29am  Talking in an animated way of the ignorance of men who think they can be cured by science.

3.40am  Bottle of ether on the table…

3.42am  Drinking it in one gulp

3.43am  Hospital assistant with face like an angel trying to stop me

3.45am  Tell him he does not understand my mission.

3.55am  Doctors coming along.

4am  Harangue on the impotence of their art.

4.02am  Thrusting me into a straightjacket

6am  Am in an asylum outside Paris…

Gérard De Nerval Aurélia 1855reference
Gérard De Nerval, whose tweets these are, was famous during his colourful life for extravagant orgies, eating ice-cream out of skulls and for taking his pet lobster for walks in the gardens of the Palais Royal on a blue silk lead.
He hanged himself from a Paris street light in 1855.
After his death his critics read and reread his masterpiece Les Chimères (a fragment of which appears below), graphic proclaiming it to be an infinite hallucination set in a jewel of immense value. We honour Gérard De Nerval here to remind ourselves that the next patient we imprison using mental health laws deserves our infinite respect, however rough their diamonds appear to be.

(1983, 2007)

ac  approved clinician

amhp  approved mental health professional

asw  approved social worker

cto  community treatment order

echr  European Convention on Human Rights

ect  electro-convulsive therapy

gscc  General Social Care Council

imca  independent mental capacity advocate

imha  independent mental health advocate

lhb  local health board

lssa  local social services authority

mca  Mental Capacity Act 2005

mhac  Mental Health Act Commission

mhrt  Mental Health Review Tribunal

nhsft  nhs foundation trust

pct  primary care trust

rc  responsible clinician

rmo  responsible medical officer

sct  supervised community treatment

soad  Second Opinion Appointed Doctor

Before reading the subsequent pages which reflect the 1983 Mental Health Act it is vital to understand how the Act has been amended and added to by the 2007 Mental Health Act—which does not replace it—but rather sits beside it.

(required in the 2007 act)

Respect patients’ past and present wishes and feelings.

Minimize restrictions on liberty and involvement of patients in planning, developing and delivering care and treatment appropriate to them.

Avoid unlawful discrimination.

Pay due attention to the effectiveness of treatment.

Respect the views of carers and other interested parties.

Respect for diversity, including, in particular, diversity of religion, culture and sexual orientation (within the meaning of the Equality Act 2006).

Patient wellbeing and safety, and public safety need balancing.

In 2007, three key measures were introduced:

1

Community treatment orders (ctos) allow compulsory treatment in the community. As a safeguard, there is a duty to consider what risk there would be of a deterioration of the patient’s condition if he were not detained (as a result, for example, of his refusing the treatment he requires for his mental disorder). ctos have the same duration and renewal periods as section 3 (p400): 6 months initially, then renewed for 6 months, then renewed annually.

2

The criteria for a cto is that the patient is detained after an application for admission for treatment, and it is necessary for his health and safety or for the protection of other persons that he receives treatment, which can be provided outside hospital (subject to a power of recall). cto roles:

Ensuring the patient receives the treatment stipulated.

Preventing harm to the patient’s health or safety.

Protection of others.

3

People diagnosed with severe antisocial personality disorders are now within the scope of mental health law and can be detained even if they have committed no crime, if they are deemed a danger to themselves or others.

A new statutory advocacy service for detained patients, and:

Children are protected from being put in adult wards (section 140).

2 professionals from diverse disciplines must now agree to detention renewal.

No ect can be given in the face of capacitous refusal, other than in emergency. Emergency ect can only be given if it is immediately necessary to save life or immediately necessary to prevent a serious deterioration.

16- and 17-year-olds’ capacitous refusal of treatment cannot be overridden by parental authority; a soad is needed for ect to be given; and there must be a referral for a mhr Tribunal annually for patients who do not request a hearing.

There is a new ‘treatability’ test, ensuring compulsory treatment must be of ‘therapeutic benefit’. The wording is: ‘Any reference in the Act to medical treatment, in relation to mental disorder, shall be construed as a reference to medical treatment the purpose of which is to alleviate, or prevent a worsening of, the disorder or one or more of its symptoms or manifestations.’

Patients may be transferred from one place of safety to another. The hope is that patients detained by police officers on section 136 will be quickly transferred from a police station to a therapeutic environment.
Procedures governing use of compulsory powers (2007)511

Decisions to begin assessment and initial treatment of a patient under compulsory powers must be based on a preliminary opinion by two doctors and a social worker (or another suitably trained mental health professional) that a patient needs further assessment or urgent treatment by specialist mental health services and, without this, might be at risk of serious harm or pose a risk of serious harm to others.

A patient will be given a full assessment of his or her health and social care needs and receive a formal care plan; the initial period of assessment and treatment under compulsory powers is up to 28 days; after that, continuing use of compulsory powers must be authorized by a new independent decision making body, the Mental Health Tribunal, which gets advice from independent experts as well as taking evidence from the clinical team, the patient ± his or her representatives, and other agencies, as appropriate.

The Tribunal (or the Court in the case of mentally disordered offenders) can make a care and treatment order to authorize the care and treatment specified in a care plan recommended by the clinical team. This must be designed to give therapeutic benefit to the patient, or to manage behaviour associated with mental disorder that might lead to serious harm to other people. The 1st 2 orders can be up to 6 months each; subsequent orders may be for periods of up to 12 months.

one new provision is that it is now possible for people with dangerous personality disorders to be detained before a crime has been committed.

Methodology/criteria for using ctos (community treatment orders)

A soad certificate must be issued authorizing the treatment. The soad is appointed in the normal way by the mhac. The criteria for the soad authorization is simply that ‘it is appropriate for the treatment to be given’. With soads, the certifying doctor has a duty to consult 2 statutory consultees but no duty to consult the patient or the responsible clinician.

The treatment is immediately necessary and the patient has capacity and consents to its administration; or…

The treatment is immediately necessary and the patient lacks capacity, but a deputy or the court of protection consents to it on his or her behalf.

The patient lacks capacity and may resist the treatment, but force may be justified as proportionate response to the likelihood of serious harm to the patient, and the treatment is either immediately necessary to save the patient’s life; or (not being irreversible) is immediately necessary to prevent serious deterioration; or (being neither irreversible nor hazardous) is immediately necessary to alleviate serious suffering; or (being neither irreversible nor hazardous, and the minimum interference necessary) is immediately necessary to prevent the patient from behaving violently or being a danger to her/himself or others.

(for 2007 law, see p398)

graphicThe patient must have a mental disorder and need detention for treatment of it, or to protect himself or others, before compulsion may be used (if voluntary means have failed).

