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Abstract

The pathogenesis of atherosclerosis has an inflammatory component that is deemed to play an important role in the development of alterations in the vessel wall, ultimately resulting in plaques and other abnormalities that narrow the artery's lumen. The extent and the speed of development of this inflammatory component is currently thought to be largely modulated by cytokines and growth factors. Among all classes of dietary unsaturated fatty acids studied so far, only omega-3 fatty acids down-regulate ex vivo expression of PDGF-A, PDGF-B and MCP-1 in mononuclear cells. This down-regulation persists despite stimulation/differentiation of these cells by adherence. The down-regulation is specific and selective for PDGF-A, PDGF-B and MCP-1, which are thought to promote atherogenesis. This was found to be reflected in a reduced progression/increased regression of coronary lesions in a coronary angiography study, lending support to the importance of PDGF-A, PDGF-B and MCP-1 in the pathogenesis of atherosclerosis.

Atherosclerosis, coronary artery disease, secondary prevention, mononuclear cells, volunteer study

References

[1]

Ross
R
. Atherosclerosis-an inflammatory disease.
N Engl J Med
.
1999
;
340
:
115
–126

[2]

Rollins
BL
. Monocyte chemoattractant protein 1: a potential regulator of monocyte recruitment in inflammatory disease.
Mol Med Today
.
1996
;
2
:
198
–204

[3]

Kaminski
WE
, Jendraschak E, Kiefl R, von Schacky C. Dietary ω-3 fatty acids lower levels of PDGF mRNA in human mononuclear cells.
Blood
.
1993
;
81
:
1871
–1879

[4]

Jendraschak
E
, Kaminski WE, Kiefl R, von Schacky C. IGF-1, PDGF and CD-18 are adherence-responsive genes: regulation during human monocyte differentiation.
Biochim Biophys Acta
.
1998
;
1396
:
320
–335

[5]

Baumann
KH
, Hessel F, Larass I, et al. Dietary ω-3, ω-6, and ω-9 unsaturated fatty acids and growth factor and cytokine gene expression in unstimulated and stimulated monocytes: a randomized volunteer study.
Arterioscler Thromb Vase Biol
.
1999
;
19
:
59
–66

[6]

Jendraschak
E
, Kaminski WE, Hessel F, Kiefl R, von Schacky C. Growth factor mRNA profiles in unstimulated human mononuclear cells: Identification of genes which are constitutively and variably expressed.
Biochem Biophys Res Commun
.
1993
;
196
:
25
–31

[7]

von Schacky
C
, Angerer P, Kothny W, Theisen K, Mudra H. The effect of dietary ψ-3 fatty acids on coronary atherosclerosis. A randomized, double-blind placebo-controlled trial.
Ann Int Med
.
1999
;
130
:
554
–562

[8]

Brown
BG
, Zhao XQ, Poulin D, Albers JJ. Regression of coronary atherosclerosis. Does it occur and does it have clinical meaning?
Eur Heart J
.
1995
;
16
(Suppl E):
2
–5

[9]

Sacks
FM
, Stone PH, Gibson CM, Silverman DI, Rosner B, Pasternak RC. Controlled trial of fish oil for regression of human coronary atherosclerosis. HARP research group.
J Am Coll Cardiol
.
1995
;
25
:
1492
–1498

[10]

Angerer
P
, Kothny W, von Schacky C. Dietary ψ-3 fatty acids and human carotid atherosclerosis in patients with coronary artery disease: results of a randomized double-blind two-year intervention trial.
Eur Heart J
.
1998
;
19
:
125
(Abstr Suppl)

[11]

Burr
ML
, Fehily AM, Gilbert IF, et al. Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction. Diet and reinfarction trial (DART).
Lancet
.
1989
;
ii
:
757
–761

[12]

GISSI-Prevenzione Investigators. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial Infarction: Results of the GISSI-Prevenzione Trial.

Lancet
.
1999
;
354
:
447
–455

[13]

Angerer
P
, von Schacky C. n-3 polyunsaturated fatty acids and the cardiovascular system.
Curr Opin Lipidol
.
2000
;
11
:
57
–63

[14]

Goodfellow
J
, Bellamy ME, Ramsey MW, Jones CJ, Lewis MJ. Dietary supplementation with marine omega-3 fatty acids improve systemic large artery endothelial function in subjects with hypercholesterolemia.
J Am Coll Cardiol
.
2000
;
35
:
265
–270

[15]

Billman
GE
, Kang JX, Leaf A. Prevention of sudden cardiac death by dietary pure omega-3 polyunsaturated fatty acids in dogs.
Circulation
.
1999
;
99
:
2452
–2457

[16]

Christensen
JH
, Gustenhoff P, Korup E, et al. Effect of fish oil on heart rate variability in survivors of myocardial infarction: a double blind randomised controlled trial.
Br Med J
.
1996
;
312
:
677
–678

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