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Latest GENETICS articles

Brief Investigations
Potassium-selective channelrhodopsins can exert hyper- or depolarizing effects in excitable cells of Caenorhabditis elegans, depending on experimental conditions
Christiane Ruse and others
Among the most frequent applications of optogenetic tools are those for depolarization of excitable cells such as neurons and muscles. Equally important are inhibitory tools that act through cellular hyperpolarization, which often rely on chloride conductance. Yet, in vivo , re- and ...
Investigation
Diploidy confers genomic instability in Schizosaccharomyces pombe
Joshua M Park and others
Whole genome duplication, or polyploidy, has been implicated in driving genome instability and tumorigenesis. Recent studies suggest that polyploidy in tumors promotes cancer genome evolution, progression, and chemoresistance resulting in worse prognosis of survival. The mechanisms by which whole ...
Investigation
rDNA copy number variation affects yeast fitness in response to different environments
Kevin Thornton and others
Ribosomal DNA (rDNA) in eukaryotes is maintained in hundreds of copies with rDNA copy number varying greatly among individuals within a species. In the budding yeast Saccharomyces cerevisiae , the rDNA copy number across wild isolates ranges from 90 to 300 copies. Previous studies showed that 35 ...
Investigation
TF2TG: an online resource mining the potential gene targets of transcription factors in Drosophila
Yanhui Hu and others
Sequence-specific transcription factors (TFs) are key regulators of many biological processes, controlling the expression of their target genes through binding to the cis- regulatory regions such as promoters and enhancers. Each TF has unique DNA binding site motifs, and large-scale experiments ...
Fungal Genetics and Genomics
Proximity labeling identification of plasma membrane eisosome proteins in Candida albicans
Carla E Lanze and others
The ability of Candida albicans to resist stressful conditions in the host and grow invasively into tissues contributes to the virulence of this human fungal pathogen. Plasma membrane subdomains known as the MCC (Membrane Compartment of Can1) or eisosomes are important for these processes. ...

Latest G3 articles

Genome Report
Chromosome-level genome assembly of Protandrena (Anthemurgus) passiflorae (Hymenoptera: Andrenidae), a host-plant specialist bee
Katherine A Parys and others
The passion flower bee, Protandrena ( Anthemurgus ) passiflorae (Robertson) is a monolectic, host-plant specialist of the passionflower plant Passiflora lutea L. Using a single adult male individual, we generated long-read PacBio HiFi, HiC, and short-read RNA sequencing data to build a ...
Investigation
Transposable elements and heterochromatic regions are enriched for structural variation and sequence divergence in the genome of wild type C. elegans
Zachary D Bush and others
Genomic structural variations (SVs) and transposable elements (TEs) can be significant contributors to genome evolution, gene expression alterations, and genetic disease risk. Recent advancements in long-read sequencing have greatly improved the quality of de novo genome assemblies and enhanced the ...
Fungal Genetics and Genomics
Mapping genomic regions associated with temperature stress in the wheat pathogen Zymoseptoria tritici
Jessica Stapley and others
Climate change can alter interactions between plants and their pathogens, which could adversely affect crop production. To better understand the molecular mechanisms underlying the responses of pathogenic fungal to temperature stress, we conducted a quantitative trait loci (QTL) mapping study in ...
Commentary
Consequences of drive on the evolution of genomes and species
Logan T Edvalson and Amanda M Larracuente
Meiosis ordinarily ensures the fair segregation of alleles to gametes, a fundamental principle of Mendelian genetics. Meiotic drivers (hereafter drivers) are selfish genetic elements that subvert the fairness of meiosis by biasing their transmission to the next generation at the expense of the ...
Plant Genetics and Genomics
A global assembly of landrace oat (Avena sativa L.) accessions is a discovery resource for adaptive variation, association mapping, and trait deployment
Afrina Rahman and others
Crop adaptation to environmental shifts will require genetic resources that are different from those currently deployed. The rapid global shift to both warmer temperatures and unpredictable atmospheric events must be considered in developing new breeding populations for local environments. Oats ( ...

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