The period of assessment (and treatment) lapses after 28 days.

Patient’s appeals must be sent within 14 days to the Mental Health Tribunal (composed of a doctor, lay person, and lawyer).

An approved social worker (or the nearest relative) makes the application on the recommendation of 2 doctors (not from the same hospital), one of whom is ‘approved’ under the Act (in practice a psychiatric consultant or senior registrar). The other doctor should ideally know the patient in a professional capacity. If this is not possible, the Code of Practice recommends that the second doctor should be an ‘approved’ doctor.

The exact mental disorder must be stated.

Detention is renewable for a further 6 months (annually thereafter).

2 doctors must sign the appropriate forms and know why treatment in the community is contraindicated. They must have seen the patient within 24h. They must state that treatment is likely to benefit the patient, or prevent deterioration; or that it is necessary for the health or safety of the patient or the protection of others.

The admission to hospital must be an urgent necessity.

May be used if admission under section 2 would cause undesirable delay (admission must follow the recommendation rapidly).

An approved social worker or the nearest relative makes the application after recommendation from one doctor (eg the gp).

The gp should keep a supply of the relevant forms, as the social worker may be unobtainable (eg with another emergency).

It is usually converted to a section 2 on arrival in hospital, following the recommendation of the duty psychiatrist. If the second recommendation is not completed, the patient should be discharged as soon as the decision not to is made. The Section should not be allowed to lapse.

The doctor in charge (or, if a consultant psychiatrist, his or her deputy, applies to the hospital administrator, day or night.

A patient in an a&e department is not in a ward, so cannot be detained under this section. Common law is all that is available, to provide temporary restraint ‘on a lunatic who has run amok and is a manifest danger either to himself or to others’ while awaiting an assessment by a psychiatrist.

Plan where the patient is to go before the 72h has elapsed, eg by liaising with psychiatrists for admission under section 2.

Any authorized psychiatric nurse may forcibly detain a voluntary ‘mental’ patient who is taking his own discharge against advice, if such a discharge would be likely to involve serious harm to the patient (eg suicide) or others.

During the 6h the nurse must find the necessary personnel to sign a section 5 application or allow the patient’s discharge.

Enables patients to receive community care if it cannot be provided without using compulsory powers.

Application is made by an ‘approved social worker (asw)’ or ‘nearest relative’ and also needs two medical recommendations.

The guardian, usually a social worker, can require the patient to live in a specified place, to attend at specified places for treatment and to allow authorized persons access.

The patient continues to suffer from a mental disorder and would benefit from continued hospital treatment.

Further admission is needed for the health or safety of the patient—which cannot be achieved except by forced detention.

This is as a result of the Mental Health (Patients in the Community) Act 1995—incorporated within the 1983 Act.

It allows formal supervision to ensure that a patient who has been detained for treatment under the Act receives follow-up care.

The application is made at the time of detention for treatment by the Responsible Medical Officer. It is supported by an asw and a doctor involved in the patient’s treatment in the community.

A supervisor is appointed who can convey the patient to a place where treatment is given.

Section 117 requires provision of after-care for patients who have been detained on the ‘long sections’ (3, 37, 47, or 48). The cpa is not part of the Act but stipulates that no patient should be discharged without planned aftercare: the systematic assessment of health and social needs, an agreed care plan, the allocation of a keyworker, and regular reviews of progress.

(for ≥72h) allows police to arrest a person ‘in a place to which the public have access’ who is believed to be suffering from a mental disorder. The patient must be conveyed to a ‘place of safety’ (usually a designated a&e department—better than a police station; a police station is rarely a place of safety and most people dying in police custody will have mental health problems and will have been on the receiving end of excess force employed by undertrained officers). In a hospital there can be a full assessment by a doctor (usually a psychiatrist) and an approved social worker. The patient must be discharged after assessment or detained under section 2 or 3.

This empowers an approved social worker who believes that someone is being ill-treated or is neglecting himself to apply to a magistrate to search for and admit such patients. The asw or a registered medical practitioner must accompany the police.

Capacity entails being able to grasp and retain information relevant to a decision, and to weigh it as part of a process of making that decision.
Mental Capacity Act 2005reference

Consent to treatment comes in Part 4 of the Mental Health Act; it applies to:

Treatments for mental disorder.

All formal patients unless detained under sections 4, 5, 35, 135 and 136. The Act doesn’t apply to those subject to Guardianship or Supervised Discharge, who have the right to refuse treatment, except in emergencies.

Where a person is deemed to have given their consent to treatment under Section 57 or Section 58, the person can withdraw that consent at any time. The treatment must then stop and the appropriate procedures followed, unless discontinuing treatment would cause ‘serious suffering’ to the patient, in which case continued treatment may be justified.

Some treatments are deemed so restricting that patients cannot automatically have them even if they do consent. Also, 3 people (1 doctor and 2 others who cannot be doctors) must certify that the person concerned is capable of understanding the nature, purpose and likely effects of the treatment and has consented to it (competence). They are appointed by the Mental Health Act Commission. Treatments falling into this category are destruction of brain tissue, or functioning and implantation of hormones to reduce male sex drive.

Applies to people who are detained under certain Sections without consent, or where the person is not able to consent, eg to ect or drugs for a mental disorder if 3 months since the person first had the drugs during their current period of detention under the Act. In the first 3 months the treatment can be given without consent. The 3-month period starts from when drugs are first given.

If the person is capable of understanding the nature, purpose and effects of the treatment and consents to it, the Responsible Medical Officer (rmo) must certify that understanding and consent are present. If the person is capable of understanding the nature, purpose and likely effects of the treatment and doesn’t consent to it, or has ⬇capacity so cannot consent, then a doctor is appointed by the Mental Health Act Commission to give a 2nd opinion. She must consult 2 professionals involved in the patient’s treatment; one must be a nurse.

The certificates must state the treatment plan in precise terms, eg the number of ect treatments. If the plan changes, new certificates are required.

The provisions of Section 58 don’t prevent urgent treatment (sect 62).

The requirements of Section 57 and Section 58 need not be followed for urgent treatment to save the patient’s life or to…

Prevent serious deterioration, so long as the treatment is not irreversible.

Alleviate serious suffering (if the treatment isn’t irreversible or hazardous).

Prevent the patient behaving violently or endangering self or others, so long as the treatment is neither irreversible nor hazardous, and is not excessive.

This allows a Court to send a person to hospital for treatment, or to make the person subject to Guardianship, when the outcome might otherwise have been a prison sentence. The Order is instead of imprisonment, a fine, or probation. The person concerned…

Will have been convicted by a Magistrates Court or Crown Court of an offence punishable with imprisonment (except in the case of murder, where the Court has to impose a sentence of life imprisonment in all cases).

