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Aims Among patients with myocardial infarction (MI) with preserved left ventricular ejection fraction (LVEF), the REDUCE-AMI trial did not demonstrate a benefit of beta-blocker vs. no beta-blocker treatment on all-cause mortality and recurrent myocardial infarction. The aim of this pre-specified sub-study was to ...

Aims Chronic coronary syndromes (CCS) occur commonly in the absence of flow-limiting epicardial coronary stenosis. Ischaemia or angina with non-obstructive coronary arteries (INOCA/ANOCA) may be caused by coronary microvascular disease, coronary artery spasm, myocardial bridging, diffuse atherosclerosis, or a combination ...

Drawing on expert consensus 1 and two recent prospective studies, 2 , 3 current ESC heart failure guidelines recommend a natriuresis-guided approach to decongestion in Acute Heart Failure (AHF). 4 Some experts have questioned this practice. 5–7 To shed light on these contrasting viewpoints, we brought together ...

Aims The diagnostic criteria for Type 2 myocardial infarction identify a heterogeneous group of patients with variable outcomes and no clear treatment implications. We aimed to determine the implications of a new clinical classification for myocardial infarction with more objective diagnostic criteria using cardiac ...

Aims Closing the evidence-practice gap for the treatment of acute coronary syndrome (ACS) is central to improving quality of care. Under the European Society of Cardiology (ESC) framework, we aimed to develop updated quality indicators (QIs) for the evaluation of quality of care and outcomes for patients with ACS. Methods ...

Aims The long-term effects of early left ventricular (LV) unloading after venoarterial extracorporeal membrane oxygenation (VA-ECMO) remain unclear. Methods and results The EARLY-UNLOAD trial was a single-centre, investigator-initiated, open-label, randomized clinical trial involving 116 patients with cardiogenic shock ...

Left ventricular thrombosis (LVT) is a severe complication that often arises in patients with left ventricular systolic dysfunction, particularly within 1–14 days after a ST-segment elevation myocardial infarction (STEMI), and is associated with increased risks of stroke, embolization, and mortality. 1 , 2 Despite ...

Aims B-type natriuretic peptide (BNP) and mid-regional pro-atrial natriuretic peptide (MR-proANP) testing are guideline-recommended to aid in the diagnosis of acute heart failure. Nevertheless, the diagnostic performance of these biomarkers is uncertain. Methods and results We performed a systematic review and individual ...

Prof. Dr Filippo Crea An interview with Prof. Filippo Crea Optimal diagnosis and treatment of patients with acute or chronic chest pain are an important and sometimes challenging task for every cardiologist. To emphasize the underlying mechanism of myocardial ischaemia rather than focusing only on epicardial obstruction, ...

Global warming, driven by increased greenhouse gas emissions, has led to unprecedented extreme weather events, contributing to higher morbidity and mortality rates from a variety of health conditions, including cardiovascular disease (CVD). The disruption of multiple planetary boundaries has increased the probability of ...

Descriptions of acute myocardial infarction (MI) in the medical literature date back to the 19th century, with taxonomy and diagnostic criteria evolving since that time. 1 One example of this evolution is the discovery and development of assays for detecting cardiac troponin (cTn) allowing for the identification of an ...

Aims The Shock Academic Research Consortium (SHARC) recently proposed pragmatic consensus definitions to standardize classification of cardiogenic shock (CS) in registries and clinical trials. We aimed to describe contemporary CS epidemiology using the SHARC definitions in a cardiac intensive care unit (CICU) population. ...

Aims The impact of systemic inflammation in acute myocardial infarction complicated by cardiogenic shock (AMI-CS) is still a matter of debate. The present ECLS-SHOCK sub-study investigates the association of C-reactive protein (CRP) levels with short-term outcomes in patients with AMI-CS. Methods and results Patients with ...

Aims Microaxial flow pump and venoarterial extracorporeal membrane oxygenation (VA-ECMO) are increasingly used in infarct-related cardiogenic shock. This study provides a comparative overview of real-world resource utilization associated with these devices (PROSPERO: CRD42024505174). Methods and results EMBASE, MEDLINE, ...

Aims Acute pulmonary embolism (PE) increases pulmonary pressure and impair right ventricular (RV) function. Echocardiographic investigation can quantify this mismatch as the tricuspid annular plane systolic excursion (TAPSE) to pulmonary arterial systolic pressure (PASP) ratio. The aim of the study was to investigate the ...

Cardiogenic shock is a life-threatening condition characterized by inadequate cardiac output, leading to end-organ hypoperfusion and associated mortality rates ranging between 40 and 50%. The critical role of microcirculatory impairments in the progression of organ failure during shock has been highlighted in several ...

Inflammation reduction with low-dose colchicine and canakinumab has been shown to lower the risk of cardiovascular (CV) events in three large trials, both in patients with chronic coronary disease and after myocardial infarction (MI). 1–3 The effects of colchicine in a CV trial conducted during the COVID-19 pandemic are ...

Aims This prospective, two-centre study derived and validated predictive algorithms for the Siemens Atellica IM high-sensitivity cardiac troponin I (hs-cTnI) assay in the emergency department (ED). Methods and results Algorithms for predicting 30-day myocardial infarction (MI) Types 1 and 2 and death or non-ST-elevation MI ...

Eligible patients met the following inclusion criteria: Selected exclusion criteria are as follows: Heart failure in the past 2 years and/or LVEF < 40%, new ACS in the past 6 months, episode of arrhythmia requiring beta-blockers in the past year, current angina or ischaemia requiring beta-blockers, and pregnant or ...

Aims Mortality in patients with acute myocardial infarction-related cardiogenic shock (AMICS) is high, but a widely accepted tool for individual risk assessment is lacking. A reliable prediction model could assist in clinical decision-making, patient selection for clinical trials, and comparison of AMICS populations. ...