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Wherever the art of medicine is loved, there is also a love of humanity.
Hippocrates
Over the past several decades, knowledge regarding the pathobiology of thrombotic cardiovascular disease has substantially increased. The crux of ischaemic vascular disease is well established to be a complex interplay of atherosclerosis, inflammation, and thrombosis. The understanding of venous thromboembolism, hypercoagulable states, and atrial fibrillation has also witnessed impressive progress, and these disorders have become important areas of investigation with translation into several aspects of clinical medicine. At the same time, the number of therapeutic agents that have become available has dramatically increased, in parallel with the discovery of new biological targets and pathways.
We have undertaken this textbook edition keeping in mind the marked evolution in our understanding of the pathobiological background of thrombosis as well as the tremendous growth in therapeutic options. We edited a first edition of this textbook (Therapeutic Strategies in Thrombosis, by Clinical Publishing) in 2006 and a second edition (Therapeutic Advances in Thrombosis, by Wiley-Blackwell) in 2012. The expansion in the number of available intravenous and oral antithrombotic agents has been particularly remarkable in recent years: direct and specific coagulation factor inhibitors, as well as new antiplatelet agents have been developed and are quickly finding their place in daily practice. In creating a third textbook edition, now endorsed by the European Society of Cardiology (ESC) and the ESC Working Group on Thrombosis, we have partnered with expert authors globally for a complete rewriting of chapters. The book includes 30 chapters and is divided into four key sections: pathophysiology of thrombosis, clinical pharmacology of antithrombotic drugs, therapeutic strategies, and special situations. The chapters address virtually all thrombotic and antithrombotic aspects of atherosclerotic disease, venous disease, valvular and structural heart disease, and atrial fibrillation. Great efforts have been made to present contemporary data on each of these topics, emphasizing the newest developments (‘What’s new’), providing practical guidance by including ESC Guideline recommendations, and summarizing foreseeable developments (‘What’s next’). In an era of rapid access to online information and declining attention to hardcover books, we believe that a comprehensive effort to put together the best and most up-to-date knowledge in an important therapeutic area is needed, worthwhile, and welcome.
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