May not have been convicted, but may be charged with an imprisonable offence. Without convicting the person, the Court can make a Hospital Order under Section 37 if there is mental illness or severe mental impairment.

The initial period is 6 months from the Order’s date. It can be renewed under Section 20 for 6 months and then annually. The Court must be satisfied that…

There really is a mental illness, as evidenced by 2 doctors who must agree at least in part as to the type of mental illness or impairment present…and…

The nature and degree of the mental disorder makes it appropriate for the person to be detained in hospital for medical treatment (that the treatment is likely to alleviate or prevent a deterioration of the person’s condition in the case of psychopathic disorder or mental impairment)…and…

Making a Section 37 Order is the best way to deal with the person…and …

A specific hospital is willing and able to admit the person within 28 days.

Where a treatment plan is being carried out under Section 57 (or 58 without consent), the rmo must report to the Mental Health Act Commission if the period of detention is renewed under Section 20.

The Commission may demand a report at any other time if it wishes.

The Commission can cancel the certificate under which treatment is given.

In the case of people subject to Restriction Orders a report on the treatment being given must be provided for the Commission:

1

6 months after the restriction order or direction is made, and

2

At times when the rmo reports to the Home Office on the person’s condition.

eg after being admitted to a rest home during an infection when a patient lacked capacity, and the doctor ‘acted in his best interests’. dols provide the person with a representative, and…

dols allow a challenge in the Court of Protection against ‘false imprisonment.’

dols give a right for deprivation of liberty to be reviewed regularly.

Source: patient.co.uk/doctor/

Enriching consent: making decisions truly informed (gmc advice)515
We mustn’t assume that because a patient lacks capacity today for one issue that he will lack capacity on all issues. We must plan for changes in capacity. Extra support will be needed for those with dementia and learning difficulties. nb: where possible, use multimedia formats to explain issues: we know these are better at making difficult decisions truly informed.
Children under 16 disagreeing with their parents517

Capacity matters, not age. Parents’ wishes are not supreme if the child has capacity (above). If you take a decision for a patient, you must have a ‘reasonable belief’ that capacity is lacking and that the act is in his/her best interests.

Medicolegal issues—use of Common Law in clinical situations
Adapted from Feldman 2000:A 30 year old male is brought to a&e after an overdose. There is no history available and the patient refuses to say anything, other than he wants to be left alone to die. He refuses to give blood for a drug level and is refusing any treatment. What should we do?’ Should we assume he has full capacity? If so, he may die—but autonomy is maintained. Or should the clinician act in the patient’s best interests (the doctrine of necessity) as part of their duty of care? Most people who self-harm are depressed—but this does not prove incapacity. However, in the acute setting, Feldman asserts that ‘there are usually good grounds for reasonable doubt with respect to the patient’s capacity to make a fully informed and reasoned choice, and to proceed with whatever action is necessary to save his life under the common law’.

The Mental Health Act is an enabling act (it needn’t be used in all valid situations). Its use gives certain legal safeguards for patients and staff. ‘A 40 year old female with alcohol problems has been admitted to hospital following a head injury 2 days ago. She has shown fluctuating levels of confusion, agitation and is now trying to leave the ward.’ Here, due to refusal or lack of capacity, the transient nature of the disturbance, and the need for intervention, common law is applicable. If stronger measures are needed, or the situation persists, it is wise to use the Mental Health Act to detain a patient with delirium; however it is not commonly used.

Lying thus in the sun one is liberated from doubts and from misgivings; it is not that problems and difficulties are resolved, it is that they are banished. The sun’s radiation penetrates the mind…anaesthetizing thought.
AE Ellis 1958 The Rackreference

Some people find that depressions start in winter, and remit in spring or summer. It is postulated that disordered secretion of the indole melatonin from the pineal gland is to blame in some patients with sad. Melatonin, the hormone of darkness, is secreted by the pineal only at night, eg at 30μg/night.

Sleep disturbance is often seen in depression, and manipulating the sleep–wake cycle is one methodology for treating depression, so maybe dysregulated circadian rhythms really are causal. Our circadian rhythms are regulated by a core biological clock in the hypothalamic suprachiasmatic nucleus. Its pacemaker activity is regulated by light (and nonphotic modulatory pathways) via serotonergic input from the raphe, and melatonin originating from the pineal gland. We note with interest that agomelatine, a new antidepressant, acts as an agonist at melatonergic mt1 and mt2 receptors and as an antagonist at 5-ht2c receptors. It is known to resynchronize the sleep-awake cycle (in animals).

As a rule, the more that typical winter symptoms (hypersomnia, carbohydrate craving and weight gain) predominate, the more likely that light therapy should be a treatment of first choice. But if winter episodes are characterized by early morning wakening and weight loss, and especially if there are non-seasonal recurrences, traditional antidepressants are advised.

The antidepressant effect of light is potentiated by early-morning administration in circadian time, optimally at ~8.5 hours after melatonin onset or 2.5 hours after a sleep’s midpoint.
A dose–response effect exists between the amount of light administered in phototherapy and the degree of improvement in depression (as measured on Hamilton ratings). 6h/day of increased light brought about a 53% decrease in scores, whereas treatments of 2h (or red-light treatment) produced only a 25% reduction. These effects were correlated with suppressed plasma melatonin concentrations at 23.00h. Variables of uncertain importance include: the type of light (device and spectrum), distance between patient and source, and the duration of treatment.
Therapy should stimulate the nasal retina, as retinal ganglion cells projecting to suprachiasmatic nuclei are unequally distributed.

However, evidence in this area is often contradictory, and it is probably unwise to rush into recommending light for all patients whose recurrent depressions start in the autumn or winter. This might have the undesirable effect of enticing such patients to book unaffordable winter holidays to exotic locations—with inevitable disappointments and recriminations.

Antidepressants
Sedative antidepressants are usually avoided and selective serotonin reuptake inhibitors (ssris) are often 1st choice. Newer antidepessants to consider: agomelatine, an agonist of melatonergic MT1 & MT2 receptors and antagonist of 5-HT2 receptors. It appears to resynchronize disturbed circadian rhythms and to reduces depression. It also causes less sexual dysfunction compared with ssris (5% vs 62%).  Venlafaxine and reboxetine may also have a role. In patients with established winter recurrences, it is usual to instigate treatment as soon as symptoms re-emerge in the autumn and to phase out treatment in spring. For patients who also experience non-seasonal episodes, year-round prophylaxis may be deployed, sometimes regularly increasing the antidepressant dose during the winter months.

