Collection
SARS-CoV-2 and COVID-19
FEMS Journals
FEMS are pleased to present a new Virtual Issue featuring the latest microbiology research on SARS-CoV-2 and COVID-19.
This is a free-to-read collection featuring articles from across the FEMS Journals. It aims to provide high quality and up to date research, including work on the development of vaccines during the time of COVID-19 (watch our FEMS Webinar on the subject), RNA respiratory viruses: influenza and coronaviruses, and Long-term and herd immunity against SARS-CoV-2.
We report here the first two French cases of COVID-associated cryptococcosis. We particularly emphasize the importance of performing blood cultures for the diagnosis of this infection, which is generally not suspected in this context.
Manuscript shows possible sources of cross-reactivity of pre-pandemic sera with SARS-CoV-2 proteins.
This review examines the role of SARS-CoV-2 nonstructural protein 1 (nsp1) in epigenetic silencing of innate antiviral immune response genes and discusses potential molecular mechanisms underlying the nsp1-mediated epigenetic reprogramming.
Because of the COVID-19 pandemic and the numerous mutations of the virus, it is necessary to research and find effective vaccines against it.
The role of traditional Indian system of medicine in managing the dysbiotic microbiome in the gut-lung axis is discussed in this review.
Editor's Choice
While future viral outbreaks are unavoidable, we should be able to forecast the time and location of the outbreaks and minimize their potential impacts through consistently funded research in the fields of virology and antiviral drug discovery. Visual representation of countries at risk for originating new viral outbreaks.
While future viral outbreaks are unavoidable, we should be able to forecast the time and location of the outbreaks and minimize their potential impacts through consistently funded research in the fields of virology and antiviral drug discovery. Visual representation of countries at risk for originating new viral outbreaks.
The present study reports on long-term adverse events in individuals vaccinated against COVID-19 with different vaccine platforms, and shows that although all the investigated COVID-19 vaccines led to some complications, protein subunit vaccines seem to be safer.
Quotients that contribute to success are discussed, and suggestions in the context of COVID-19 are provided to facilitate student success in science, technology, engineering, mathematics, and medicine (STEMM).
Tracking SARS-CoV-2 variants in wastewater is primarily performed by detecting characteristic mutations of the variants. Unlike the Delta variant, the emergence of the Omicron variant and its sublineages as variants of concern has posed a challenge in using characteristic mutations for wastewater ...
Analysis of a global dashboard of COVID-19 wastewater monitoring indicates that most monitoring is in High Income Countries and there is a need for great equity and open data sharing.
Wastewater surveillance has proven to be an effective tool to monitor the transmission and emergence of infectious agents at a community scale. Workflows for wastewater surveillance generally rely on concentration steps to increase the probability of detection of low-abundance targets, but ...
We review the unique advantages of the zebrafish model that may help to the identification and repurposing of drugs to treat COVID-19, to reveal the mechanism of action and side-effects of Spike-based vaccines, and to decipher the role of aging in COVID-19.
Background Infections with respiratory viruses [e.g. influenza and respiratory syncytial virus (RSV)] can increase the risk of severe pneumococcal infections. Likewise, pneumococcal coinfection is associated with poorer outcomes in viral respiratory infection. However, there are limited data ...
Adjuvant to improve SARS-CoV-2 humoral response and maternal–fetal transference.
The resource commitment required for wastewater-based surveillance inversely scales with infection prevalence.
Membrane computing technology simulates the effect of generalized or focused vaccination and lockdown in a town with detailed demographic complexity, experiencing an in silico SARS-Cov-2 epidemic over the course of 2.3 years.
This study demonstrates the impact of natural immunity on cellular and humoral immune kinetics, upon SARS-CoV-2 vaccination with the Janssen and Pfizer vaccine.
Wastewater grab samples are efficient and compare well to 24-hour composite samples when monitoring for the presence of SARS-CoV-2 in a low transmission community.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA is commonly excreted in the feces and urine of infected individuals and is, therefore, detected in wastewaters where infection is present in the surrounding population. Water reclamation plants (WRPs) that treat these wastewaters ...
Many colleges and universities utilized wastewater surveillance testing for SARS-CoV-2 RNA as a tool to help monitor and mitigate the COVID-19 pandemic on campuses across the USA during the 2020–2021 academic year. We sought to assess the efficacy of one such program by analyzing data on relative ...
With more than 6 million SARS-CoV-2 genomes sequenced, it is possible to look at the mutational frequencies along the mRNA viral genome; only ∼15 loci have significant mutations that stand out above the ‘white noise' background of random mutations.
Estimating COVID-19 case rates directly from SARS-CoV-2 RNA concentrations in domestic wastewater.
IgG responses to RBD and NP are dominated by conformational and linear epitopes, respectively.
COVID-19 patient bacteremias in a Greek referral hospital.
The purpose of this study was to conduct a preliminary assessment of the levels of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in wastewater at the Salitrillo Wastewater Treatment Plant in Texas during the initial peak of coronavirus disease 2019 (COVID-19) outbreak. Raw ...
Membrane computing technology is able to reproduce in-silico the demographic complexity of a town where COVID-19 is introduced. The model predicts the effect of non-pharmaceutical interventions on the epidemiogical dynamics, severity and mortality of the disease.