Since the early 1980s, most uk inpatients with psychosis have had the focus of their care moved from hospital to the community. The aim has been to save money and improve care, but in the uk this policy is now being partly reversed. Has community care failed, or have there been successes? Five questions keep recurring, each (ominously) prefixed by a ‘Surely…’

1

Surely hospitals will always be needed for severely affected people? In general, the problem is not the severity of the mental illness, but its social context which determines if community care is appropriate.

2
Surely community care, if it is done properly, will be more expensive than hospital care, where resources can be concentrated? Not so—at least not necessarily so. Some concentration of resources can take place in the community in day hospitals and mental illness hostels. It is also true that the ‘bed and breakfast’ element of inpatient care is expensive, if the running and maintenance costs associated with deploying inpatient psychiatric services are taken into account. In most studies, costs of each type of service doesn’t differ much, and sometimes good community care turns out cheaper.,
3
Surely there will be more homicides and suicides if disturbed patients are not kept in hospital? Offending by the mentally ill is of great public concern (60 homicides/yr in England). A cohort study however found rates of violent offending are low and the strongest association with offending was previous offending. Psychiatric variables were less important, with diagnosis and number of previous admissions showing no significant association. Substance misuse and sexual abuse are associated with increased offending risk.
4

Surely if inpatient psychiatric beds are not available, however good the daytime team is in the community, some patients will still need somewhere to go at night? The implication is that the skills available in bed-and-breakfast accommodation may be inadequate at times of day when there is no other support, other than the general practitioner. Studies that have looked at this have certainly found an increase in non-hospital residential care in those selected for community care, and this increase may be as much as 280% over 5yrs. In the uk, new proposals guarantee 24-hour open access to skilled help, but it is not known what pressures this will put services under.

5

Surely community care will involve a huge bureaucracy in pursuit of the unattainable goal of 100% safety? This will be so if every patient has a lengthy care plan and repeated risk assessments. Concern for safety may also spawn a non-therapeutic custodial relationship.

Advantages reported for community care are: better social functioning, satisfaction with life, employment, and drug compliance—but in randomized studies in the uk these advantages are not always manifest. Furthermore, trends have been repeatedly found indicating that the longer studies go on for, the harder it is to maintain the initial advantages of community care. If it is hard for teams to keep up their enthusiasm during a trial, it will probably be even harder when the trial period has ended, or when team members are ill. These constraints may in part explain the observation that with inadequately funded and supervised community care, patients can fail to get essential services, and when hospitals are being run down, and a patient’s condition worsens, so that ‘sectioning’ followed by admission becomes impossible, the patient is left in the community ‘rotting with his rights on’. Assertive community care and case management is one way out of this impasse (here a key-worker has direct responsibility for care plans). This set-up helps ensure more people remain in contact with psychiatric services (nnt=15); this inevitably increases hospital admission rates., When combined with family therapy and social skills training results are good.
Social deprivation is positively associated with premature mortality, and poverty makes almost all diseases more likely (but not Hodgkin’s disease, eczema, bulimia, or melanoma). See Health and social class, p463. In the uk, the number of homeless people is 1–2 million. >30% suffer from mental illness (10% have schizophrenia), most do not know where to go for help, and most have no doctor. A 3-tier strategy may help.
1

Emergency shelters

2

Transitional accommodation

3

Long-term housing.

The cost in health terms to society and the individual is enormous. Diseases and symptoms such as diarrhoea, which may pass as a minor inconveniences to the well-housed, may be a major hurdle for the homeless, with severe social and psychological effects. Capture–recapture techniques show that the unobserved population of the homeless is about twice that observed. This method of enumeration collects samples (lists) and looks for tags (duplicates) in subsequent counts, and from this determines the degree of under-counting. If all in the subsequent count are duplicates, then there is no underestimate of the original count. Statistical techniques can allow for migration in and out of the population area. These studies show that psychiatric morbidity is greatest in the observed homeless populations: the implication is that the psychiatric illness makes these people more ‘visible’.

In the uk, as in many other Western countries, what started out as an enlightened policy of looking after people with mental health problems in the community (p405) has resulted in large numbers of psychiatric patients living on the street in great poverty—relieved by occasional admissions to often overcrowded acute units. This ‘revolving door’ model of care has failed many patients, not least because continuity of care is compromised.

One way to tackle poverty is to pay people not to be poor: in the 1990s, in Singapore, poor families were paid SP$26,400 over 20yrs if they had ≤2 children. But economic success in Singapore evolved independently from this idea which was perhaps too Quixotic (ie innocently impractical, see box).

is an income-related (means-tested) benefit paid to those who do not have enough money to live on. Income is subtracted from a standard fixed income level (the ‘applicable amount’), and the difference is the amount of Income Support payable. The person’s capital is also taken into account. Income Support is a non-contributory benefit. This means that a person does not have to have paid any National Insurance contributions in order to qualify for Income Support. The rates of Income Support are fixed each year by government and are usually increased every April. Income Support acts as a ‘passport’ to certain other help. A claimant and her/his partner will automatically qualify for:

Free school meals

Free prescriptions

Free dental care

Vouchers for spectacles

Free milk and vitamins for expectant mothers and children under 5

Free vitamins for nursing mothers

Maximum housing benefit

Maximum council tax benefit.

There is no evidence that simply living in a deprived area makes a person more prone to illness and death. All the excess mortality and morbidity is explained by the person being poor. Their immediate neighbours who are not poor do not share the same risk. So we need to target care at poor people wherever they live, not at poor areas.

Two contrasting ideas:

1

The economic arguments for keeping non-violent mentally ill criminals out of prison and rehabilitating them are self-evident.

2

Prison provides an ideal opportunity to treat people who are mentally ill who might otherwise be hard to reach. They should have optimum treatment to improve their quality of life, as well as to lessen the risk of reoffending.

Nobility and mental illness: Don Quixote takes on all comers

graphic

‘The innkeeper acquainted all in the inn with the lunacy of his guest (Don Quixote), about his standing vigil over his armour and the knighting he expected. They marvelled at so odd a form of madness and went to watch him at a distance, and saw that with a serene expression he sometimes pranced to and fro; at other times, leaning on his lance, he turned his eyes to his armour without turning them away for a long time. Night had fallen; but the moon shone with such a lustre as might almost vie with the sun who lent it; so that everything our new knight did was seen clearly by everyone. Just then it occurred to one of the mule-drivers in the inn to water his pack of mules, and for this it was necessary to move Don Quixote’s armour, which was on the trough; our knight, seeing them approach, called in a booming voice:

“Oh thou, whosoever thou art, reckless knight, who would touch the armour of the most valiant knight whoever took up arms! Take heed what thou doest, and touch it not, unless thou wouldst pay for thy audacity with thy life.”

The muleteer cared not a jot for this reasoning—it would have been better for him if he had, for it meant caring for his health. Instead, picking the armour up by the straps, he tossed it a good distance. And seeing this, Don Quixote lifted his gaze to the skies and, turning his thoughts (as it seemed) to his lady Dulcinea, he said:

“Help me, my lady, in this the first insult aimed at this thy servant’s breast; in this my first crisis let not thy grace and protection fail me.”

And, continuing this line of argument, and dropping his shield, he raised his lance in both hands and gave the mule-driver such a clout on the head as to demolish him; if this first blow had been followed by a second, he would have had no need for a doctor (‘maestro’) to cure him. Having done this, Don Quixote picked up his armour and began to pace again with the same gravity as before. A short time later, unaware of what had happened—for the first mule driver lay stunned—a second approached, also intending to water his mules, and when he began to remove the armour so as to get to the trough, without so much as a by-your-leave or even a word, Don Quixote let slip his shield and raised his lance, and without quite reducing the second mule-driver’s head to smithereens, he thrice sliced it, fracturing the skull in four places. When they heard the noise, all the people in the inn hurried over, among them the innkeeper. When he saw this, Don Quixote took up his shield, placed his hand on his sword, saying:

“Oh queen of beauty, whose spark and fire warms the sickness in my heart (debilitado corazón mío)! From your greatness, it is time that you do bend your eye on this thy slavish knight, who expects so vast an exploit.”

And with this he acquired, it seemed to him, so much courage, that if all the mule-drivers in the world charged him he would never retreat one step. The wounded men’s comrades, seeing their two fallen friends, began to rain stones down on Don Quixote, and he did all he could to deflect them with his shield, not daring to move away from the trough and leave his armour unprotected. The innkeeper implored them to stop as he had already told them the knight was mad, and whatever the number of deaths no wind of blame could ever extinguish his innocence.’
Don Quijote de la Mancha by Miguel de Cervantes 1547–1616; see translations by Shelton (1605), Grossman (2003, HarperCollins) & Jarvis (oup) chapter 3 (p33–5).
graphicWe present the idealistic knight-errant who teaches us to value the very things he is deluded by: heroism and valour.
Risk of major depression is 3-fold that of those with no recent pregnancy. Causes: social circumstances; sleep deprivation; genetic; hormonal change.graphic

Although most postnatal depression resolves in ≲6 months, don’t put off treatment, and just hope for the best.

For the patient, 6 months is a long, long time.

For the infant, 6 months is more than a long time: it’s literally an age.

Suicide is a waste, but for a young family, a mother’s suicide is especially destructive—unthinkable, indeed, for those who have not experienced it.

Postnatal depression impairs infant cognitive and social skills.,
“I had the normal baby blues in the 1st couple of weeks following his birth. I was weepy at the drop of a hat, recovering quickly after a good cry. Often I would gaze at my son, crying from pure joy. But then things changed…I began to look at him and feel absolutely nothing. An empty void. Then the visions started. I would be holding him and see, in my mind, him alone in the woods as it snowed around him, crying for help that never came. The vision was overpowering, and I wept for that baby lost in the woods. I swore that I would never do such a thing but it seemed a betrayal of him just to see that image, which haunted me endlessly. I had difficulties with breastfeeding and took it as a sign that I was failing as a mother. That, the awful vision, and anything that went the slightest bit wrong, only solidified my conviction that I should never have been given charge of this tiny, precious life. I would lie awake at night, listening to him breathe, afraid that if I nodded off he might die. But I also daydreamed endlessly about how nice life was before being a mother. Often I wished desperately that I could just give him back, then hated myself.”
graphicHave a low threshold for referring to multidisciplinary teams in mother-and-baby units. The first step is to try not to be caught unawares by a major depression that apparently strikes like a bolt from the blue, but which, in reality, has been building up over time. Pregnancy and infant–motherhood is supposed to be a time of unclouded joy. We often collude with this view. We are always hearing ourselves saying: “Oh Mrs Salt, what a lovely baby! You must be so pleased—and you always wanted a little boy. We are so delighted for you…” But what if she is not delighted? She hardly dares confess her traitorous thoughts that she is unaccountably sad, that she spends the nights crying, and that her exhausted days are filled with a sense of foreboding that she or some other agency will harm the child. The place to start to pre-empt these feelings is in the antenatal clinic. graphicInvolve fathers; explain: “When the baby comes you’ll need help and rest—don’t think you can do it all yourself: become a team—eg taking turns in getting the baby off to sleep”. In the puerperium give permission for the new mother to tell her woe. When this is revealed, counselling, and input from a health visitor and a psychiatrist is wise, as is close follow-up. You may need to arrange emergency admission under the Mental Health Act: but the point of being prepared for postnatal depression is to avoid things getting this bad. Interventions for persistent depression need to address relationship difficulties as well as depressive symptoms.
Short-term, fluoxetine is as good as cognitive-behaviour therapy. More trials with longer follow-up are needed to compare drugs and psychotherapy. Although all antidepressants are excreted in breast milk, tricyclics and ssris are rarely detectable by standard tests. Observe babies for possible ses; it may be best to stop breastfeeding if large doses are used.
Adding lithium (p354) or ect may help. Evidence on oestrogen is conflicting (use is non-standard)—dose example: 3 months of transdermal 17β-estradiol (200μg/day) for 3 months on its own, then with added dydrogesterone 10mg/day for 12 days each month for 3 more months. ci: uterine, cervical, or breast neoplasia; past thromboembolism/thrombophlebitis; breastfeeding.
Edinburgh postnatal depression scale (epds)542,551

1  I’ve been able to laugh … see the funny side of things:

As much as always could

Not quite so much now

Definitely not so much

Now not at all

2  I’ve looked forward with enjoyment to things:

As much as I ever did

Rather less than before

Definitely less than before

Hardly at all

3I’ve blamed myself unnecessarily when things went wrong:

 

Yes, most of the time

Yes, some of the time

Not very often

 

No, never

4  I’ve been anxious or worried for no good reason:

No, not at all

Hardly ever

Yes, sometimes

Yes, very often

5  I’ve felt scared/panicky for no very good reason:

Yes, quite a lot

Yes, sometimes

No, not much

No, not at all

6Things have been getting on top of me:

Yes, most of the time I haven’t been able to cope at all

Yes, sometimes I haven’t been coping as well as usual

No, most of the time I have coped quite well

No, I have been coping as well as ever

7I’ve been so unhappy that it is difficult to sleep:

Yes, most of the time

Yes, sometimes

Not very often

No, not at all

8I’ve felt sad or miserable:

Yes, most of the time

Yes, quite often

Not very often

No, not at all

9I’ve been so unhappy that I’ve been crying:

Yes, most of the time

Yes, quite often

Only occasionally

No, never

10Thoughts of harming myself have occurred to me:

Yes, quite often

Sometimes

Hardly ever

Instructions Underline what comes closest to how you have felt in the last 7 days.