Human coronavirus OC43 persists for up to 48 h on leather, suggesting that leathers could act as fomites for transmission of coronaviruses.
Microbiological laboratory skills can be developed using a hybrid model combining synchronous on-site and online learning for students working in pairs.
The microbiology examination assignment at Istanbul Technical University during the coronavirus pandemic is an excellent example of assessing wider scientific literacy with respect to application in society.
Severe acute respiratory syndrome causing coronavirus 2 (SARS-CoV-2) has set off a pandemic with more than 3.8 million COVID-19 casualties. Although several emergency authorized vaccines are effective against the circulating strains, it is more important than ever to provide comprehensive information on the immunopathology of this agent.
Antibody testing for SARS-CoV-2 is widespread despite poor test validation and limited knowledge on antibody responses, which makes it crucial to understand both the potential, limitations and interpretation of serology.
A novel yeast biosensor concept for the detection of human-pathogenic viruses.
The authors expect their results will help advance understanding of the immune molecular regulatory networks influenced by the ACE2 receptor-mediated interaction in other body tissues, which could help find the secondary health complications associated with SARS-CoV-2 infection.
Development of vaccines in the times of COVID-19.
The authors analyze factors regarding asymptomatic COVID-19 and discuss the importance of identifying key clues to the development of therapeutic versatility against SARS-CoV-2.
Editor's Choice
This review reframes and puts into perspective SARS-CoV-2 receptor usage in the broader landscape of coronavirus spike interactions with animal host cell receptors.
This review reframes and puts into perspective SARS-CoV-2 receptor usage in the broader landscape of coronavirus spike interactions with animal host cell receptors.
Duration of SARS-CoV-2 RT-PCR positivity in Covid-19 patients.
In order to cope with the rapid spread of the COVID-19 pandemic, we compared and validated two SARS-CoV-2 RT-PCR systems.
Mini Review
Influenza virus and coronaviruses continue to cause pandemics across the globe and here we discuss their common and different properties.
Influenza virus and coronaviruses continue to cause pandemics across the globe and here we discuss their common and different properties.
Mini Review
An updated review of emerging cornoaviruses SARS-CoV, MERS-CoV, SARS-CoV-2, and potential therapeutic and preventive approaches.
An updated review of emerging cornoaviruses SARS-CoV, MERS-CoV, SARS-CoV-2, and potential therapeutic and preventive approaches.
Editor's Choice
Although wild birds are hosts to numerous species of gammacoronaviruses and deltacoronaviruses, some of which infect domestic birds or are able to spill-over into mammals, we reveal the limitations to our current understanding of their diversity, ecology and evolution.
Although wild birds are hosts to numerous species of gammacoronaviruses and deltacoronaviruses, some of which infect domestic birds or are able to spill-over into mammals, we reveal the limitations to our current understanding of their diversity, ecology and evolution.
Transcriptome-based drug repositioning for COVID-19 recovered two antiviral drugs and identified several candidate drugs, including saquinavir, ribavirin, dinoprost and dexamethasone.
Mini Review
This manuscript compares the effects of MERS, SARS and COVID-19 that may arise as damage to separate organ systems or as part of an immune mediated multi-organ failure.
This manuscript compares the effects of MERS, SARS and COVID-19 that may arise as damage to separate organ systems or as part of an immune mediated multi-organ failure.
The evidence of long-term clinical dynamic on SARS-CoV-2 re-positive case are less and awareness of atypical presentations such as this one is important to prompt the improvement of the management of COVID-19.
COVID-2019 pathology in the lung, bronchus, heart and intestine, which was first performed in China.
The authors analyze factors regarding COVID-19 and herd immunity, such percentage of immune population, the length and effectiveness of immune response and stability of the viral epitopes.
The global emergency due to the novel type of coronavirus (2019-nCoV) appeared in China highlights the high zoonotic potential of coronaviruses and the need of international collaboration to block viral spread.
On September 20, 2012, a Saudi Arabian physician reported the isolation of a novel coronavirus from a patient with pneumonia on ProMED mail. Within a few days, the same virus was detected in a Qatari patient receiving intensive care in a London hospital, a situation reminiscent of the role air ...
From the mid-1960s onwards, it was believed that only two human coronavirus species infect humans: HCoV-229E and HCoV-OC43. Then, in 2003, a novel member of the coronavirus family was introduced into the human population: SARS-CoV, causing an aggressive lung disease. Fortunately, this virus was ...
The pathogenesis of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is an important issue for the treatment and prevention of severe acute respiratory syndrome. Recently, SARS-CoV has been demonstrated to induce cell apoptosis in Vero-E6 cells. The possible role of SARS-CoV ...
Severe acute respiratory syndrome (SARS) is caused by SARS-coronavirus (SARS-CoV). Infection of Vero E6 cells with SARS-CoV inhibits cell proliferation. Our previous study indicated that Akt, which is poorly phosphorylated in confluent cultures of Vero E6 cells, is phosphorylated and then ...
Quasispecies composition and tissue distribution of feline coronaviruses (FCoVs) were studied in naturally infected cats. The genomic complexity of FCoVs was investigated using single-strand conformational polymorphism (SSCP) analysis of N and ORF7b amplicons, and the evolutionary process was ...