Never

1  I’ve been able to laugh … see the funny side of things:

As much as always could

Not quite so much now

Definitely not so much

Now not at all

2  I’ve looked forward with enjoyment to things:

As much as I ever did

Rather less than before

Definitely less than before

Hardly at all

3I’ve blamed myself unnecessarily when things went wrong:

 

Yes, most of the time

Yes, some of the time

Not very often

 

No, never

4  I’ve been anxious or worried for no good reason:

No, not at all

Hardly ever

Yes, sometimes

Yes, very often

5  I’ve felt scared/panicky for no very good reason:

Yes, quite a lot

Yes, sometimes

No, not much

No, not at all

6Things have been getting on top of me:

Yes, most of the time I haven’t been able to cope at all

Yes, sometimes I haven’t been coping as well as usual

No, most of the time I have coped quite well

No, I have been coping as well as ever

7I’ve been so unhappy that it is difficult to sleep:

Yes, most of the time

Yes, sometimes

Not very often

No, not at all

8I’ve felt sad or miserable:

Yes, most of the time

Yes, quite often

Not very often

No, not at all

9I’ve been so unhappy that I’ve been crying:

Yes, most of the time

Yes, quite often

Only occasionally

No, never

10Thoughts of harming myself have occurred to me:

Yes, quite often

Sometimes

Hardly ever

Instructions Underline what comes closest to how you have felt in the last 7 days.

Never

Ask to score answers 0, 1, 2, or 3 according to increased severity; some (★above) are reverse scored (3, 2, 1, 0). Add scores for 1–10 for the total. Let her complete the scale herself, eg at the 8-week check-up, unless literary difficulty. graphicA score of 12/30 has a sensitivity of 77% for postnatal depression (specificity: 93%).

Never trust this sort of thing totally! ~40% lie on the form, being afraid that health visitors would call in social services (± removal of baby).

is not very good; in one study; face-to-face detection may be better.1
A longitudinal study over 11 years shows that a good clinical interview (in contrast to the epds) can identify mothers whose children are at an ⬆risk (4-fold) of developing psychiatric disorder in later childhood.
Notes

graphicRead this chapter with dsm-v: a diagnostic and statistical manual that codifies all mental illness, but note that this flawed book ignores the social context of symptoms, and over-medicalizes them.

We thank Dr Anish Patel, our Specialist Reader, and Dr Rashmi Singh, our Junior Reader, for their contribution to this chapter.

graphic The external recipe for happiness. stable family life + a good marriage + more wealth than your neighbours (absolute wealth is irrelevant)

+ health + a cohesive trusting community. The internal recipe is elusive.

Logotherapy, Shakespeare, and healing through meaning… “razing out the written troubles of the brain and other rooted sorrows”—Macbeth

Don’t exhaust your patient by ordering every possible test!

3 millennia of failed explanations…from the blogsphere: When the voices take over I call it “gettng posessed”. Thephining is not the way out

After 236 sessions with Joyce the therapist strikes gold, but…oh boy! Joyce had to pay for it!

1

Do our sufferings make us more human? Only if we can breathe meaning into them. Toothache doesn’t make us more human because it has no meaning beyond the obvious and banal; but there is a kind of suffering ‘which is a more effective key, a more rewarding principle for exploring the world in thought and action than personal good fortune’. (Deitrich Bonhoeffer). This suffering makes our souls. Not all our patients regret their psychological illnesses: sometimes, in retrospect, these patients refer to their break through, not their breakdown. It is this power to grow and to transform experience which is human and humanizing. This is also why, paradoxically, illness is not the opposite of health. For humans, the true opposite to health is being stuck In Status Quo—that state which brooks no development. So if you find yourself writing isq (in status quo) in patients’ notes you are invoking a kind of death.

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‘The moment I put my foot on the step the idea came to me without anything seeming to have paved the way for it, that the transformations I’d used to define the Fuchsian functions were identical with those of non-Euclidean geometry…the idea came with…suddenness, and immediate certainty.’

A Koestler The Act of Creationreference

2

If psychiatrists have no authority to cure us of our life-lie (livslognen),

who has? Only dramatists who com bine tragedy with comedy to awake us from our sleepwalking, and inoculate us against self-contempt.
Ibsen The Wild Duckreference

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Moderate cannabis use ⬆ risk of psychotic symptoms in young people but has a much stronger effect in those with a pre-existing predisposition to psychosis.

,High-yield cannabis (‘skunk’) can cause thought broadcasting, paranoia, depersonalization & visual/auditory hallucinations.

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Tout comprendre c’est tout pardoner—‘To understand all is to forgive all’. I have found it necessary to inscribe this phrase around the bell of my stethoscope. This bell then tolls in my mind’s ear whenever my patient is making me angry or despairing—in other words whenever I have not understood. ‘ Tout comprendre c’est tout pardoner’ is the most magnanimous phrase ever created, and was first promulgated by Madame Anne Louise Germaine de Staël: “ tout comprendre rend très indulgent”—”To understand all is to become very lenient.”

The phrase was stolen by Tolstoy in the last chapter of Book 1 of War … Peace. Can we forgive this theft? Of course; not just because the theft gave anonymous immortality to Madame de Staël, but because Tolstoy probably needed to believe he had created it to sustain him in the illusion of his own infallible magnanimity, without which his great literary enterprise would have been impossible.  Vive nos illusions: Vive nos illusions magnifique!

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The converse of this aphorism is the Parris dictum: “When people are anxious it isn’t clever to make a virtue of listening. Sometimes our patients simply need to be told.” Sometimes they need space for selfexpression. Which approach is right—when? We only know this by knowing our patients: this entails listening, which is why, 9 times out of 10, Storr is right: but 9 out of 10 is not always.

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graphic  Narcissism+paranoia ≈“authoritarian”. When paranoid, antisocial, narcissistic, schizoid, and schizotypal elements conjoin with sadism we have a perfect storm (Hitler, Stalin, Saddam Hussein, Kim Jong-iletc are such examples). As ever, if you identify this combination, get senior help (from the Royal Navy? or the Pope? or John Lennon?).

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Schizotypal ≈ the socially anxious, friendless loner with magical thinking, odd fantasies ± clairvoyance.

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Parallax=apparent angular displacement of a celestial body due to a change in the position of the observer. With a baseline of known length between 2 observations, the distance to the object becomes known.

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Tai Chi in Confucian philosophy is the mother of yin and yang, the Supreme Ultimate Fist which transcends and harmonizes those ‘internal necessities in our our being’ which forever drive us on.

Herman Melville Moby Dick Ch 36reference

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Hypnotic phenomena share features with conversion (hysterical) symptoms, eg lack of concern, involuntariness with implicit knowledge, and a compliant tone (la belle indifference). Theories of consciousness postulate an altered relationship between self-awareness and the supervisory attentional system in both conditions (fontal and cingulate cortex are implicated).

Most subside spontaneously, but if they do not it is important to refer early to a psychiatrist, before associated behaviour becomes habitual.

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graphicPoets, medical students (such as John Keats) and other harmless or immortal romantics tend to favour midnight as the proposed time for self-destruction: see p553 for Keats’ midnight death wish “to cease upon the midnight with no pain.” For once, Keats was wrong: just before lunch is in fact the favoured time for suicide (11am) in some communities.

The safest time is 4–8am. We should pay no attention to the phase of the moon: day of the week is much more important (Mondays are fatal).

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Once a person has self-harmed, the risk of death by suicide rises by a factor of 50–100. BMJ 2011 1167

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Suicide is powerful: Mohammed Bouazizi (a poor street vendor in Sidi Bouzid, Tunisia) set himself alight after humiliation by an official wanting a bribe, on Dec 17 2010, so sparking the demise of 4 Arab dictators.

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Use clinical judgment and assessment tools: medscape.com/viewarticle/730857_5?src=emailthis

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graphicIf in doubt about the energy with which we may pursue our own destruction,let us call to mind a notable Japanese pilot who, during World War II, persistently volunteered to be a Kamikazi pilot to run suicide missions against US ships, in the defence of Okinawa. The authorities just as persistently refused his request—he had a wife and 3 daughters. He kept on reapplying, determinedly. Not wanting to risk her husband’s failure again, and not wanting to stand in Destiny’s way, his wife killed their 3 daughters, and then herself, so removing the obstacle to her husband’s mission—and on May 28, 1945, he finally took to the air, and achieved his end.

2

nice says: ‘the decision to discharge a person without follow-up after an act of self-harm shouldn’t be based solely on the presence of low risk of repetition of self-harm and the absence of a mental illness, because many such people may have a range of other social and personal problems that may later increase risk. These problems may be amenable to interventions’.

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snri = serotinin and noradrenaline reuptake inhibitor. Avoid if bp⬆, u&e⬆⬇, or heart disease. Specialist use only if >300mg; monitor bp if on >200mg/day. Starting dose: 37.5mg/12h po. se: Constipation; nausea; dizziness; dry mouth; bp⬆; adh⬆; Na⬇; T°⬆; dyspnoea, hallucinations, arthralgia etc: see bnf.

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Had Rockland asylum banned witnessing ect, the greatest poem extolling the humanity of mental illness vs military-industrial greed could not have arisen. Carl Solomon’s post-ect babble flowed directly into Allen Ginsberg’s Howl: “I saw the best minds of my generation destroyed by madness, starving hysterical naked, dragging themselves through the negro streets at dawn looking for an angry fix, / Angelheaded hipsters burning for the ancient heavenly connection to the starry dynamo in the machinery of night… I’m with you in Rockland in my dreams you walk dripping from a sea-journey on the highway across America in tears.”

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⋆“Men do not care how nobly they live, but only how long, but it is within the reach of every man to live nobly, but within no man’s power to live long. ⋆Life without the courage for death is slavery. ⋆Most powerful is he who has himself in his own power. ⋆Toil to make yourself remarkable by some talent or other. ⋆Fire is the test of gold; adversity, of strong men. ⋆There is no great genius without some touch of madness.”

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The Papez circuit of emotion runs from the hippocampus to the amygdala and thence to serotonergic pacemaker cells in the dorsal raphe nucleus (drn).graphic The drn projects to the dentate gyrus directly and indirectly via pacemaker cells in the entorhinal cortex. The direct route promotes neurogenesis in the dentate; the indirect route has 2 purposes: to imprint ongoing moments of consciousness onto new dentate cells for retention as memory, and to provide –ve feedback for regulation. Pathologic overdrive of the drn causes overdrive of the entorhinal cortex, which leads to excitotoxic cell death of neurons in the hippocampus involved in the –ve feedback loop. The disinhibited amygdala and drn then orchestrate the syndromes of chronic stress. Recovery from chronic stress requires repopulating the dentate gyrus and restoring the feedback loop.

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Anorexics possibly differ from others in being unable to adapt to corticotrophin releasing factor (crf) elevations. Signs of crf dysfunction and hpa-axis hyperactivity: ⬆physical activity, ⬇reproductive hormones, ⬇sexual behaviour, amenorrhea, hypotension, bradycardia, anxiety, ⬇social interaction, ⬆vigilance, ⬇immune system function, ⬇food intake, impaired weight gain, affecting both energy intake and utilization.

2

Screen if bmi⬇; amenorrhoea; poor growth if >8yrs; unexplained vomiting; poorly-compliant type 1 dm.

3

Parents describe parent-to-parent consultations as an intense emotional experience that helps them to feel less alone, to feel empowered to progress, and to reflect on changes in family interactions.

4

If hypersomnia, hyperphagia, and hypersexuality are features, suspect the Kleine–Levin syndrome.

1

DaTSCAN comprises ioflupane labelled with radioactive iodide. It is injected during spect imaging to detect loss of dopaminergic neuron terminals in the striatum. Specificity in Lewy body dementia: ~100%.

2

Supported by the Alzheimer’s Soc. (if it’s not a substitute for 1st class care); restraint is unacceptable.

1

Social Servicesuk often refuse 24h help saying that needs aren’t complex enough; Courts may reverse this.

2

Ineligible if: receiving state pension; <35h of care/wk; income >£95/wk after tax; a full-time student.

3

Real hypersexuality (libido⬆) is rare. Most inappropriate sexual behaviors are related to disinhibition or lack of taking into account contextual environment and feelings of others.

1

0.8mg folic acid, 0.5mg vit B120 + 20mg vit B6 /day po ⬇mild cognitive impairment (mci) if baseline homocysteine >11μmol/l. b vitamins also ⬇ rates of mri brain atrophy in mci (Celeste de Jager’s vitacog trials).

1

A counter argument from the periodically depressed poet Thomas Krampf: “one can have a vision but no vision is worth anything if one is too sick to implement it”—and many writers have found their creativity flourish more when treatment is underway. M Berlin 2008 Poets on Prozac, Baltimore.

1

Narcissus was the 1st celebrity to be famous just for being beautiful. He carelessly spurned all lovers, including Echo. Mortified by his callousness, all but her voice was consumed by grief. This disembodied voice now repeats for us the 3 cardinal facts about narcissists:

They never understand others.

Loving a narcissist is a recipe for death.

If you manage to escape death, your narcissistic lover may blame you for his death; analysis of suicide notes reveals a class of suicides whose final act is to blame their lovers. To help these characters outgrow narcissistic resentments, we may confront their illusions. This is powerful but dangerous. Narcissus discovered the torment of unrequited love only after falling in love with his own image as glimpsed in a pool. As often as he stoops to kiss it, so it fragments and vanishes. Dying of lovesickness, he gains insight into others’ pain, whereupon he morphs into a handsome daffodil with a superb scent, which, to this day, blows to us each spring from Arcadia.See Ovid & J Holmes Narcissism Icon Books

2

Attention deficit hyperactivity disorder (adhd, p212) is increasingly recognized in adults, often with oppositional defiant disorder. Exercise regimens and methylphenidate may help.

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dspd: give something an acronym and it half exists. Add an nnt (~5!) and the trick is done; we rush to memorize, categorize and research it. To study its causes perhaps we should confront our imagined worlds of myth, language, legalisms, and pure and impure invention, rather than value-free biological or mental health categories. But to be thoroughly sceptical about this scepticism: show us any value-free construct.

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Antilibidinal drugs may ⬇testosterone to young-boy levels—but risk liver damage, breast growth, hot flushes, depression and ⬇bone density, eg oral cyproterone acetate (Androcur®). Long-acting drugs (leuprolide, goserelin, triptorelin) can be injected and may be better. ssris are sometimes used (unreliably) to ⬇libido and sexual preoccupation and compulsive re-offending.

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Further reading: I Levi Basic Notes in Psychotherapy, Petroc Press isbn 1-900603-50-0

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Miriam was the threshing-floor on which he threshed out all his beliefs. While he trampled his ideas upon her soul, the truth came out for him…because of her, he gradually realized where he was wrong. And what he realized, she realized.’DH Laurence p227 of Sons and Lovers But Lucy was mute. Can it be worth taking such a patient to group therapy? Mira accused her of not pulling her weight—this was unhelpful—but another group member piped up with something like “You can be in another world where there’s too much space and meaning to speak…she can only hear your complaining like dead leaves rustling. What you say may have force here… not where she is…listen to her silence.”AS Byatt 2003 p77 of A Whistling Woman

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See Sylvia Plath 1963 A Birthday Present in Ariel, Penguin, 50

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bmj 2002; 325: 722.1. Good doctor, bad doctor—a psychodynamic approach; Jeremy Holmes (whom we thank for permission to quote from his excellent article).

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Abreaction: cathartic reliving of buried traumas; repressed terrors are made conscious and tamed.

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Projecting our own undesirable impulses to another, so pretending that the subjective is objective.

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Displacement: redirection of an undesired intense emotion towards someone neutral and harmless.

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Reaction formation: doing the opposite of true desires (eg training to be a pilot to cover up fear of flying).

5

In sport, for example, we sublimate (and make safe) brutal urges into rituals of formal competition.

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cat is collaborative programme for looking at the way a person thinks, feels and acts, and the events and relationships that underlie these experiences (often from childhood or earlier in life). It combines understandings from cognitive psychotherapies and psychoanalytic approaches into an integrated whole.

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A Based on a consistent finding in a majority of studies in high-quality systematic reviews or evidence from high-quality studies. B Based on ≥1 high-quality trial, a weak or inconsistent finding in high-quality reviews or a consistent finding in reviews that don’t meet all the high-quality criteria. C Based on evidence from single studies that don’t meet all the criteria of ‘high-quality’. D Based on evidence from structured expert consensus.

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All constructed identities are fakes, adult or adolescent, but in adulthood we have more time to reassemble our selected fakes into coherent patterns. For this reason adults are not simply burnt-out adolescents.

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In narcolepsy we succumb to irresistible attacks of inappropriate sleep ± vivid hallucinations, cataplexy (sudden hypotonia), and sleep paralysis (box 2). Mutations lead to loss of hypothalamic hypocretin-containing neurons, via autoimmune destruction. hla dr2+ve. graphic:

Methyl-phenidate, 10–15mg po after breakfast and lunch) may cause dependence and psychosis

Modafinil (~200mg/d po, before noon; se: anxiety, aggression, dry mouth, euphoria, insomnia, bp⬆, dyskinesia, alk phos⬆

Gamma-hydroxybutyrate (ghb).

2

Sleep-related dissociative disorder, sleep enuresis, exploding head syndrome, hypnagogic or hypnopompic hallucinations, catathrenia (end-inspiratory apnoea + groaning), sleep-related eating disorders, drug-induced parasomnias, myoclonus nocturnus; nocturnal bruxism, ie teeth grinding..

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There is overlap with: Asperger’s; multiple complex developmental disorder; schizoaffective disorder.

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Punking is male-on-male violence, humiliation, and shaming to affirm masculinity, toughness, dominance and control.

When boys who believe they merit privilege are instead harassed or called gay, they can be driven to avenge ‘wrongs’, and assert a victorious masculinity. Mass shootings may result.

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Un arc-en-ciel étrange entoure ce puits sombre, Seuil de l’ancien chaos dont le néant est l’ombre Spirale engloutissant les Mondes et les Jours!

graphicTranslation ©JML

Around this tunnel plays a strange rainbow arc On the edge of primeval chaos whose hollow form is the spiral dark That swallows up Worlds and Days!

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This Act operates in England; Scottish law is different. The situation in the uk is changing and these pages should be read along with current legislation in the area where you are working.

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High rates of postnatal relapse occur if past psychosis, perhapsgraphic triggered by postdelivery fall in estrogens, causing dysregulation of cns dopaminergic systems. Oestrogens may not prevent this, but of the 40% of women relapsing, those on the high doses of estradiol (800μg/day) need less psychotropics, and are discharged sooner than those on low doses.

Methodological problems abound in this area.

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